SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1nkv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FK6_A_LNLA1201_1
(NON-SPECIFIC LIPID
TRANSFER PROTEIN)		 1nkv HYPOTHETICAL PROTEIN
YJHP
(Escherichia
coli) 		5 / 12 LEU A  51
ALA A  55
ARG A  87
ALA A 100
ILE A  91
 None
 0.80A 1fk6A-1nkvA:
undetectable		 1fk6A-1nkvA:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXB_A_ROCA100_4
(HIV-1 PROTEASE)		 1nkv HYPOTHETICAL PROTEIN
YJHP
(Escherichia
coli) 		4 / 4 GLY A  97
ASP A  94
GLY A  44
THR A  63
 None
 0.72A 1hxbB-1nkvA:
undetectable		 1hxbB-1nkvA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZZ_A_SAMA635_0
(ACLACINOMYCIN-10-HYD
ROXYLASE)		 1nkv HYPOTHETICAL PROTEIN
YJHP
(Escherichia
coli) 		5 / 12 TYR A  25
GLY A  44
GLY A  46
ASP A  94
TRP A 114
 None
 1.00A 1qzzA-1nkvA:
16.8		 1qzzA-1nkvA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOH_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 1nkv HYPOTHETICAL PROTEIN
YJHP
(Escherichia
coli) 		4 / 5 LEU A 186
GLY A 111
PRO A  19
ALA A 187
 None
 0.97A 2aohA-1nkvA:
undetectable		 2aohA-1nkvA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_B_SAMB2002_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 1nkv HYPOTHETICAL PROTEIN
YJHP
(Escherichia
coli) 		4 / 7 GLY A  46
TYR A  25
ASP A  66
ASP A  94
 None
 0.68A 2g72B-1nkvA:
11.1		 2g72B-1nkvA:
24.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_B_SAMB2002_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 1nkv HYPOTHETICAL PROTEIN
YJHP
(Escherichia
coli) 		4 / 7 TYR A  25
GLY A  46
ASP A  66
ASP A  94
 None
 1.03A 2g72B-1nkvA:
11.1		 2g72B-1nkvA:
24.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		 1nkv HYPOTHETICAL PROTEIN
YJHP
(Escherichia
coli) 		5 / 12 LEU A 137
LEU A 130
ILE A 246
HIS A  58
LEU A  28
 None
 1.11A 2jn3A-1nkvA:
undetectable		 2jn3A-1nkvA:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_A_SAMA400_0
(UNCHARACTERIZED
PROTEIN TFU_2867)		 1nkv HYPOTHETICAL PROTEIN
YJHP
(Escherichia
coli) 		5 / 12 GLY A  44
GLY A  46
ASP A  94
VAL A 110
GLY A 111
 None
 0.33A 2qe6A-1nkvA:
10.2		 2qe6A-1nkvA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_B_SAMB400_0
(UNCHARACTERIZED
PROTEIN TFU_2867)		 1nkv HYPOTHETICAL PROTEIN
YJHP
(Escherichia
coli) 		5 / 12 GLY A  44
GLY A  46
ASP A  94
VAL A 110
GLY A 111
 None
 0.33A 2qe6B-1nkvA:
10.2		 2qe6B-1nkvA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DLC_A_SAMA220_0
(PUTATIVE
S-ADENOSYL-L-METHION
INE-DEPENDENT
METHYLTRANSFERASE)		 1nkv HYPOTHETICAL PROTEIN
YJHP
(Escherichia
coli) 		5 / 12 TYR A  25
GLY A  44
GLY A  46
SER A  68
ASP A  94
 None
 0.69A 3dlcA-1nkvA:
14.1		 3dlcA-1nkvA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DXY_A_SAMA1_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 1nkv HYPOTHETICAL PROTEIN
YJHP
(Escherichia
coli) 		5 / 11 GLY A  44
GLY A  46
ILE A  65
ASP A  94
ALA A  95
 None
 0.82A 3dxyA-1nkvA:
12.2		 3dxyA-1nkvA:
25.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_B_SAMB401_0
(O-METHYLTRANSFERASE)		 1nkv HYPOTHETICAL PROTEIN
YJHP
(Escherichia
coli) 		5 / 12 TRP A 240
MET A  50
LEU A  51
GLY A  44
ALA A 108
 None
 1.20A 3i5uB-1nkvA:
16.5		 3i5uB-1nkvA:
