SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1nav'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1BSX_A_T3A1_1
(PROTEIN (THYROID
HORMONE RECEPTOR
BETA))		 1nav HORMONE RECEPTOR
ALPHA 1, THRA1
(Homo
sapiens) 		12 / 12 ILE A 221
ILE A 222
ARG A 228
MET A 256
MET A 259
ALA A 263
LEU A 276
LEU A 292
ILE A 299
HIS A 381
MET A 388
PHE A 401
 None
IH5  A 600 (-4.3A)
IH5  A 600 (-4.2A)
IH5  A 600 (-3.6A)
IH5  A 600 (-4.7A)
IH5  A 600 ( 3.8A)
IH5  A 600 (-4.0A)
IH5  A 600 (-4.7A)
IH5  A 600 (-4.7A)
IH5  A 600 (-3.7A)
IH5  A 600 (-3.8A)
IH5  A 600 (-4.4A)
 0.66A 1bsxA-1navA:
37.4		 1bsxA-1navA:
83.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1BSX_A_T3A1_1
(PROTEIN (THYROID
HORMONE RECEPTOR
BETA))		 1nav HORMONE RECEPTOR
ALPHA 1, THRA1
(Homo
sapiens) 		6 / 12 ILE A 222
MET A 259
LEU A 292
ILE A 377
MET A 388
PHE A 401
 IH5  A 600 (-4.3A)
IH5  A 600 (-4.7A)
IH5  A 600 (-4.7A)
None
IH5  A 600 (-3.8A)
IH5  A 600 (-4.4A)
 1.44A 1bsxA-1navA:
37.4		 1bsxA-1navA:
83.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1BSX_B_T3B2_1
(PROTEIN (THYROID
HORMONE RECEPTOR
BETA))		 1nav HORMONE RECEPTOR
ALPHA 1, THRA1
(Homo
sapiens) 		12 / 12 ILE A 221
ILE A 222
ARG A 228
MET A 256
MET A 259
ALA A 263
LEU A 276
LEU A 292
ILE A 299
HIS A 381
MET A 388
PHE A 401
 None
IH5  A 600 (-4.3A)
IH5  A 600 (-4.2A)
IH5  A 600 (-3.6A)
IH5  A 600 (-4.7A)
IH5  A 600 ( 3.8A)
IH5  A 600 (-4.0A)
IH5  A 600 (-4.7A)
IH5  A 600 (-4.7A)
IH5  A 600 (-3.7A)
IH5  A 600 (-3.8A)
IH5  A 600 (-4.4A)
 0.66A 1bsxB-1navA:
37.5		 1bsxB-1navA:
83.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1BSX_B_T3B2_1
(PROTEIN (THYROID
HORMONE RECEPTOR
BETA))		 1nav HORMONE RECEPTOR
ALPHA 1, THRA1
(Homo
sapiens) 		6 / 12 ILE A 222
MET A 259
LEU A 292
ILE A 377
MET A 388
PHE A 401
 IH5  A 600 (-4.3A)
IH5  A 600 (-4.7A)
IH5  A 600 (-4.7A)
None
IH5  A 600 (-3.8A)
IH5  A 600 (-4.4A)
 1.44A 1bsxB-1navA:
37.5		 1bsxB-1navA:
83.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_2
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1nav HORMONE RECEPTOR
ALPHA 1, THRA1
(Homo
sapiens) 		3 / 3 ILE A 258
LEU A 261
VAL A 265
 None
 0.35A 1mz9B-1navA:
undetectable		 1mz9B-1navA:
11.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XZX_X_T3X500_1
(THYROID HORMONE
RECEPTOR BETA-1)		 1nav HORMONE RECEPTOR
ALPHA 1, THRA1
(Homo
sapiens) 		12 / 12 ILE A 221
ILE A 222
ALA A 225
ARG A 228
MET A 256
MET A 259
LEU A 276
LEU A 292
ILE A 299
HIS A 381
