SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1nne'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_B_RALB600_1
(ESTROGEN RECEPTOR)		 1nne DNA MISMATCH REPAIR
PROTEIN MUTS
(Thermus
aquaticus) 		5 / 12 GLU A 333
LEU A 332
LEU A 287
LEU A 359
LEU A 356
 None
 1.16A 1errB-1nneA:
undetectable		 1errB-1nneA:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IBG_H_OBNH1_2
(IGG2B-KAPPA 40-50
FAB (HEAVY CHAIN)
IGG2B-KAPPA 40-50
FAB (LIGHT CHAIN))		 1nne DNA MISMATCH REPAIR
PROTEIN MUTS
(Thermus
aquaticus) 		4 / 7 SER A 290
HIS A 173
ARG A 172
LEU A 166
 None
 0.99A 1ibgL-1nneA:
0.5		 1ibgL-1nneA:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_1
(DNA GYRASE SUBUNIT B)		 1nne DNA MISMATCH REPAIR
PROTEIN MUTS
(Thermus
aquaticus) 		5 / 12 GLU A 613
ARG A 554
ILE A 553
ILE A 599
ALA A 603
 None
 1.25A 1kijB-1nneA:
undetectable		 1kijB-1nneA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OG5_A_SWFA502_1
(CYTOCHROME P450 2C9)		 1nne DNA MISMATCH REPAIR
PROTEIN MUTS
(Thermus
aquaticus) 		5 / 12 ARG A 354
LEU A 375
LEU A 517
THR A 281
LEU A 326
 None
 1.05A 1og5A-1nneA:
0.0		 1og5A-1nneA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_B_FUAB703_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1nne DNA MISMATCH REPAIR
PROTEIN MUTS
(Thermus
aquaticus) 		5 / 12 PHE A 263
LEU A 601
VAL A 605
VAL A 262
THR A 256
 None
 1.22A 1q23B-1nneA:
undetectable		 1q23B-1nneA:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_C_TFPC208_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 1nne DNA MISMATCH REPAIR
PROTEIN MUTS
(Thermus
aquaticus) 		4 / 5 PHE A  34
LEU A 107
PHE A  43
SER A  63
 None
 1.23A 1wrlC-1nneA:
undetectable		 1wrlC-1nneA:
7.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_E_TFPE212_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 1nne DNA MISMATCH REPAIR
PROTEIN MUTS
(Thermus
aquaticus) 		4 / 7 PHE A  34
LEU A 107
PHE A  43
SER A  63
 None
 1.18A 1wrlE-1nneA:
undetectable		 1wrlE-1nneA:
7.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_A_MK1A901_2
(POL POLYPROTEIN)		 1nne DNA MISMATCH REPAIR
PROTEIN MUTS
(Thermus
aquaticus) 		3 / 3 ASP A 472
VAL A 452
PRO A 436
 None
 0.80A 2avvA-1nneA:
undetectable		 2avvA-1nneA:
8.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_C_SAMC301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 1nne DNA MISMATCH REPAIR
PROTEIN MUTS
(Thermus
aquaticus) 		5 / 12 LEU A 527
LEU A 372
GLU A 368
GLY A 367
ARG A 308
 None
 1.16A 2bm9C-1nneA:
undetectable		 2bm9C-1nneA:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXQ_A_IMNA2001_1
(SERUM ALBUMIN)		 1nne DNA MISMATCH REPAIR
PROTEIN MUTS
(Thermus
aquaticus) 		5 / 10 ALA A  77
PHE A  78
ALA A  82
LEU A  86
LEU A 116
 None
 1.11A 2bxqA-1nneA:
0.0		 2bxqA-1nneA:
25.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CEO_B_T44B1395_1
