SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1nmo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_D_PPFD412_1
(PHOSPHONOACETATE
HYDROLASE)
1nmo HYPOTHETICAL PROTEIN
YBGI

(Escherichia
coli)
4 / 8 ASP A 101
HIS A  63
HIS A  64
HIS A  97
FE  A 302 (-2.3A)
FE  A 302 (-3.7A)
FE  A 301 (-3.3A)
None
0.93A 1ei6D-1nmoA:
0.2
1ei6D-1nmoA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBY_A_9CRA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)
1nmo HYPOTHETICAL PROTEIN
YBGI

(Escherichia
coli)
5 / 12 ILE A 179
ALA A 182
ALA A 183
ALA A 169
HIS A 201
None
0.84A 1fbyA-1nmoA:
undetectable
1fbyA-1nmoA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBY_B_9CRB1500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)
1nmo HYPOTHETICAL PROTEIN
YBGI

(Escherichia
coli)
5 / 12 ILE A 179
ALA A 182
ALA A 183
ALA A 169
HIS A 201
None
0.84A 1fbyB-1nmoA:
undetectable
1fbyB-1nmoA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_U_9CRU502_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)
1nmo HYPOTHETICAL PROTEIN
YBGI

(Escherichia
coli)
5 / 12 ALA A 182
ALA A 183
ALA A 169
ILE A 200
HIS A 201
None
0.85A 1fm6U-1nmoA:
undetectable
1fm6U-1nmoA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_5
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)
1nmo HYPOTHETICAL PROTEIN
YBGI

(Escherichia
coli)
3 / 3 THR A 134
LEU A 133
VAL A 137
None
0.49A 1mz9E-1nmoA:
undetectable
1mz9E-1nmoA:
14.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OQ5_A_CELA701_2
(CARBONIC ANHYDRASE
II)
1nmo HYPOTHETICAL PROTEIN
YBGI

(Escherichia
coli)
4 / 4 HIS A  63
VAL A  42
THR A 172
LEU A 150
FE  A 302 (-3.7A)
None
None
None
1.38A 1oq5A-1nmoA:
0.0
1oq5A-1nmoA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XIU_B_9CRB202_1
(RXR-LIKE PROTEIN)
1nmo HYPOTHETICAL PROTEIN
YBGI

(Escherichia
coli)
5 / 12 ILE A 179
ALA A 182
ALA A 183
ALA A 169
HIS A 201
None
0.81A 1xiuB-1nmoA:
undetectable
1xiuB-1nmoA:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_C_REAC503_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)
1nmo HYPOTHETICAL PROTEIN
YBGI

(Escherichia
coli)
5 / 10 ILE A 179
ALA A 182
ALA A 183
ALA A 169
ILE A 200
None
0.88A 2aclC-1nmoA:
undetectable
2aclC-1nmoA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_E_REAE504_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)
1nmo HYPOTHETICAL PROTEIN
YBGI

(Escherichia
coli)
5 / 11 ILE A 179
ALA A 182
ALA A 183
ALA A 169
ILE A 200
None
0.96A 2aclE-1nmoA:
undetectable
2aclE-1nmoA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOF_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)
1nmo HYPOTHETICAL PROTEIN
YBGI

(Escherichia
coli)
4 / 5 GLY A 139
PRO A 154
ALA A 213
ILE A 191
None
0.96A 2aofA-1nmoA:
undetectable
2aofA-1nmoA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_B_SAMB2002_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)
1nmo HYPOTHETICAL PROTEIN
YBGI

(Escherichia
coli)
5 / 12 TYR A  66
LEU A  83
ILE A  91
VAL A  60
ALA A  47
None
1.10A 2g72B-1nmoA:
undetectable
2g72B-1nmoA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_E_HAEE3003_1
(COLLAGENASE 3)
1nmo HYPOTHETICAL PROTEIN
YBGI

(Escherichia
coli)
4 / 4 HIS A  63
GLU A 219
HIS A  64
HIS A  97
FE  A 302 (-3.7A)
FE  A 302 ( 2.4A)
FE  A 301 (-3.3A)
None
1.20A 2ozrE-1nmoA:
undetectable
2ozrE-1nmoA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_B_RIMB299_1
(MATRIX PROTEIN 2)
1nmo HYPOTHETICAL PROTEIN
YBGI

(Escherichia
coli)
4 / 6 LEU A 112
LEU A 115
TRP A 170
ILE A 191
None
1.15A 2rlfB-1nmoA:
0.0
2rlfC-1nmoA:
0.0
2rlfB-1nmoA:
13.88
2rlfC-1nmoA:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_C_RIMC399_1
(MATRIX PROTEIN 2)
1nmo HYPOTHETICAL PROTEIN
YBGI

(Escherichia
coli)
4 / 6 LEU A 112
LEU A 115
TRP A 170
ILE A 191
None
0.97A 2rlfC-1nmoA:
0.0
2rlfD-1nmoA:
0.0
2rlfC-1nmoA:
13.88
2rlfD-1nmoA:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFH_A_CL6A1414_1
(ERYTHROMYCIN B/D
C-12 HYDROXYLASE)
1nmo HYPOTHETICAL PROTEIN
YBGI

