SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1nhc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E06_B_IPBB600_0
(ODORANT-BINDING
PROTEIN)		 1nhc POLYGALACTURONASE I
(Aspergillus
niger) 		4 / 4 ILE A 172
MET A 135
VAL A 165
GLY A 187
 None
 1.44A 1e06B-1nhcA:
0.0		 1e06B-1nhcA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4001_1
(SERUM ALBUMIN)		 1nhc POLYGALACTURONASE I
(Aspergillus
niger) 		4 / 5 ARG A 262
ALA A 258
ASP A 208
GLY A 228
 SO4  A2711 (-3.1A)
None
SO4  A2711 ( 4.1A)
None
 1.17A 1e7cA-1nhcA:
undetectable		 1e7cA-1nhcA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QHS_A_CLMA999_0
(PROTEIN
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE))		 1nhc POLYGALACTURONASE I
(Aspergillus
niger) 		5 / 12 VAL A 247
ILE A 249
ILE A 210
ILE A 190
VAL A 244
 None
 0.95A 1qhsA-1nhcA:
undetectable		 1qhsA-1nhcA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QHY_A_CLMA999_0
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE)		 1nhc POLYGALACTURONASE I
(Aspergillus
niger) 		5 / 12 VAL A 247
ILE A 249
ILE A 210
ILE A 190
VAL A 244
 None
 0.93A 1qhyA-1nhcA:
undetectable		 1qhyA-1nhcA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R5L_A_VIVA301_0
(PROTEIN
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN))		 1nhc POLYGALACTURONASE I
(Aspergillus
niger) 		5 / 12 ILE A 281
ILE A 249
VAL A 247
VAL A 196
ILE A 198
 None
 1.21A 1r5lA-1nhcA:
undetectable		 1r5lA-1nhcA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG7_A_MTXA161_2
(DIHYDROFOLATE
REDUCTASE)		 1nhc POLYGALACTURONASE I
(Aspergillus
niger) 		3 / 3 ILE A 293
ILE A 333
THR A 265
 None
 0.58A 1rg7A-1nhcA:
undetectable		 1rg7A-1nhcA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX3_A_MTXA161_2
(DIHYDROFOLATE
REDUCTASE)		 1nhc POLYGALACTURONASE I
(Aspergillus
niger) 		3 / 3 LYS A 245
ILE A 212
THR A 265
 None
 0.84A 1rx3A-1nhcA:
undetectable		 1rx3A-1nhcA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOZ_A_CIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 1nhc POLYGALACTURONASE I
(Aspergillus
niger) 		5 / 12 ALA A 157
ILE A 158
PHE A 220
LEU A 231
ILE A 212
 None
 1.08A 1xozA-1nhcA:
undetectable		 1xozA-1nhcA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_E_MK1E902_2
(POL POLYPROTEIN)		 1nhc POLYGALACTURONASE I
(Aspergillus
niger) 		3 / 3 ASP A 186
ILE A 233
VAL A 196
 None
 0.66A 2avvD-1nhcA:
undetectable		 2avvD-1nhcA:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_D_SAMD301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 1nhc POLYGALACTURONASE I
(Aspergillus
niger) 		3 / 3 ASP A 173
ASP A 113
ASN A 205
 None
 0.70A 2bm9D-1nhcA:
undetectable		 2bm9D-1nhcA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DPM_A_SAMA300_0
(PROTEIN
(ADENINE-SPECIFIC
METHYLTRANSFERASE
DPNII 1))		 1nhc POLYGALACTURONASE I
(Aspergillus
niger) 		5 / 12 TRP A 120
GLY A 182
GLY A 181
ASN A 174
ASP A 208
 None
None
None
None
SO4  A2711 ( 4.1A)
 0.97A 2dpmA-1nhcA:
undetectable		 2dpmA-1nhcA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7W_C_SALC1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 1nhc POLYGALACTURONASE I
(Aspergillus
niger) 		4 / 7 ILE A 150
PHE A  79
PHE A  97
ILE A  95
 None
 0.74A 2y7wC-1nhcA:
undetectable		 2y7wC-1nhcA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOC_C_ERYC3402_0
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 1nhc POLYGALACTURONASE I
(Aspergillus
niger) 		5 / 12 SER A  75
PHE A 170
PHE A  79
ILE A 150
PHE A  85
 None
 1.05A 3aocC-1nhcA:
undetectable		 3aocC-1nhcA:
14.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARR_A_PNXA606_1
(CHITINASE A)		 1nhc POLYGALACTURONASE I
(Aspergillus
niger) 		4 / 7 GLY A 177
ASP A 115
TRP A 119
ARG A 118
 None
 1.23A 3arrA-1nhcA:
undetectable		 3arrA-1nhcA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA606_1
(CHITINASE A)		 1nhc POLYGALACTURONASE I
(Aspergillus
niger) 		4 / 7 GLY A 177
ASP A 115
TRP A 119
ARG A 118
 None
 1.27A 3aruA-1nhcA:
undetectable		 3aruA-1nhcA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_B_SAMB238_1
(N,N-DIMETHYLTRANSFER
ASE)		 1nhc POLYGALACTURONASE I