MET A 388
PHE A 401
 None
IH5  A 600 (-4.3A)
IH5  A 600 (-3.5A)
IH5  A 600 (-4.2A)
IH5  A 600 (-3.6A)
IH5  A 600 (-4.7A)
IH5  A 600 (-4.0A)
IH5  A 600 (-4.7A)
IH5  A 600 (-4.7A)
IH5  A 600 (-3.7A)
IH5  A 600 (-3.8A)
IH5  A 600 (-4.4A)
 0.69A 1xzxX-1navA:
37.1		 1xzxX-1navA:
83.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XZX_X_T3X500_1
(THYROID HORMONE
RECEPTOR BETA-1)		 1nav HORMONE RECEPTOR
ALPHA 1, THRA1
(Homo
sapiens) 		7 / 12 ILE A 222
ALA A 225
MET A 259
LEU A 292
ILE A 377
MET A 388
PHE A 401
 IH5  A 600 (-4.3A)
IH5  A 600 (-3.5A)
IH5  A 600 (-4.7A)
IH5  A 600 (-4.7A)
None
IH5  A 600 (-3.8A)
IH5  A 600 (-4.4A)
 1.25A 1xzxX-1navA:
37.1		 1xzxX-1navA:
83.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1Y0X_X_T44X500_1
(THYROID HORMONE
RECEPTOR BETA-1)		 1nav HORMONE RECEPTOR
ALPHA 1, THRA1
(Homo
sapiens) 		11 / 12 ILE A 222
ALA A 225
ARG A 228
MET A 256
MET A 259
LEU A 292
ILE A 299
HIS A 381
MET A 388
PHE A 401
PHE A 405
 IH5  A 600 (-4.3A)
IH5  A 600 (-3.5A)
IH5  A 600 (-4.2A)
IH5  A 600 (-3.6A)
IH5  A 600 (-4.7A)
IH5  A 600 (-4.7A)
IH5  A 600 (-4.7A)
IH5  A 600 (-3.7A)
IH5  A 600 (-3.8A)
IH5  A 600 (-4.4A)
None
 0.71A 1y0xX-1navA:
37.3		 1y0xX-1navA:
83.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1Y0X_X_T44X500_1
(THYROID HORMONE
RECEPTOR BETA-1)		 1nav HORMONE RECEPTOR
ALPHA 1, THRA1
(Homo
sapiens) 		9 / 12 ILE A 222
ALA A 225
ARG A 266
LEU A 292
ILE A 299
HIS A 381
MET A 388
PHE A 401
PHE A 405
 IH5  A 600 (-4.3A)
IH5  A 600 (-3.5A)
None
IH5  A 600 (-4.7A)
IH5  A 600 (-4.7A)
IH5  A 600 (-3.7A)
IH5  A 600 (-3.8A)
IH5  A 600 (-4.4A)
None
 0.79A 1y0xX-1navA:
37.3		 1y0xX-1navA:
83.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1Y0X_X_T44X500_1
(THYROID HORMONE
RECEPTOR BETA-1)		 1nav HORMONE RECEPTOR
ALPHA 1, THRA1
(Homo
sapiens) 		7 / 12 ILE A 222
ALA A 225
MET A 259
LEU A 292
ILE A 377
MET A 388
PHE A 401
 IH5  A 600 (-4.3A)
IH5  A 600 (-3.5A)
IH5  A 600 (-4.7A)
IH5  A 600 (-4.7A)
None
IH5  A 600 (-3.8A)
IH5  A 600 (-4.4A)
 1.27A 1y0xX-1navA:
37.3		 1y0xX-1navA:
83.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1Y0X_X_T44X500_2
(THYROID HORMONE
RECEPTOR BETA-1)		 1nav HORMONE RECEPTOR
ALPHA 1, THRA1
(Homo
sapiens) 		4 / 5 ILE A 221
SER A 260
ARG A 262
LEU A 276
 None
IH5  A 600 ( 4.0A)
None
IH5  A 600 (-4.0A)
 0.21A 1y0xX-1navA:
37.3		 1y0xX-1navA:
83.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2H77_A_T3A1_1
(THRA PROTEIN)		 1nav HORMONE RECEPTOR
