SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1nex'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P93_C_DEXC3999_1
(GLUCOCORTICOID
RECEPTOR)		 1nex CDC4 PROTEIN
(Saccharomyces
cerevisiae) 		5 / 12 ASN B 332
GLY B 330
LEU B 320
GLN B 347
LEU B 338
 None
 1.29A 1p93C-1nexB:
0.0		 1p93C-1nexB:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK7_B_ADNB1246_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1nex CENTROMERE
DNA-BINDING PROTEIN
COMPLEX CBF3 SUBUNIT
D
(Saccharomyces
cerevisiae) 		4 / 8 ARG A 159
GLY A 150
VAL A 154
ILE A 135
 None
 0.84A 1pk7B-1nexA:
undetectable		 1pk7B-1nexA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA507_0
(CHORISMATE SYNTHASE)		 1nex CDC4 PROTEIN
(Saccharomyces
cerevisiae) 		3 / 3 LEU B 362
ASN B 324
ARG B 700
 None
 0.92A 2qhfA-1nexB:
0.0		 2qhfA-1nexB:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RHM_D_BEZD194_0
(PUTATIVE KINASE)		 1nex CENTROMERE
DNA-BINDING PROTEIN
COMPLEX CBF3 SUBUNIT
D
CDC4 PROTEIN
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		4 / 5 PRO A 163
ILE A 166
ARG A 161
ASP B 294
 None
 1.50A 2rhmD-1nexA:
undetectable		 2rhmD-1nexA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VN1_A_FK5A501_2
(70 KDA
PEPTIDYLPROLYL
ISOMERASE)		 1nex CDC4 PROTEIN
(Saccharomyces
cerevisiae) 		4 / 6 LEU B 353
SER B 744
ASP B 742
GLU B 357
 None
 1.27A 2vn1B-1nexB:
0.0		 2vn1B-1nexB:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VUF_B_FUAB2002_1
(SERUM ALBUMIN)		 1nex CDC4 PROTEIN
(Saccharomyces
cerevisiae) 		4 / 9 ILE B 594
ARG B 655
ALA B 648
VAL B 635
 None
 1.02A 2vufB-1nexB:
undetectable		 2vufB-1nexB:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_A_CELA682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1nex CDC4 PROTEIN
(Saccharomyces
cerevisiae) 		5 / 8 LEU B 640
SER B 641
LEU B 628
TYR B 662
ILE B 577
 None
 1.49A 3ln1A-1nexB:
undetectable		 3ln1A-1nexB:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBG_C_ACTC800_0
(FAD-LINKED
SULFHYDRYL OXIDASE
ALR)		 1nex CDC4 PROTEIN
(Saccharomyces
cerevisiae) 		3 / 3 ASP B 401
ARG B 405
ALA B 399
 None
 0.74A 3mbgC-1nexB:
undetectable		 3mbgC-1nexB:
12.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_2_BO221405_1
(PROTEASOME COMPONENT
PRE3
PROTEASOME COMPONENT
PUP1)		 1nex CDC4 PROTEIN
(Saccharomyces
cerevisiae) 		5 / 12 THR B 592
THR B 593
GLY B 636
ALA B 649
SER B 653
 None
 0.87A 3mg02-1nexB:
undetectable
3mg0V-1nexB:
undetectable		 3mg02-1nexB:
18.53
3mg0V-1nexB:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IMA_D_ADND604_1
(PYRUVATE KINASE)		 1nex CDC4 PROTEIN
(Saccharomyces
cerevisiae) 		3 / 3 ARG B 700
GLU B 323
ASN B 324
 None
 0.80A 4imaD-1nexB:
undetectable		 4imaD-1nexB:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IP7_D_ADND604_1
(PYRUVATE KINASE
ISOZYMES L)		 1nex CDC4 PROTEIN
(Saccharomyces
cerevisiae) 		3 / 3 ARG B 700
GLU B 323
ASN B 324
 None
 0.83A 4ip7D-1nexB:
undetectable		 4ip7D-1nexB:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JQ1_B_NPSB401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 1nex CDC4 PROTEIN
