SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1nj8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_B_9CRB165_1
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 1nj8 PROLINE-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		5 / 12 PHE A 177
ILE A  43
VAL A 256
ILE A 257
ILE A 261
 None
 1.02A 1epbB-1nj8A:
undetectable		 1epbB-1nj8A:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IGX_A_EPAA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 1nj8 PROLINE-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		4 / 8 VAL A 220
TYR A 250
ILE A 106
LEU A 223
 None
 0.91A 1igxA-1nj8A:
undetectable		 1igxA-1nj8A:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UPF_A_URFA999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 1nj8 PROLINE-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		4 / 5 ALA A  56
TYR A 125
ILE A 124
ASP A  49
 None
 1.13A 1upfA-1nj8A:
undetectable		 1upfA-1nj8A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UPF_C_URFC999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 1nj8 PROLINE-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		4 / 5 ALA A  56
TYR A 125
ILE A 124
ASP A  49
 None
 1.12A 1upfC-1nj8A:
undetectable		 1upfC-1nj8A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_C_CHDC3525_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE III)		 1nj8 PROLINE-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		4 / 7 HIS A 264
ASP A 206
THR A 207
TYR A 185
 None
 1.31A 1v54A-1nj8A:
0.0
1v54C-1nj8A:
undetectable		 1v54A-1nj8A:
20.61
1v54C-1nj8A:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_P_CHDP4525_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE III)		 1nj8 PROLINE-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		4 / 7 HIS A 264
ASP A 206
THR A 207
TYR A 185
 None
 1.31A 1v54N-1nj8A:
0.0
1v54P-1nj8A:
undetectable		 1v54N-1nj8A:
20.61
1v54P-1nj8A:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_C_CHDC3525_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE III)		 1nj8 PROLINE-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		4 / 7 HIS A 264
ASP A 206
THR A 207
TYR A 185
 None
 1.31A 1v55A-1nj8A:
undetectable
1v55C-1nj8A:
undetectable		 1v55A-1nj8A:
20.61
1v55C-1nj8A:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_A_8MOA501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 1nj8 PROLINE-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		5 / 11 PHE A 178
PHE A 177
GLY A 251
ILE A 127
PHE A  41
 None
 1.04A 1z11A-1nj8A:
undetectable		 1z11A-1nj8A:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_B_8MOB501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 1nj8 PROLINE-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		5 / 11 PHE A 178
PHE A 177
GLY A 251
ILE A 127
PHE A  41
 None
 1.04A 1z11B-1nj8A:
undetectable		 1z11B-1nj8A:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1nj8 PROLINE-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		4 / 7 HIS A 264
ASP A 206
THR A 207
TYR A 185
 None
 1.32A 2dyrA-1nj8A:
0.0
2dyrC-1nj8A:
undetectable		 2dyrA-1nj8A:
20.61
2dyrC-1nj8A:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1nj8 PROLINE-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		4 / 7 HIS A 264
ASP A 206
THR A 207
TYR A 185
 None
 1.32A 2dyrN-1nj8A:
undetectable
2dyrP-1nj8A:
undetectable		 2dyrN-1nj8A:
20.61
2dyrP-1nj8A:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1nj8 PROLINE-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		4 / 6 HIS A 264
ASP A 206
THR A 207
TYR A 185
 None
 1.30A 2dysA-1nj8A:
undetectable
2dysC-1nj8A:
undetectable		 2dysA-1nj8A:
20.61
2dysC-1nj8A:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_P_CHDP304_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1nj8 PROLINE-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		4 / 6 HIS A 264
ASP A 206
THR A 207
TYR A 185
 None
 1.27A 2dysN-1nj8A:
undetectable
2dysP-1nj8A:
undetectable		 2dysN-1nj8A:
20.61
2dysP-1nj8A:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1nj8 PROLINE-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		4 / 7 HIS A 264
ASP A 206
THR A 207
TYR A 185
 None
 1.29A 2eijA-1nj8A:
0.0
2eijC-1nj8A:
undetectable		 2eijA-1nj8A:
20.61
2eijC-1nj8A:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1nj8 PROLINE-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		4 / 7 HIS A 264
ASP A 206
THR A 207
TYR A 185
 None
 1.29A 2eijN-1nj8A:
undetectable
2eijP-1nj8A:
undetectable		 2eijN-1nj8A:
20.61
2eijP-1nj8A:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1nj8 PROLINE-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		4 / 7 HIS A 264
ASP A 206
THR A 207
TYR A 185
 None
 1.31A 2eikA-1nj8A:
0.9
2eikC-1nj8A:
undetectable		 2eikA-1nj8A:
20.61
2eikC-1nj8A:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1nj8 PROLINE-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		4 / 7 HIS A 264
ASP A 206
THR A 207
TYR A 185
 None
 1.31A 2eikN-1nj8A:
undetectable
2eikP-1nj8A:
undetectable		 2eikN-1nj8A:
20.61
2eikP-1nj8A:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1nj8 PROLINE-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		4 / 7 HIS A 264
ASP A 206
THR A 207
TYR A 185
 None
 1.32A 2eilA-1nj8A:
undetectable
2eilC-1nj8A:
undetectable		 2eilA-1nj8A:
20.61
2eilC-1nj8A:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1nj8 PROLINE-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		4 / 7 HIS A 264
ASP A 206
THR A 207
TYR A 185
 None
 1.30A 2eilN-1nj8A:
undetectable
2eilP-1nj8A:
undetectable		 2eilN-1nj8A:
20.61
