SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1nio'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JB0_A_PQNA2001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 1nio B-LUFFIN
(Luffa
aegyptiaca) 		5 / 9 PHE A 151
ARG A 113
ALA A 117
LEU A 114
GLY A 109
 None
 1.49A 1jb0A-1nioA:
0.1		 1jb0A-1nioA:
14.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_G_SAMG199_0
(METHIONINE REPRESSOR)		 1nio B-LUFFIN
(Luffa
aegyptiaca) 		5 / 10 GLU A 123
GLU A 189
ALA A 185
ALA A 184
GLY A 220
 None
 1.25A 1mjqG-1nioA:
undetectable
1mjqH-1nioA:
undetectable		 1mjqG-1nioA:
19.25
1mjqH-1nioA:
19.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MRG_A_ADNA300_1
(ALPHA-MOMORCHARIN)		 1nio B-LUFFIN
(Luffa
aegyptiaca) 		8 / 9 ILE A  72
PHE A  84
GLY A 109
TYR A 111
ILE A 155
ALA A 159
GLU A 160
ARG A 163
 None
 0.23A 1mrgA-1nioA:
40.6		 1mrgA-1nioA:
69.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MRJ_A_ADNA300_1
(ALPHA-TRICHOSANTHIN)		 1nio B-LUFFIN
(Luffa
aegyptiaca) 		6 / 8 ILE A  72
GLY A 109
TYR A 111
ILE A 155
GLU A 160
ARG A 163
 None
 0.27A 1mrjA-1nioA:
40.6		 1mrjA-1nioA:
60.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_E_MTXE621_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 1nio B-LUFFIN
(Luffa
aegyptiaca) 		5 / 12 ALA A  92
PHE A  84
SER A 108
ILE A 155
LEU A 114
 None
 1.02A 2oipE-1nioA:
undetectable		 2oipE-1nioA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WX2_B_TPFB1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 1nio B-LUFFIN
(Luffa
aegyptiaca) 		4 / 8 TYR A  82
TYR A  75
ALA A 150
ALA A 146
 None
 0.84A 2wx2B-1nioA:
undetectable		 2wx2B-1nioA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_A_ZMRA1776_2
(NEURAMINIDASE A)		 1nio B-LUFFIN
(Luffa
aegyptiaca) 		4 / 6 ARG A 163
ILE A 154
LEU A 139
TYR A 107
 None
 1.05A 2ya7A-1nioA:
undetectable		 2ya7A-1nioA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_B_ZMRB1776_2
(NEURAMINIDASE A)		 1nio B-LUFFIN
(Luffa
aegyptiaca) 		4 / 6 ARG A 163
ILE A 154
LEU A 139
TYR A 107
 None
 1.02A 2ya7B-1nioA:
undetectable		 2ya7B-1nioA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_D_ZMRD1776_2
(NEURAMINIDASE A)		 1nio B-LUFFIN
(Luffa
aegyptiaca) 		4 / 6 ARG A 163
ILE A 154
LEU A 139
TYR A 107
 None
 1.05A 2ya7D-1nioA:
undetectable		 2ya7D-1nioA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KHM_A_TPFA501_1
(STEROL 14
ALPHA-DEMETHYLASE)		 1nio B-LUFFIN
(Luffa
aegyptiaca) 		4 / 8 TYR A  82
TYR A  75
ALA A 150
ALA A 146
 None
 0.94A 3khmA-1nioA:
undetectable		 3khmA-1nioA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L4D_A_TPFA490_1
(STEROL 14-ALPHA
DEMETHYLASE)		 1nio B-LUFFIN
(Luffa
aegyptiaca) 		4 / 8 TYR A  82
TYR A  75
ALA A 150
ALA A 146
 None
 0.91A 3l4dA-1nioA:
undetectable		 3l4dA-1nioA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LS4_H_TCIH220_2
(HEAVY CHAIN OF
ANTIBODY FAB
FRAGMENT
LIGHT CHAIN OF
ANTIBODY FAB
FRAGMENT)		 1nio B-LUFFIN
(Luffa
aegyptiaca) 		4 / 5 TYR A  15
ILE A  61