ALPHA 1, THRA1
(Homo
sapiens) 		12 / 12 ILE A 222
ALA A 225
ARG A 228
MET A 256
MET A 259
ALA A 263
LEU A 276
SER A 277
LEU A 292
ILE A 299
HIS A 381
PHE A 401
 IH5  A 600 (-4.3A)
IH5  A 600 (-3.5A)
IH5  A 600 (-4.2A)
IH5  A 600 (-3.6A)
IH5  A 600 (-4.7A)
IH5  A 600 ( 3.8A)
IH5  A 600 (-4.0A)
IH5  A 600 (-4.3A)
IH5  A 600 (-4.7A)
IH5  A 600 (-4.7A)
IH5  A 600 (-3.7A)
IH5  A 600 (-4.4A)
 0.71A 2h77A-1navA:
37.8		 2h77A-1navA:
99.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2H77_A_T3A1_1
(THRA PROTEIN)		 1nav HORMONE RECEPTOR
ALPHA 1, THRA1
(Homo
sapiens) 		6 / 12 ILE A 222
ALA A 225
MET A 259
LEU A 292
ILE A 377
PHE A 401
 IH5  A 600 (-4.3A)
IH5  A 600 (-3.5A)
IH5  A 600 (-4.7A)
IH5  A 600 (-4.7A)
None
IH5  A 600 (-4.4A)
 1.35A 2h77A-1navA:
37.8		 2h77A-1navA:
99.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2H79_A_T3A1_1
(THRA PROTEIN)		 1nav HORMONE RECEPTOR
ALPHA 1, THRA1
(Homo
sapiens) 		11 / 12 ILE A 221
ILE A 222
ALA A 225
MET A 256
ALA A 263
LEU A 276
SER A 277
LEU A 292
ILE A 299
HIS A 381
PHE A 401
 None
IH5  A 600 (-4.3A)
IH5  A 600 (-3.5A)
IH5  A 600 (-3.6A)
IH5  A 600 ( 3.8A)
IH5  A 600 (-4.0A)
IH5  A 600 (-4.3A)
IH5  A 600 (-4.7A)
IH5  A 600 (-4.7A)
IH5  A 600 (-3.7A)
IH5  A 600 (-4.4A)
 0.42A 2h79A-1navA:
37.5		 2h79A-1navA:
99.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2H79_A_T3A1_1
(THRA PROTEIN)		 1nav HORMONE RECEPTOR
ALPHA 1, THRA1
(Homo
sapiens) 		11 / 12 ILE A 222
ALA A 225
ARG A 228
MET A 256
ALA A 263
LEU A 276
SER A 277
LEU A 292
ILE A 299
HIS A 381
PHE A 401
 IH5  A 600 (-4.3A)
IH5  A 600 (-3.5A)
IH5  A 600 (-4.2A)
IH5  A 600 (-3.6A)
IH5  A 600 ( 3.8A)
IH5  A 600 (-4.0A)
IH5  A 600 (-4.3A)
IH5  A 600 (-4.7A)
IH5  A 600 (-4.7A)
IH5  A 600 (-3.7A)
IH5  A 600 (-4.4A)
 0.68A 2h79A-1navA:
37.5		 2h79A-1navA:
99.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GWS_X_T3X500_1
(THYROID HORMONE
RECEPTOR BETA)		 1nav HORMONE RECEPTOR
ALPHA 1, THRA1
(Homo
sapiens) 		7 / 12 ALA A 225
ARG A 228
ALA A 263
LEU A 276
LEU A 292
ILE A 299
PHE A 405
 IH5  A 600 (-3.5A)
IH5  A 600 (-4.2A)
IH5  A 600 ( 3.8A)
IH5  A 600 (-4.0A)
IH5  A 600 (-4.7A)
IH5  A 600 (-4.7A)
None
 1.49A 3gwsX-1navA:
37.2		 3gwsX-1navA:
83.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GWS_X_T3X500_1
(THYROID HORMONE
RECEPTOR BETA)		 1nav HORMONE RECEPTOR
ALPHA 1, THRA1
(Homo
sapiens) 		12 / 12 ILE A 221
ILE A 222
ALA A 225
ARG A 228
MET A 256
MET A 259
ALA A 263