(THYROXINE-BINDING
GLOBULIN)		 1nne DNA MISMATCH REPAIR
PROTEIN MUTS
(Thermus
aquaticus) 		5 / 10 ALA A  93
LEU A  54
LEU A  50
LEU A  33
ARG A  84
 None
 1.37A 2ceoB-1nneA:
undetectable		 2ceoB-1nneA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F7F_A_NIOA601_1
(NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE, PUTATIVE)		 1nne DNA MISMATCH REPAIR
PROTEIN MUTS
(Thermus
aquaticus) 		4 / 6 PHE A 698
SER A 736
GLY A 583
THR A 582
 None
SO4  A 852 (-2.6A)
SO4  A 852 (-4.9A)
None
 1.19A 2f7fA-1nneA:
undetectable		 2f7fA-1nneA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_E_SC2E1289_1
(FICOLIN-2)		 1nne DNA MISMATCH REPAIR
PROTEIN MUTS
(Thermus
aquaticus) 		4 / 6 ARG A 286
ASP A 149
THR A 152
ASP A 331
 None
 0.91A 2j2pE-1nneA:
undetectable
2j2pF-1nneA:
0.0		 2j2pE-1nneA:
13.25
2j2pF-1nneA:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		 1nne DNA MISMATCH REPAIR
PROTEIN MUTS
(Thermus
aquaticus) 		5 / 12 PHE A 619
ILE A 622
THR A 624
LEU A 260
LEU A 551
 None
 1.13A 2jn3A-1nneA:
undetectable		 2jn3A-1nneA:
9.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_F_ASDF1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 1nne DNA MISMATCH REPAIR
PROTEIN MUTS
(Thermus
aquaticus) 		5 / 8 LEU A 382
LEU A 378
ALA A 351
LEU A 335
ALA A 344
 None
 1.47A 2vcvF-1nneA:
undetectable		 2vcvF-1nneA:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		 1nne DNA MISMATCH REPAIR
PROTEIN MUTS
(Thermus
aquaticus) 		4 / 8 LEU A 349
LEU A 504
LEU A 399
ARG A 509
 None
 1.03A 2xn3A-1nneA:
0.0
2xn3B-1nneA:
0.0		 2xn3A-1nneA:
17.73
2xn3B-1nneA:
4.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN6_A_T44A1370_1
(THYROXINE-BINDING
GLOBULIN)		 1nne DNA MISMATCH REPAIR
PROTEIN MUTS
(Thermus
aquaticus) 		5 / 10 GLN A 229
LEU A 236
LEU A 148
LEU A 238
ARG A 221
 None
 1.18A 2xn6A-1nneA:
undetectable
2xn6B-1nneA:
0.0		 2xn6A-1nneA:
17.19
2xn6B-1nneA:
4.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN6_A_T44A1370_1
(THYROXINE-BINDING
GLOBULIN)		 1nne DNA MISMATCH REPAIR
PROTEIN MUTS
(Thermus
aquaticus) 		5 / 10 LEU A  54
LEU A  50
LEU A  33
LEU A  85
ARG A  84
 None
 1.17A 2xn6A-1nneA:
undetectable
2xn6B-1nneA:
0.0		 2xn6A-1nneA:
17.19
2xn6B-1nneA:
4.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN7_A_T44A1355_1
(THYROXINE-BINDING
GLOBULIN)		 1nne DNA MISMATCH REPAIR
PROTEIN MUTS
(Thermus
aquaticus) 		5 / 10 LEU A  54
LEU A  50
LEU A  33
LEU A  85
ARG A  84
 None
 1.13A 2xn7A-1nneA:
undetectable
2xn7B-1nneA:
undetectable		 2xn7A-1nneA:
17.06
2xn7B-1nneA:
4.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCR_A_CHDA4_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1nne DNA MISMATCH REPAIR
PROTEIN MUTS
(Thermus
aquaticus) 		3 / 3 LEU A 372
PRO A 373
LEU A 359
 None
 0.48A 3hcrA-1nneA:
undetectable		 3hcrA-1nneA:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JAY_A_SAMA1102_1
