SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1nig'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A52_A_ESTA1_1
(ESTROGEN RECEPTOR)		 1nig HYPOTHETICAL PROTEIN
TA1238
(Thermoplasma
acidophilum) 		5 / 10 ALA A  32
LEU A  36
LEU A 102
ILE A 142
LEU A  51
 None
 1.42A 1a52A-1nigA:
undetectable		 1a52A-1nigA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A52_B_ESTB2_1
(ESTROGEN RECEPTOR)		 1nig HYPOTHETICAL PROTEIN
TA1238
(Thermoplasma
acidophilum) 		5 / 10 ALA A  32
LEU A  36
LEU A 102
ILE A 142
LEU A  51
 None
 1.40A 1a52B-1nigA:
0.0		 1a52B-1nigA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_B_ESTB600_1
(ESTROGEN RECEPTOR)		 1nig HYPOTHETICAL PROTEIN
TA1238
(Thermoplasma
acidophilum) 		5 / 9 ALA A  32
LEU A  36
LEU A 102
ILE A 142
LEU A  51
 None
 1.40A 1ereB-1nigA:
undetectable		 1ereB-1nigA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD2_A_CHDA2_0
(FERROCHELATASE)		 1nig HYPOTHETICAL PROTEIN
TA1238
(Thermoplasma
acidophilum) 		4 / 8 MET A 131
LEU A 135
SER A  66
VAL A   9
 None
 1.09A 2qd2A-1nigA:
undetectable		 2qd2A-1nigA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CFQ_B_DIFB1_1
(TRANSTHYRETIN)		 1nig HYPOTHETICAL PROTEIN
TA1238
(Thermoplasma
acidophilum) 		4 / 7 SER A 109
ALA A  29
LEU A 102
SER A 105
 None
 0.95A 3cfqA-1nigA:
undetectable
3cfqB-1nigA:
undetectable		 3cfqA-1nigA:
21.29
3cfqB-1nigA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q95_A_ESLA700_1
(ESTROGEN RECEPTOR)		 1nig HYPOTHETICAL PROTEIN
TA1238
(Thermoplasma
acidophilum) 		5 / 12 LEU A 102
ALA A 106
GLU A  26
GLY A  35
LEU A  34
 None
 1.12A 3q95A-1nigA:
undetectable		 3q95A-1nigA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UUD_A_ESTA600_1
(ESTROGEN RECEPTOR)		 1nig HYPOTHETICAL PROTEIN
TA1238
(Thermoplasma
acidophilum) 		5 / 11 LEU A 102
ALA A 106
GLU A  26
GLY A  35
LEU A  34
 None
 1.15A 3uudA-1nigA:
0.4		 3uudA-1nigA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKJ_A_SUZA201_1
(TRANSTHYRETIN)		 1nig HYPOTHETICAL PROTEIN
TA1238
(Thermoplasma
acidophilum) 		4 / 7 ALA A  29
LEU A 102
SER A 105
SER A 109
 None
 0.93A 4ikjA-1nigA:
undetectable
4ikjB-1nigA:
undetectable		 4ikjA-1nigA:
17.09
4ikjB-1nigA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKJ_B_SUZB201_1
(TRANSTHYRETIN)		 1nig HYPOTHETICAL PROTEIN
TA1238
(Thermoplasma
acidophilum) 		4 / 8 SER A 109
ALA A  29
LEU A 102
SER A 105
 None
 0.98A 4ikjA-1nigA:
undetectable
4ikjB-1nigA:
undetectable		 4ikjA-1nigA:
17.09
4ikjB-1nigA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKK_A_SUZA201_1
(TRANSTHYRETIN)		 1nig HYPOTHETICAL PROTEIN
TA1238
(Thermoplasma
acidophilum) 		4 / 8 ALA A  29
LEU A 102
SER A 105
SER A 109
 None
 0.96A 4ikkA-1nigA:
undetectable
4ikkB-1nigA:
undetectable		 4ikkA-1nigA:
17.09
4ikkB-1nigA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKK_B_SUZB201_1
(TRANSTHYRETIN)		 1nig HYPOTHETICAL PROTEIN
TA1238
(Thermoplasma
acidophilum) 		4 / 7 SER A 109
ALA A  29
LEU A 102
SER A 105
 None
 0.99A 4ikkA-1nigA:
undetectable
4ikkB-1nigA:
undetectable		 4ikkA-1nigA:
17.09
4ikkB-1nigA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXB_A_ESTA1000_1
(ESTROGEN RECEPTOR)		 1nig HYPOTHETICAL PROTEIN
TA1238
(Thermoplasma
acidophilum) 		5 / 10 LEU A 102
ALA A 106
GLU A  26
GLY A  35
LEU A  34
 None
 1.26A 5dxbA-1nigA:
0.2		 5dxbA-1nigA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUK_A_Z80A201_1
(BETA-LACTOGLOBULIN)		 1nig HYPOTHETICAL PROTEIN
TA1238
(Thermoplasma
acidophilum) 		5 / 10 ALA A  32
ILE A  50
ILE A 142
VAL A 107
ALA A  29
 None
 1.07A 5nukA-1nigA:
undetectable		 5nukA-1nigA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1nig HYPOTHETICAL PROTEIN
TA1238
(Thermoplasma
acidophilum) 		4 / 6 ILE A  54
LEU A  51
ARG A 104
MET A 100
 None
 0.98A 6nmfN-1nigA:
0.0
6nmfW-1nigA:
undetectable		 6nmfN-1nigA:
13.13
6nmfW-1nigA:
18.18