LEU A  53
PHE A   5
 None
 1.28A 3ls4L-1nioA:
undetectable		 3ls4L-1nioA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PCQ_A_PQNA847_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 1nio B-LUFFIN
(Luffa
aegyptiaca) 		5 / 9 PHE A 151
ARG A 113
ALA A 117
LEU A 114
GLY A 109
 None
 1.49A 3pcqA-1nioA:
0.0		 3pcqA-1nioA:
14.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3U6T_A_KANA4699_1
(RIBOSOME
INACTIVATING PROTEIN)		 1nio B-LUFFIN
(Luffa
aegyptiaca) 		10 / 10 TYR A  71
ILE A  72
GLU A  86
SER A 108
ASN A 110
TYR A 111
ILE A 155
ALA A 159
GLU A 160
ARG A 163
 None
 0.71A 3u6tA-1nioA:
40.9		 3u6tA-1nioA:
68.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4JTP_A_ASCA802_0
(RRNA N-GLYCOSIDASE)		 1nio B-LUFFIN
(Luffa
aegyptiaca) 		5 / 5 TYR A  71
ILE A  72
ASN A 110
TYR A 111
ILE A 155
 None
 0.50A 4jtpA-1nioA:
40.9		 4jtpA-1nioA:
68.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4O0O_A_URFA303_1
(RRNA N-GLYCOSIDASE)		 1nio B-LUFFIN
(Luffa
aegyptiaca) 		5 / 5 TYR A  71
ASN A 110
TYR A 111
ILE A 155
ARG A 163
 None
 0.28A 4o0oA-1nioA:
41.0		 4o0oA-1nioA:
68.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YP2_B_NCAB302_0
(RIBOSOME-INACTIVATIN
G PROTEIN MOMORDIN I)		 1nio B-LUFFIN
(Luffa
aegyptiaca) 		9 / 9 TYR A  71
ILE A  72
PHE A  84
GLY A 109
TYR A 111
ILE A 155
ALA A 159
GLU A 160
ARG A 163
 None
 0.37A 4yp2B-1nioA:
41.0		 4yp2B-1nioA:
70.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5CF9_B_NCAB302_0
(RIBOSOME-INACTIVATIN
G PROTEIN MOMORDIN I)		 1nio B-LUFFIN
(Luffa
aegyptiaca) 		9 / 9 TYR A  71
ILE A  72
PHE A  84
GLY A 109
TYR A 111
ILE A 155
ALA A 159
GLU A 160
ARG A 163
 None
 0.34A 5cf9B-1nioA:
41.1		 5cf9B-1nioA:
70.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_A_SAMA301_0
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)		 1nio B-LUFFIN
(Luffa
aegyptiaca) 		5 / 12 ALA A 118
ALA A 147
PHE A 151
GLY A 149
PRO A 126
 None
 1.38A 5jglA-1nioA:
undetectable		 5jglA-1nioA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L8R_A_PQNA844_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 1nio B-LUFFIN
(Luffa
aegyptiaca) 		5 / 9 PHE A 151
ARG A 113
ALA A 117
LEU A 114
GLY A 109
 None
 1.50A 5l8rA-1nioA:
0.4		 5l8rA-1nioA:
14.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5Z3J_A_NCAA302_0
(ABRIN A-CHAIN)		 1nio B-LUFFIN
(Luffa
aegyptiaca) 		5 / 6 TYR A  71
TYR A 111
ILE A 155
GLU A 160
ARG A 163
 None
 0.39A 5z3jA-1nioA:
34.2		 5z3jA-1nioA:
33.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_C_AQ4C602_1
(CYTOCHROME P450 1A1)		 1nio B-LUFFIN
(Luffa
aegyptiaca) 		3 / 3 SER A 100
SER A  81
ALA A  92
 None
 0.74A 6dwnC-1nioA:
undetectable		 6dwnC-1nioA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FI4_B_DVAB8_0
(14-3-3 PROTEIN SIGMA
PRO-SEP-LEU-PRO-DVA)		 1nio B-LUFFIN
(Luffa
aegyptiaca) 		4 / 5 SER A 230
VAL A 232
LYS A 231
ASN A 236
 None
 1.46A 6fi4A-1nioA:
undetectable
6fi4B-1nioA:
undetectable		 6fi4A-1nioA:
20.83
6fi4B-1nioA:
2.67