2eilP-1nj8A:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_A_CHDA525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1nj8 PROLINE-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		4 / 6 HIS A 264
ASP A 206
THR A 207
TYR A 185
 None
 1.29A 2eimA-1nj8A:
undetectable
2eimC-1nj8A:
undetectable		 2eimA-1nj8A:
20.61
2eimC-1nj8A:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1nj8 PROLINE-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		4 / 6 HIS A 264
ASP A 206
THR A 207
TYR A 185
 None
 1.30A 2eimN-1nj8A:
0.0
2eimP-1nj8A:
undetectable		 2eimN-1nj8A:
20.61
2eimP-1nj8A:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1nj8 PROLINE-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		4 / 6 HIS A 264
ASP A 206
THR A 207
TYR A 185
 None
 1.29A 2einA-1nj8A:
undetectable
2einC-1nj8A:
undetectable		 2einA-1nj8A:
20.61
2einC-1nj8A:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1nj8 PROLINE-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		4 / 6 HIS A 264
ASP A 206
THR A 207
TYR A 185
 None
 1.34A 2einN-1nj8A:
undetectable
2einP-1nj8A:
undetectable		 2einN-1nj8A:
20.61
2einP-1nj8A:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_A_FFOA505_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1nj8 PROLINE-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		4 / 6 GLU A 338
LYS A 324
PHE A 325
PRO A 321
 None
 1.40A 2vmyA-1nj8A:
undetectable		 2vmyA-1nj8A:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y69_A_CHDA1517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1nj8 PROLINE-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		4 / 7 HIS A 264
ASP A 206
THR A 207
TYR A 185
 None
 1.31A 2y69A-1nj8A:
undetectable
2y69C-1nj8A:
undetectable		 2y69A-1nj8A:
20.61
2y69C-1nj8A:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1nj8 PROLINE-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		4 / 6 HIS A 264
ASP A 206
THR A 207
TYR A 185
 None
 1.33A 2zxwA-1nj8A:
undetectable
2zxwC-1nj8A:
undetectable		 2zxwA-1nj8A:
20.61
2zxwC-1nj8A:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1nj8 PROLINE-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		4 / 6 HIS A 264
ASP A 206
THR A 207
TYR A 185
 None
 1.30A 2zxwN-1nj8A:
undetectable
2zxwP-1nj8A:
undetectable		 2zxwN-1nj8A:
20.61
2zxwP-1nj8A:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1nj8 PROLINE-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		4 / 7 HIS A 264
ASP A 206
THR A 207
TYR A 185
 None
 1.34A 3abkA-1nj8A:
undetectable
3abkC-1nj8A:
undetectable		 3abkA-1nj8A:
20.61
3abkC-1nj8A:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1nj8 PROLINE-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		4 / 7 HIS A 264
ASP A 206
THR A 207
TYR A 185
 None
 1.31A 3abkN-1nj8A:
undetectable
3abkP-1nj8A:
undetectable		 3abkN-1nj8A:
20.61
3abkP-1nj8A:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1nj8 PROLINE-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		4 / 7 HIS A 264
ASP A 206
THR A 207
TYR A 185
 None
 1.32A 3abmN-1nj8A:
0.0
3abmP-1nj8A:
undetectable		 3abmN-1nj8A:
20.61
3abmP-1nj8A:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1nj8 PROLINE-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		4 / 6 HIS A 264
ASP A 206
THR A 207
TYR A 185
 None
 1.37A 3ag1A-1nj8A:
undetectable
3ag1C-1nj8A:
undetectable		 3ag1A-1nj8A:
20.61
3ag1C-1nj8A:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1nj8 PROLINE-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		4 / 6 HIS A 264
ASP A 206
THR A 207
TYR A 185
 None
 1.37A 3ag1N-1nj8A:
0.0
3ag1P-1nj8A:
undetectable		 3ag1N-1nj8A:
20.61
3ag1P-1nj8A:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_A_CHDA525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1nj8 PROLINE-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		4 / 7 HIS A 264
ASP A 206
THR A 207
TYR A 185
 None
 1.33A 3ag2A-1nj8A:
0.0
3ag2C-1nj8A:
undetectable		 3ag2A-1nj8A:
20.61
3ag2C-1nj8A:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1nj8 PROLINE-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		4 / 7 HIS A 264
ASP A 206
THR A 207
TYR A 185
 None
 1.32A 3ag2N-1nj8A:
undetectable
3ag2P-1nj8A:
undetectable		 3ag2N-1nj8A:
20.61
3ag2P-1nj8A:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1nj8 PROLINE-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		4 / 7 HIS A 264
ASP A 206
THR A 207
TYR A 185
 None
 1.34A 3ag3A-1nj8A:
undetectable
3ag3C-1nj8A:
undetectable		 3ag3A-1nj8A:
20.61
3ag3C-1nj8A:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1nj8 PROLINE-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		4 / 7 HIS A 264
ASP A 206
THR A 207
TYR A 185
 None
 1.31A 3ag3N-1nj8A:
undetectable
3ag3P-1nj8A:
undetectable		 3ag3N-1nj8A:
20.61
3ag3P-1nj8A:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1nj8 PROLINE-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		4 / 7 HIS A 264
ASP A 206
THR A 207
TYR A 185
 None
 1.33A 3ag4A-1nj8A:
undetectable
3ag4C-1nj8A:
undetectable		 3ag4A-1nj8A:
20.61
3ag4C-1nj8A:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1nj8 PROLINE-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		4 / 7 HIS A 264
ASP A 206
THR A 207
TYR A 185
 None
 1.34A 3ag4N-1nj8A:
undetectable
3ag4P-1nj8A:
undetectable		 3ag4N-1nj8A:
20.61
3ag4P-1nj8A:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1nj8 PROLINE-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		4 / 6 HIS A 264
ASP A 206
THR A 207
TYR A 185
 None
 1.34A 3asnA-1nj8A:
0.0
3asnC-1nj8A:
undetectable		 3asnA-1nj8A:
20.61
3asnC-1nj8A:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_B_H3PB552_1
(GLUTAMATE
DEHYDROGENASE)		 1nj8 PROLINE-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		3 / 3 TYR A 125