(STRUCTURAL PROTEIN
VP3)		 1nne DNA MISMATCH REPAIR
PROTEIN MUTS
(Thermus
aquaticus) 		3 / 3 ARG A 334
ASP A 348
ASP A 331
 None
 0.86A 3jayA-1nneA:
undetectable		 3jayA-1nneA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1102_1
(STRUCTURAL PROTEIN
VP3)		 1nne DNA MISMATCH REPAIR
PROTEIN MUTS
(Thermus
aquaticus) 		3 / 3 ARG A 334
ASP A 348
ASP A 331
 None
 0.93A 3jb2A-1nneA:
3.7		 3jb2A-1nneA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB3_A_SAMA1102_1
(STRUCTURAL PROTEIN
VP3)		 1nne DNA MISMATCH REPAIR
PROTEIN MUTS
(Thermus
aquaticus) 		3 / 3 ARG A 334
ASP A 348
ASP A 331
 None
 0.93A 3jb3A-1nneA:
2.0		 3jb3A-1nneA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVR_A_URFA2001_1
(URIDINE
PHOSPHORYLASE)		 1nne DNA MISMATCH REPAIR
PROTEIN MUTS
(Thermus
aquaticus) 		5 / 10 THR A 158
GLY A 144
PHE A 147
LEU A 160
LEU A 166
 None
 1.30A 3kvrA-1nneA:
undetectable		 3kvrA-1nneA:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVR_B_URFB2011_1
(URIDINE
PHOSPHORYLASE)		 1nne DNA MISMATCH REPAIR
PROTEIN MUTS
(Thermus
aquaticus) 		5 / 10 THR A 158
GLY A 144
PHE A 147
LEU A 160
LEU A 166
 None
 1.27A 3kvrB-1nneA:
undetectable		 3kvrB-1nneA:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PP7_B_SVRB499_1
(PYRUVATE KINASE)		 1nne DNA MISMATCH REPAIR
PROTEIN MUTS
(Thermus
aquaticus) 		5 / 10 ASN A 585
HIS A 696
TYR A 737
GLY A 588
ALA A 587
 BEF  A 998 (-3.4A)
SO4  A 852 (-4.3A)
None
ADP  A 999 (-3.4A)
ADP  A 999 (-4.4A)
 1.46A 3pp7B-1nneA:
undetectable		 3pp7B-1nneA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QEO_B_LLTB261_1
(DEOXYCYTIDINE KINASE)		 1nne DNA MISMATCH REPAIR
PROTEIN MUTS
(Thermus
aquaticus) 		4 / 7 VAL A 646
LEU A 650
PHE A 693
LEU A 578
 None
 1.06A 3qeoB-1nneA:
undetectable		 3qeoB-1nneA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQT_A_30ZA1920_1
(ANDROGEN RECEPTOR)		 1nne DNA MISMATCH REPAIR
PROTEIN MUTS
(Thermus
aquaticus) 		4 / 6 PRO A  69
GLY A  44
LEU A   5
GLU A   8
 None
 0.97A 3zqtA-1nneA:
undetectable		 3zqtA-1nneA:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FWD_A_BO2A801_1
(TTC1975 PEPTIDASE)		 1nne DNA MISMATCH REPAIR
PROTEIN MUTS
(Thermus
aquaticus) 		5 / 9 VAL A 728
VAL A 579
ILE A 581
GLY A 583
ALA A 587
 None
None
None
SO4  A 852 (-4.9A)
ADP  A 999 (-4.4A)
 1.12A 4fwdA-1nneA:
4.0		 4fwdA-1nneA:
28.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0U_F_ASWF101_1
(DNA TOPOISOMERASE
2-BETA)		 1nne DNA MISMATCH REPAIR
PROTEIN MUTS
(Thermus
aquaticus) 		4 / 6 ARG A 110
ALA A 104
GLU A  99
GLN A  26
 None
 1.12A 4g0uA-1nneA:
undetectable		 4g0uA-1nneA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IOM_A_FOLA608_0
(FORMATE--TETRAHYDROF
OLATE LIGASE)		 1nne DNA MISMATCH REPAIR
PROTEIN MUTS
(Thermus
aquaticus) 		4 / 7 ALA A 344
PRO A 346
LEU A 335
LEU A 339
 None