(Saccharomyces
cerevisiae) 		4 / 8 VAL B 301
TRP B 305
ILE B 309
LEU B 290
 None
 0.92A 4jq1B-1nexB:
undetectable		 4jq1B-1nexB:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KHP_A_PARA1606_1
(16S RIBOSOMAL RNA
30S RIBOSOMAL
PROTEIN S9
30S RIBOSOMAL
PROTEIN S10)		 1nex CDC4 PROTEIN
(Saccharomyces
cerevisiae) 		3 / 3 TYR B 548
ARG B 485
SER B 532
 None
 1.06A 4khpI-1nexB:
0.0
4khpJ-1nexB:
0.0		 4khpI-1nexB:
16.00
4khpJ-1nexB:
11.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVL_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1nex CDC4 PROTEIN
(Saccharomyces
cerevisiae) 		5 / 11 SER B 653
THR B 592
THR B 593
GLY B 636
ALA B 649
 None
 0.94A 4qvlV-1nexB:
undetectable
4qvlb-1nexB:
undetectable		 4qvlV-1nexB:
20.80
4qvlb-1nexB:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVL_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1nex CDC4 PROTEIN
(Saccharomyces
cerevisiae) 		5 / 11 SER B 653
THR B 592
THR B 593
GLY B 636
ALA B 649
 None
 0.95A 4qvlH-1nexB:
undetectable
4qvlN-1nexB:
undetectable		 4qvlH-1nexB:
20.80
4qvlN-1nexB:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVM_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1nex CDC4 PROTEIN
(Saccharomyces
cerevisiae) 		5 / 11 SER B 653
THR B 592
THR B 593
GLY B 636
ALA B 649
 None
 0.95A 4qvmV-1nexB:
undetectable
4qvmb-1nexB:
undetectable		 4qvmV-1nexB:
20.80
4qvmb-1nexB:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVM_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1nex CDC4 PROTEIN
(Saccharomyces
cerevisiae) 		5 / 11 SER B 653
THR B 592
THR B 593
GLY B 636
ALA B 649
 None
 0.95A 4qvmH-1nexB:
undetectable
4qvmN-1nexB:
undetectable		 4qvmH-1nexB:
20.80
4qvmN-1nexB:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1nex CDC4 PROTEIN
(Saccharomyces
cerevisiae) 		5 / 11 SER B 653
THR B 592
THR B 593
GLY B 636
ALA B 649
 None
 0.98A 4qvpV-1nexB:
undetectable
4qvpb-1nexB:
undetectable		 4qvpV-1nexB:
20.80
4qvpb-1nexB:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1nex CDC4 PROTEIN
(Saccharomyces
cerevisiae) 		5 / 11 SER B 653
THR B 592
THR B 593
GLY B 636
ALA B 649
 None
 0.99A 4qvpH-1nexB:
undetectable
4qvpN-1nexB:
undetectable		 4qvpH-1nexB:
20.80
4qvpN-1nexB:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1nex CDC4 PROTEIN
(Saccharomyces
cerevisiae) 		5 / 11 SER B 653
THR B 592
THR B 593
GLY B 636
ALA B 649
 None
 0.98A 4qvqV-1nexB:
undetectable
4qvqb-1nexB:
undetectable		 4qvqV-1nexB:
20.80
4qvqb-1nexB:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1nex CDC4 PROTEIN
(Saccharomyces
cerevisiae) 		5 / 11 SER B 653
THR B 592
THR B 593
GLY B 636
ALA B 649
 None
 0.98A 4qvqH-1nexB:
undetectable
4qvqN-1nexB:
undetectable		 4qvqH-1nexB:
20.80
4qvqN-1nexB:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1nex CDC4 PROTEIN
(Saccharomyces
cerevisiae) 		5 / 11 SER B 653
THR B 592
THR B 593
GLY B 636
ALA B 649
 None
 0.94A 4qvwV-1nexB:
undetectable
4qvwb-1nexB:
undetectable		 4qvwV-1nexB:
20.80
4qvwb-1nexB:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1nex CDC4 PROTEIN
(Saccharomyces
cerevisiae) 		5 / 11 SER B 653
