SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1nf2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DM6_A_IMNA1401_1
(NADP-DEPENDENT
LEUKOTRIENE B4
12-HYDROXYDEHYDROGEN
ASE)		 1nf2 PHOSPHATASE
(Thermotoga
maritima) 		5 / 10 TYR A 105
ILE A 106
ILE A 184
PRO A  85
ILE A  83
 None
 0.93A 2dm6A-1nf2A:
4.1
2dm6B-1nf2A:
undetectable		 2dm6A-1nf2A:
23.01
2dm6B-1nf2A:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_B_HSMB1162_1
(ALLERGEN ARG R 1)		 1nf2 PHOSPHATASE
(Thermotoga
maritima) 		3 / 3 GLU A 117
HIS A 101
GLU A 118
 None
 0.80A 2x45B-1nf2A:
0.0		 2x45B-1nf2A:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1162_1
(ALLERGEN ARG R 1)		 1nf2 PHOSPHATASE
(Thermotoga
maritima) 		3 / 3 GLU A 117
HIS A 101
GLU A 118
 None
 0.82A 2x45C-1nf2A:
0.0		 2x45C-1nf2A:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGP_A_PCFA1213_0
(WNT INHIBITORY
FACTOR 1)		 1nf2 PHOSPHATASE
(Thermotoga
maritima) 		5 / 12 LEU A 266
PHE A  56
PHE A  39
VAL A  37
PHE A   7
 None
 1.10A 2ygpA-1nf2A:
undetectable		 2ygpA-1nf2A:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V81_A_NVPA901_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 1nf2 PHOSPHATASE
(Thermotoga
maritima) 		4 / 8 LEU A 198
VAL A   6
TYR A  36
LEU A  72
 None
 1.01A 3v81A-1nf2A:
2.2		 3v81A-1nf2A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_A_ZPCA1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 1nf2 PHOSPHATASE
(Thermotoga
maritima) 		4 / 7 TYR A  36
VAL A  38
ILE A  63
GLU A 208
 None
 1.04A 4a97E-1nf2A:
0.0		 4a97E-1nf2A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_H_ZPCH1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 1nf2 PHOSPHATASE
(Thermotoga
maritima) 		4 / 8 TYR A  36
VAL A  38
ILE A  63
GLU A 208
 None
 1.06A 4a97G-1nf2A:
undetectable		 4a97G-1nf2A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_I_ZPCI1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 1nf2 PHOSPHATASE
(Thermotoga
maritima) 		4 / 7 TYR A  36
VAL A  38
ILE A  63
GLU A 208
 None
 1.01A 4a97H-1nf2A:
undetectable		 4a97H-1nf2A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_J_ZPCJ1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 1nf2 PHOSPHATASE
(Thermotoga
maritima) 		4 / 8 TYR A  36
VAL A  38
ILE A  63
GLU A 208
 None
 1.02A 4a97I-1nf2A:
undetectable		 4a97I-1nf2A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_A_SAMA301_1
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 1nf2 PHOSPHATASE
(Thermotoga
maritima) 		3 / 3 TYR A  71
THR A  59
GLU A  75
 None
 0.82A 4df3A-1nf2A:
3.9		 4df3A-1nf2A:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_B_SAMB301_1
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 1nf2 PHOSPHATASE
(Thermotoga
maritima) 		3 / 3 TYR A  71
THR A  59
GLU A  75
 None
 0.83A 4df3B-1nf2A:
3.8		 4df3B-1nf2A:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PUO_C_NVPC901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 1nf2 PHOSPHATASE
(Thermotoga
maritima) 		4 / 8 LEU A 198
VAL A   6
TYR A  36
LEU A  72
 None
 0.99A 4puoC-1nf2A:
2.1		 4puoC-1nf2A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNU_A_QDNA602_1
(CYTOCHROME P450 2D6)		 1nf2 PHOSPHATASE
(Thermotoga
maritima) 		5 / 11 LEU A 195
PHE A   7
GLY A 226
LEU A 227
PHE A 222
 None
 1.00A 4wnuA-1nf2A:
undetectable		 4wnuA-1nf2A:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_ACTA811_0
(GEPHYRIN)		 1nf2 PHOSPHATASE
(Thermotoga
maritima) 		3 / 3 LEU A 198
LEU A  72
ARG A 201
 None
 0.65A 6fgcA-1nf2A:
0.0		 6fgcA-1nf2A:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA810_0
(GEPHYRIN)		 1nf2 PHOSPHATASE
(Thermotoga
maritima) 		3 / 3 LEU A 198
LEU A  72
ARG A 201
 None
 0.65A 6fgdA-1nf2A:
0.0		 6fgdA-1nf2A:
19.95