 0.74A 4iomA-1nneA:
undetectable		 4iomA-1nneA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JJK_A_FOLA601_0
(FORMATE--TETRAHYDROF
OLATE LIGASE)		 1nne DNA MISMATCH REPAIR
PROTEIN MUTS
(Thermus
aquaticus) 		4 / 8 ALA A 344
PRO A 346
LEU A 335
LEU A 339
 None
 0.73A 4jjkA-1nneA:
undetectable		 4jjkA-1nneA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1X_A_STRA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 1nne DNA MISMATCH REPAIR
PROTEIN MUTS
(Thermus
aquaticus) 		4 / 8 LEU A 382
VAL A 506
LEU A 332
LEU A 517
 None
 0.91A 4l1xA-1nneA:
undetectable		 4l1xA-1nneA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LA0_A_198A601_1
(SERUM ALBUMIN)		 1nne DNA MISMATCH REPAIR
PROTEIN MUTS
(Thermus
aquaticus) 		5 / 10 LEU A 134
PRO A 175
PHE A 194
GLU A 177
LEU A 145
 None
 1.48A 4la0A-1nneA:
2.2		 4la0A-1nneA:
25.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LA0_B_198B601_1
(SERUM ALBUMIN)		 1nne DNA MISMATCH REPAIR
PROTEIN MUTS
(Thermus
aquaticus) 		5 / 9 LEU A 134
PRO A 175
PHE A 194
GLU A 177
LEU A 145
 None
 1.45A 4la0B-1nneA:
0.0		 4la0B-1nneA:
25.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UDA_A_DEXA1985_2
(MINERALOCORTICOID
RECEPTOR)		 1nne DNA MISMATCH REPAIR
PROTEIN MUTS
(Thermus
aquaticus) 		4 / 6 LEU A 601
LEU A 618
PHE A 547
VAL A 609
 None
 1.09A 4udaA-1nneA:
undetectable		 4udaA-1nneA:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_C_CHDC102_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 1nne DNA MISMATCH REPAIR
PROTEIN MUTS
(Thermus
aquaticus) 		4 / 7 GLU A  83
LEU A  85
LEU A  92
LEU A  33
 None
 0.81A 4wg0B-1nneA:
undetectable
4wg0C-1nneA:
undetectable		 4wg0B-1nneA:
3.44
4wg0C-1nneA:
3.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_E_CHDE104_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 1nne DNA MISMATCH REPAIR
PROTEIN MUTS
(Thermus
aquaticus) 		5 / 11 ALA A 351
LEU A 352
LEU A 517
LEU A 375
LEU A 378
 None
 0.98A 4wg0C-1nneA:
undetectable
4wg0D-1nneA:
undetectable
4wg0E-1nneA:
undetectable		 4wg0C-1nneA:
3.44
4wg0D-1nneA:
3.44
4wg0E-1nneA:
3.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_F_CHDF103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 1nne DNA MISMATCH REPAIR
PROTEIN MUTS
(Thermus
aquaticus) 		5 / 11 LEU A  92
GLU A  83
LEU A  85
ALA A  77
TYR A  40
 None
 1.15A 4wg0F-1nneA:
undetectable
4wg0G-1nneA:
undetectable
4wg0H-1nneA:
undetectable		 4wg0F-1nneA:
3.44
4wg0G-1nneA:
3.44
4wg0H-1nneA:
3.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_F_CHDF103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 1nne DNA MISMATCH REPAIR
PROTEIN MUTS
(Thermus
aquaticus) 		5 / 11 LEU A  92
LEU A  33
GLU A  83
LEU A  85
ALA A  77
 None
 1.03A 4wg0F-1nneA:
undetectable
4wg0G-1nneA:
undetectable
4wg0H-1nneA:
undetectable		 4wg0F-1nneA:
3.44
4wg0G-1nneA:
3.44
4wg0H-1nneA:
3.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_G_CHDG103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 1nne DNA MISMATCH REPAIR
PROTEIN MUTS
(Thermus
aquaticus) 		5 / 11 ALA A 351
LEU A 352
LEU A 517
LEU A 375
LEU A 378
 None
 1.00A 4wg0E-1nneA:
undetectable
4wg0F-1nneA:
undetectable
4wg0G-1nneA:
undetectable		 4wg0E-1nneA:
3.44
4wg0F-1nneA:
3.44
4wg0G-1nneA:
3.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_I_CHDI103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 1nne DNA MISMATCH REPAIR
PROTEIN MUTS
(Thermus
aquaticus) 		5 / 11 ALA A  77
GLU A  83
LEU A  85
LEU A  92
LEU A  33
 None
 1.00A 4wg0G-1nneA:
undetectable
4wg0H-1nneA:
undetectable
4wg0I-1nneA:
undetectable		 4wg0G-1nneA:
3.44
4wg0H-1nneA:
3.44
4wg0I-1nneA:
3.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_I_CHDI103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 1nne DNA MISMATCH REPAIR
PROTEIN MUTS
(Thermus
aquaticus) 		5 / 11 ALA A  77
TYR A  40
GLU A  83
LEU A  85
LEU A  92
 None
 1.12A 4wg0G-1nneA:
undetectable
4wg0H-1nneA:
undetectable
4wg0I-1nneA:
undetectable		 4wg0G-1nneA:
3.44
4wg0H-1nneA:
3.44
4wg0I-1nneA:
3.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_L_CHDL103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 1nne DNA MISMATCH REPAIR
PROTEIN MUTS
(Thermus
aquaticus) 		4 / 7 LEU A  92
LEU A  33
GLU A  83
LEU A  85
 None
 0.73A 4wg0L-1nneA:
undetectable
4wg0M-1nneA:
undetectable		 4wg0L-1nneA:
3.44
4wg0M-1nneA:
3.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_M_CHDM103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 1nne DNA MISMATCH REPAIR
PROTEIN MUTS
(Thermus
aquaticus) 		5 / 11 ALA A  77
GLU A  83
LEU A  85
LEU A  92
LEU A  33
 None
 1.05A 4wg0K-1nneA:
undetectable
4wg0L-1nneA:
undetectable
4wg0M-1nneA:
undetectable		 4wg0K-1nneA:
3.44
4wg0L-1nneA:
3.44
4wg0M-1nneA:
3.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQE_A_AG2A506_1
(HOMOSPERMIDINE
SYNTHASE)		 1nne DNA MISMATCH REPAIR
PROTEIN MUTS
(Thermus
aquaticus) 		4 / 6 ARG A 285
ARG A 280
VAL A 529
ASP A 528
 None
 1.30A 4xqeA-1nneA:
2.1		 4xqeA-1nneA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQE_B_AG2B505_1
(HOMOSPERMIDINE
SYNTHASE)		 1nne DNA MISMATCH REPAIR
PROTEIN MUTS
(Thermus
aquaticus) 		4 / 6 ARG A 285
ARG A 280
VAL A 529
ASP A 528
 None
 1.28A 4xqeB-1nneA:
undetectable		 4xqeB-1nneA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZB_D_ACTD403_0
(PROTON-GATED ION
CHANNEL)		 1nne DNA MISMATCH REPAIR
PROTEIN MUTS
(Thermus
aquaticus) 		4 / 4 ILE A 400
ARG A 509
TYR A 404
GLU A 381
 None
 1.39A 4zzbD-1nneA:
undetectable		 4zzbD-1nneA:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_E_ACTE406_0
(PROTON-GATED ION
CHANNEL)		 1nne DNA MISMATCH REPAIR
PROTEIN MUTS
(Thermus
aquaticus) 		4 / 5 ILE A 400
ARG A 509
TYR A 404
GLU A 381
 None
 1.26A 4zzcE-1nneA:
2.8		 4zzcE-1nneA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BS8_G_MFXG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 1nne DNA MISMATCH REPAIR
PROTEIN MUTS
(Thermus
aquaticus) 		4 / 7 ALA A 531
ARG A 363
GLY A 367
GLU A 368
 None
 0.91A 5bs8A-1nneA:
undetectable
5bs8C-1nneA:
undetectable
5bs8D-1nneA:
undetectable		 5bs8A-1nneA:
21.95
5bs8C-1nneA:
21.95
5bs8D-1nneA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_K_6V8K305_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-5)		 1nne DNA MISMATCH REPAIR
PROTEIN MUTS
(Thermus
aquaticus) 		5 / 11 ALA A 228
ALA A 226
VAL A 150
GLY A 233
GLY A 234
 None
 0.81A 5lf7K-1nneA:
undetectable
5lf7L-1nneA:
undetectable		 5lf7K-1nneA:
14.49
5lf7L-1nneA:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_Y_6V8Y306_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-5)		 1nne DNA MISMATCH REPAIR
PROTEIN MUTS
(Thermus
aquaticus) 		5 / 11 ALA A 228
ALA A 226
VAL A 150
GLY A 233
GLY A 234
 None
 0.82A 5lf7Y-1nneA:
undetectable
5lf7Z-1nneA:
undetectable		 5lf7Y-1nneA:
14.49
5lf7Z-1nneA:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MTH_A_ACTA301_0
(ANTIBODY FAB HEAVY
CHAIN)		 1nne DNA MISMATCH REPAIR
PROTEIN MUTS
(Thermus
aquaticus) 		4 / 4 THR A 437
VAL A 452
PRO A 455
THR A 453
 None
 1.33A 5mthA-1nneA:
0.0
5mthH-1nneA:
0.0		 5mthA-1nneA:
12.45
5mthH-1nneA:
12.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TT3_H_EZLH303_1
(ALPHA-CARBONIC
ANHYDRASE)		 1nne DNA MISMATCH REPAIR
PROTEIN MUTS
(Thermus
aquaticus) 		4 / 8 VAL A 674
LEU A 703
THR A 701
ALA A 702
 None
 0.93A 5tt3H-1nneA:
undetectable		 5tt3H-1nneA:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 1nne DNA MISMATCH REPAIR
PROTEIN MUTS
(Thermus
aquaticus) 		3 / 3 ARG A 687
PHE A 693
LEU A 650
 None
 0.67A 5x1bC-1nneA:
2.2		 5x1bC-1nneA:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X24_A_LSNA503_1
(CYTOCHROME P450 2C9)		 1nne DNA MISMATCH REPAIR
PROTEIN MUTS
(Thermus
aquaticus) 		4 / 6 PRO A 118
GLY A 119
THR A 120
ASN A 132
 None
 1.00A 5x24A-1nneA:
0.0		 5x24A-1nneA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA502_1
(CYTOCHROME P450 2C9)		 1nne DNA MISMATCH REPAIR
PROTEIN MUTS
(Thermus
aquaticus) 		4 / 6 PRO A 118
GLY A 119
THR A 120
ASN A 132
 None
 0.86A 5xxiA-1nneA:
0.0		 5xxiA-1nneA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_A_NOVA403_2
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		 1nne DNA MISMATCH REPAIR
PROTEIN MUTS
(Thermus
aquaticus) 		4 / 6 PHE A  90
ARG A  91
LEU A  31
ALA A  53
 None
 0.98A 6b89B-1nneA:
9.7		 6b89B-1nneA:
7.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_B_RFPB502_2
(RIFAMPIN
MONOOXYGENASE)		 1nne DNA MISMATCH REPAIR
PROTEIN MUTS
(Thermus
aquaticus) 		4 / 6 GLN A 289
VAL A 529
LEU A 257
PRO A 295
 None
 1.25A 6brdB-1nneA:
undetectable		 6brdB-1nneA:
7.58