THR B 592
THR B 593
GLY B 636
ALA B 649
 None
 0.95A 4qvwH-1nexB:
undetectable
4qvwN-1nexB:
undetectable		 4qvwH-1nexB:
20.80
4qvwN-1nexB:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1nex CDC4 PROTEIN
(Saccharomyces
cerevisiae) 		5 / 11 SER B 653
THR B 592
THR B 593
GLY B 636
ALA B 649
 None
 0.94A 4qw0V-1nexB:
undetectable
4qw0b-1nexB:
undetectable		 4qw0V-1nexB:
20.80
4qw0b-1nexB:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1nex CDC4 PROTEIN
(Saccharomyces
cerevisiae) 		5 / 11 SER B 653
THR B 592
THR B 593
GLY B 636
ALA B 649
 None
 0.94A 4qw0H-1nexB:
undetectable
4qw0N-1nexB:
undetectable		 4qw0H-1nexB:
20.80
4qw0N-1nexB:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1nex CDC4 PROTEIN
(Saccharomyces
cerevisiae) 		5 / 11 SER B 653
THR B 592
THR B 593
GLY B 636
ALA B 649
 None
 0.98A 4qw1V-1nexB:
undetectable
4qw1b-1nexB:
undetectable		 4qw1V-1nexB:
20.80
4qw1b-1nexB:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1nex CDC4 PROTEIN
(Saccharomyces
cerevisiae) 		5 / 11 SER B 653
THR B 592
THR B 593
GLY B 636
ALA B 649
 None
 0.98A 4qw1H-1nexB:
undetectable
4qw1N-1nexB:
undetectable		 4qw1H-1nexB:
20.80
4qw1N-1nexB:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW3_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1nex CDC4 PROTEIN
(Saccharomyces
cerevisiae) 		5 / 11 SER B 653
THR B 592
THR B 593
GLY B 636
ALA B 649
 None
 0.95A 4qw3V-1nexB:
undetectable
4qw3b-1nexB:
undetectable		 4qw3V-1nexB:
20.80
4qw3b-1nexB:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW3_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1nex CDC4 PROTEIN
(Saccharomyces
cerevisiae) 		5 / 11 SER B 653
THR B 592
THR B 593
GLY B 636
ALA B 649
 None
 0.95A 4qw3H-1nexB:
undetectable
4qw3N-1nexB:
undetectable		 4qw3H-1nexB:
20.80
4qw3N-1nexB:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1nex CDC4 PROTEIN
(Saccharomyces
cerevisiae) 		5 / 11 SER B 653
THR B 592
THR B 593
GLY B 636
ALA B 649
 None
 0.99A 5bxnV-1nexB:
undetectable
5bxnb-1nexB:
undetectable		 5bxnV-1nexB:
18.30
5bxnb-1nexB:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1nex CDC4 PROTEIN
(Saccharomyces
cerevisiae) 		5 / 11 SER B 653
THR B 592
THR B 593
GLY B 636
ALA B 649
 None
 1.00A 5bxnH-1nexB:
undetectable
5bxnN-1nexB:
undetectable		 5bxnH-1nexB:
18.30
5bxnN-1nexB:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CZ7_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1nex CDC4 PROTEIN
(Saccharomyces
cerevisiae) 		5 / 11 SER B 653
THR B 592
THR B 593
GLY B 636
ALA B 649
 None
 0.96A 5cz7H-1nexB:
undetectable
5cz7N-1nexB:
undetectable		 5cz7H-1nexB:
20.80
5cz7N-1nexB:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1nex CDC4 PROTEIN
(Saccharomyces
cerevisiae) 		5 / 11 SER B 653
THR B 592
THR B 593
GLY B 636
ALA B 649
 None
 0.93A 5d0xV-1nexB:
undetectable
5d0xb-1nexB:
undetectable		 5d0xV-1nexB:
20.80
5d0xb-1nexB:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1nex CDC4 PROTEIN
(Saccharomyces
cerevisiae) 		5 / 11 SER B 653
THR B 592
THR B 593
GLY B 636
ALA B 649
 None
 0.94A 5d0xH-1nexB:
undetectable