LEU A 276
LEU A 292
ILE A 299
HIS A 381
PHE A 401
 None
IH5  A 600 (-4.3A)
IH5  A 600 (-3.5A)
IH5  A 600 (-4.2A)
IH5  A 600 (-3.6A)
IH5  A 600 (-4.7A)
IH5  A 600 ( 3.8A)
IH5  A 600 (-4.0A)
IH5  A 600 (-4.7A)
IH5  A 600 (-4.7A)
IH5  A 600 (-3.7A)
IH5  A 600 (-4.4A)
 0.66A 3gwsX-1navA:
37.2		 3gwsX-1navA:
83.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GWS_X_T3X500_1
(THYROID HORMONE
RECEPTOR BETA)		 1nav HORMONE RECEPTOR
ALPHA 1, THRA1
(Homo
sapiens) 		6 / 12 ILE A 222
ALA A 225
MET A 259
LEU A 292
ILE A 377
PHE A 401
 IH5  A 600 (-4.3A)
IH5  A 600 (-3.5A)
IH5  A 600 (-4.7A)
IH5  A 600 (-4.7A)
None
IH5  A 600 (-4.4A)
 1.31A 3gwsX-1navA:
37.2		 3gwsX-1navA:
83.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_B_SAMB301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 1nav HORMONE RECEPTOR
ALPHA 1, THRA1
(Homo
sapiens) 		5 / 12 GLY A 303
ILE A 299
ASP A 268
LEU A 274
ARG A 266
 None
IH5  A 600 (-4.7A)
None
None
None
 1.33A 3iv6B-1navA:
undetectable		 3iv6B-1navA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_A_CELA701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1nav HORMONE RECEPTOR
ALPHA 1, THRA1
(Homo
sapiens) 		4 / 6 VAL A 265
LEU A 236
ILE A 168
LEU A 261
 None
 0.94A 3kk6A-1navA:
undetectable		 3kk6A-1navA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_A_D16A520_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1nav HORMONE RECEPTOR
ALPHA 1, THRA1
(Homo
sapiens) 		5 / 12 ASP A 312
LEU A 311
ILE A 360
LEU A 367
THR A 314
 None
 1.07A 3nrrA-1navA:
undetectable		 3nrrA-1navA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_B_D16B520_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1nav HORMONE RECEPTOR
ALPHA 1, THRA1
(Homo
sapiens) 		5 / 12 ASP A 312
LEU A 311
ILE A 360
LEU A 367
THR A 314
 None
 1.07A 3nrrB-1navA:
undetectable		 3nrrB-1navA:
19.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UVV_A_T3A501_1
(THYROID HORMONE
RECEPTOR ALPHA)		 1nav HORMONE RECEPTOR
ALPHA 1, THRA1
(Homo
sapiens) 		12 / 12 ILE A 221
ILE A 222
ALA A 225
MET A 256
ALA A 263
LEU A 276
LEU A 287
LEU A 292
ILE A 299
HIS A 381
MET A 388
PHE A 401
 None
IH5  A 600 (-4.3A)
IH5  A 600 (-3.5A)
IH5  A 600 (-3.6A)
IH5  A 600 ( 3.8A)
IH5  A 600 (-4.0A)
None
IH5  A 600 (-4.7A)
IH5  A 600 (-4.7A)
IH5  A 600 (-3.7A)
IH5  A 600 (-3.8A)
IH5  A 600 (-4.4A)
 0.51A 3uvvA-1navA:
36.4		 3uvvA-1navA:
90.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UVV_A_T3A501_2
(THYROID HORMONE
