SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ne7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A27_A_ESTA350_1
(17-BETA-HYDROXYSTERO
ID-DEHYDROGENASE)		 1ne7 GLUCOSAMINE-6-PHOSPH
ATE ISOMERASE
(Homo
sapiens) 		5 / 12 SER A 155
VAL A 190
GLY A 191
MET A 194
VAL A 220
 16G  A4299 ( 4.8A)
None
None
None
None
 1.48A 1a27A-1ne7A:
3.6		 1a27A-1ne7A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_3
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 1ne7 GLUCOSAMINE-6-PHOSPH
ATE ISOMERASE
(Homo
sapiens) 		4 / 5 THR A  68
LEU A  39
VAL A 135
LEU A 202
 None
 0.77A 1fbmE-1ne7A:
undetectable		 1fbmE-1ne7A:
11.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_2
(DNA GYRASE SUBUNIT B)		 1ne7 GLUCOSAMINE-6-PHOSPH
ATE ISOMERASE
(Homo
sapiens) 		3 / 3 ASN A 147
PHE A 134
VAL A 188
 None
 0.69A 1kijA-1ne7A:
0.0		 1kijA-1ne7A:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F9W_A_PAUA6002_0
(PANTOTHENATE KINASE)		 1ne7 GLUCOSAMINE-6-PHOSPH
ATE ISOMERASE
(Homo
sapiens) 		4 / 8 GLY A 139
ASP A 141
THR A 225
ILE A 144
 AGP  A2298 ( 3.9A)
None
None
None
 0.85A 2f9wA-1ne7A:
undetectable
2f9wB-1ne7A:
undetectable		 2f9wA-1ne7A:
21.00
2f9wB-1ne7A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6H_A_CXXA802_1
(TRANSPORTER)		 1ne7 GLUCOSAMINE-6-PHOSPH
ATE ISOMERASE
(Homo
sapiens) 		4 / 7 ILE A  20
PHE A  63
ILE A  99
PHE A  93
 None
 1.06A 2q6hA-1ne7A:
0.0		 2q6hA-1ne7A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QB4_A_DSMA802_1
(TRANSPORTER)		 1ne7 GLUCOSAMINE-6-PHOSPH
ATE ISOMERASE
(Homo
sapiens) 		4 / 7 ILE A  20
PHE A  63
ILE A  99
PHE A  93
 None
 1.06A 2qb4A-1ne7A:
0.0		 2qb4A-1ne7A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_D_VDYD6178_1
(VITAMIN D
HYDROXYLASE)		 1ne7 GLUCOSAMINE-6-PHOSPH
ATE ISOMERASE
(Homo
sapiens) 		5 / 12 ILE A  20
MET A  89
LEU A  52
VAL A 238
LEU A 202
 None
 1.24A 3a51D-1ne7A:
0.0		 3a51D-1ne7A:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OWX_B_XRAB233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1ne7 GLUCOSAMINE-6-PHOSPH
ATE ISOMERASE
(Homo
sapiens) 		5 / 11 VAL A 199
PHE A  27
GLY A 130
GLY A 129
ILE A 125
 None
GLC  A 295 (-4.1A)
None
None
None
 1.39A 3owxA-1ne7A:
2.4
3owxB-1ne7A:
2.4		 3owxA-1ne7A:
20.88
3owxB-1ne7A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUK_D_AERD601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 1ne7 GLUCOSAMINE-6-PHOSPH
ATE ISOMERASE
(Homo
sapiens) 		5 / 11 ALA A  12
ILE A 201
ALA A 243
THR A 244
VAL A 252
 None
 1.21A 3rukD-1ne7A:
undetectable		 3rukD-1ne7A:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U7S_A_017A202_1
(POL POLYPROTEIN)		 1ne7 GLUCOSAMINE-6-PHOSPH
ATE ISOMERASE
(Homo
sapiens) 		5 / 9 LEU A  37
ALA A 196