TYR A 174
ILE A 252
 None
 0.59A 3eteA-1nj8A:
undetectable
3eteB-1nj8A:
undetectable		 3eteA-1nj8A:
22.92
3eteB-1nj8A:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDU_D_ROCD100_3
(PROTEASE)		 1nj8 PROLINE-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		3 / 3 ARG A 255
VAL A 128
THR A 130
 None
 0.87A 3nduD-1nj8A:
undetectable		 3nduD-1nj8A:
12.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDW_A_RITA100_2
(PROTEASE)		 1nj8 PROLINE-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		5 / 9 ARG A 317
ALA A 299
ILE A 349
GLY A 340
ILE A 283
 None
 1.04A 3ndwB-1nj8A:
undetectable		 3ndwB-1nj8A:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_E_CLME221_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1nj8 PROLINE-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		3 / 3 PHE A 196
CYH A 249
HIS A 221
 None
 1.26A 3u9fF-1nj8A:
undetectable		 3u9fF-1nj8A:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_C_IMNC701_1
(CYCLOOXYGENASE-2)		 1nj8 PROLINE-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		5 / 12 LEU A  11
SER A   8
TYR A  29
VAL A  19
GLY A  27
 None
 1.12A 4coxC-1nj8A:
undetectable		 4coxC-1nj8A:
21.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4HVC_A_HFGA1602_0
(BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE)		 1nj8 PROLINE-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		5 / 12 VAL A  81
PRO A 100
GLU A 152
HIS A 154
PHE A 227
 None
 1.22A 4hvcA-1nj8A:
42.6		 4hvcA-1nj8A:
36.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4HVC_A_HFGA1602_0
(BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE)		 1nj8 PROLINE-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		6 / 12 VAL A  81
PRO A 100
GLU A 152
HIS A 154
THR A 219
GLY A 251
 None
 0.44A 4hvcA-1nj8A:
42.6		 4hvcA-1nj8A:
36.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4HVC_B_HFGB1602_0
(BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE)		 1nj8 PROLINE-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		5 / 12 LEU A  67
GLU A  80
VAL A  81
PRO A 100
PHE A 196
 None
 1.05A 4hvcB-1nj8A:
42.7		 4hvcB-1nj8A:
36.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4HVC_B_HFGB1602_0
(BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE)		 1nj8 PROLINE-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		7 / 12 LEU A  67
VAL A  81
PRO A 100
GLU A 152
HIS A 154
THR A 219
GLY A 251
 None
 0.37A 4hvcB-1nj8A:
42.7		 4hvcB-1nj8A:
36.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4HVC_B_HFGB1602_0
(BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE)		 1nj8 PROLINE-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		5 / 12 LEU A  67
VAL A  81
PRO A 100
HIS A 154
PHE A 196
 None
 0.91A 4hvcB-1nj8A:
42.7		 4hvcB-1nj8A:
36.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4K88_A_HFGA602_0
(PROLINE--TRNA LIGASE)		 1nj8 PROLINE-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		7 / 12 GLU A  80
VAL A  81
PRO A 100
THR A 101
GLU A 103
GLU A 152
HIS A 221
 None
 0.73A 4k88A-1nj8A:
41.8		 4k88A-1nj8A:
36.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4K88_A_HFGA602_0
(PROLINE--TRNA LIGASE)		 1nj8 PROLINE-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		6 / 12 GLU A  80
VAL A  81
PRO A 100
THR A 101
GLU A 103
PHE A 196
 None
 1.12A 4k88A-1nj8A:
41.8		 4k88A-1nj8A:
36.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWV_A_BCZA513_1
(NEURAMINIDASE)		 1nj8 PROLINE-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		3 / 3 ARG A 213
GLU A   2
ARG A 139
 None
 0.82A 4mwvA-1nj8A:
undetectable		 4mwvA-1nj8A:
20.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4OLF_A_HFGA802_0
(PROLINE--TRNA LIGASE)		 1nj8 PROLINE-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		5 / 12 VAL A  81
PRO A 100
GLU A 152
HIS A 154
PHE A 227
 None
 1.28A 4olfA-1nj8A:
42.4		 4olfA-1nj8A:
35.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4OLF_A_HFGA802_0
(PROLINE--TRNA LIGASE)		 1nj8 PROLINE-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		6 / 12 VAL A  81
PRO A 100
GLU A 152
HIS A 154
THR A 219
GLY A 251
 None
 0.43A 4olfA-1nj8A:
42.4		 4olfA-1nj8A:
35.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4OLF_A_HFGA802_0
(PROLINE--TRNA LIGASE)		 1nj8 PROLINE-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		5 / 12 VAL A  81
PRO A 100
HIS A 154
PHE A 196
THR A 219
 None
 0.96A 4olfA-1nj8A:
42.4		 4olfA-1nj8A:
35.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_A_GCSA304_1
(CHITOSANASE)		 1nj8 PROLINE-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		4 / 4 TYR A  29
ILE A 257
THR A 149
TYR A   7
 None
 1.44A 4oltA-1nj8A:
0.0		 4oltA-1nj8A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_B_GCSB304_1
(CHITOSANASE)		 1nj8 PROLINE-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		4 / 5 TYR A  29
ILE A 257
THR A 149
TYR A   7
 None
 1.43A 4oltB-1nj8A:
0.0		 4oltB-1nj8A:
21.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4Q15_A_HFGA803_0
(PROLINE--TRNA LIGASE)		 1nj8 PROLINE-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		5 / 12 LEU A  67
GLU A  80
VAL A  81
ARG A 132
PHE A 196
 None
 1.32A 4q15A-1nj8A:
42.9		 4q15A-1nj8A:
35.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4Q15_A_HFGA803_0
(PROLINE--TRNA LIGASE)		 1nj8 PROLINE-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		5 / 12 LEU A  67
GLU A  80
VAL A  81
PRO A 100
PHE A 196
 None
 1.10A 4q15A-1nj8A:
42.9		 4q15A-1nj8A:
35.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4Q15_A_HFGA803_0
(PROLINE--TRNA LIGASE)		 1nj8 PROLINE-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		6 / 12 LEU A  67
VAL A  81