26.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_D_ROCD201_2
(HIV-1 PROTEASE)		 1nkv HYPOTHETICAL PROTEIN
YJHP
(Escherichia
coli) 		4 / 4 GLY A  97
ASP A  94
GLY A  44
THR A  63
 None
 0.74A 3k4vC-1nkvA:
undetectable		 3k4vC-1nkvA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_B_SALB404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 1nkv HYPOTHETICAL PROTEIN
YJHP
(Escherichia
coli) 		4 / 7 ALA A 226
PRO A 227
ARG A 235
ALA A 197
 None
 1.10A 3twpB-1nkvA:
3.1		 3twpB-1nkvA:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_C_SALC404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 1nkv HYPOTHETICAL PROTEIN
YJHP
(Escherichia
coli) 		4 / 7 ALA A 226
PRO A 227
ARG A 235
ALA A 197
 None
 1.00A 3twpC-1nkvA:
2.3		 3twpC-1nkvA:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV8_A_SAMA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 1nkv HYPOTHETICAL PROTEIN
YJHP
(Escherichia
coli) 		5 / 12 GLY A  44
GLY A  46
ASP A  66
ASP A  94
ALA A 112
 None
 0.56A 4iv8A-1nkvA:
17.4		 4iv8A-1nkvA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV8_B_SAMB301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 1nkv HYPOTHETICAL PROTEIN
YJHP
(Escherichia
coli) 		5 / 12 GLY A  44
GLY A  46
ASP A  66
ASP A  94
ALA A 112
 None
 0.57A 4iv8B-1nkvA:
18.2		 4iv8B-1nkvA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KRH_A_SAMA900_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
2)		 1nkv HYPOTHETICAL PROTEIN
YJHP
(Escherichia
coli) 		5 / 12 GLY A  44
GLY A  46
SER A  68
ASP A  94
ALA A  95
 None
 0.66A 4krhA-1nkvA:
19.2		 4krhA-1nkvA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGH_B_SAMB401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 1nkv HYPOTHETICAL PROTEIN
YJHP
(Escherichia
coli) 		5 / 12 ASP A  42
GLY A  44
ASP A  66
ASP A  94
TRP A 114
 None
 0.99A 4pghB-1nkvA:
12.6		 4pghB-1nkvA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_B_SAMB301_0
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 1nkv HYPOTHETICAL PROTEIN
YJHP
(Escherichia
coli) 		5 / 12 GLY A  44
GLY A  46
SER A  68
ALA A 112
TRP A 114
 None
 0.79A 4qtuB-1nkvA:
13.8		 4qtuB-1nkvA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_D_SAMD301_0
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 1nkv HYPOTHETICAL PROTEIN
YJHP
(Escherichia
coli) 		5 / 12 GLY A  44
GLY A  46
SER A  68
ALA A 112
TRP A 114
 None
 0.86A 4qtuD-1nkvA:
14.4		 4qtuD-1nkvA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WBO_B_ANWB601_0
(RHODOPSIN KINASE)		 1nkv HYPOTHETICAL PROTEIN
YJHP
(Escherichia
coli) 		4 / 8 LEU A 125
ALA A 116
ILE A 115
ALA A 107
 None
 0.76A 4wboB-1nkvA:
undetectable		 4wboB-1nkvA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DPD_B_SAMB601_0
(PROTEIN LYSINE
METHYLTRANSFERASE 1)		 1nkv HYPOTHETICAL PROTEIN
YJHP
(Escherichia
coli) 		5 / 12 TYR A  25
GLY A  44
ASP A  66
SER A  68
ILE A 115
 None
 1.02A 5dpdB-1nkvA:
11.8		 5dpdB-1nkvA:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E72_A_SAMA400_1
(N2,
N2-DIMETHYLGUANOSINE
TRNA
METHYLTRANSFERASE)		 1nkv HYPOTHETICAL PROTEIN
YJHP
(Escherichia
coli) 		4 / 4 ASP A  42
GLY A  46
ASP A  66
ASP A  94
 None
 0.55A 5e72A-1nkvA:
16.2		 5e72A-1nkvA:
22.35