SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ni6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AA6_B_STRB402_1
(MINERALOCORTICOID
RECEPTOR)		 1ni6 HEME OXYGENASE 1
(Homo
sapiens) 		5 / 12 LEU A 129
MET A 186
MET A 191
LEU A  13
THR A  21
 None
 1.35A 2aa6B-1ni6A:
undetectable		 2aa6B-1ni6A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QWX_B_ML1B233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1ni6 HEME OXYGENASE 1
(Homo
sapiens) 		4 / 7 GLY A 144
GLY A 163
PHE A  47
PHE A  37
 None
 0.99A 2qwxA-1ni6A:
undetectable
2qwxB-1ni6A:
undetectable		 2qwxA-1ni6A:
22.05
2qwxB-1ni6A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_A_DGXA1_2
(NUCLEAR RECEPTOR
ROR-GAMMA)		 1ni6 HEME OXYGENASE 1
(Homo
sapiens) 		3 / 3 TRP A 101
VAL A 115
ARG A 113
 None
 0.98A 3b0wA-1ni6A:
0.0		 3b0wA-1ni6A:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW5_A_TOPA208_1
(DIHYDROFOLATE
REDUCTASE)		 1ni6 HEME OXYGENASE 1
(Homo
sapiens) 		5 / 11 ALA A 206
LEU A 118
VAL A 121
ILE A  65
THR A 205
 None
 1.32A 3jw5A-1ni6A:
undetectable		 3jw5A-1ni6A:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP5_B_KANB2002_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 1ni6 HEME OXYGENASE 1
(Homo
sapiens) 		3 / 3 ALA A  31
ARG A  35
LYS A  39
 None
 0.90A 3kp5B-1ni6A:
undetectable		 3kp5B-1ni6A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_C_SAMC300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 1ni6 HEME OXYGENASE 1
(Homo
sapiens) 		5 / 12 GLU A  29
GLY A 143
SER A 142
LEU A 147
ALA A  28
 None
 1.18A 3ou6C-1ni6A:
undetectable		 3ou6C-1ni6A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PO7_A_ZONA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 1ni6 HEME OXYGENASE 1
(Homo
sapiens) 		4 / 8 TYR A  78
LEU A  61
TYR A 137
TYR A 182
 None
 1.27A 3po7A-1ni6A:
undetectable		 3po7A-1ni6A:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TTR_A_LQZA90_1
(LACTOTRANSFERRIN)		 1ni6 HEME OXYGENASE 1
(Homo
sapiens) 		3 / 3 PRO A 109
THR A 108
LEU A 213
 None
 0.70A 3ttrA-1ni6A:
undetectable		 3ttrA-1ni6A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_B_RBFB201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 1ni6 HEME OXYGENASE 1
(Homo
sapiens) 		4 / 8 ILE A  65
LEU A  54
VAL A 115
LEU A 118
 None
 0.99A 4r38B-1ni6A:
undetectable		 4r38B-1ni6A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_A_377A401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 1ni6 HEME OXYGENASE 1
(Homo
sapiens) 		4 / 5 GLU A  66
GLU A  62
TYR A 137
TYR A  78
 None
 1.14A 4twdA-1ni6A:
undetectable
4twdE-1ni6A:
undetectable		 4twdA-1ni6A:
21.04
4twdE-1ni6A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4F_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 1ni6 HEME OXYGENASE 1
(Homo
sapiens) 		4 / 7 LEU A  49
PRO A 106
LEU A 217
GLU A 216
 None
 1.05A 4z4fA-1ni6A:
undetectable		 4z4fA-1ni6A:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1ni6 HEME OXYGENASE 1
(Homo
sapiens) 		4 / 6 ILE A  65
LEU A 129
PHE A  74
TYR A 182
 None
 1.06A 5b1aN-1ni6A:
1.9
5b1aW-1ni6A:
0.0		 5b1aN-1ni6A:
17.99
5b1aW-1ni6A:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZWR_B_9KLB402_0
(EST-Y29)		 1ni6 HEME OXYGENASE 1
(Homo
sapiens) 		5 / 12 TYR A  58
ILE A  57
LEU A 118
ALA A 133
LEU A 129
 None
 1.43A 5zwrB-1ni6A:
undetectable		 5zwrB-1ni6A:
21.43