(Aspergillus
niger) 		3 / 3 TYR A 267
GLU A 360
ASP A 357
 None
 0.89A 3bxoB-1nhcA:
undetectable		 3bxoB-1nhcA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EIG_A_MTXA200_2
(DIHYDROFOLATE
REDUCTASE)		 1nhc POLYGALACTURONASE I
(Aspergillus
niger) 		4 / 5 ASP A 296
ARG A 262
ILE A 293
VAL A 331
 None
SO4  A2711 (-3.1A)
None
None
 1.23A 3eigA-1nhcA:
undetectable		 3eigA-1nhcA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_A_SAMA301_1
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 1nhc POLYGALACTURONASE I
(Aspergillus
niger) 		3 / 3 SER A 199
ASP A 169
ASP A 251
 None
 0.81A 3iv6A-1nhcA:
undetectable		 3iv6A-1nhcA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_A_SAMA301_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 1nhc POLYGALACTURONASE I
(Aspergillus
niger) 		3 / 3 SER A 301
ASP A 288
ASP A 327
 None
 0.87A 3uj7A-1nhcA:
undetectable		 3uj7A-1nhcA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_H_ACTH502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 1nhc POLYGALACTURONASE I
(Aspergillus
niger) 		3 / 3 SER A 351
GLY A 352
GLN A 330
 None
 0.64A 3v4tH-1nhcA:
undetectable		 3v4tH-1nhcA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GH8_A_MTXA201_2
(DIHYDROFOLATE
REDUCTASE)		 1nhc POLYGALACTURONASE I
(Aspergillus
niger) 		3 / 3 LYS A 245
ILE A 212
THR A 265
 None
 0.88A 4gh8A-1nhcA:
undetectable		 4gh8A-1nhcA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_A_SAMA301_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 1nhc POLYGALACTURONASE I
(Aspergillus
niger) 		3 / 3 SER A 301
ASP A 288
ASP A 327
 None
 0.82A 4mwzA-1nhcA:
undetectable		 4mwzA-1nhcA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_C_STRC601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 1nhc POLYGALACTURONASE I
(Aspergillus
niger) 		4 / 5 ILE A 212
ARG A 262
ASP A 207
VAL A 160
 None
SO4  A2711 (-3.1A)
SO4  A2711 (-3.7A)
None
 1.24A 4nkxC-1nhcA:
0.0		 4nkxC-1nhcA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_D_STRD601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 1nhc POLYGALACTURONASE I
(Aspergillus
niger) 		4 / 5 ILE A 212
ARG A 262
ASP A 207
VAL A 160
 None
SO4  A2711 (-3.1A)
SO4  A2711 (-3.7A)
None
 1.27A 4nkxD-1nhcA:
0.0		 4nkxD-1nhcA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1E_A_C2FA3000_0
(DIHYDROPTEROATE
SYNTHASE DHPS)		 1nhc POLYGALACTURONASE I
(Aspergillus
niger) 		5 / 12 ILE A 158
ILE A 276
GLY A 215
SER A 193
ILE A 212
 None
 1.05A 4o1eA-1nhcA:
undetectable		 4o1eA-1nhcA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1E_B_C2FB4000_0
(DIHYDROPTEROATE
SYNTHASE DHPS)		 1nhc POLYGALACTURONASE I
(Aspergillus
niger) 		5 / 12 ILE A 158
ILE A 276
GLY A 215
SER A 193
ILE A 212
 None
 1.02A 4o1eB-1nhcA:
undetectable		 4o1eB-1nhcA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_A_RBFA201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 1nhc POLYGALACTURONASE I
(Aspergillus
niger) 		4 / 8 ILE A 190
VAL A 261
LEU A 231
ILE A 281
 None
 0.82A 4r38A-1nhcA:
undetectable		 4r38A-1nhcA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_D_RBFD201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 1nhc POLYGALACTURONASE I
(Aspergillus
niger) 		4 / 8 ILE A 190
VAL A 261
LEU A 231
ILE A 281
 None
 0.86A 4r38D-1nhcA:
undetectable		 4r38D-1nhcA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_A_Z80A401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 1nhc POLYGALACTURONASE I
(Aspergillus
niger) 		5 / 11 ILE A 190
ILE A 210
PHE A 220
VAL A 160
ALA A 201
 None
 0.67A 5lg3A-1nhcA:
undetectable		 5lg3A-1nhcA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_E_Z80E401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 1nhc POLYGALACTURONASE I
(Aspergillus
niger) 		5 / 12 ILE A 190
ILE A 210
PHE A 220
VAL A 160
ALA A 201
 None
 0.71A 5lg3E-1nhcA:
undetectable		 5lg3E-1nhcA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QXS_B_FOZB403_0
(THYMIDYLATE SYNTHASE)		 1nhc POLYGALACTURONASE I
(Aspergillus
niger) 		5 / 12 LEU A  66
ILE A  95
GLY A 114
PHE A  85
ILE A 150
 None
 1.09A 6qxsB-1nhcA:
0.0		 6qxsB-1nhcA:
22.69