RECEPTOR ALPHA)		 1nav HORMONE RECEPTOR
ALPHA 1, THRA1
(Homo
sapiens) 		3 / 3 ARG A 228
MET A 259
ARG A 262
 IH5  A 600 (-4.2A)
IH5  A 600 (-4.7A)
None
 0.49A 3uvvA-1navA:
36.4		 3uvvA-1navA:
90.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LNW_A_T3A501_1
(THYROID HORMONE
RECEPTOR ALPHA)		 1nav HORMONE RECEPTOR
ALPHA 1, THRA1
(Homo
sapiens) 		12 / 12 ILE A 222
ALA A 225
ARG A 228
MET A 256
ALA A 263
LEU A 276
SER A 277
LEU A 292
ILE A 299
HIS A 381
MET A 388
PHE A 401
 IH5  A 600 (-4.3A)
IH5  A 600 (-3.5A)
IH5  A 600 (-4.2A)
IH5  A 600 (-3.6A)
IH5  A 600 ( 3.8A)
IH5  A 600 (-4.0A)
IH5  A 600 (-4.3A)
IH5  A 600 (-4.7A)
IH5  A 600 (-4.7A)
IH5  A 600 (-3.7A)
IH5  A 600 (-3.8A)
IH5  A 600 (-4.4A)
 0.77A 4lnwA-1navA:
37.5		 4lnwA-1navA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LNW_A_T3A501_1
(THYROID HORMONE
RECEPTOR ALPHA)		 1nav HORMONE RECEPTOR
ALPHA 1, THRA1
(Homo
sapiens) 		6 / 12 ILE A 222
ALA A 225
LEU A 292
ILE A 377
MET A 388
PHE A 401
 IH5  A 600 (-4.3A)
IH5  A 600 (-3.5A)
IH5  A 600 (-4.7A)
None
IH5  A 600 (-3.8A)
IH5  A 600 (-4.4A)
 1.28A 4lnwA-1navA:
37.5		 4lnwA-1navA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LNW_A_T3A501_2
(THYROID HORMONE
RECEPTOR ALPHA)		 1nav HORMONE RECEPTOR
ALPHA 1, THRA1
(Homo
sapiens) 		3 / 3 ILE A 221
MET A 259
ARG A 262
 None
IH5  A 600 (-4.7A)
None
 0.29A 4lnwA-1navA:
37.5		 4lnwA-1navA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LNW_A_T3A502_1
(THYROID HORMONE
RECEPTOR ALPHA)		 1nav HORMONE RECEPTOR
ALPHA 1, THRA1
(Homo
sapiens) 		5 / 8 GLU A 339
GLN A 342
MET A 369
VAL A 371
ARG A 375
 None
 1.32A 4lnwA-1navA:
37.5		 4lnwA-1navA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LNW_A_T3A502_1
(THYROID HORMONE
RECEPTOR ALPHA)		 1nav HORMONE RECEPTOR
ALPHA 1, THRA1
(Homo
sapiens) 		7 / 8 SER A 326
ASP A 328
GLU A 339
GLN A 342
VAL A 371
THR A 372
ARG A 375
 None
 1.22A 4lnwA-1navA:
37.5		 4lnwA-1navA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LNX_A_T3A502_1
(THYROID HORMONE
RECEPTOR ALPHA)		 1nav HORMONE RECEPTOR
ALPHA 1, THRA1
(Homo
sapiens) 		12 / 12 ILE A 222
ALA A 225
ARG A 228
MET A 256
ALA A 263
LEU A 276
SER A 277
LEU A 292
ILE A 299
HIS A 381
MET A 388
PHE A 401
 IH5  A 600 (-4.3A)
IH5  A 600 (-3.5A)
IH5  A 600 (-4.2A)
IH5  A 600 (-3.6A)
IH5  A 600 ( 3.8A)
IH5  A 600 (-4.0A)
IH5  A 600 (-4.3A)
IH5  A 600 (-4.7A)
IH5  A 600 (-4.7A)
IH5  A 600 (-3.7A)
IH5  A 600 (-3.8A)
IH5  A 600 (-4.4A)
 0.78A 4lnxA-1navA:
