SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1nh3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FSL_A_NIOA145_1
(LEGHEMOGLOBIN A)		 1nh3 DNA TOPOISOMERASE I
(Homo
sapiens) 		4 / 8 PHE A 527
ILE A 512
PHE A 565
VAL A 525
 None
 0.89A 1fslA-1nh3A:
undetectable		 1fslA-1nh3A:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FSL_B_NIOB145_1
(LEGHEMOGLOBIN A)		 1nh3 DNA TOPOISOMERASE I
(Homo
sapiens) 		4 / 8 PHE A 527
ILE A 512
PHE A 565
VAL A 525
 None
 0.87A 1fslB-1nh3A:
0.0		 1fslB-1nh3A:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZLQ_A_ACTA1507_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 1nh3 DNA TOPOISOMERASE I
(Homo
sapiens) 		3 / 3 GLN A 421
HIS A 367
ARG A 364
 None
 0.99A 1zlqA-1nh3A:
undetectable		 1zlqA-1nh3A:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA508_0
(CHORISMATE SYNTHASE)		 1nh3 DNA TOPOISOMERASE I
(Homo
sapiens) 		4 / 5 LEU A 479
ASP A 464
ALA A 476
ILE A 457
 None
 0.93A 2qhfA-1nh3A:
undetectable		 2qhfA-1nh3A:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1nh3 DNA TOPOISOMERASE I
(Homo
sapiens) 		3 / 3 LEU A 429
ILE A 435
ARG A 434
 None
 0.55A 4mk4B-1nh3A:
undetectable		 4mk4B-1nh3A:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KXI_A_NCTA402_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4
NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
BETA-2)		 1nh3 DNA TOPOISOMERASE I
(Homo
sapiens) 		4 / 8 THR A 295
CYH A 300
TYR A 242
TRP A 282
 None
 1.38A 5kxiA-1nh3A:
0.0
5kxiB-1nh3A:
2.0		 5kxiA-1nh3A:
19.86
5kxiB-1nh3A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KXI_D_NCTD402_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4
NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
BETA-2)		 1nh3 DNA TOPOISOMERASE I
(Homo
sapiens) 		4 / 8 THR A 295
CYH A 300
TYR A 242
TRP A 282
 None
 1.35A 5kxiD-1nh3A:
0.0
5kxiE-1nh3A:
0.0		 5kxiD-1nh3A:
19.86
5kxiE-1nh3A:
20.51