PRO A 100
THR A 101
HIS A 154
GLY A 251
 None
 0.46A 4q15A-1nj8A:
42.9		 4q15A-1nj8A:
35.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4Q15_A_HFGA803_0
(PROLINE--TRNA LIGASE)		 1nj8 PROLINE-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		6 / 12 LEU A  67
VAL A  81
PRO A 100
THR A 101
HIS A 154
PHE A 196
 None
 0.95A 4q15A-1nj8A:
42.9		 4q15A-1nj8A:
35.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4Q15_A_HFGA803_0
(PROLINE--TRNA LIGASE)		 1nj8 PROLINE-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		5 / 12 VAL A  81
PRO A 100
THR A 101
HIS A 154
PHE A 227
 None
 1.18A 4q15A-1nj8A:
42.9		 4q15A-1nj8A:
35.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4Q15_A_HFGA803_1
(PROLINE--TRNA LIGASE)		 1nj8 PROLINE-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		3 / 3 GLU A 103
THR A 219
HIS A 221
 None
 0.75A 4q15A-1nj8A:
42.9		 4q15A-1nj8A:
35.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4Q15_B_HFGB803_0
(PROLINE--TRNA LIGASE)		 1nj8 PROLINE-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		5 / 12 LEU A  67
GLU A  80
VAL A  81
PRO A 100
PHE A 196
 None
 1.10A 4q15B-1nj8A:
43.2		 4q15B-1nj8A:
35.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4Q15_B_HFGB803_0
(PROLINE--TRNA LIGASE)		 1nj8 PROLINE-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		6 / 12 LEU A  67
VAL A  81
PRO A 100
THR A 101
GLU A 152
GLY A 251
 None
 0.42A 4q15B-1nj8A:
43.2		 4q15B-1nj8A:
35.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4Q15_B_HFGB803_0
(PROLINE--TRNA LIGASE)		 1nj8 PROLINE-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		5 / 12 LEU A  67
VAL A  81
PRO A 100
THR A 101
PHE A 196
 None
 1.02A 4q15B-1nj8A:
43.2		 4q15B-1nj8A:
35.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4Q15_B_HFGB803_0
(PROLINE--TRNA LIGASE)		 1nj8 PROLINE-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		5 / 12 VAL A  81
PRO A 100
THR A 101
GLU A 152
PHE A 227
 None
 1.17A 4q15B-1nj8A:
43.2		 4q15B-1nj8A:
35.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4Q15_B_HFGB803_1
(PROLINE--TRNA LIGASE)		 1nj8 PROLINE-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		3 / 3 GLU A 103
THR A 219
HIS A 221
 None
 0.75A 4q15B-1nj8A:
43.2		 4q15B-1nj8A:
35.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOP_A_HQEA503_1
(CATALASE)		 1nj8 PROLINE-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		5 / 9 PRO A 121
TYR A 246
LEU A 120
PHE A 235
ASP A 243
 None
 1.41A 4qopA-1nj8A:
0.0		 4qopA-1nj8A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOP_B_HQEB503_1
(CATALASE)		 1nj8 PROLINE-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		5 / 9 PRO A 121
TYR A 246
LEU A 120
PHE A 235
ASP A 243
 None
 1.41A 4qopB-1nj8A:
0.0		 4qopB-1nj8A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOP_D_HQED503_1
(CATALASE)		 1nj8 PROLINE-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		5 / 9 PRO A 121
TYR A 246
LEU A 120
PHE A 235
ASP A 243
 None
 1.41A 4qopD-1nj8A:
0.0		 4qopD-1nj8A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_A_GCSA303_1
(CHITOSANASE)		 1nj8 PROLINE-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		4 / 6 TYR A  29
ILE A 257
THR A 149
TYR A   7
 None
 1.44A 4qwpA-1nj8A:
0.0		 4qwpA-1nj8A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB302_1
(CHITOSANASE)		 1nj8 PROLINE-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		4 / 5 TYR A  29
ILE A 257
THR A 149
TYR A   7
 None
 1.46A 4qwpB-1nj8A:
0.0		 4qwpB-1nj8A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_A_LURA705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1nj8 PROLINE-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		5 / 12 LEU A  11
SER A   8
TYR A  29
VAL A  19
GLY A  27
 None
 0.98A 4rrwA-1nj8A:
0.0		 4rrwA-1nj8A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_B_LURB705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1nj8 PROLINE-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		5 / 12 LEU A  11
SER A   8
TYR A  29
VAL A  19
GLY A  27
 None
 0.98A 4rrwB-1nj8A:
undetectable		 4rrwB-1nj8A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_C_LURC705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1nj8 PROLINE-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		5 / 12 LEU A  11
SER A   8
TYR A  29
VAL A  19
GLY A  27
 None
 0.97A 4rrwC-1nj8A:
undetectable		 4rrwC-1nj8A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_A_LURA705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1nj8 PROLINE-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		5 / 12 LEU A  11
SER A   8
TYR A  29
VAL A  19
GLY A  27
 None
 0.98A 4rrzA-1nj8A:
0.0		 4rrzA-1nj8A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_B_LURB705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1nj8 PROLINE-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		5 / 12 LEU A  11
SER A   8
TYR A  29
VAL A  19
GLY A  27
 None
 0.98A 4rrzB-1nj8A:
undetectable		 4rrzB-1nj8A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_C_LURC705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1nj8 PROLINE-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		5 / 12 LEU A  11
SER A   8
TYR A  29
VAL A  19
GLY A  27
 None
 0.97A 4rrzC-1nj8A:
undetectable		 4rrzC-1nj8A:
21.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YDQ_A_HFGA802_0
(PROLINE--TRNA LIGASE)		 1nj8 PROLINE-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		6 / 12 LEU A  67
GLU A  80
VAL A  81
PRO A 100
GLU A 152
GLY A 251
 None
 0.72A 4ydqA-1nj8A:
42.0		 4ydqA-1nj8A:
35.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YDQ_A_HFGA802_0
