SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1nhw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_A_BEZA349_0
(D-AMINO ACID OXIDASE)		 1nhw ENOYL-ACYL CARRIER
REDUCTASE
(Plasmodium
falciparum) 		4 / 5 TYR A 267
TYR A 277
ILE A 323
GLY A 313
 TCC  A 600 ( 4.0A)
TCC  A 600 (-4.5A)
TCC  A 600 (-4.8A)
None
 1.01A 1kifA-1nhwA:
2.8		 1kifA-1nhwA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_B_BEZB349_0
(D-AMINO ACID OXIDASE)		 1nhw ENOYL-ACYL CARRIER
REDUCTASE
(Plasmodium
falciparum) 		4 / 5 TYR A 267
TYR A 277
ILE A 323
GLY A 313
 TCC  A 600 ( 4.0A)
TCC  A 600 (-4.5A)
TCC  A 600 (-4.8A)
None
 1.01A 1kifB-1nhwA:
2.8		 1kifB-1nhwA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_C_BEZC349_0
(D-AMINO ACID OXIDASE)		 1nhw ENOYL-ACYL CARRIER
REDUCTASE
(Plasmodium
falciparum) 		4 / 5 TYR A 267
TYR A 277
ILE A 323
GLY A 313
 TCC  A 600 ( 4.0A)
TCC  A 600 (-4.5A)
TCC  A 600 (-4.8A)
None
 1.00A 1kifC-1nhwA:
2.8		 1kifC-1nhwA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_D_BEZD349_0
(D-AMINO ACID OXIDASE)		 1nhw ENOYL-ACYL CARRIER
REDUCTASE
(Plasmodium
falciparum) 		4 / 5 TYR A 267
TYR A 277
ILE A 323
GLY A 313
 TCC  A 600 ( 4.0A)
TCC  A 600 (-4.5A)
TCC  A 600 (-4.8A)
None
 1.00A 1kifD-1nhwA:
2.8		 1kifD-1nhwA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_E_BEZE349_0
(D-AMINO ACID OXIDASE)		 1nhw ENOYL-ACYL CARRIER
REDUCTASE
(Plasmodium
falciparum) 		4 / 5 TYR A 267
TYR A 277
ILE A 323
GLY A 313
 TCC  A 600 ( 4.0A)
TCC  A 600 (-4.5A)
TCC  A 600 (-4.8A)
None
 1.00A 1kifE-1nhwA:
2.8		 1kifE-1nhwA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_F_BEZF349_0
(D-AMINO ACID OXIDASE)		 1nhw ENOYL-ACYL CARRIER
REDUCTASE
(Plasmodium
falciparum) 		4 / 5 TYR A 267
TYR A 277
ILE A 323
GLY A 313
 TCC  A 600 ( 4.0A)
TCC  A 600 (-4.5A)
TCC  A 600 (-4.8A)
None
 1.00A 1kifF-1nhwA:
2.8		 1kifF-1nhwA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_G_BEZG349_0
(D-AMINO ACID OXIDASE)		 1nhw ENOYL-ACYL CARRIER
REDUCTASE
(Plasmodium
falciparum) 		4 / 5 TYR A 267
TYR A 277
ILE A 323
GLY A 313
 TCC  A 600 ( 4.0A)
TCC  A 600 (-4.5A)
TCC  A 600 (-4.8A)
None
 1.00A 1kifG-1nhwA:
2.8		 1kifG-1nhwA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_H_BEZH349_0
(D-AMINO ACID OXIDASE)		 1nhw ENOYL-ACYL CARRIER
REDUCTASE
(Plasmodium
falciparum) 		4 / 5 TYR A 267
TYR A 277
ILE A 323
GLY A 313
 TCC  A 600 ( 4.0A)
TCC  A 600 (-4.5A)
TCC  A 600 (-4.8A)
None
 1.00A 1kifH-1nhwA:
2.8		 1kifH-1nhwA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VE9_A_BEZA352_0
(D-AMINO ACID OXIDASE)		 1nhw ENOYL-ACYL CARRIER
REDUCTASE
(Plasmodium
falciparum) 		4 / 5 TYR A 267
TYR A 277
ILE A 323
GLY A 313
 TCC  A 600 ( 4.0A)
TCC  A 600 (-4.5A)
TCC  A 600 (-4.8A)
None
 1.03A 1ve9A-1nhwA:
2.9		 1ve9A-1nhwA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DU8_G_BEZG2352_0
(D-AMINO-ACID OXIDASE)		 1nhw ENOYL-ACYL CARRIER
REDUCTASE
(Plasmodium
falciparum) 		4 / 5 TYR A 267
TYR A 277
ILE A 323
GLY A 313
 TCC  A 600 ( 4.0A)
TCC  A 600 (-4.5A)
TCC  A 600 (-4.8A)
None
 1.05A 2du8G-1nhwA:
2.8		 2du8G-1nhwA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DU8_J_BEZJ3352_0
(D-AMINO-ACID OXIDASE)		 1nhw ENOYL-ACYL CARRIER
REDUCTASE
(Plasmodium
falciparum) 		4 / 5 TYR A 267
TYR A 277
ILE A 323
GLY A 313
 TCC  A 600 ( 4.0A)
TCC  A 600 (-4.5A)
TCC  A 600 (-4.8A)
None
 1.06A 2du8J-1nhwA:
2.8		 2du8J-1nhwA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_B_SAMB300_1
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 1nhw ENOYL-ACYL CARRIER
REDUCTASE
ENOYL-ACYL CARRIER
REDUCTASE
(Plasmodium
falciparum;
Plasmodium
falciparum) 		4 / 5 SER C 388
GLY A 114
ASP A 156
ASP A 150
 None
 1.13A 2oxtB-1nhwC:
undetectable		 2oxtB-1nhwC:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PLW_A_SAMA203_0
(RIBOSOMAL RNA
METHYLTRANSFERASE,
