SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1nf1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HA2_A_SWFA3001_1
(SERUM ALBUMIN)		 1nf1 PROTEIN
(NEUROFIBROMIN)
(Homo
sapiens) 		5 / 11 PHE A1247
LEU A1239
LEU A1490
ILE A1497
ALA A1226
 None
 1.07A 1ha2A-1nf1A:
undetectable		 1ha2A-1nf1A:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_2
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1nf1 PROTEIN
(NEUROFIBROMIN)
(Homo
sapiens) 		3 / 3 LEU A1361
VAL A1364
LEU A1368
 None
 0.47A 1mz9B-1nf1A:
undetectable		 1mz9B-1nf1A:
10.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_E_MK1E902_2
(POL POLYPROTEIN)		 1nf1 PROTEIN
(NEUROFIBROMIN)
(Homo
sapiens) 		3 / 3 ASP A1516
ILE A1497
VAL A1212
 None
 0.67A 2avvD-1nf1A:
undetectable		 2avvD-1nf1A:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_A_VIAA901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 1nf1 PROTEIN
(NEUROFIBROMIN)
(Homo
sapiens) 		5 / 11 ALA A1429
ILE A1428
LEU A1300
ILE A1397
PHE A1347
 None
 1.06A 2h42A-1nf1A:
0.2		 2h42A-1nf1A:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_B_VIAB902_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 1nf1 PROTEIN
(NEUROFIBROMIN)
(Homo
sapiens) 		5 / 12 ALA A1429
ILE A1428
LEU A1300
ILE A1397
PHE A1347
 None
 1.05A 2h42B-1nf1A:
undetectable		 2h42B-1nf1A:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EVR_A_BEZA401_0
(PUTATIVE ABC
TRANSPORTER SUBUNIT,
SUBSTRATE-BINDING
COMPONENT)		 1nf1 PROTEIN
(NEUROFIBROMIN)
(Homo
sapiens) 		5 / 11 TYR A1296
LEU A1300
PHE A1389
PHE A1457
SER A1353
 None
 1.27A 4evrA-1nf1A:
0.1		 4evrA-1nf1A:
20.45