(PROLINE--TRNA LIGASE)		 1nj8 PROLINE-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		5 / 12 LEU A  67
GLU A  80
VAL A  81
PRO A 100
PHE A 196
 None
 1.00A 4ydqA-1nj8A:
42.0		 4ydqA-1nj8A:
35.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YDQ_A_HFGA802_0
(PROLINE--TRNA LIGASE)		 1nj8 PROLINE-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		6 / 12 LEU A  67
VAL A  81
PRO A 100
GLU A 152
HIS A 154
GLY A 251
 None
 0.40A 4ydqA-1nj8A:
42.0		 4ydqA-1nj8A:
35.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YDQ_A_HFGA802_0
(PROLINE--TRNA LIGASE)		 1nj8 PROLINE-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		5 / 12 LEU A  67
VAL A  81
PRO A 100
HIS A 154
PHE A 196
 None
 0.83A 4ydqA-1nj8A:
42.0		 4ydqA-1nj8A:
35.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YDQ_A_HFGA802_0
(PROLINE--TRNA LIGASE)		 1nj8 PROLINE-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		5 / 12 VAL A  81
PRO A 100
GLU A 152
HIS A 154
PHE A 227
 None
 1.22A 4ydqA-1nj8A:
42.0		 4ydqA-1nj8A:
35.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YDQ_A_HFGA802_1
(PROLINE--TRNA LIGASE)		 1nj8 PROLINE-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		4 / 4 THR A 101
GLU A 103
THR A 219
HIS A 221
 None
 0.85A 4ydqA-1nj8A:
42.0		 4ydqA-1nj8A:
35.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YDQ_B_HFGB802_0
(PROLINE--TRNA LIGASE)		 1nj8 PROLINE-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		5 / 12 GLU A  80
VAL A  81
PRO A 100
GLU A 152
GLY A 251
 None
 0.70A 4ydqB-1nj8A:
42.0		 4ydqB-1nj8A:
35.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YDQ_B_HFGB802_0
(PROLINE--TRNA LIGASE)		 1nj8 PROLINE-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		6 / 12 VAL A  81
PRO A 100
THR A 101
GLU A 152
HIS A 154
GLY A 251
 None
 0.46A 4ydqB-1nj8A:
42.0		 4ydqB-1nj8A:
35.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YDQ_B_HFGB802_0
(PROLINE--TRNA LIGASE)		 1nj8 PROLINE-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		6 / 12 VAL A  81
PRO A 100
THR A 101
GLU A 152
HIS A 154
PHE A 227
 None
 1.18A 4ydqB-1nj8A:
42.0		 4ydqB-1nj8A:
35.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YDQ_B_HFGB802_0
(PROLINE--TRNA LIGASE)		 1nj8 PROLINE-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		5 / 12 VAL A  81
PRO A 100
THR A 101
HIS A 154
PHE A 196
 None
 0.93A 4ydqB-1nj8A:
42.0		 4ydqB-1nj8A:
35.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YDQ_B_HFGB802_1
(PROLINE--TRNA LIGASE)		 1nj8 PROLINE-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		3 / 3 GLU A 103
THR A 219
HIS A 221
 None
 0.72A 4ydqB-1nj8A:
42.0		 4ydqB-1nj8A:
35.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1nj8 PROLINE-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		4 / 7 HIS A 264
ASP A 206
THR A 207
TYR A 185
 None
 1.34A 5b1aN-1nj8A:
undetectable
5b1aP-1nj8A:
undetectable		 5b1aN-1nj8A:
20.61
5b1aP-1nj8A:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1nj8 PROLINE-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		4 / 7 HIS A 264
ASP A 206
THR A 207
TYR A 185
 None
 1.34A 5b1bN-1nj8A:
undetectable
5b1bP-1nj8A:
undetectable		 5b1bN-1nj8A:
20.61
5b1bP-1nj8A:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_Y_BEZY801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 1nj8 PROLINE-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		4 / 5 ILE A 261
GLY A 332
ILE A  10
LEU A 272
 None
 0.92A 5dzkd-1nj8A:
undetectable
5dzkk-1nj8A:
undetectable
5dzky-1nj8A:
undetectable		 5dzkd-1nj8A:
21.05
5dzkk-1nj8A:
18.34
5dzky-1nj8A:
3.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5F9Z_A_HFGA702_0
(AMINOACYL-TRNA
SYNTHETASE)		 1nj8 PROLINE-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		5 / 12 LEU A  67
GLU A  80
VAL A  81
PRO A 100
PHE A 196
 None
 1.12A 5f9zA-1nj8A:
41.1		 5f9zA-1nj8A:
36.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5F9Z_A_HFGA702_0
(AMINOACYL-TRNA
SYNTHETASE)		 1nj8 PROLINE-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		5 / 12 LEU A  67
VAL A  81
PRO A 100
GLU A 152
GLY A 251
 None
 0.38A 5f9zA-1nj8A:
41.1		 5f9zA-1nj8A:
36.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5F9Z_A_HFGA702_1
(AMINOACYL-TRNA
SYNTHETASE)		 1nj8 PROLINE-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		4 / 4 THR A 101
GLU A 103
THR A 219
HIS A 221
 None
 0.79A 5f9zA-1nj8A:
41.1		 5f9zA-1nj8A:
36.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5F9Z_B_HFGB703_0
(AMINOACYL-TRNA
SYNTHETASE)		 1nj8 PROLINE-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		5 / 12 LEU A  67
GLU A  80
VAL A  81
PRO A 100
PHE A 196
 None
 1.14A 5f9zB-1nj8A:
41.6		 5f9zB-1nj8A:
36.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5F9Z_B_HFGB703_0
(AMINOACYL-TRNA
SYNTHETASE)		 1nj8 PROLINE-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		5 / 12 LEU A  67
VAL A  81
PRO A 100
GLU A 152
GLY A 251
 None
 0.40A 5f9zB-1nj8A:
41.6		 5f9zB-1nj8A:
36.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5F9Z_B_HFGB703_1
(AMINOACYL-TRNA
SYNTHETASE)		 1nj8 PROLINE-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		4 / 4 THR A 101
GLU A 103
THR A 219
HIS A 221
 None
 0.78A 5f9zB-1nj8A:
41.6		 5f9zB-1nj8A:
36.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IFU_A_GBMA801_1
(PROLINE--TRNA LIGASE)		 1nj8 PROLINE-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		6 / 12 PHE A   3
TYR A   7
ARG A 255
ILE A 257
ILE A 261
TYR A 455
 None
 0.72A 5ifuA-1nj8A:
37.0		 5ifuA-1nj8A:
35.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1nj8 PROLINE-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		5 / 12 LEU A  11
SER A   8
TYR A  29
VAL A  19
GLY A  27
 None