PUTATIVE)		 1nhw ENOYL-ACYL CARRIER
REDUCTASE
(Plasmodium
falciparum) 		5 / 12 ALA A 116
GLY A 106
GLY A 110
TRP A 113
ILE A 137
 None
NAD  A 450 (-3.8A)
NAD  A 450 (-3.3A)
None
None
 1.10A 2plwA-1nhwA:
2.9		 2plwA-1nhwA:
27.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM8_A_ACAA511_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 1nhw ENOYL-ACYL CARRIER
REDUCTASE
(Plasmodium
falciparum) 		4 / 8 ALA A 312
TYR A 111
ILE A 310
HIS A 214
 NAD  A 450 (-3.7A)
NAD  A 450 (-4.6A)
None
None
 0.93A 2zm8A-1nhwA:
undetectable		 2zm8A-1nhwA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZMA_A_ACAA501_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 1nhw ENOYL-ACYL CARRIER
REDUCTASE
(Plasmodium
falciparum) 		4 / 8 ALA A 312
TYR A 111
ILE A 310
HIS A 214
 NAD  A 450 (-3.7A)
NAD  A 450 (-4.6A)
None
None
 0.94A 2zmaA-1nhwA:
undetectable		 2zmaA-1nhwA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DEU_B_SALB306_1
(TRANSCRIPTIONAL
REGULATOR SLYA)		 1nhw ENOYL-ACYL CARRIER
REDUCTASE
(Plasmodium
falciparum) 		4 / 6 THR C 410
THR A 309
LEU A 288
THR A 266
 None
 0.97A 3deuB-1nhwC:
undetectable		 3deuB-1nhwC:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP2_A_PNNA5001_0
(TRANSCRIPTIONAL
REGULATOR TCAR)		 1nhw ENOYL-ACYL CARRIER
REDUCTASE
(Plasmodium
falciparum) 		4 / 8 THR A 229
LEU A 226
SER A 282
ASN A 218
 None
None
None
NAD  A 450 (-4.1A)
 1.03A 3kp2A-1nhwA:
0.0
3kp2B-1nhwA:
undetectable		 3kp2A-1nhwA:
22.12
3kp2B-1nhwA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KSZ_A_CYSA620_0
(LACTOPEROXIDASE)		 1nhw ENOYL-ACYL CARRIER
REDUCTASE
(Plasmodium
falciparum) 		3 / 3 ARG C 404
GLU C 402
PHE C 397
 None
 0.97A 4kszA-1nhwC:
undetectable		 4kszA-1nhwC:
8.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDT_A_ACTA409_0
(FAD:PROTEIN FMN
TRANSFERASE)		 1nhw ENOYL-ACYL CARRIER
REDUCTASE
(Plasmodium
falciparum) 		4 / 5 ILE C 391
VAL C 413
ILE C 411
VAL C 394
 None
 0.76A 4xdtA-1nhwC:
undetectable		 4xdtA-1nhwC:
8.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUE_A_SAMA303_1
(CATECHOL
O-METHYLTRANSFERASE)		 1nhw ENOYL-ACYL CARRIER
REDUCTASE
ENOYL-ACYL CARRIER
REDUCTASE
(Plasmodium
falciparum;
Plasmodium
falciparum) 		4 / 5 GLY A 313
TYR C 375
SER C 376
ASP C 414
 None
 1.12A 4xueA-1nhwA:
7.1		 4xueA-1nhwA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YMG_B_SAMB1001_0
(PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE)		 1nhw ENOYL-ACYL CARRIER
REDUCTASE
ENOYL-ACYL CARRIER
REDUCTASE
(Plasmodium
falciparum;
Plasmodium
falciparum) 		5 / 12 GLY A 313
TYR C 375
SER C 376
ASP C 414
ALA A 312
 None
None
None
None
NAD  A 450 (-3.7A)
 1.14A 4ymgB-1nhwA:
5.8		 4ymgB-1nhwA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YOD_F_BEZF201_0
(NS3 PROTEASE)		 1nhw ENOYL-ACYL CARRIER
REDUCTASE
(Plasmodium
falciparum) 		4 / 5 HIS A 214
ALA A 169
SER A 244
TYR A 243
 None
NAD  A 450 (-3.5A)
None
None
 1.30A 5yodF-1nhwA:
undetectable		 5yodF-1nhwA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6J_A_ACTA404_0
(L-LYSINE
3-HYDROXYLASE)		 1nhw ENOYL-ACYL CARRIER
REDUCTASE
ENOYL-ACYL CARRIER
REDUCTASE
(Plasmodium
falciparum;
Plasmodium
falciparum) 		4 / 6 ILE C 391
TYR A 111
LEU A 265
VAL C 413
 None
NAD  A 450 (-4.6A)
NAD  A 450 (-3.7A)
None
 1.25A 6f6jA-1nhwC:
undetectable		 6f6jA-1nhwC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FDY_U_DB8U302_1
(-)		 1nhw ENOYL-ACYL CARRIER
REDUCTASE
(Plasmodium
falciparum) 		5 / 9 VAL C 413
PHE C 397
SER C 396
LEU C 398
ILE A 310
 None
 0.87A 6fdyU-1nhwC:
undetectable		 6fdyU-1nhwC:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_C_LLLC301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 1nhw ENOYL-ACYL CARRIER
REDUCTASE
(Plasmodium
falciparum) 		4 / 6 ASP A 176
TYR A 251
GLU A 196
ASP A 197
 None
 1.41A 6mn5C-1nhwA:
undetectable		 6mn5C-1nhwA:
14.61