SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1nfi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EE2_A_CHDA1150_0
(ALCOHOL
DEHYDROGENASE)		 1nfi I-KAPPA-B-ALPHA
(Homo
sapiens) 		5 / 11 SER E 252
LEU E 272
HIS E 222
LEU E 221
ILE E 265
 None
 1.30A 1ee2A-1nfiE:
undetectable		 1ee2A-1nfiE:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EE2_B_CHDB1250_1
(ALCOHOL
DEHYDROGENASE)		 1nfi I-KAPPA-B-ALPHA
(Homo
sapiens) 		5 / 11 SER E 252
LEU E 272
HIS E 222
LEU E 221
ILE E 265
 None
 1.30A 1ee2B-1nfiE:
undetectable		 1ee2B-1nfiE:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA11_1
(CES1 PROTEIN)		 1nfi I-KAPPA-B-ALPHA
(Homo
sapiens) 		4 / 8 PRO E 137
LEU E 163
GLY E 161
LEU E 131
 None
 0.79A 1ya4A-1nfiE:
undetectable		 1ya4A-1nfiE:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB1283_1
(CES1 PROTEIN)		 1nfi I-KAPPA-B-ALPHA
(Homo
sapiens) 		4 / 7 PRO E 137
LEU E 163
GLY E 161
LEU E 131
 None
 0.79A 1ya4B-1nfiE:
undetectable		 1ya4B-1nfiE:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AB2_A_SNLA502_2
(MINERALOCORTICOID
RECEPTOR)		 1nfi I-KAPPA-B-ALPHA
(Homo
sapiens) 		4 / 6 LEU E 227
LEU E 232
LEU E 221
LEU E 256
 None
 0.97A 2ab2A-1nfiE:
undetectable		 2ab2A-1nfiE:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXG_A_IBPA2002_1
(SERUM ALBUMIN)		 1nfi I-KAPPA-B-ALPHA
(Homo
sapiens) 		4 / 8 ALA E 220
ALA E 241
LEU E 202
VAL E 203
 None
 0.75A 2bxgA-1nfiE:
undetectable		 2bxgA-1nfiE:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HKK_A_ALEA300_1
(CARBONIC ANHYDRASE 2)		 1nfi I-KAPPA-B-ALPHA
(Homo
sapiens) 		4 / 6 ASN E 180
HIS E 184
ASN E 145
ILE E 120
 None
 1.14A 2hkkA-1nfiE:
undetectable		 2hkkA-1nfiE:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_B_ASDB1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 1nfi I-KAPPA-B-ALPHA
(Homo
sapiens) 		4 / 6 LEU E 196
ALA E 190
LEU E 187
ALA E 220
 None
 0.82A 2vcvB-1nfiE:
1.0		 2vcvB-1nfiE:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_K_ASDK1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 1nfi I-KAPPA-B-ALPHA
(Homo
sapiens) 		4 / 6 LEU E 196
ALA E 190
LEU E 187
ALA E 220
 None
 0.84A 2vcvK-1nfiE:
1.0		 2vcvK-1nfiE:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_C_SAMC530_1
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 1nfi I-KAPPA-B-ALPHA
(Homo
sapiens) 		3 / 3 TYR E 248
GLU E 213
ASN E 182
 None
 0.98A 2y7hC-1nfiE:
undetectable		 2y7hC-1nfiE:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGR_A_T27A556_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H
P51 RT)		 1nfi I-KAPPA-B-ALPHA
(Homo
sapiens) 		5 / 11 LEU E 235
VAL E 203
TYR E 195
LEU E 232
GLU E 200
 None
 1.36A 3bgrA-1nfiE:
0.0
3bgrB-1nfiE:
undetectable		 3bgrA-1nfiE:
17.30
3bgrB-1nfiE:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA150_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 1nfi I-KAPPA-B-ALPHA
(Homo
sapiens) 		5 / 12 ASN E 145
VAL E 119
LEU E 115
ILE E 120
THR E 113
 None
 1.06A 3elzA-1nfiE:
undetectable		 3elzA-1nfiE:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_C_CHDC150_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 1nfi I-KAPPA-B-ALPHA
(Homo
sapiens) 		5 / 12 ASN E 145
VAL E 119
LEU E 115
ILE E 120
THR E 113
 None
 0.99A 3elzC-1nfiE:
undetectable		 3elzC-1nfiE:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8W_A_FLPA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1nfi I-KAPPA-B-ALPHA
(Homo
sapiens) 		5 / 12 VAL E  97
LEU E 115
LEU E  78
GLY E 132
ALA E 133
 None
 0.93A 3n8wA-1nfiE:
1.0		 3n8wA-1nfiE:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Z_A_FLPA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1nfi I-KAPPA-B-ALPHA
(Homo
sapiens) 		5 / 12 VAL E  97
LEU E 115
LEU E  78
