SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ne2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHF_A_FOLA187_0
(DIHYDROFOLATE
REDUCTASE)		 1ne2 HYPOTHETICAL PROTEIN
TA1320
(Thermoplasma
acidophilum) 		5 / 12 ILE A 139
PHE A 128
PRO A 116
LEU A 151
THR A 135
 None
 1.10A 1dhfA-1ne2A:
2.5		 1dhfA-1ne2A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EIZ_A_SAMA301_1
(FTSJ)		 1ne2 HYPOTHETICAL PROTEIN
TA1320
(Thermoplasma
acidophilum) 		3 / 3 ASP A  78
ASP A  82
ASP A 100
 None
 0.67A 1eizA-1ne2A:
13.1		 1eizA-1ne2A:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EJ0_A_SAMA301_1
(FTSJ)		 1ne2 HYPOTHETICAL PROTEIN
TA1320
(Thermoplasma
acidophilum) 		3 / 3 ASP A  78
ASP A  82
ASP A 100
 None
 0.69A 1ej0A-1ne2A:
13.1		 1ej0A-1ne2A:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QAO_A_SAMA245_0
(ERMC'
METHYLTRANSFERASE)		 1ne2 HYPOTHETICAL PROTEIN
TA1320
(Thermoplasma
acidophilum) 		6 / 12 GLY A  56
GLY A  58
ILE A  79
ASP A  80
ASP A 100
ASN A 114
 None
 0.43A 1qaoA-1ne2A:
14.2		 1qaoA-1ne2A:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VQ1_A_SAMA301_1
(N5-GLUTAMINE
METHYLTRANSFERASE,
HEMK)		 1ne2 HYPOTHETICAL PROTEIN
TA1320
(Thermoplasma
acidophilum) 		3 / 3 GLY A  56
ASP A  78
ASN A 114
 None
 0.33A 1vq1A-1ne2A:
14.1		 1vq1A-1ne2A:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ADM_A_SAMA500_0
(ADENINE-N6-DNA-METHY
LTRANSFERASE TAQI)		 1ne2 HYPOTHETICAL PROTEIN
TA1320
(Thermoplasma
acidophilum) 		6 / 11 THR A  29
ILE A  79
ASP A  80
ALA A  83
ASP A 100
PHE A 128
 None
 0.76A 2admA-1ne2A:
6.5		 2admA-1ne2A:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ADM_B_SAMB500_0
(ADENINE-N6-DNA-METHY
LTRANSFERASE TAQI)		 1ne2 HYPOTHETICAL PROTEIN
TA1320
(Thermoplasma
acidophilum) 		5 / 11 THR A  29
ILE A  79
ALA A  83
ASP A 100
PHE A 128
 None
 0.83A 2admB-1ne2A:
6.6		 2admB-1ne2A:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J0D_A_ERYA1498_0
(CYTOCHROME P450 3A4)		 1ne2 HYPOTHETICAL PROTEIN
TA1320
(Thermoplasma
acidophilum) 		5 / 12 SER A  66
ILE A  47
ILE A 112
THR A  29
ALA A  31
 None
 1.18A 2j0dA-1ne2A:
undetectable		 2j0dA-1ne2A:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_A_SAMA302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 1ne2 HYPOTHETICAL PROTEIN
TA1320
(Thermoplasma
acidophilum) 		7 / 12 ASP A  54
GLY A  56
GLY A  58
LEU A  62
ILE A  79
ASP A  80
ASN A 114
 None
 0.55A 2nxeA-1ne2A:
17.4		 2nxeA-1ne2A:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_B_SAMB303_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 1ne2 HYPOTHETICAL PROTEIN
TA1320
(Thermoplasma
acidophilum) 		7 / 12 ASP A  54
GLY A  56
GLY A  58
LEU A  62
ILE A  79
ASP A  80
ASN A 114
 None
 0.57A 2nxeB-1ne2A:
17.4		 2nxeB-1ne2A:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3B_A_FOLA401_0
(DIHYDROFOLATE
REDUCTASE)		 1ne2 HYPOTHETICAL PROTEIN
TA1320
(Thermoplasma
acidophilum) 		5 / 12 ILE A 139
PHE A 128
PRO A 116
LEU A 151
THR A 135
 None
 1.11A 2w3bA-1ne2A:
undetectable		 2w3bA-1ne2A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3B_B_FOLB401_0
