SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1nhy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EIZ_A_SAMA301_0
(FTSJ)		 1nhy ELONGATION FACTOR
1-GAMMA 1
(Saccharomyces
cerevisiae) 		5 / 12 ALA A   8
GLY A  19
LEU A  24
LEU A  26
LEU A 163
 None
 0.96A 1eizA-1nhyA:
undetectable		 1eizA-1nhyA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EJ0_A_SAMA301_0
(FTSJ)		 1nhy ELONGATION FACTOR
1-GAMMA 1
(Saccharomyces
cerevisiae) 		5 / 12 ALA A   8
GLY A  19
LEU A  24
LEU A  26
LEU A 163
 None
 0.93A 1ej0A-1nhyA:
undetectable		 1ej0A-1nhyA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_E_MK1E902_2
(POL POLYPROTEIN)		 1nhy ELONGATION FACTOR
1-GAMMA 1
(Saccharomyces
cerevisiae) 		3 / 3 ASP A 130
ILE A 115
VAL A 140
 None
 0.68A 2avvD-1nhyA:
undetectable		 2avvD-1nhyA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O5Y_H_STRH249_1
(CHIMERIC ANTIBODY
FAB 1E9-DB3)		 1nhy ELONGATION FACTOR
1-GAMMA 1
(Saccharomyces
cerevisiae) 		4 / 7 ASN A  67
THR A  14
TRP A  15
SER A 167
 None
 0.99A 2o5yH-1nhyA:
undetectable
2o5yL-1nhyA:
undetectable		 2o5yH-1nhyA:
22.04
2o5yL-1nhyA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_Q_TFPQ201_1
(PROTEIN S100-A4)		 1nhy ELONGATION FACTOR
1-GAMMA 1
(Saccharomyces
cerevisiae) 		4 / 8 PHE A 177
GLY A 178
ILE A 115
PHE A 208
 None
 0.96A 3ko0O-1nhyA:
undetectable
3ko0Q-1nhyA:
0.0		 3ko0O-1nhyA:
19.18
3ko0Q-1nhyA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NV6_A_CAMA422_0
(CYTOCHROME P450)		 1nhy ELONGATION FACTOR
1-GAMMA 1
(Saccharomyces
cerevisiae) 		3 / 3 GLY A 178
ILE A 188
VAL A 189
 None
 0.48A 3nv6A-1nhyA:
undetectable		 3nv6A-1nhyA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WSJ_A_MK1A201_2
(PROTEASE)		 1nhy ELONGATION FACTOR
1-GAMMA 1
(Saccharomyces
cerevisiae) 		4 / 7 ARG A  98
LEU A 102
ASP A 106
ILE A 139
 None
 0.86A 3wsjB-1nhyA:
undetectable		 3wsjB-1nhyA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MA8_C_Z80C301_1
(MAJOR PRION PROTEIN)		 1nhy ELONGATION FACTOR
1-GAMMA 1
(Saccharomyces
cerevisiae) 		4 / 5 LEU A  84
GLY A  85
ILE A  97
GLN A 100
 None
 1.17A 4ma8C-1nhyA:
undetectable		 4ma8C-1nhyA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WS0_A_URFA301_1
(URACIL-DNA
GLYCOSYLASE)		 1nhy ELONGATION FACTOR
1-GAMMA 1
(Saccharomyces
cerevisiae) 		4 / 7 GLY A   4
GLN A   3
TYR A  58
PHE A  52
 None
 1.00A 4ws0A-1nhyA:
undetectable		 4ws0A-1nhyA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WS1_A_URFA301_1
(URACIL-DNA
GLYCOSYLASE)		 1nhy ELONGATION FACTOR
1-GAMMA 1
(Saccharomyces
cerevisiae) 		4 / 8 GLY A   4
GLN A   3
TYR A  58
PHE A  52
 None
 0.99A 4ws1A-1nhyA:
undetectable		 4ws1A-1nhyA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C6P_A_4YHA601_1
(PROTEIN C)		 1nhy ELONGATION FACTOR
1-GAMMA 1
(Saccharomyces
cerevisiae) 		4 / 6 ALA A 103
SER A 101
GLN A  95
ASP A 162
 None
 1.18A 5c6pA-1nhyA:
0.0		 5c6pA-1nhyA:
18.22