 1.18A 5ikrA-1nj8A:
0.0		 5ikrA-1nj8A:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1nj8 PROLINE-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		5 / 12 VAL A 433
VAL A 418
LEU A 417
GLY A 439
LEU A 429
 None
 1.12A 5iktB-1nj8A:
0.0		 5iktB-1nj8A:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1nj8 PROLINE-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		4 / 7 HIS A 264
ASP A 206
THR A 207
TYR A 185
 None
 1.35A 5iy5A-1nj8A:
undetectable
5iy5C-1nj8A:
undetectable		 5iy5A-1nj8A:
20.61
5iy5C-1nj8A:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_D_ACTD803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 1nj8 PROLINE-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		4 / 4 GLU A 398
PRO A 419
ILE A 400
LEU A 397
 None
 1.27A 5m45D-1nj8A:
0.0		 5m45D-1nj8A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_J_ACTJ803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 1nj8 PROLINE-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		4 / 4 GLU A 398
PRO A 419
ILE A 400
LEU A 397
 None
 1.26A 5m45J-1nj8A:
0.0		 5m45J-1nj8A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUM_A_Z80A201_1
(BETA-LACTOGLOBULIN)		 1nj8 PROLINE-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		5 / 8 VAL A 371
ILE A 349
LEU A 367
ILE A 302
ILE A 283
 None
 1.12A 5numA-1nj8A:
undetectable		 5numA-1nj8A:
10.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1nj8 PROLINE-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		4 / 6 HIS A 264
ASP A 206
THR A 207
TYR A 185
 None
 1.37A 5x19N-1nj8A:
undetectable
5x19P-1nj8A:
undetectable		 5x19N-1nj8A:
20.61
5x19P-1nj8A:
17.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5XIO_A_HFGA801_0
(PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE))		 1nj8 PROLINE-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		7 / 12 GLU A  80
VAL A  81
PRO A 100
GLU A 152
HIS A 154
THR A 219
GLY A 251
 None
 0.48A 5xioA-1nj8A:
40.8		 5xioA-1nj8A:
37.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5XIO_A_HFGA801_0
(PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE))		 1nj8 PROLINE-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		5 / 12 GLU A  80
VAL A  81
PRO A 100
HIS A 154
PHE A 196
 None
 0.93A 5xioA-1nj8A:
40.8		 5xioA-1nj8A:
37.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5XIO_A_HFGA801_1
(PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE))		 1nj8 PROLINE-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		3 / 3 THR A 101
GLU A 103
HIS A 221
 None
 0.76A 5xioA-1nj8A:
40.8		 5xioA-1nj8A:
37.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5XIO_B_HFGB802_0
(PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE))		 1nj8 PROLINE-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		8 / 12 GLU A  80
VAL A  81
PRO A 100
THR A 101
GLU A 152
HIS A 154
THR A 219
HIS A 221
 None
 0.67A 5xioB-1nj8A:
40.8		 5xioB-1nj8A:
37.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5XIO_B_HFGB802_0
(PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE))		 1nj8 PROLINE-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		8 / 12 GLU A  80
VAL A  81
PRO A 100
THR A 101
HIS A 154
PHE A 196
THR A 219
HIS A 221
 None
 1.03A 5xioB-1nj8A:
40.8		 5xioB-1nj8A:
37.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5XIP_A_HFGA1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 1nj8 PROLINE-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		5 / 12 LEU A  67
GLU A  80
VAL A  81
PRO A 100
GLY A 251
 None
 0.93A 5xipA-1nj8A:
42.0		 5xipA-1nj8A:
35.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5XIP_A_HFGA1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 1nj8 PROLINE-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		5 / 12 LEU A  67
GLU A  80
VAL A  81
PRO A 100
PHE A 196
 None
 1.06A 5xipA-1nj8A:
42.0		 5xipA-1nj8A:
35.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5XIP_A_HFGA1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 1nj8 PROLINE-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		7 / 12 LEU A  67
VAL A  81
PRO A 100
THR A 101
HIS A 154
PHE A 196
THR A 219
 None
 0.89A 5xipA-1nj8A:
42.0		 5xipA-1nj8A:
35.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5XIP_A_HFGA1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 1nj8 PROLINE-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		7 / 12 LEU A  67
VAL A  81
PRO A 100
THR A 101
HIS A 154
THR A 219
GLY A 251
 None
 0.44A 5xipA-1nj8A:
42.0		 5xipA-1nj8A:
35.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5XIP_A_HFGA1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 1nj8 PROLINE-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		5 / 12 VAL A  81
PRO A 100
THR A 101
HIS A 154
PHE A 227
 None
 1.16A 5xipA-1nj8A:
42.0		 5xipA-1nj8A:
35.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5XIP_B_HFGB1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 1nj8 PROLINE-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		7 / 12 GLU A  80
PRO A 100
THR A 101
GLU A 103
PHE A 196
THR A 219
HIS A 221
 None
 1.18A 5xipB-1nj8A:
41.9		 5xipB-1nj8A:
35.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5XIP_B_HFGB1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 1nj8 PROLINE-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		7 / 12 GLU A  80
VAL A  81
PRO A 100
THR A 101
PHE A 196
THR A 219
HIS A 221
 None
 1.15A 5xipB-1nj8A:
41.9		 5xipB-1nj8A:
35.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5XIP_B_HFGB1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 1nj8 PROLINE-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		7 / 12 PRO A 100
THR A 101
GLU A 103
HIS A 154