5d0xN-1nexB:
undetectable		 5d0xH-1nexB:
20.80
5d0xN-1nexB:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1nex CDC4 PROTEIN
(Saccharomyces
cerevisiae) 		5 / 12 SER B 653
THR B 592
THR B 593
GLY B 636
ALA B 649
 None
 0.95A 5l5zV-1nexB:
undetectable
5l5zb-1nexB:
undetectable		 5l5zV-1nexB:
20.80
5l5zb-1nexB:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1nex CDC4 PROTEIN
(Saccharomyces
cerevisiae) 		5 / 12 SER B 653
THR B 592
THR B 593
GLY B 636
ALA B 649
 None
 0.96A 5l5zH-1nexB:
undetectable
5l5zN-1nexB:
undetectable		 5l5zH-1nexB:
20.80
5l5zN-1nexB:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1nex CDC4 PROTEIN
(Saccharomyces
cerevisiae) 		5 / 11 SER B 653
THR B 592
THR B 593
GLY B 636
ALA B 649
 None
 0.98A 5l66V-1nexB:
undetectable
5l66b-1nexB:
undetectable		 5l66V-1nexB:
20.80
5l66b-1nexB:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1nex CDC4 PROTEIN
(Saccharomyces
cerevisiae) 		5 / 11 SER B 653
THR B 592
THR B 593
GLY B 636
ALA B 649
 None
 0.98A 5l66H-1nexB:
undetectable
5l66N-1nexB:
undetectable		 5l66H-1nexB:
20.80
5l66N-1nexB:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LW1_E_ADNE401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 8)		 1nex CENTROMERE
DNA-BINDING PROTEIN
COMPLEX CBF3 SUBUNIT
D
(Saccharomyces
cerevisiae) 		5 / 10 VAL A  18
ALA A  23
LEU A  29
VAL A  79
LEU A  87
 None
 0.86A 5lw1E-1nexA:
undetectable		 5lw1E-1nexA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LW1_H_ADNH401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 8)		 1nex CENTROMERE
DNA-BINDING PROTEIN
COMPLEX CBF3 SUBUNIT
D
(Saccharomyces
cerevisiae) 		5 / 9 VAL A  18
ALA A  23
LEU A  29
VAL A  79
LEU A  87
 None
 0.87A 5lw1H-1nexA:
undetectable		 5lw1H-1nexA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0X_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 1nex CDC4 PROTEIN
(Saccharomyces
cerevisiae) 		5 / 12 ILE B 471
VAL B 466
ILE B 435
ALA B 431
VAL B 447
 None
 1.12A 5n0xA-1nexB:
undetectable		 5n0xA-1nexB:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4I_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 1nex CDC4 PROTEIN
(Saccharomyces
cerevisiae) 		5 / 12 ILE B 471
VAL B 466
ILE B 435
ALA B 431
VAL B 447
 None
 1.10A 5n4iA-1nexB:
undetectable		 5n4iA-1nexB:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWW_A_ACAA18_2
(SCRFP-TAG,GP41)		 1nex CDC4 PROTEIN
(Saccharomyces
cerevisiae) 		3 / 3 LYS B 724
TRP B 365
SER B 744
 None
 1.39A 5nwwA-1nexB:
0.0		 5nwwA-1nexB:
6.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XOO_A_ADNA506_1
(GLYCOSAMINOGLYCAN
XYLOSYLKINASE)		 1nex CDC4 PROTEIN
CENTROMERE
DNA-BINDING PROTEIN
COMPLEX CBF3 SUBUNIT
D
(Saccharomyces
cerevisiae) 		4 / 6 TYR B 289
LEU A 146
LYS A 116
LEU A 124
 None
 1.21A 5xooA-1nexB:
undetectable		 5xooA-1nexB:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_A_ZOTA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 1nex CDC4 PROTEIN
(Saccharomyces
cerevisiae) 		5 / 12 LEU B 362
GLY B 723
PHE B 694
PHE B 743
VAL B 705
 None
 1.36A 6a94A-1nexB:
undetectable		 6a94A-1nexB:
22.71