GLY E 132
ALA E 133
 None
 0.91A 3n8zA-1nfiE:
undetectable		 3n8zA-1nfiE:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_A_FLPA701_1
(CYCLOOXYGENASE-2)		 1nfi I-KAPPA-B-ALPHA
(Homo
sapiens) 		5 / 12 VAL E  97
LEU E 115
LEU E  78
GLY E 132
ALA E 133
 None
 0.95A 3pghA-1nfiE:
undetectable		 3pghA-1nfiE:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_C_FLPC701_1
(CYCLOOXYGENASE-2)		 1nfi I-KAPPA-B-ALPHA
(Homo
sapiens) 		5 / 12 VAL E  97
LEU E 115
LEU E  78
GLY E 132
ALA E 133
 None
 0.95A 3pghC-1nfiE:
1.0		 3pghC-1nfiE:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_C_FLRC700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1nfi I-KAPPA-B-ALPHA
(Homo
sapiens) 		5 / 12 VAL E  97
LEU E 115
LEU E  78
GLY E 132
ALA E 133
 None
 1.05A 3rr3C-1nfiE:
1.1		 3rr3C-1nfiE:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_D_FLRD700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1nfi I-KAPPA-B-ALPHA
(Homo
sapiens) 		5 / 12 VAL E  97
LEU E 115
LEU E  78
GLY E 132
ALA E 133
 None
 1.06A 3rr3D-1nfiE:
undetectable		 3rr3D-1nfiE:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_E_IPHE101_0
(INSULIN)		 1nfi I-KAPPA-B-ALPHA
(Homo
sapiens) 		5 / 11 ILE E 198
LEU E 205
ALA E 207
LEU E 148
LEU E 187
 None
 1.09A 4p65E-1nfiE:
undetectable
4p65F-1nfiE:
undetectable
4p65J-1nfiE:
undetectable
4p65L-1nfiE:
undetectable		 4p65E-1nfiE:
7.77
4p65F-1nfiE:
11.76
4p65J-1nfiE:
11.76
4p65L-1nfiE:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_G_IPHG101_0
(INSULIN)		 1nfi I-KAPPA-B-ALPHA
(Homo
sapiens) 		5 / 11 LEU E 187
VAL E 160
LEU E 148
LEU E 205
ALA E 207
 None
 1.03A 4p65B-1nfiE:
undetectable
4p65D-1nfiE:
undetectable
4p65G-1nfiE:
undetectable
4p65H-1nfiE:
undetectable		 4p65B-1nfiE:
11.76
4p65D-1nfiE:
11.76
4p65G-1nfiE:
7.77
4p65H-1nfiE:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_I_IPHI101_0
(INSULIN)		 1nfi I-KAPPA-B-ALPHA
(Homo
sapiens) 		6 / 12 VAL E 160
LEU E 148
LEU E 187
ILE E 198
LEU E 205
ALA E 207
 None
 1.06A 4p65B-1nfiE:
undetectable
4p65D-1nfiE:
undetectable
4p65I-1nfiE:
undetectable
4p65J-1nfiE:
undetectable		 4p65B-1nfiE:
11.76
4p65D-1nfiE:
11.76
4p65I-1nfiE:
7.77
4p65J-1nfiE:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_K_IPHK101_0
(INSULIN)		 1nfi I-KAPPA-B-ALPHA
(Homo
sapiens) 		5 / 12 VAL E 160
LEU E 148
ILE E 198
LEU E 205
ALA E 207
 None
 1.05A 4p65F-1nfiE:
undetectable
4p65H-1nfiE:
undetectable
4p65K-1nfiE:
undetectable
4p65L-1nfiE:
undetectable		 4p65F-1nfiE:
11.76
4p65H-1nfiE:
11.76
4p65K-1nfiE:
7.77
4p65L-1nfiE:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1I_B_LOCB502_2
(TUBULIN BETA CHAIN)		 1nfi I-KAPPA-B-ALPHA
(Homo
sapiens) 		5 / 12 LEU E 237
LEU E 232
ALA E 220
VAL E 209
ALA E 241
 None
 0.98A 4x1iB-1nfiE:
undetectable		 4x1iB-1nfiE:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDR_A_ADNA402_1
(FAD:PROTEIN FMN
TRANSFERASE)		 1nfi I-KAPPA-B-ALPHA
(Homo
sapiens) 		5 / 12 LEU E  78
HIS E  84
ILE E  83
ILE E  82
PRO E 114
 None
 0.96A 4xdrA-1nfiE:
0.0		 4xdrA-1nfiE:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 1nfi I-KAPPA-B-ALPHA
(Homo
sapiens) 		5 / 8 LEU E 163
GLY E 161
VAL E 162
ALA E 127
LEU E 115
 None
 1.10A 4zauA-1nfiE:
undetectable		 4zauA-1nfiE:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NM5_B_LOCB502_2
(TUBULIN BETA-2B
CHAIN)		 1nfi I-KAPPA-B-ALPHA
(Homo
sapiens) 		5 / 12 LEU E 205
LEU E 187
ALA E 207
ILE E 198
ALA E 190
 None
 1.29A 5nm5B-1nfiE:
undetectable		 5nm5B-1nfiE:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCV_A_1N1A404_2
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 1nfi I-KAPPA-B-ALPHA
(Homo
sapiens) 		4 / 5 VAL E  97
HIS E  79
LEU E 101
CYH E 135
 None
 1.15A 5vcvA-1nfiE:
undetectable		 5vcvA-1nfiE:
23.38