PHE A 196
THR A 219
HIS A 221
 None
 1.06A 5xipB-1nj8A:
41.9		 5xipB-1nj8A:
35.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5XIP_B_HFGB1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 1nj8 PROLINE-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		7 / 12 VAL A  81
PRO A 100
THR A 101
HIS A 154
PHE A 196
THR A 219
HIS A 221
 None
 1.00A 5xipB-1nj8A:
41.9		 5xipB-1nj8A:
35.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5XIP_B_HFGB1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 1nj8 PROLINE-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		5 / 12 VAL A  81
PRO A 100
THR A 101
HIS A 154
PHE A 227
 None
 1.15A 5xipB-1nj8A:
41.9		 5xipB-1nj8A:
35.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5XIP_C_HFGC1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 1nj8 PROLINE-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		6 / 12 GLU A  80
VAL A  81
PRO A 100
GLU A 103
PHE A 196
THR A 219
 None
 1.26A 5xipC-1nj8A:
42.0		 5xipC-1nj8A:
35.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5XIP_C_HFGC1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 1nj8 PROLINE-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		9 / 12 LEU A  67
VAL A  81
PRO A 100
THR A 101
GLU A 103
GLU A 152
HIS A 154
THR A 219
GLY A 251
 None
 0.62A 5xipC-1nj8A:
42.0		 5xipC-1nj8A:
35.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5XIP_C_HFGC1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 1nj8 PROLINE-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		8 / 12 LEU A  67
VAL A  81
PRO A 100
THR A 101
GLU A 103
HIS A 154
PHE A 196
THR A 219
 None
 0.96A 5xipC-1nj8A:
42.0		 5xipC-1nj8A:
35.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5XIP_C_HFGC1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 1nj8 PROLINE-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		5 / 12 VAL A  81
PRO A 100
THR A 101
GLU A 152
PHE A 227
 None
 1.10A 5xipC-1nj8A:
42.0		 5xipC-1nj8A:
35.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5XIP_D_HFGD1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 1nj8 PROLINE-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		6 / 12 GLU A  80
VAL A  81
PRO A 100
GLU A 103
PHE A 196
THR A 219
 None
 1.26A 5xipD-1nj8A:
42.6		 5xipD-1nj8A:
35.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5XIP_D_HFGD1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 1nj8 PROLINE-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		5 / 12 LEU A  67
VAL A  81
PRO A 100
ARG A 132
PHE A 196
 None
 1.46A 5xipD-1nj8A:
42.6		 5xipD-1nj8A:
35.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5XIP_D_HFGD1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 1nj8 PROLINE-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		7 / 12 LEU A  67
VAL A  81
PRO A 100
THR A 101
GLU A 103
GLU A 152
THR A 219
 None
 0.70A 5xipD-1nj8A:
42.6		 5xipD-1nj8A:
35.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5XIP_D_HFGD1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 1nj8 PROLINE-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		7 / 12 LEU A  67
VAL A  81
PRO A 100
THR A 101
GLU A 103
PHE A 196
THR A 219
 None
 1.06A 5xipD-1nj8A:
42.6		 5xipD-1nj8A:
35.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5XIP_D_HFGD1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 1nj8 PROLINE-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		5 / 12 VAL A  81
PRO A 100
THR A 101
GLU A 152
PHE A 227
 None
 1.12A 5xipD-1nj8A:
42.6		 5xipD-1nj8A:
35.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5XIQ_A_HFGA1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 1nj8 PROLINE-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		6 / 12 LEU A  67
GLU A  80
VAL A  81
PRO A 100
PHE A 196
THR A 219
 None
 1.15A 5xiqA-1nj8A:
42.5		 5xiqA-1nj8A:
36.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5XIQ_A_HFGA1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 1nj8 PROLINE-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		7 / 12 LEU A  67
VAL A  81
PRO A 100
GLU A 152
HIS A 154
THR A 219
GLY A 251
 None
 0.47A 5xiqA-1nj8A:
42.5		 5xiqA-1nj8A:
36.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5XIQ_A_HFGA1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 1nj8 PROLINE-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		6 / 12 LEU A  67
VAL A  81
PRO A 100
HIS A 154
PHE A 196
THR A 219
 None
 0.98A 5xiqA-1nj8A:
42.5		 5xiqA-1nj8A:
36.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5XIQ_A_HFGA1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 1nj8 PROLINE-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		5 / 12 VAL A  81
PRO A 100
GLU A 152
HIS A 154
PHE A 227
 None
 1.20A 5xiqA-1nj8A:
42.5		 5xiqA-1nj8A:
36.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5XIQ_B_HFGB1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 1nj8 PROLINE-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		6 / 12 LEU A  67
GLU A  80
VAL A  81
PRO A 100
PHE A 196
THR A 219
 None
 1.13A 5xiqB-1nj8A:
42.3		 5xiqB-1nj8A:
36.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5XIQ_B_HFGB1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 1nj8 PROLINE-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		6 / 12 LEU A  67
VAL A  81
PRO A 100
GLU A 152
HIS A 154
THR A 219
 None
 0.51A 5xiqB-1nj8A:
42.3		 5xiqB-1nj8A:
36.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5XIQ_B_HFGB1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 1nj8 PROLINE-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		6 / 12 LEU A  67
VAL A  81
PRO A 100
HIS A 154
PHE A 196
THR A 219
 None
 0.98A 5xiqB-1nj8A:
42.3		 5xiqB-1nj8A:
