SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1nnl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4S_A_TPVA201_2
(PROTEIN (HIV-1
PROTEASE))		 1nnl L-3-PHOSPHOSERINE
PHOSPHATASE
(Homo
sapiens) 		4 / 8 ALA A 186
GLY A 178
ILE A 177
PHE A 131
 None
 0.75A 1d4sB-1nnlA:
undetectable		 1d4sB-1nnlA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSH_C_MK1C402_1
(HIV-II PROTEASE)		 1nnl L-3-PHOSPHOSERINE
PHOSPHATASE
(Homo
sapiens) 		5 / 12 GLY A 180
ASP A  20
ILE A 194
GLY A 197
ILE A 201
 None
CA  A2001 (-2.3A)
None
None
None
 0.89A 1hshC-1nnlA:
undetectable		 1hshC-1nnlA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IGX_A_EPAA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 1nnl L-3-PHOSPHOSERINE
PHOSPHATASE
(Homo
sapiens) 		4 / 8 VAL A 105
VAL A  25
ILE A 177
LEU A 107
 None
 0.88A 1igxA-1nnlA:
undetectable		 1igxA-1nnlA:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_A_ACTA142_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 1nnl L-3-PHOSPHOSERINE
PHOSPHATASE
(Homo
sapiens) 		4 / 5 GLU A  33
ILE A  31
GLY A  30
LYS A  36
 None
None
CL  A1505 (-3.3A)
None
 1.09A 2qeuA-1nnlA:
undetectable
2qeuC-1nnlA:
undetectable		 2qeuA-1nnlA:
22.71
2qeuC-1nnlA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_C_IBPC1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)		 1nnl L-3-PHOSPHOSERINE
PHOSPHATASE
(Homo
sapiens) 		5 / 10 THR A 182
ILE A 108
LEU A 107
VAL A 116
GLY A 111
 None
None
None
None
CL  A1505 (-3.5A)
 1.25A 2wd9C-1nnlA:
4.0		 2wd9C-1nnlA:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKW_A_P1BA1478_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1nnl L-3-PHOSPHOSERINE
PHOSPHATASE
(Homo
sapiens) 		4 / 7 LEU A   7
GLU A 218
ILE A 194
ILE A 125
 None
 0.73A 2xkwA-1nnlA:
undetectable		 2xkwA-1nnlA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_B_TFPB202_2
(PROTEIN S100-A4)		 1nnl L-3-PHOSPHOSERINE
PHOSPHATASE
(Homo
sapiens) 		4 / 6 LEU A 219
PHE A 216
ILE A 177
PHE A 106
 None
 0.97A 3ko0B-1nnlA:
undetectable		 3ko0B-1nnlA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S53_A_017A201_1
(PROTEASE)		 1nnl L-3-PHOSPHOSERINE
PHOSPHATASE
(Homo
sapiens) 		5 / 9 GLY A 180
ASP A  20
ILE A 194
GLY A 197
ILE A 201
 None
CA  A2001 (-2.3A)
None
None
None
 0.92A 3s53A-1nnlA:
undetectable		 3s53A-1nnlA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IQQ_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 1nnl L-3-PHOSPHOSERINE
PHOSPHATASE
(Homo
sapiens) 		5 / 8 LYS A 158
ILE A  91
ASP A 179
GLY A 178
PHE A  19
 CL  A1500 (-3.2A)
None
CA  A2001 (-2.9A)
None
None
 1.42A 4iqqD-1nnlA:
undetectable		 4iqqD-1nnlA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1X_A_017A101_1
(ASPARTYL PROTEASE)		 1nnl L-3-PHOSPHOSERINE
PHOSPHATASE
(Homo
sapiens) 		5 / 11 GLY A 180
ASP A  20
ILE A 194
GLY A 197
ILE A 201
 None
CA  A2001 (-2.3A)
None
None
None
 0.94A 4q1xA-1nnlA:
undetectable		 4q1xA-1nnlA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1Y_A_017A106_1
(ASPARTYL PROTEASE)		 1nnl L-3-PHOSPHOSERINE
PHOSPHATASE
(Homo
sapiens) 		5 / 10 GLY A 180
ASP A  20
ILE A 194
GLY A 197
ILE A 201
 None
CA  A2001 (-2.3A)
None
None
None
 0.93A 4q1yA-1nnlA:
undetectable		 4q1yA-1nnlA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R3A_A_RBFA402_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 1nnl L-3-PHOSPHOSERINE
PHOSPHATASE
(Homo
sapiens) 		4 / 8 THR A  24
LEU A 107
VAL A 161
GLY A 178
 None
 0.86A 4r3aA-1nnlA:
undetectable		 4r3aA-1nnlA:
22.66