SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ni5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_A_CHDA1503_0
(FERROCHELATASE)		 1ni5 PUTATIVE CELL CYCLE
PROTEIN MESJ
(Escherichia
coli) 		3 / 3 LEU A 332
PRO A 333
LEU A 336
 None
 0.51A 1hrkA-1ni5A:
2.6		 1hrkA-1ni5A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_F_AG2F7016_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 1ni5 PUTATIVE CELL CYCLE
PROTEIN MESJ
(Escherichia
coli) 		4 / 8 LEU A 155
ASP A  24
LEU A  23
GLY A  22
 None
 0.90A 1n13A-1ni5A:
undetectable
1n13F-1ni5A:
undetectable		 1n13A-1ni5A:
7.41
1n13F-1ni5A:
11.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_H_AG2H7012_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 1ni5 PUTATIVE CELL CYCLE
PROTEIN MESJ
(Escherichia
coli) 		4 / 6 LEU A 155
ASP A  24
LEU A  23
GLY A  22
 None
 0.92A 1n13H-1ni5A:
undetectable
1n13K-1ni5A:
undetectable		 1n13H-1ni5A:
11.63
1n13K-1ni5A:
7.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_J_AG2J7013_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 1ni5 PUTATIVE CELL CYCLE
PROTEIN MESJ
(Escherichia
coli) 		4 / 7 LEU A 155
ASP A  24
LEU A  23
GLY A  22
 None
 0.91A 1n13G-1ni5A:
undetectable
1n13J-1ni5A:
undetectable		 1n13G-1ni5A:
7.41
1n13J-1ni5A:
11.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1M_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 1ni5 PUTATIVE CELL CYCLE
PROTEIN MESJ
(Escherichia
coli) 		4 / 8 VAL A 423
GLY A 345
VAL A 411
ILE A 404
 None
 0.80A 2a1mB-1ni5A:
0.0		 2a1mB-1ni5A:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_E_AG2E671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 1ni5 PUTATIVE CELL CYCLE
PROTEIN MESJ
(Escherichia
coli) 		4 / 7 LEU A 155
ASP A  24
LEU A  23
GLY A  22
 None
 0.91A 2qqcD-1ni5A:
0.0
2qqcE-1ni5A:
0.0		 2qqcD-1ni5A:
11.29
2qqcE-1ni5A:
7.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_K_AG2K671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 1ni5 PUTATIVE CELL CYCLE
PROTEIN MESJ
(Escherichia
coli) 		4 / 8 LEU A 155
ASP A  24
LEU A  23
GLY A  22
 None
 0.90A 2qqcH-1ni5A:
undetectable
2qqcK-1ni5A:
undetectable		 2qqcH-1ni5A:
11.29
2qqcK-1ni5A:
7.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQD_B_AG2B671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 1ni5 PUTATIVE CELL CYCLE
PROTEIN MESJ
(Escherichia
coli) 		4 / 8 LEU A 155
ASP A  24
LEU A  23
GLY A  22
 None
 0.88A 2qqdB-1ni5A:
undetectable
2qqdC-1ni5A:
undetectable		 2qqdB-1ni5A:
11.63
2qqdC-1ni5A:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCN_B_CHDB2_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1ni5 PUTATIVE CELL CYCLE
PROTEIN MESJ
(Escherichia
coli) 		3 / 3 LEU A  16
LEU A 105
ARG A 103
 None
 0.76A 3hcnB-1ni5A:
2.5		 3hcnB-1ni5A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_B_RITB600_2
(CYTOCHROME P450 3A4)		 1ni5 PUTATIVE CELL CYCLE
PROTEIN MESJ
(Escherichia
coli) 		5 / 9 ARG A 187
ILE A  89
THR A 113
ARG A 160
GLY A  22
 None
 1.29A 3nxuB-1ni5A:
0.0		 3nxuB-1ni5A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q1E_D_T44D328_1
(5-HYDROXYISOURATE
HYDROLASE)		 1ni5 PUTATIVE CELL CYCLE
PROTEIN MESJ
(Escherichia
coli) 		5 / 9 LEU A   9
PRO A 154
THR A 113
LEU A 151
LEU A 111
 None
 1.23A 3q1eB-1ni5A:
0.0
3q1eD-1ni5A:
0.0		 3q1eB-1ni5A:
13.19
3q1eD-1ni5A:
13.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFE_C_TMGC1_1
(SUCCINATE
DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR SUBUNIT,
MITOCHONDRIAL
SUCCINATE
DEHYDROGENASE
CYTOCHROME B560
SUBUNIT,
MITOCHONDRIAL)		 1ni5 PUTATIVE CELL CYCLE
PROTEIN MESJ
(Escherichia
coli) 		4 / 8 PRO A 154
ILE A 152
TRP A  35
ILE A  15
 None
 1.07A 3sfeB-1ni5A:
1.4
3sfeC-1ni5A:
undetectable		 3sfeB-1ni5A:
18.82
3sfeC-1ni5A:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1ni5 PUTATIVE CELL CYCLE
PROTEIN MESJ
(Escherichia
coli) 		3 / 3 LEU A 332
PRO A 333
LEU A 336
 None
 0.45A 3w1wB-1ni5A:
3.5		 3w1wB-1ni5A:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D1Y_A_RBFA1176_1
(PUTATIVE PROTEASE I)		 1ni5 PUTATIVE CELL CYCLE
PROTEIN MESJ
(Escherichia
coli) 		4 / 8 ASN A 266
TRP A 309
THR A 240
TRP A 261
 None
 1.44A 4d1yA-1ni5A:
undetectable
4d1yB-1ni5A:
2.6		 4d1yA-1ni5A:
17.69
4d1yB-1ni5A:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PO0_A_NPSA602_1
(SERUM ALBUMIN)		 1ni5 PUTATIVE CELL CYCLE
PROTEIN MESJ
(Escherichia
coli) 		5 / 8 LYS A 361
ALA A 362
GLY A 364
LEU A 366
LEU A 403
 None
 1.32A 4po0A-1ni5A:
2.8		 4po0A-1ni5A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FXT_A_0LAA1376_1
(DNA POLYMERASE III
SUBUNIT BETA)		 1ni5 PUTATIVE CELL CYCLE
PROTEIN MESJ
(Escherichia
coli) 		4 / 7 LEU A 295
PRO A 270
ILE A 258
LEU A 241
 None
 1.03A 5fxtA-1ni5A:
undetectable		 5fxtA-1ni5A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NU7_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 4)		 1ni5 PUTATIVE CELL CYCLE
PROTEIN MESJ
(Escherichia
coli) 		4 / 8 LEU A 262
ALA A 283
MET A 246
GLN A 235
 None
 0.96A 5nu7A-1ni5A:
undetectable		 5nu7A-1ni5A:
16.13