36.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5XIQ_B_HFGB1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 1nj8 PROLINE-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		5 / 12 VAL A  81
PRO A 100
GLU A 152
HIS A 154
PHE A 227
 None
 1.23A 5xiqB-1nj8A:
42.3		 5xiqB-1nj8A:
36.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5XIQ_B_HFGB1002_1
(PROLYL-TRNA
SYNTHETASE (PRORS))		 1nj8 PROLINE-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		3 / 3 THR A 101
GLU A 103
HIS A 221
 None
 0.67A 5xiqB-1nj8A:
42.3		 5xiqB-1nj8A:
36.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5XIQ_C_HFGC1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 1nj8 PROLINE-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		5 / 12 GLU A  80
VAL A  81
ARG A 132
PHE A 196
THR A 219
 None
 1.47A 5xiqC-1nj8A:
42.6		 5xiqC-1nj8A:
36.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5XIQ_C_HFGC1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 1nj8 PROLINE-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		5 / 12 GLU A  80
VAL A  81
PRO A 100
PHE A 196
THR A 219
 None
 1.17A 5xiqC-1nj8A:
42.6		 5xiqC-1nj8A:
36.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5XIQ_C_HFGC1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 1nj8 PROLINE-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		6 / 12 VAL A  81
PRO A 100
THR A 101
GLU A 152
HIS A 154
PHE A 227
 None
 1.13A 5xiqC-1nj8A:
42.6		 5xiqC-1nj8A:
36.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5XIQ_C_HFGC1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 1nj8 PROLINE-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		6 / 12 VAL A  81
PRO A 100
THR A 101
GLU A 152
HIS A 154
THR A 219
 None
 0.59A 5xiqC-1nj8A:
42.6		 5xiqC-1nj8A:
36.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5XIQ_C_HFGC1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 1nj8 PROLINE-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		6 / 12 VAL A  81
PRO A 100
THR A 101
HIS A 154
PHE A 196
THR A 219
 None
 1.02A 5xiqC-1nj8A:
42.6		 5xiqC-1nj8A:
36.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5XIQ_D_HFGD1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 1nj8 PROLINE-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		6 / 12 LEU A  67
GLU A  80
VAL A  81
PRO A 100
PHE A 196
THR A 219
 None
 1.12A 5xiqD-1nj8A:
42.3		 5xiqD-1nj8A:
36.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5XIQ_D_HFGD1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 1nj8 PROLINE-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		7 / 12 LEU A  67
VAL A  81
PRO A 100
GLU A 152
HIS A 154
THR A 219
GLY A 251
 None
 0.50A 5xiqD-1nj8A:
42.3		 5xiqD-1nj8A:
36.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5XIQ_D_HFGD1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 1nj8 PROLINE-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		6 / 12 LEU A  67
VAL A  81
PRO A 100
HIS A 154
PHE A 196
THR A 219
 None
 0.96A 5xiqD-1nj8A:
42.3		 5xiqD-1nj8A:
36.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5XIQ_D_HFGD1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 1nj8 PROLINE-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		5 / 12 VAL A  81
PRO A 100
GLU A 152
HIS A 154
PHE A 227
 None
 1.21A 5xiqD-1nj8A:
42.3		 5xiqD-1nj8A:
36.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5XIQ_D_HFGD1002_1
(PROLYL-TRNA
SYNTHETASE (PRORS))		 1nj8 PROLINE-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		3 / 3 THR A 101
GLU A 103
HIS A 221
 None
 0.74A 5xiqD-1nj8A:
42.3		 5xiqD-1nj8A:
36.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1nj8 PROLINE-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		4 / 7 HIS A 264
ASP A 206
THR A 207
TYR A 185
 None
 1.35A 5zcqN-1nj8A:
0.0
5zcqP-1nj8A:
undetectable		 5zcqN-1nj8A:
20.61
5zcqP-1nj8A:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HLO_A_GBQA1501_1
(SUBSTANCE-P
RECEPTOR,GLGA
GLYCOGEN
SYNTHASE,SUBSTANCE-P
RECEPTOR)		 1nj8 PROLINE-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		5 / 9 ILE A 451
TRP A 193
GLU A 427
VAL A 433
ILE A 405
 None
 1.46A 6hloA-1nj8A:
2.9		 6hloA-1nj8A:
20.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6MN8_A_HFGA603_0
(UNCHARACTERIZED
PROTEIN)		 1nj8 PROLINE-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		5 / 12 LEU A  67
GLU A  80
VAL A  81
PRO A 100
GLU A 152
 None
 0.83A 6mn8A-1nj8A:
40.2		 6mn8A-1nj8A:
37.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6MN8_A_HFGA603_0
(UNCHARACTERIZED
PROTEIN)		 1nj8 PROLINE-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		7 / 12 LEU A  67
VAL A  81
PRO A 100
GLU A 152
HIS A 154
THR A 219
GLY A 251
 None
 0.52A 6mn8A-1nj8A:
40.2		 6mn8A-1nj8A:
37.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1nj8 PROLINE-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		4 / 6 HIS A 264
ASP A 206
THR A 207
TYR A 185
 None
 1.34A 6nknA-1nj8A:
0.0
6nknC-1nj8A:
undetectable		 6nknA-1nj8A:
20.61
6nknC-1nj8A:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_C_CHDC303_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1nj8 PROLINE-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		4 / 6 HIS A 264
ASP A 206
THR A 207
TYR A 185
 None
 1.39A 6nmpA-1nj8A:
0.0
6nmpC-1nj8A:
0.0		 6nmpA-1nj8A:
20.61
6nmpC-1nj8A:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_P_CHDP302_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1nj8 PROLINE-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		4 / 7 HIS A 264
ASP A 206
THR A 207
TYR A 185
 None
 1.41A 6nmpN-1nj8A:
undetectable
6nmpP-1nj8A:
undetectable		 6nmpN-1nj8A:
20.61
6nmpP-1nj8A:
17.96