ASP A 195
ILE A 201
LEU A  39
 None
 1.04A 3u7sA-1ne7A:
undetectable		 3u7sA-1ne7A:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U7S_A_017A202_1
(POL POLYPROTEIN)		 1ne7 GLUCOSAMINE-6-PHOSPH
ATE ISOMERASE
(Homo
sapiens) 		5 / 9 LEU A  37
ALA A 196
ILE A 201
PRO A  40
LEU A  39
 None
None
None
AGP  A2298 (-4.0A)
None
 1.07A 3u7sA-1ne7A:
undetectable		 3u7sA-1ne7A:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_A_CLQA303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1ne7 GLUCOSAMINE-6-PHOSPH
ATE ISOMERASE
(Homo
sapiens) 		5 / 12 GLY A 130
GLY A 129
ILE A 125
VAL A 199
PHE A  35
 None
 1.28A 4fglA-1ne7A:
2.1
4fglB-1ne7A:
2.3		 4fglA-1ne7A:
20.88
4fglB-1ne7A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB0_B_ACTB401_0
(UNCHARACTERIZED
PROTEIN)		 1ne7 GLUCOSAMINE-6-PHOSPH
ATE ISOMERASE
(Homo
sapiens) 		4 / 5 GLU A 198
VAL A 236
LEU A 265
VAL A 266
 None
 1.04A 4lb0B-1ne7A:
undetectable		 4lb0B-1ne7A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M51_A_BEZA501_0
(AMIDOHYDROLASE
FAMILY PROTEIN)		 1ne7 GLUCOSAMINE-6-PHOSPH
ATE ISOMERASE
(Homo
sapiens) 		4 / 6 ILE A  99
ILE A  24
PHE A  93
LEU A  39
 None
 0.96A 4m51A-1ne7A:
undetectable		 4m51A-1ne7A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 1ne7 GLUCOSAMINE-6-PHOSPH
ATE ISOMERASE
(Homo
sapiens) 		5 / 9 THR A  44
ALA A 169
ILE A 203
GLY A 137
ASP A 141
 SO4  A2296 ( 3.7A)
None
None
AGP  A2298 (-3.8A)
None
 0.95A 4qvqK-1ne7A:
undetectable
4qvqL-1ne7A:
undetectable		 4qvqK-1ne7A:
19.05
4qvqL-1ne7A:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 1ne7 GLUCOSAMINE-6-PHOSPH
ATE ISOMERASE
(Homo
sapiens) 		5 / 9 THR A  44
ALA A 169
ILE A 203
GLY A 137
ASP A 141
 SO4  A2296 ( 3.7A)
None
None
AGP  A2298 (-3.8A)
None
 0.95A 4qvqY-1ne7A:
undetectable
4qvqZ-1ne7A:
undetectable		 4qvqY-1ne7A:
19.05
4qvqZ-1ne7A:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJQ_A_ERYA1101_0
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 1ne7 GLUCOSAMINE-6-PHOSPH
ATE ISOMERASE
(Homo
sapiens) 		5 / 11 SER A 151
MET A  89
ASP A 141
GLU A 148
GLY A 142
 16G  A4299 (-3.6A)
None
None
None
None
 1.33A 4zjqA-1ne7A:
0.0		 4zjqA-1ne7A:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KLA_A_ACTA1505_0
(MATERNAL PROTEIN
PUMILIO)		 1ne7 GLUCOSAMINE-6-PHOSPH
ATE ISOMERASE
(Homo
sapiens) 		3 / 3 HIS A 262
LYS A   1
PHE A 255
 None
 1.25A 5klaA-1ne7A:
0.0		 5klaA-1ne7A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0S_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 1ne7 GLUCOSAMINE-6-PHOSPH
ATE ISOMERASE
(Homo
sapiens) 		5 / 12 ILE A 203
GLY A 137
VAL A 135
VAL A 199
ILE A   5
 None
AGP  A2298 (-3.8A)
None
None
None
 1.11A 5n0sA-1ne7A:
undetectable		 5n0sA-1ne7A:
21.85