(Escherichia
coli)
5 / 8 LEU A   6
ILE A  10
LEU A   9
THR A 234
LEU A 236
None
1.45A 2xfhA-1nmoA:
undetectable
2xfhA-1nmoA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AV6_A_SAMA1_0
(DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1)
1nmo HYPOTHETICAL PROTEIN
YBGI

(Escherichia
coli)
5 / 12 PHE A 210
GLY A 158
GLY A 139
LEU A 142
VAL A 165
None
1.04A 3av6A-1nmoA:
undetectable
3av6A-1nmoA:
11.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1009_1
(SERUM ALBUMIN)
1nmo HYPOTHETICAL PROTEIN
YBGI

(Escherichia
coli)
4 / 8 SER A 196
GLN A 176
VAL A 128
CYH A 171
None
1.01A 3b9lA-1nmoA:
undetectable
3b9lA-1nmoA:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E00_A_9CRA7223_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)
1nmo HYPOTHETICAL PROTEIN
YBGI

(Escherichia
coli)
5 / 12 ILE A 179
ALA A 182
ALA A 183
ALA A 169
ILE A 200
None
0.91A 3e00A-1nmoA:
undetectable
3e00A-1nmoA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FAL_A_REAA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)
1nmo HYPOTHETICAL PROTEIN
YBGI

(Escherichia
coli)
5 / 10 ILE A 179
ALA A 182
ALA A 183
ALA A 169
ILE A 200
None
0.87A 3falA-1nmoA:
undetectable
3falA-1nmoA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FAL_C_REAC501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)
1nmo HYPOTHETICAL PROTEIN
YBGI

(Escherichia
coli)
5 / 10 ILE A 179
ALA A 182
ALA A 183
ALA A 169
ILE A 200
None
0.99A 3falC-1nmoA:
undetectable
3falC-1nmoA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FC6_A_REAA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)
1nmo HYPOTHETICAL PROTEIN
YBGI

(Escherichia
coli)
5 / 11 ILE A 179
ALA A 182
ALA A 183
ALA A 169
ILE A 200
None
1.01A 3fc6A-1nmoA:
undetectable
3fc6A-1nmoA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MIH_A_CUA357_0
(PEPTIDYL-GLYCINE
ALPHA-AMIDATING
MONOOXYGENASE)
1nmo HYPOTHETICAL PROTEIN
YBGI

(Escherichia
coli)
3 / 3 HIS A  97
HIS A  64
HIS A  63
None
FE  A 301 (-3.3A)
FE  A 302 (-3.7A)
0.67A 3mihA-1nmoA:
undetectable
3mihA-1nmoA:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OAP_A_9CRA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)
1nmo HYPOTHETICAL PROTEIN
YBGI

(Escherichia
coli)
5 / 12 ILE A 179
ALA A 182
ALA A 183
ALA A 169
ILE A 200
None
0.94A 3oapA-1nmoA:
undetectable
3oapA-1nmoA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_C_ACTC4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)
1nmo HYPOTHETICAL PROTEIN
YBGI

(Escherichia
coli)
4 / 4 GLY A 214
GLY A 193
THR A 172
LEU A 112
None
0.86A 3si7C-1nmoA:
undetectable
3si7D-1nmoA:
undetectable
3si7C-1nmoA:
22.07
3si7D-1nmoA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_D_ACTD4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)
1nmo HYPOTHETICAL PROTEIN
YBGI

(Escherichia
coli)
4 / 5 LEU A 112
GLY A 214
GLY A 193
THR A 172
None
0.84A 3si7C-1nmoA:
0.0
3si7D-1nmoA:
0.0
3si7C-1nmoA:
22.07
3si7D-1nmoA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UVV_B_9CRB501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)
1nmo HYPOTHETICAL PROTEIN
YBGI

(Escherichia
coli)
5 / 12 ILE A 179
ALA A 182
ALA A 183
ALA A 169
ILE A 200
None
0.96A 3uvvB-1nmoA:
undetectable
3uvvB-1nmoA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M5M_A_DX4A401_0
(2-AMINO-4-HYDROXY-6-
HYDROXYMETHYLDIHYDRO
PTERIDINE
PYROPHOSPHOKINASE)
1nmo HYPOTHETICAL PROTEIN
YBGI

(Escherichia
coli)
4 / 8 GLY A 107
THR A 172
LEU A 127
ASN A 108
None
1.25A 4m5mA-1nmoA:
undetectable
4m5mA-1nmoA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NQA_H_9CRH501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)
1nmo HYPOTHETICAL PROTEIN
YBGI

(Escherichia
coli)
5 / 12 ILE A 179
ALA A 182
ALA A 183
ALA A 169
HIS A 201
None
0.78A 4nqaH-1nmoA:
undetectable
4nqaH-1nmoA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZT_A_ACTA202_0
(RETINOL-BINDING
PROTEIN 2)
1nmo HYPOTHETICAL PROTEIN
YBGI

