SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1nlr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOC_C_ERYC3402_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 1nlr ENDO-1,4-BETA-GLUCAN
ASE
(Streptomyces
lividans) 		3 / 3 THR A 183
SER A 162
LYS A 123
 None
MHO  A 122 ( 3.5A)
MHO  A 122 ( 3.5A)
 0.83A 3aocC-1nlrA:
undetectable		 3aocC-1nlrA:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS6_A_EPAA1_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1nlr ENDO-1,4-BETA-GLUCAN
ASE
(Streptomyces
lividans) 		5 / 12 VAL A 180
VAL A 198
VAL A 220
ALA A  85
SER A  87
 None
 1.02A 3hs6A-1nlrA:
0.0		 3hs6A-1nlrA:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_A_FLPA701_1
(CYCLOOXYGENASE-2)		 1nlr ENDO-1,4-BETA-GLUCAN
ASE
(Streptomyces
lividans) 		5 / 12 VAL A 180
VAL A 198
VAL A 220
ALA A  85
SER A  87
 None
 1.02A 3pghA-1nlrA:
undetectable		 3pghA-1nlrA:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_C_FLPC701_1
(CYCLOOXYGENASE-2)		 1nlr ENDO-1,4-BETA-GLUCAN
ASE
(Streptomyces
lividans) 		5 / 12 VAL A 180
VAL A 198
VAL A 220
ALA A  85
SER A  87
 None
 1.02A 3pghC-1nlrA:
undetectable		 3pghC-1nlrA:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_B_FLRB700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1nlr ENDO-1,4-BETA-GLUCAN
ASE
(Streptomyces
lividans) 		5 / 12 VAL A 180
VAL A 198
VAL A 220
ALA A  85
SER A  87
 None
 1.08A 3rr3B-1nlrA:
undetectable		 3rr3B-1nlrA:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_C_FLRC700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1nlr ENDO-1,4-BETA-GLUCAN
ASE
(Streptomyces
lividans) 		5 / 12 VAL A 180
VAL A 198
VAL A 220
ALA A  85
SER A  87
 None
 1.07A 3rr3C-1nlrA:
undetectable		 3rr3C-1nlrA:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_D_FLRD700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1nlr ENDO-1,4-BETA-GLUCAN
ASE
(Streptomyces
lividans) 		5 / 12 VAL A 180
VAL A 198
VAL A 220
ALA A  85
SER A  87
 None
 1.08A 3rr3D-1nlrA:
undetectable		 3rr3D-1nlrA:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KUK_A_RBFA201_1
(BLUE-LIGHT
PHOTORECEPTOR)		 1nlr ENDO-1,4-BETA-GLUCAN
ASE
(Streptomyces
lividans) 		5 / 12 SER A 102
ASN A 100
GLN A  30
ASN A  21
GLN A  20
 MHO  A 122 ( 4.1A)
MHO  A 122 ( 4.7A)
None
None
None
 1.31A 4kukA-1nlrA:
undetectable		 4kukA-1nlrA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWX_A_ZMRA513_2
(NEURAMINIDASE)		 1nlr ENDO-1,4-BETA-GLUCAN
ASE
(Streptomyces
lividans) 		3 / 3 ARG A 146
TRP A 148
ILE A 169
 None
 0.98A 4mwxA-1nlrA:
undetectable		 4mwxA-1nlrA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UIL_H_QI9H1223_0
(FAB 314.1)		 1nlr ENDO-1,4-BETA-GLUCAN
ASE
(Streptomyces
lividans) 		6 / 12 ALA A 200
SER A 102
GLY A  92
PHE A  39
GLN A  30
PRO A  58
 None
MHO  A 122 ( 4.1A)
None
None
None
None
 1.38A 4uilH-1nlrA:
undetectable
4uilL-1nlrA:
undetectable		 4uilH-1nlrA:
23.37
4uilL-1nlrA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP1_A_LDPA708_1
(DOPAMINE
TRANSPORTER, ISOFORM
B)		 1nlr ENDO-1,4-BETA-GLUCAN
ASE
(Streptomyces
lividans) 		5 / 10 ALA A 200
VAL A  60
TYR A  17
SER A 217
SER A 218
 None
 1.19A 4xp1A-1nlrA:
undetectable		 4xp1A-1nlrA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YVX_A_GMRA401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 1nlr ENDO-1,4-BETA-GLUCAN
ASE
(Streptomyces
lividans) 		5 / 12 TYR A  57
SER A  70
LEU A  75
PHE A 216
SER A  87
 None
 1.22A 4yvxA-1nlrA:
undetectable		 4yvxA-1nlrA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECO_A_LEUA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 1nlr ENDO-1,4-BETA-GLUCAN
ASE
(Streptomyces
lividans) 		4 / 6 THR A 147
ALA A 141
THR A 140
VAL A 150
 None
 0.92A 5ecoA-1nlrA:
undetectable		 5ecoA-1nlrA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K4P_A_SORA611_0
(PROBABLE
PHOSPHATIDYLETHANOLA
MINE TRANSFERASE
MCR-1)		 1nlr ENDO-1,4-BETA-GLUCAN
ASE
(Streptomyces
lividans) 		4 / 6 GLY A  92
SER A 170
GLY A 171
ASN A 214
 None
 0.92A 5k4pA-1nlrA:
undetectable		 5k4pA-1nlrA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_D_HISD402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 1nlr ENDO-1,4-BETA-GLUCAN
ASE
(Streptomyces
lividans) 		4 / 8 GLY A   9
THR A  12
ASN A  68
VAL A  18
 None
 0.80A 6czmD-1nlrA:
undetectable
6czmF-1nlrA:
undetectable		 6czmD-1nlrA:
19.35
6czmF-1nlrA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH0_A_017A101_2
(PROTEASE)		 1nlr ENDO-1,4-BETA-GLUCAN
ASE
(Streptomyces
lividans) 		3 / 3 LEU A 188
ASP A 104
ILE A 123
 None
MHO  A 122 ( 3.8A)
MHO  A 122 ( 4.0A)
 0.60A 6dh0B-1nlrA:
undetectable		 6dh0B-1nlrA:
15.61