SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1n97'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EE2_B_CHDB1250_0
(ALCOHOL
DEHYDROGENASE)		 1n97 CYP175A1
(Thermus
thermophilus) 		3 / 3 MET A 132
LEU A 135
SER A 136
 None
 0.57A 1ee2A-1n97A:
0.0		 1ee2A-1n97A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KGL_A_RTLA175_0
(CELLULAR
RETINOL-BINDING
PROTEIN TYPE I)		 1n97 CYP175A1
(Thermus
thermophilus) 		5 / 12 PHE A  35
ALA A  44
ARG A 274
GLY A 289
LEU A   6
 None
 1.06A 1kglA-1n97A:
undetectable		 1kglA-1n97A:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_E_THAE5_2
(LIVER
CARBOXYLESTERASE I)		 1n97 CYP175A1
(Thermus
thermophilus) 		3 / 3 PHE A 341
LEU A 144
LEU A 218
 HEM  A 602 ( 4.9A)
None
HEM  A 602 ( 4.9A)
 0.66A 1mx1E-1n97A:
undetectable		 1mx1E-1n97A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1n97 CYP175A1
(Thermus
thermophilus) 		3 / 3 LEU A  21
PRO A  20
LEU A  24
 None
 0.53A 2po5B-1n97A:
undetectable		 2po5B-1n97A:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1498_1
(CYTOCHROME P450 3A4)		 1n97 CYP175A1
(Thermus
thermophilus) 		5 / 12 LEU A 236
LEU A 237
PHE A 310
ALA A 229
ARG A 355
 None
None
None
HEM  A 602 ( 4.2A)
None
 1.09A 2v0mC-1n97A:
33.4		 2v0mC-1n97A:
24.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E4E_A_4PZA501_1
(CYTOCHROME P450 2E1)		 1n97 CYP175A1
(Thermus
thermophilus) 		3 / 3 ALA A 221
THR A 225
CYH A 336
 HEM  A 602 (-3.3A)
HEM  A 602 (-3.8A)
HEM  A 602 (-2.2A)
 0.52A 3e4eA-1n97A:
32.0		 3e4eA-1n97A:
26.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E4E_B_4PZB501_1
(CYTOCHROME P450 2E1)		 1n97 CYP175A1
(Thermus
thermophilus) 		3 / 3 ALA A 221
THR A 225
CYH A 336
 HEM  A 602 (-3.3A)
HEM  A 602 (-3.8A)
HEM  A 602 (-2.2A)
 0.48A 3e4eB-1n97A:
32.0		 3e4eB-1n97A:
26.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_B_ECLB600_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1n97 CYP175A1
(Thermus
thermophilus) 		4 / 8 LEU A 219
TYR A 191
GLY A  78
ILE A 164
 None
 0.82A 3jusB-1n97A:
37.4		 3jusB-1n97A:
26.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_B_TFPB202_1
(PROTEIN S100-A4)		 1n97 CYP175A1
(Thermus
thermophilus) 		3 / 3 GLU A 131
LEU A 128
ASP A 129
 None
 0.48A 3ko0A-1n97A:
undetectable		 3ko0A-1n97A:
14.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MDT_B_VORB506_1
(CHOLESTEROL
24-HYDROXYLASE)		 1n97 CYP175A1
(Thermus
thermophilus) 		5 / 11 TYR A  68
ALA A 221
THR A 225
ALA A 268
THR A 372
 HEM  A 602 (-4.6A)
HEM  A 602 (-3.3A)
HEM  A 602 (-3.8A)
HEM  A 602 ( 4.0A)
None
 0.93A 3mdtB-1n97A:
40.0		 3mdtB-1n97A:
31.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MDT_B_VORB506_1
(CHOLESTEROL
24-HYDROXYLASE)		 1n97 CYP175A1
(Thermus
thermophilus) 		5 / 11 TYR A  68
LEU A  71
THR A 225
ALA A 268
THR A 372
 HEM  A 602 (-4.6A)
EDO  A 715 ( 4.9A)
HEM  A 602 (-3.8A)
HEM  A 602 ( 4.0A)
None
 1.08A 3mdtB-1n97A:
40.0		 3mdtB-1n97A:
31.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MDV_B_CL6B506_1
(CHOLESTEROL