37.5		 4lnxA-1navA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LNX_A_T3A502_1
(THYROID HORMONE
RECEPTOR ALPHA)		 1nav HORMONE RECEPTOR
ALPHA 1, THRA1
(Homo
sapiens) 		6 / 12 ILE A 222
ALA A 225
LEU A 292
ILE A 377
MET A 388
PHE A 401
 IH5  A 600 (-4.3A)
IH5  A 600 (-3.5A)
IH5  A 600 (-4.7A)
None
IH5  A 600 (-3.8A)
IH5  A 600 (-4.4A)
 1.29A 4lnxA-1navA:
37.5		 4lnxA-1navA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LNX_A_T3A502_2
(THYROID HORMONE
RECEPTOR ALPHA)		 1nav HORMONE RECEPTOR
ALPHA 1, THRA1
(Homo
sapiens) 		3 / 3 ILE A 221
MET A 259
ARG A 262
 None
IH5  A 600 (-4.7A)
None
 0.26A 4lnxA-1navA:
37.5		 4lnxA-1navA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LNX_A_T44A501_1
(THYROID HORMONE
RECEPTOR ALPHA)		 1nav HORMONE RECEPTOR
ALPHA 1, THRA1
(Homo
sapiens) 		5 / 6 GLU A 339
GLN A 342
VAL A 371
THR A 372
ARG A 375
 None
 1.12A 4lnxA-1navA:
37.5		 4lnxA-1navA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LNX_A_T44A501_1
(THYROID HORMONE
RECEPTOR ALPHA)		 1nav HORMONE RECEPTOR
ALPHA 1, THRA1
(Homo
sapiens) 		5 / 6 SER A 326
GLU A 339
GLN A 342
THR A 372
ARG A 375
 None
 1.35A 4lnxA-1navA:
37.5		 4lnxA-1navA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_C_CHDC102_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 1nav HORMONE RECEPTOR
ALPHA 1, THRA1
(Homo
sapiens) 		4 / 7 GLU A 315
LEU A 319
LEU A 261
LEU A 374
 None
 0.75A 4wg0B-1navA:
undetectable
4wg0C-1navA:
undetectable		 4wg0B-1navA:
4.94
4wg0C-1navA:
4.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_L_CHDL103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 1nav HORMONE RECEPTOR
ALPHA 1, THRA1
(Homo
sapiens) 		4 / 7 LEU A 261
LEU A 374
GLU A 315
LEU A 319
 None
 0.79A 4wg0L-1navA:
undetectable
4wg0M-1navA:
undetectable		 4wg0L-1navA:
4.94
4wg0M-1navA:
4.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XOY_A_DX4A401_0
(MITOGEN-ACTIVATED
PROTEIN KINASE 1)		 1nav HORMONE RECEPTOR
ALPHA 1, THRA1
(Homo
sapiens) 		4 / 6 ALA A 317
GLN A 320
LEU A 318
LEU A 236
 None
 1.18A 4xoyA-1navA:
undetectable		 4xoyA-1navA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XTA_A_DIFA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1nav HORMONE RECEPTOR
ALPHA 1, THRA1
(Homo
sapiens) 		4 / 9 SER A 260
ALA A 263
LEU A 287
ILE A 222
 IH5  A 600 ( 4.0A)
IH5  A 600 ( 3.8A)
None
IH5  A 600 (-4.3A)
 0.86A 4xtaA-1navA:
22.6		 4xtaA-1navA:
