SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1nee'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETA_1_T441128_1
(TRANSTHYRETIN)		 1nee PROBABLE TRANSLATION
INITIATION FACTOR 2
BETA SUBUNIT
(Methanothermobac
ter
thermautotrophic
us) 		4 / 5 LYS A 122
GLU A 124
ALA A 130
LEU A 132
 None
 1.19A 1eta1-1neeA:
undetectable		 1eta1-1neeA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETB_1_T441128_1
(TRANSTHYRETIN)		 1nee PROBABLE TRANSLATION
INITIATION FACTOR 2
BETA SUBUNIT
(Methanothermobac
ter
thermautotrophic
us) 		4 / 6 LYS A 122
GLU A 124
ALA A 130
LEU A 132
 None
 1.16A 1etb1-1neeA:
undetectable		 1etb1-1neeA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETB_2_T442129_1
(TRANSTHYRETIN)		 1nee PROBABLE TRANSLATION
INITIATION FACTOR 2
BETA SUBUNIT
(Methanothermobac
ter
thermautotrophic
us) 		4 / 6 LYS A 122
GLU A 124
ALA A 130
LEU A 132
 None
 1.21A 1etb2-1neeA:
undetectable		 1etb2-1neeA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_3
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1nee PROBABLE TRANSLATION
INITIATION FACTOR 2
BETA SUBUNIT
(Methanothermobac
ter
thermautotrophic
us) 		3 / 3 THR A  68
LEU A  66
LEU A  59
 None
 0.49A 1mz9C-1neeA:
undetectable		 1mz9C-1neeA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_B_1N1B2000_1
(P38A)		 1nee PROBABLE TRANSLATION
INITIATION FACTOR 2
BETA SUBUNIT
(Methanothermobac
ter
thermautotrophic
us) 		5 / 10 ARG A 114
ILE A 118
ILE A  92
ILE A  88
ASN A  52
 None
 1.43A 3ohtA-1neeA:
undetectable
3ohtB-1neeA:
undetectable		 3ohtA-1neeA:
18.18
3ohtB-1neeA:
18.18