SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ni3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JLF_A_NVPA999_1
(HIV-1 RT A-CHAIN
HIV-1 RT B-CHAIN)		 1ni3 YCHF GTP-BINDING
PROTEIN
(Schizosaccharomy
ces
pombe) 		4 / 8 LEU A 110
VAL A  26
GLY A  27
GLU A 150
 None
 0.93A 1jlfA-1ni3A:
undetectable
1jlfB-1ni3A:
2.1		 1jlfA-1ni3A:
23.87
1jlfB-1ni3A:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SKX_A_RFPA1_2
(ORPHAN NUCLEAR
RECEPTOR PXR)		 1ni3 YCHF GTP-BINDING
PROTEIN
(Schizosaccharomy
ces
pombe) 		4 / 5 LYS A 250
PHE A 126
LEU A 246
MET A 265
 None
 1.32A 1skxA-1ni3A:
0.0		 1skxA-1ni3A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I30_A_SALA1200_1
(SERUM ALBUMIN)		 1ni3 YCHF GTP-BINDING
PROTEIN
(Schizosaccharomy
ces
pombe) 		4 / 4 LEU A 166
ILE A 215
ILE A 188
ALA A 187
 None
 0.76A 2i30A-1ni3A:
2.1		 2i30A-1ni3A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA509_0
(CHORISMATE SYNTHASE)		 1ni3 YCHF GTP-BINDING
PROTEIN
(Schizosaccharomy
ces
pombe) 		3 / 3 ARG A 204
GLN A 201
PRO A 202
 None
 1.00A 2qhfA-1ni3A:
0.0		 2qhfA-1ni3A:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_A_TFPA202_1
(PROTEIN S100-A4)		 1ni3 YCHF GTP-BINDING
PROTEIN
(Schizosaccharomy
ces
pombe) 		5 / 12 LEU A 110
PHE A 109
GLU A 150
LEU A 151
ASP A 149
 None
 1.14A 3ko0A-1ni3A:
undetectable
3ko0B-1ni3A:
undetectable
3ko0C-1ni3A:
undetectable
3ko0D-1ni3A:
undetectable		 3ko0A-1ni3A:
12.47
3ko0B-1ni3A:
12.47
3ko0C-1ni3A:
12.47
3ko0D-1ni3A:
12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_L_TFPL202_1
(PROTEIN S100-A4)		 1ni3 YCHF GTP-BINDING
PROTEIN
(Schizosaccharomy
ces
pombe) 		5 / 12 GLU A 150
LEU A 151
ASP A 149
LEU A 110
PHE A 109
 None
 1.16A 3ko0K-1ni3A:
undetectable
3ko0L-1ni3A:
undetectable
3ko0M-1ni3A:
undetectable
3ko0N-1ni3A:
undetectable		 3ko0K-1ni3A:
12.47
3ko0L-1ni3A:
12.47
3ko0M-1ni3A:
12.47
3ko0N-1ni3A:
12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_P_TFPP202_1
(PROTEIN S100-A4)		 1ni3 YCHF GTP-BINDING
PROTEIN
(Schizosaccharomy
ces
pombe) 		5 / 12 GLU A 150
LEU A 151
ASP A 149
LEU A 110
PHE A 109
 None
 1.16A 3ko0M-1ni3A:
undetectable
3ko0N-1ni3A:
undetectable
3ko0O-1ni3A:
undetectable
3ko0P-1ni3A:
undetectable		 3ko0M-1ni3A:
12.47
3ko0N-1ni3A:
12.47
3ko0O-1ni3A:
12.47
3ko0P-1ni3A:
12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PRS_A_RITA1001_1
(ENDOTHIAPEPSIN)		 1ni3 YCHF GTP-BINDING
PROTEIN
(Schizosaccharomy
ces
pombe) 		5 / 10 ALA A 125
TYR A 229
LEU A 144
ILE A  25
ILE A 297
 None
 1.08A 3prsA-1ni3A:
undetectable		 3prsA-1ni3A:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_D_ACTD4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 1ni3 YCHF GTP-BINDING
PROTEIN
(Schizosaccharomy
ces
pombe) 		4 / 5 LEU A 151
LEU A 105
GLY A 106
GLY A 104
 None
 0.73A 3si7C-1ni3A:
0.0
3si7D-1ni3A:
0.0		 3si7C-1ni3A:
22.78
3si7D-1ni3A:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TYE_B_YTZB902_1
(DIHYDROPTEROATE
SYNTHASE)		 1ni3 YCHF GTP-BINDING
PROTEIN
(Schizosaccharomy
ces
pombe) 		3 / 3 PHE A 109
LYS A  33
SER A  34
 None
SO4  A 393 (-3.0A)
SO4  A 393 (-3.3A)
 1.35A 3tyeB-1ni3A:
2.8		 3tyeB-1ni3A:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_C_RTLC201_0
(RETINOL-BINDING
PROTEIN 2)		 1ni3 YCHF GTP-BINDING
PROTEIN
(Schizosaccharomy
ces
pombe) 		5 / 12 ILE A 141
TYR A 229
VAL A 227
LEU A 144
LEU A 105
 None
 1.14A 4qzuC-1ni3A:
undetectable		 4qzuC-1ni3A:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE0_A_VORA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1ni3 YCHF GTP-BINDING
PROTEIN
(Schizosaccharomy
ces
pombe) 		5 / 9 TYR A 229
THR A 261
ILE A 263
GLY A 301
THR A  23
 None
 1.43A 4ze0A-1ni3A:
undetectable		 4ze0A-1ni3A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZB_C_ACTC401_0
(PROTON-GATED ION
CHANNEL)		 1ni3 YCHF GTP-BINDING
PROTEIN
(Schizosaccharomy
ces
pombe) 		4 / 7 ILE A  40
PHE A  36
VAL A  63
ILE A 298
 None
 0.96A 4zzbC-1ni3A:
2.1
4zzbD-1ni3A:
2.2		 4zzbC-1ni3A:
21.90
4zzbD-1ni3A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AJQ_A_DB8A800_2
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 1ni3 YCHF GTP-BINDING
PROTEIN
(Schizosaccharomy
ces
pombe) 		4 / 4 VAL A 138
ILE A 141
ASN A 243
VAL A 123
 None
 1.25A 5ajqA-1ni3A:
0.0		 5ajqA-1ni3A:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TT3_H_EZLH303_1
(ALPHA-CARBONIC
ANHYDRASE)		 1ni3 YCHF GTP-BINDING
PROTEIN
(Schizosaccharomy
ces
pombe) 		4 / 8 VAL A 192
LEU A 221
THR A 223
ALA A 224
 None
 0.92A 5tt3H-1ni3A:
undetectable		 5tt3H-1ni3A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MXT_A_K5YA1401_0
(ENDOLYSIN, BETA-2
ADRENERGIC RECEPTOR
CHIMERA)		 1ni3 YCHF GTP-BINDING
PROTEIN
(Schizosaccharomy
ces
pombe) 		5 / 12 VAL A  63
VAL A  89
PHE A  36
ILE A 263
TYR A 120
 None
 1.14A 6mxtA-1ni3A:
0.0		 6mxtA-1ni3A:
24.07