SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1nl4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NSI_A_H4BA600_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 1nl4 PROTEIN
FARNESYLTRANSFERASE
ALPHA SUBUNIT
(Rattus
norvegicus) 		4 / 6 ILE A 267
TRP A 277
PHE A 314
GLU A 274
 None
 1.49A 1nsiA-1nl4A:
undetectable
1nsiB-1nl4A:
undetectable		 1nsiA-1nl4A:
18.72
1nsiB-1nl4A:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NSI_D_H4BD603_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 1nl4 PROTEIN
FARNESYLTRANSFERASE
ALPHA SUBUNIT
(Rattus
norvegicus) 		4 / 6 TRP A 277
PHE A 314
GLU A 274
ILE A 267
 None
 1.46A 1nsiC-1nl4A:
0.4
1nsiD-1nl4A:
1.5		 1nsiC-1nl4A:
18.72
1nsiD-1nl4A:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_F_9CRF1600_1
(RETINOIC ACID
RECEPTOR, BETA)		 1nl4 PROTEIN
FARNESYLTRANSFERASE
ALPHA SUBUNIT
(Rattus
norvegicus) 		5 / 12 LEU A 284
LEU A 280
ILE A 283
LEU A 256
LEU A 295
 None
 1.01A 1xdkF-1nl4A:
0.0		 1xdkF-1nl4A:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CEO_B_T44B1395_1
(THYROXINE-BINDING
GLOBULIN)		 1nl4 PROTEIN
FARNESYLTRANSFERASE
ALPHA SUBUNIT
(Rattus
norvegicus) 		5 / 10 ALA A 202
GLN A 225
LEU A 226
LEU A 193
ASN A 194
 None
 1.38A 2ceoB-1nl4A:
0.0		 2ceoB-1nl4A:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GJ5_A_VD3A164_1
(BETA-LACTOGLOBULIN)		 1nl4 PROTEIN
FARNESYLTRANSFERASE
ALPHA SUBUNIT
(Rattus
norvegicus) 		4 / 5 ASP A 224
LEU A 227
LYS A 228
ARG A 240
 None
 1.28A 2gj5A-1nl4A:
undetectable		 2gj5A-1nl4A:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 1nl4 PROTEIN
FARNESYLTRANSFERASE
ALPHA SUBUNIT
(Rattus
norvegicus) 		4 / 7 ILE A 267
TRP A 277
PHE A 314
GLU A 274
 None
 1.49A 3e7gA-1nl4A:
undetectable
3e7gB-1nl4A:
undetectable		 3e7gA-1nl4A:
19.91
3e7gB-1nl4A:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_B_H4BB1902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 1nl4 PROTEIN
FARNESYLTRANSFERASE
ALPHA SUBUNIT
(Rattus
norvegicus) 		4 / 7 TRP A 277
PHE A 314
GLU A 274
ILE A 267
 None
 1.49A 3e7gA-1nl4A:
undetectable
3e7gB-1nl4A:
undetectable		 3e7gA-1nl4A:
19.91
3e7gB-1nl4A:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UVV_A_T3A501_1
(THYROID HORMONE
RECEPTOR ALPHA)		 1nl4 PROTEIN
FARNESYLTRANSFERASE
ALPHA SUBUNIT
(Rattus
norvegicus) 		5 / 12 ILE A 283
LEU A 284
LEU A 295
LEU A 299
ILE A 318
 None
 1.09A 3uvvA-1nl4A:
1.3		 3uvvA-1nl4A:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_D_H4BD600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 1nl4 PROTEIN
FARNESYLTRANSFERASE
ALPHA SUBUNIT
(Rattus
norvegicus) 		4 / 7 TRP A 277
PHE A 314
GLU A 274
ILE A 267
 None
 1.44A 4cx7C-1nl4A:
0.0
4cx7D-1nl4A:
0.4		 4cx7C-1nl4A:
18.72
4cx7D-1nl4A:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWK_A_BEZA301_0
(GLUTATHIONE-SPECIFIC
GAMMA-GLUTAMYLCYCLOT
RANSFERASE)		 1nl4 PROTEIN
FARNESYLTRANSFERASE
ALPHA SUBUNIT
(Rattus
norvegicus) 		5 / 10 TYR A 279
GLY A 282
LEU A 284
LEU A 256
TYR A 250
 None
 1.40A 5hwkA-1nl4A:
0.0		 5hwkA-1nl4A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWK_B_BEZB301_0
(GLUTATHIONE-SPECIFIC
GAMMA-GLUTAMYLCYCLOT
RANSFERASE)		 1nl4 PROTEIN
FARNESYLTRANSFERASE
ALPHA SUBUNIT
(Rattus
norvegicus) 		5 / 10 TYR A 279
GLY A 282
LEU A 284
LEU A 256
TYR A 250
 None
 1.41A 5hwkB-1nl4A:
undetectable		 5hwkB-1nl4A:
21.20