(DIHYDROFOLATE
REDUCTASE)		 1ne2 HYPOTHETICAL PROTEIN
TA1320
(Thermoplasma
acidophilum) 		5 / 12 ILE A 139
PHE A 128
PRO A 116
LEU A 151
THR A 135
 None
 1.18A 2w3bB-1ne2A:
2.9		 2w3bB-1ne2A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZBP_A_SAMA300_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 1ne2 HYPOTHETICAL PROTEIN
TA1320
(Thermoplasma
acidophilum) 		6 / 12 GLY A  56
GLY A  58
LEU A  62
ILE A  79
ASP A  80
ASN A 114
 None
 0.56A 2zbpA-1ne2A:
17.5		 2zbpA-1ne2A:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUL_A_SAMA376_0
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 1ne2 HYPOTHETICAL PROTEIN
TA1320
(Thermoplasma
acidophilum) 		5 / 12 GLY A  56
GLY A  58
LEU A  62
ASN A 114
PRO A 116
 None
 0.91A 2zulA-1ne2A:
15.0		 2zulA-1ne2A:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUL_A_SAMA376_0
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 1ne2 HYPOTHETICAL PROTEIN
TA1320
(Thermoplasma
acidophilum) 		6 / 12 GLY A  56
GLY A  58
LEU A  62
VAL A 101
ASN A 114
PHE A 128
 None
 0.57A 2zulA-1ne2A:
15.0		 2zulA-1ne2A:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_C_SAMC302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 1ne2 HYPOTHETICAL PROTEIN
TA1320
(Thermoplasma
acidophilum) 		6 / 12 ASP A  54
GLY A  56
LEU A  62
ASP A  78
ILE A  79
ASP A  80
 None
 0.50A 3cjtC-1ne2A:
18.3		 3cjtC-1ne2A:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_G_SAMG302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 1ne2 HYPOTHETICAL PROTEIN
TA1320
(Thermoplasma
acidophilum) 		6 / 12 GLY A  56
GLY A  58
LEU A  62
ILE A  79
ASP A  80
ASN A 114
 None
 0.53A 3cjtG-1ne2A:
18.1		 3cjtG-1ne2A:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_K_SAMK302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 1ne2 HYPOTHETICAL PROTEIN
TA1320
(Thermoplasma
acidophilum) 		5 / 12 GLY A  56
LEU A  62
ILE A  79
ASP A  80
ASN A 114
 None
 0.51A 3cjtK-1ne2A:
18.2		 3cjtK-1ne2A:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_O_SAMO302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 1ne2 HYPOTHETICAL PROTEIN
TA1320
(Thermoplasma
acidophilum) 		6 / 12 GLY A  56
GLY A  58
LEU A  62
ILE A  79
ASP A  80
ASN A 114
 None
 0.49A 3cjtO-1ne2A:
18.2		 3cjtO-1ne2A:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DMF_A_SAMA388_0
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 1ne2 HYPOTHETICAL PROTEIN
TA1320
(Thermoplasma
acidophilum) 		6 / 12 GLY A  56
GLY A  58
ASP A 100
VAL A 101
ASN A 114
PHE A 128
 None
 0.56A 3dmfA-1ne2A:
15.1		 3dmfA-1ne2A:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DMH_A_SAMA384_0
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 1ne2 HYPOTHETICAL PROTEIN
TA1320
(Thermoplasma
acidophilum) 		5 / 12 GLY A  56
GLY A  58
LEU A  62
ASN A 114
PRO A 116
 None
 0.94A 3dmhA-1ne2A:
14.6		 3dmhA-1ne2A:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DMH_A_SAMA384_0
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 1ne2 HYPOTHETICAL PROTEIN
TA1320
(Thermoplasma
acidophilum) 		6 / 12 GLY A  56
GLY A  58
LEU A  62
VAL A 101
ASN A 114
