SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1nfa'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW3_A_TOPA208_1
(DIHYDROFOLATE
REDUCTASE)		 1nfa HUMAN TRANSCRIPTION
FACTOR NFATC1
(Homo
sapiens) 		5 / 10 MET A 114
ALA A 116
LEU A  61
LEU A 163
THR A  91
 None
 1.15A 3jw3A-1nfaA:
undetectable		 3jw3A-1nfaA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_A_MTLA870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 1nfa HUMAN TRANSCRIPTION
FACTOR NFATC1
(Homo
sapiens) 		4 / 8 SER A  23
ASN A 170
GLU A 173
ILE A 172
 None
 1.08A 4d33A-1nfaA:
0.0		 4d33A-1nfaA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 1nfa HUMAN TRANSCRIPTION
FACTOR NFATC1
(Homo
sapiens) 		4 / 7 SER A  23
ASN A 170
GLU A 173
ILE A 172
 None
 1.08A 4d33B-1nfaA:
0.0		 4d33B-1nfaA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D39_A_MTLA870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 1nfa HUMAN TRANSCRIPTION
FACTOR NFATC1
(Homo
sapiens) 		4 / 8 SER A  23
ASN A 170
GLU A 173
ILE A 172
 None
 1.09A 4d39A-1nfaA:
0.0		 4d39A-1nfaA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D39_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 1nfa HUMAN TRANSCRIPTION
FACTOR NFATC1
(Homo
sapiens) 		4 / 7 SER A  23
ASN A 170
GLU A 173
ILE A 172
 None
 1.08A 4d39B-1nfaA:
0.0		 4d39B-1nfaA:
17.79