SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ndl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X8V_A_ESLA472_1
(CYTOCHROME P450 51)		 1ndl NUCLEOSIDE
DIPHOSPHATE KINASE
(Drosophila
melanogaster) 		4 / 6 MET A  69
VAL A  66
LEU A  65
PHE A  61
 None
 1.06A 1x8vA-1ndlA:
0.0		 1x8vA-1ndlA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_B_SAMB602_0
(HYPOTHETICAL PROTEIN)		 1ndl NUCLEOSIDE
DIPHOSPHATE KINASE
(Drosophila
melanogaster) 		5 / 12 THR A   8
GLY A 120
SER A 121
VAL A  12
ILE A 117
 None
 0.94A 2b25B-1ndlA:
undetectable		 2b25B-1ndlA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_C_X2NC1479_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 1ndl NUCLEOSIDE
DIPHOSPHATE KINASE
(Drosophila
melanogaster) 		5 / 12 MET A  11
PHE A   9
PRO A  14
VAL A  17
MET A  69
 None
 1.31A 2x2nC-1ndlA:
undetectable		 2x2nC-1ndlA:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XF3_A_J01A500_1
(ORF12)		 1ndl NUCLEOSIDE
DIPHOSPHATE KINASE
(Drosophila
melanogaster) 		5 / 10 VAL A  12
ILE A 118
LEU A  92
ARG A  89
GLY A  88
 None
 1.19A 2xf3A-1ndlA:
undetectable		 2xf3A-1ndlA:
13.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4APJ_A_ACTA1635_0
(ANGIOTENSIN-CONVERTI
NG ENZYME
BRADYKININ-POTENTIAT
ING PEPTIDE B)		 1ndl NUCLEOSIDE
DIPHOSPHATE KINASE
(Drosophila
melanogaster) 		4 / 6 HIS A 119
GLU A 130
ASP A 122
SER A 126
 None
 1.16A 4apjA-1ndlA:
undetectable
4apjP-1ndlA:
undetectable		 4apjA-1ndlA:
13.02
4apjP-1ndlA:
9.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYF_A_NCAA1201_0
(TANKYRASE-2)		 1ndl NUCLEOSIDE
DIPHOSPHATE KINASE
(Drosophila
melanogaster) 		4 / 7 GLY A 120
ALA A 127
SER A 121
GLU A   6
 None
 0.93A 4hyfA-1ndlA:
undetectable		 4hyfA-1ndlA:
21.55