(Escherichia
coli)
4 / 6 TYR A  66
THR A  85
LEU A  86
GLN A  46
None
1.24A 4qztA-1nmoA:
undetectable
4qztA-1nmoA:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2O_B_CLQB1079_0
(SAPOSIN-B)
1nmo HYPOTHETICAL PROTEIN
YBGI

(Escherichia
coli)
3 / 3 MET A   1
GLU A   5
LEU A   9
None
0.80A 4v2oB-1nmoA:
undetectable
4v2oB-1nmoA:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESG_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)
1nmo HYPOTHETICAL PROTEIN
YBGI

(Escherichia
coli)
5 / 12 PHE A 210
ILE A 179
VAL A 164
GLY A 193
THR A 218
None
1.33A 5esgA-1nmoA:
undetectable
5esgA-1nmoA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_A_BZMA301_0
(ISATIN HYDROLASE A)
1nmo HYPOTHETICAL PROTEIN
YBGI

(Escherichia
coli)
5 / 12 LEU A  98
HIS A  64
TRP A  68
SER A 177
GLY A 174
None
FE  A 301 (-3.3A)
None
None
None
1.19A 5nnaA-1nmoA:
undetectable
5nnaA-1nmoA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_B_BZMB301_0
(ISATIN HYDROLASE A)
1nmo HYPOTHETICAL PROTEIN
YBGI

(Escherichia
coli)
5 / 12 LEU A  98
HIS A  64
TRP A  68
SER A 177
GLY A 174
None
FE  A 301 (-3.3A)
None
None
None
1.17A 5nnaB-1nmoA:
undetectable
5nnaB-1nmoA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_C_BZMC301_0
(ISATIN HYDROLASE A)
1nmo HYPOTHETICAL PROTEIN
YBGI

(Escherichia
coli)
5 / 12 LEU A  98
HIS A  64
TRP A  68
SER A 177
GLY A 174
None
FE  A 301 (-3.3A)
None
None
None
1.16A 5nnaC-1nmoA:
undetectable
5nnaC-1nmoA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_D_BZMD301_0
(ISATIN HYDROLASE A)
1nmo HYPOTHETICAL PROTEIN
YBGI

(Escherichia
coli)
5 / 12 LEU A  98
HIS A  64
TRP A  68
SER A 177
GLY A 174
None
FE  A 301 (-3.3A)
None
None
None
1.20A 5nnaD-1nmoA:
undetectable
5nnaD-1nmoA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1807_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)
1nmo HYPOTHETICAL PROTEIN
YBGI

(Escherichia
coli)
5 / 7 LEU A 226
LEU A  48
ILE A  10
LEU A   6
ILE A  91
None
1.38A 5vkqA-1nmoA:
undetectable
5vkqB-1nmoA:
undetectable
5vkqA-1nmoA:
8.79
5vkqB-1nmoA:
8.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1804_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)
1nmo HYPOTHETICAL PROTEIN
YBGI

(Escherichia
coli)
5 / 8 LEU A 236
VAL A 238
ILE A 223
GLY A 222
LEU A 100
None
1.20A 5vkqB-1nmoA:
undetectable
5vkqC-1nmoA:
undetectable
5vkqB-1nmoA:
8.79
5vkqC-1nmoA:
8.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Y_D_9CRD501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)
1nmo HYPOTHETICAL PROTEIN
YBGI

(Escherichia
coli)
5 / 12 ILE A 179
ALA A 182
ALA A 183
ALA A 169
ILE A 200
None
0.82A 6a5yD-1nmoA:
undetectable
6a5yD-1nmoA:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Z_D_9CRD501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)
1nmo HYPOTHETICAL PROTEIN
YBGI

(Escherichia
coli)
5 / 12 ILE A 179
ALA A 182
ALA A 183
ALA A 169
ILE A 200
None
0.86A 6a5zD-1nmoA:
undetectable
6a5zD-1nmoA:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Z_L_9CRL501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)
1nmo HYPOTHETICAL PROTEIN
YBGI

(Escherichia
coli)
6 / 12 ILE A 179
ALA A 182
ALA A 183
ALA A 169
ILE A 200
HIS A 201
None
0.79A 6a5zL-1nmoA:
undetectable
6a5zL-1nmoA:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A60_D_9CRD501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)
1nmo HYPOTHETICAL PROTEIN
YBGI

(Escherichia
coli)
6 / 12 ILE A 179
ALA A 182
ALA A 183
ALA A 169
ILE A 200
HIS A 201
None
0.79A 6a60D-1nmoA:
undetectable
6a60D-1nmoA:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AYC_A_1YNA502_2
(PROTEIN CYP51)
1nmo HYPOTHETICAL PROTEIN
YBGI

(Escherichia
coli)
4 / 7 VAL A 238
PRO A  99
LEU A  98
LEU A  14
None
1.07A 6aycA-1nmoA:
undetectable
6aycA-1nmoA:
13.36