28.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XTA_A_DIFA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1nav HORMONE RECEPTOR
ALPHA 1, THRA1
(Homo
sapiens) 		4 / 9 SER A 260
ALA A 263
LEU A 292
ILE A 222
 IH5  A 600 ( 4.0A)
IH5  A 600 ( 3.8A)
IH5  A 600 (-4.7A)
IH5  A 600 (-4.3A)
 0.97A 4xtaA-1navA:
22.6		 4xtaA-1navA:
28.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ZO1_X_T3X500_1
(THYROID HORMONE
RECEPTOR BETA)		 1nav HORMONE RECEPTOR
ALPHA 1, THRA1
(Homo
sapiens) 		10 / 12 ILE A 222
ALA A 225
ARG A 228
MET A 256
MET A 259
ALA A 263
LEU A 276
HIS A 381
MET A 388
PHE A 401
 IH5  A 600 (-4.3A)
IH5  A 600 (-3.5A)
IH5  A 600 (-4.2A)
IH5  A 600 (-3.6A)
IH5  A 600 (-4.7A)
IH5  A 600 ( 3.8A)
IH5  A 600 (-4.0A)
IH5  A 600 (-3.7A)
IH5  A 600 (-3.8A)
IH5  A 600 (-4.4A)
 0.75A 4zo1X-1navA:
37.4		 4zo1X-1navA:
81.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ZO1_X_T3X500_1
(THYROID HORMONE
RECEPTOR BETA)		 1nav HORMONE RECEPTOR
ALPHA 1, THRA1
(Homo
sapiens) 		6 / 12 ILE A 222
ALA A 263
ARG A 266
LEU A 276
MET A 388
PHE A 401
 IH5  A 600 (-4.3A)
IH5  A 600 ( 3.8A)
None
IH5  A 600 (-4.0A)
IH5  A 600 (-3.8A)
IH5  A 600 (-4.4A)
 1.13A 4zo1X-1navA:
37.4		 4zo1X-1navA:
81.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_E_IPHE101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 1nav HORMONE RECEPTOR
ALPHA 1, THRA1
(Homo
sapiens) 		4 / 7 ILE A 170
HIS A 175
LEU A 318
ALA A 321
 None
 0.87A 5hrqE-1navA:
undetectable
5hrqF-1navA:
undetectable
5hrqJ-1navA:
undetectable		 5hrqE-1navA:
9.25
5hrqF-1navA:
9.69
5hrqJ-1navA:
9.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OG9_A_TESA503_1
(-)		 1nav HORMONE RECEPTOR
ALPHA 1, THRA1
(Homo
sapiens) 		5 / 9 LEU A 287
LEU A 276
MET A 388
ALA A 225
MET A 259
 None
IH5  A 600 (-4.0A)
IH5  A 600 (-3.8A)
IH5  A 600 (-3.5A)
IH5  A 600 (-4.7A)
 1.30A 5og9A-1navA:
undetectable		 5og9A-1navA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TL8_A_X2NA502_1
(PROTEIN CYP51)		 1nav HORMONE RECEPTOR
ALPHA 1, THRA1
(Homo
sapiens) 		5 / 12 PHE A 232
ALA A 174
PHE A 349
PHE A 363
ALA A 308
 None
 1.19A 5tl8A-1navA:
undetectable		 5tl8A-1navA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UTU_F_ADNF503_1
(ADENOSYLHOMOCYSTEINA
SE)		 1nav HORMONE RECEPTOR
ALPHA 1, THRA1
(Homo
sapiens) 		5 / 12 LEU A 276
THR A 219
LEU A 292
HIS A 381
MET A 256
 IH5  A 600 (-4.0A)
IH5  A 600 (-4.6A)
IH5  A 600 (-4.7A)
IH5  A 600 (-3.7A)
IH5  A 600 (-3.6A)
 1.36A 5utuF-1navA:
undetectable		 5utuF-1navA:
21.73