PHE A 128
 None
 0.55A 3dmhA-1ne2A:
14.6		 3dmhA-1ne2A:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DOU_A_SAMA1_1
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 1ne2 HYPOTHETICAL PROTEIN
TA1320
(Thermoplasma
acidophilum) 		3 / 3 ASP A  78
ASP A  82
ASP A 100
 None
 0.63A 3douA-1ne2A:
12.9		 3douA-1ne2A:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_J_SAMJ300_0
(PUTATIVE RRNA
METHYLASE)		 1ne2 HYPOTHETICAL PROTEIN
TA1320
(Thermoplasma
acidophilum) 		5 / 12 GLY A  58
ASN A  59
ASP A  78
ILE A  79
ASN A 114
 None
 1.05A 3eeyJ-1ne2A:
14.3		 3eeyJ-1ne2A:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GRV_A_ADNA300_1
(DIMETHYLADENOSINE
TRANSFERASE)		 1ne2 HYPOTHETICAL PROTEIN
TA1320
(Thermoplasma
acidophilum) 		6 / 11 GLY A  56
GLY A  58
ILE A  79
ASP A  80
ASP A 100
ASN A 114
 None
 0.86A 3grvA-1ne2A:
15.3		 3grvA-1ne2A:
25.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GRY_A_SAMA300_0
(DIMETHYLADENOSINE
TRANSFERASE)		 1ne2 HYPOTHETICAL PROTEIN
TA1320
(Thermoplasma
acidophilum) 		6 / 12 GLY A  56
GLY A  58
ILE A  79
ASP A  80
ASP A 100
ASN A 114
 None
 0.87A 3gryA-1ne2A:
15.4		 3gryA-1ne2A:
25.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_C_SAMC300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 1ne2 HYPOTHETICAL PROTEIN
TA1320
(Thermoplasma
acidophilum) 		3 / 3 GLY A  58
ASP A  78
ASP A 100
 None
 0.35A 3ou7C-1ne2A:
13.5		 3ou7C-1ne2A:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q87_B_SAMB300_0
(N6 ADENINE SPECIFIC
DNA METHYLASE)		 1ne2 HYPOTHETICAL PROTEIN
TA1320
(Thermoplasma
acidophilum) 		5 / 12 THR A  29
GLY A  56
ASP A  78
ASP A 100
ASN A 114
 None
 1.09A 3q87B-1ne2A:
15.0		 3q87B-1ne2A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Q_A_9PLA501_1
(CYTOCHROME P450 2A6)		 1ne2 HYPOTHETICAL PROTEIN
TA1320
(Thermoplasma
acidophilum) 		5 / 10 PHE A 128
ALA A 132
THR A 135
ILE A  53
PHE A  77
 None
 1.49A 3t3qA-1ne2A:
undetectable		 3t3qA-1ne2A:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V8V_B_SAMB801_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE L)		 1ne2 HYPOTHETICAL PROTEIN
TA1320
(Thermoplasma
acidophilum) 		6 / 11 GLY A  58
ASP A  78
ASP A  80
ASP A 100
VAL A 101
ASN A 114
 None
 0.64A 3v8vB-1ne2A:
12.1		 3v8vB-1ne2A:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DCM_A_SAMA401_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE G)		 1ne2 HYPOTHETICAL PROTEIN
TA1320
(Thermoplasma
acidophilum) 		5 / 11 ASP A  54
GLY A  56
GLY A  58
ASN A 114
PRO A 116
 None
 0.78A 4dcmA-1ne2A:
13.6		 4dcmA-1ne2A:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DCM_A_SAMA401_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE G)		 1ne2 HYPOTHETICAL PROTEIN
TA1320
(Thermoplasma
acidophilum) 		5 / 11 ASP A  54
GLY A  56
GLY A  58
ASP A  78
ASN A 114
 None
 0.43A 4dcmA-1ne2A:
13.6		 4dcmA-1ne2A:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV8_A_SAMA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 1ne2 HYPOTHETICAL PROTEIN
TA1320
(Thermoplasma
acidophilum) 		5 / 12 GLY A  56
GLY A  58
ASP A  78
ILE A  79
ASP A 100