24-HYDROXYLASE)		 1n97 CYP175A1
(Thermus
thermophilus) 		5 / 12 THR A 217
ALA A 221
THR A 225
ALA A 268
THR A 372
 None
HEM  A 602 (-3.3A)
HEM  A 602 (-3.8A)
HEM  A 602 ( 4.0A)
None
 0.72A 3mdvB-1n97A:
40.3		 3mdvB-1n97A:
31.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_A_C2FA1100_0
(GLYCINE
N-METHYLTRANSFERASE)		 1n97 CYP175A1
(Thermus
thermophilus) 		4 / 6 SER A 228
LEU A 133
HIS A 130
THR A 231
 None
EDO  A 718 (-3.8A)
None
None
 1.44A 3thrB-1n97A:
undetectable		 3thrB-1n97A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DM8_B_REAB1501_1
(RETINOIC ACID
RECEPTOR BETA)		 1n97 CYP175A1
(Thermus
thermophilus) 		5 / 12 LEU A  43
ALA A  44
LEU A 279
LEU A 286
LEU A  56
 None
 1.06A 4dm8B-1n97A:
undetectable		 4dm8B-1n97A:
21.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ENH_A_FVXA602_1
(CHOLESTEROL
24-HYDROXYLASE)		 1n97 CYP175A1
(Thermus
thermophilus) 		5 / 12 ALA A 221
THR A 225
ALA A 268
TRP A 269
THR A 372
 HEM  A 602 (-3.3A)
HEM  A 602 (-3.8A)
HEM  A 602 ( 4.0A)
EDO  A 715 ( 4.4A)
None
 0.92A 4enhA-1n97A:
40.2		 4enhA-1n97A:
31.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGK_A_0TXA302_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1n97 CYP175A1
(Thermus
thermophilus) 		4 / 6 GLN A 244
PHE A 354
PHE A 357
PHE A 353
 None
 1.23A 4fgkA-1n97A:
undetectable		 4fgkA-1n97A:
18.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4J14_A_X2NA602_1
(CHOLESTEROL
24-HYDROXYLASE)		 1n97 CYP175A1
(Thermus
thermophilus) 		6 / 10 ALA A  70
LEU A  71
ALA A 221
THR A 225
ALA A 268
THR A 372
 None
EDO  A 715 ( 4.9A)
HEM  A 602 (-3.3A)
HEM  A 602 (-3.8A)
HEM  A 602 ( 4.0A)
None
 0.97A 4j14A-1n97A:
39.3		 4j14A-1n97A:
31.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBS_A_DIFA503_1
(PENTALENIC ACID
SYNTHASE)		 1n97 CYP175A1
(Thermus
thermophilus) 		4 / 7 THR A 225
ALA A 268
LEU A 271
ARG A 273
 HEM  A 602 (-3.8A)
HEM  A 602 ( 4.0A)
HEM  A 602 ( 4.2A)
HEM  A 602 (-2.9A)
 0.55A 4ubsA-1n97A:
33.2		 4ubsA-1n97A:
28.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZOW_A_CLMA500_0
(MULTIDRUG
TRANSPORTER MDFA)		 1n97 CYP175A1
(Thermus
thermophilus) 		6 / 11 LEU A  74
LEU A  71
LEU A 140
LEU A 153
LEU A 190
LEU A 149
 None
EDO  A 715 ( 4.9A)
None
None
None
None
 1.44A 4zowA-1n97A:
0.0		 4zowA-1n97A:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNZ_B_TA1B902_2
(TUBULIN BETA-2B
CHAIN)		 1n97 CYP175A1
(Thermus
thermophilus) 		3 / 3 LEU A 219
LEU A 190
ARG A  77
 None
 0.48A 5hnzB-1n97A:
undetectable		 5hnzB-1n97A:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1n97 CYP175A1
(Thermus
thermophilus) 		5 / 12 LEU A 149
SER A 150
LEU A 203
ALA A 194
LEU A 190
 None
 1.31A 5iktB-1n97A:
0.0		 5iktB-1n97A:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBV_D_FI8D1904_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 1n97 CYP175A1
(Thermus
thermophilus) 		4 / 8 ARG A 319
ARG A 339
VAL A 226
ARG A  91
 SRT  A 601 (-4.4A)
SRT  A 601 (-2.9A)
HEM  A 602 ( 4.2A)
HEM  A 602 (-3.9A)
 1.09A 6fbvD-1n97A:
1.5		 6fbvD-1n97A:
16.77