 None
 0.30A 4iv8A-1ne2A:
14.5		 4iv8A-1ne2A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV8_B_SAMB301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 1ne2 HYPOTHETICAL PROTEIN
TA1320
(Thermoplasma
acidophilum) 		5 / 12 GLY A  56
GLY A  58
ASP A  78
ILE A  79
ASP A 100
 None
 0.32A 4iv8B-1ne2A:
14.6		 4iv8B-1ne2A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PB1_A_RBVA501_1
(NUPC FAMILY PROTEIN)		 1ne2 HYPOTHETICAL PROTEIN
TA1320
(Thermoplasma
acidophilum) 		5 / 12 GLY A  56
ALA A  55
TYR A 108
ASN A  95
ILE A  84
 None
 0.98A 4pb1A-1ne2A:
undetectable		 4pb1A-1ne2A:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD5_A_GEOA501_1
(NUPC FAMILY PROTEIN)		 1ne2 HYPOTHETICAL PROTEIN
TA1320
(Thermoplasma
acidophilum) 		5 / 12 GLY A  56
ALA A  55
TYR A 108
ASN A  95
ILE A  84
 None
 0.99A 4pd5A-1ne2A:
0.0		 4pd5A-1ne2A:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_B_SAMB2409_0
(RNA-DIRECTED RNA
POLYMERASE L)		 1ne2 HYPOTHETICAL PROTEIN
TA1320
(Thermoplasma
acidophilum) 		5 / 12 GLY A 143
ASN A 144
ASP A  54
ALA A 132
THR A 135
 None
 1.15A 4uckB-1ne2A:
7.0		 4uckB-1ne2A:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E72_A_SAMA400_1
(N2,
N2-DIMETHYLGUANOSINE
TRNA
METHYLTRANSFERASE)		 1ne2 HYPOTHETICAL PROTEIN
TA1320
(Thermoplasma
acidophilum) 		4 / 4 ASP A  54
GLY A  58
ASP A  78
ASP A 100
 None
 0.63A 5e72A-1ne2A:
17.2		 5e72A-1ne2A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_H_SAMH301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 1ne2 HYPOTHETICAL PROTEIN
TA1320
(Thermoplasma
acidophilum) 		5 / 12 ASP A 100
ALA A  99
ASP A  54
PHE A  77
GLY A  58
 None
 1.35A 5hfjH-1ne2A:
4.7		 5hfjH-1ne2A:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA608_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 1ne2 HYPOTHETICAL PROTEIN
TA1320
(Thermoplasma
acidophilum) 		3 / 3 GLY A 106
THR A 135
GLU A 134
 None
 0.32A 6b58A-1ne2A:
3.3		 6b58A-1ne2A:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQ4_A_ADNA401_1
(THERMOSPERMINE
SYNTHASE ACAULIS
PROTEIN)		 1ne2 HYPOTHETICAL PROTEIN
TA1320
(Thermoplasma
acidophilum) 		5 / 12 GLY A  56
ASP A  78
ILE A  79
ASP A  80
ASP A 100
 None
 0.46A 6bq4A-1ne2A:
13.1		 6bq4A-1ne2A:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQ4_B_ADNB401_1
(THERMOSPERMINE
SYNTHASE ACAULIS
PROTEIN)		 1ne2 HYPOTHETICAL PROTEIN
TA1320
(Thermoplasma
acidophilum) 		5 / 12 GLY A  56
ASP A  78
ILE A  79
ASP A  80
ASP A 100
 None
 0.47A 6bq4B-1ne2A:
13.2		 6bq4B-1ne2A:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IFT_A_SAMA301_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A)		 1ne2 HYPOTHETICAL PROTEIN
TA1320
(Thermoplasma
acidophilum) 		5 / 12 GLY A  56
GLY A  58
ILE A  79
ASP A  80
VAL A 101
 None
 0.50A 6iftA-1ne2A:
12.6		 6iftA-1ne2A:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NQA_K_SAMK500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 1ne2 HYPOTHETICAL PROTEIN
TA1320
(Thermoplasma
acidophilum) 		5 / 10 THR A  29
ASP A  54
GLY A  56
GLY A  58
ASN A 114
 None
 0.71A 6nqaK-1ne2A:
10.5		 6nqaK-1ne2A:
17.92