SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1nnw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG2_A_ADNA500_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 1nnw HYPOTHETICAL PROTEIN
(Pyrococcus
furiosus) 		5 / 12 GLY A 136
LEU A 125
ASP A  74
GLY A  71
ALA A   8
 None
 1.11A 1jg2A-1nnwA:
undetectable		 1jg2A-1nnwA:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_A_SAMA601_0
(HYPOTHETICAL PROTEIN)		 1nnw HYPOTHETICAL PROTEIN
(Pyrococcus
furiosus) 		5 / 12 GLY A  41
GLY A  71
GLY A 139
VAL A  44
ILE A  10
 None
 0.90A 2b25A-1nnwA:
undetectable		 2b25A-1nnwA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q9R_A_BEZA203_0
(PROTEIN OF UNKNOWN
FUNCTION)		 1nnw HYPOTHETICAL PROTEIN
(Pyrococcus
furiosus) 		4 / 5 LEU A 118
GLY A  71
ILE A  76
ILE A  77
 None
 0.84A 2q9rA-1nnwA:
undetectable		 2q9rA-1nnwA:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_A_SALA1302_1
(LYSR-TYPE REGULATORY
PROTEIN)		 1nnw HYPOTHETICAL PROTEIN
(Pyrococcus
furiosus) 		5 / 11 PHE A 197
GLY A 250
HIS A  98
PRO A  96
ILE A 245
 None
 1.29A 2y7kA-1nnwA:
undetectable		 2y7kA-1nnwA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_C_SALC1302_1
(LYSR-TYPE REGULATORY
PROTEIN)		 1nnw HYPOTHETICAL PROTEIN
(Pyrococcus
furiosus) 		5 / 12 PHE A 197
GLY A 250
HIS A  98
PRO A  96
ILE A 245
 None
 1.21A 2y7kC-1nnwA:
undetectable		 2y7kC-1nnwA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7W_B_SALB1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 1nnw HYPOTHETICAL PROTEIN
(Pyrococcus
furiosus) 		5 / 10 PHE A 197
GLY A 249
HIS A  98
PRO A  96
ILE A 245
 None
 1.37A 2y7wB-1nnwA:
undetectable		 2y7wB-1nnwA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGP_A_PCFA1213_0
(WNT INHIBITORY
FACTOR 1)		 1nnw HYPOTHETICAL PROTEIN
(Pyrococcus
furiosus) 		5 / 12 ILE A  76
LEU A  95
ILE A  77
PHE A 197
PRO A  50
 None
 1.13A 2ygpA-1nnwA:
undetectable		 2ygpA-1nnwA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_A_SAMA301_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 1nnw HYPOTHETICAL PROTEIN
(Pyrococcus
furiosus) 		6 / 12 ILE A  10
GLY A 196
VAL A 195
ALA A  11
LEU A  46
VAL A  53
 None
 1.21A 3fpjA-1nnwA:
undetectable		 3fpjA-1nnwA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_A_CELA682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1nnw HYPOTHETICAL PROTEIN
(Pyrococcus
furiosus) 		4 / 8 LEU A 209
LEU A  21
ILE A 220
PHE A 207
 None
 0.87A 3ln1A-1nnwA:
undetectable		 3ln1A-1nnwA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_B_CELB682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1nnw HYPOTHETICAL PROTEIN
(Pyrococcus
furiosus) 		4 / 7 LEU A 209
LEU A  21
ILE A 220
PHE A 207
 None
 0.87A 3ln1B-1nnwA:
undetectable		 3ln1B-1nnwA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NV6_A_CAMA422_0
(CYTOCHROME P450)		 1nnw HYPOTHETICAL PROTEIN
(Pyrococcus
furiosus) 		3 / 3 GLY A 114
ILE A  43
VAL A  44
 None
 0.46A 3nv6A-1nnwA:
undetectable		 3nv6A-1nnwA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V1N_A_BEZA288_0
(2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE)		 1nnw HYPOTHETICAL PROTEIN
(Pyrococcus
furiosus) 		5 / 8 GLY A  41
GLY A  71
GLY A  45
ILE A  77
LEU A 103
 None
 1.02A 3v1nA-1nnwA:
undetectable		 3v1nA-1nnwA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_B_ACTB701_0
(RNA (33-MER)
RNA POLYMERASE
3D-POL)		 1nnw HYPOTHETICAL PROTEIN
(Pyrococcus
furiosus) 		3 / 3 HIS A  98
GLY A 250
ILE A 245
 None
 0.51A 4k50A-1nnwA:
0.0		 4k50A-1nnwA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_J_ACTJ701_0
(RNA (33-MER)
RNA POLYMERASE
3D-POL)		 1nnw HYPOTHETICAL PROTEIN
(Pyrococcus
furiosus) 		3 / 3 HIS A  98
GLY A 250
ILE A 245
 None
 0.53A 4k50I-1nnwA:
0.0		 4k50I-1nnwA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLA_A_CHDA502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1nnw HYPOTHETICAL PROTEIN
(Pyrococcus
furiosus) 		4 / 8 LEU A 121
LEU A 118
LEU A 110
ILE A  68
 None
 0.88A 4klaA-1nnwA:
undetectable		 4klaA-1nnwA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_A_STRA601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 1nnw HYPOTHETICAL PROTEIN
(Pyrococcus
furiosus) 		5 / 12 LEU A 118
ILE A  77
ILE A  76
GLY A  45
ALA A  11
 None
 1.01A 4nkxA-1nnwA:
undetectable		 4nkxA-1nnwA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_D_LOCD503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 1nnw HYPOTHETICAL PROTEIN
(Pyrococcus
furiosus) 		3 / 3 SER A 194
ALA A 174
VAL A 173
 None
 0.66A 4o2bC-1nnwA:
undetectable		 4o2bC-1nnwA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_C_ADNC501_1
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 1nnw HYPOTHETICAL PROTEIN
(Pyrococcus
furiosus) 		5 / 12 SER A 194
PHE A 197
LEU A 246
PHE A  47
GLY A 196
 None
 1.20A 4pevC-1nnwA:
undetectable		 4pevC-1nnwA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1I_B_LOCB502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 1nnw HYPOTHETICAL PROTEIN
(Pyrococcus
furiosus) 		3 / 3 SER A 194
ALA A 174
VAL A 173
 None
 0.51A 4x1iA-1nnwA:
undetectable		 4x1iA-1nnwA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X20_D_LOCD502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 1nnw HYPOTHETICAL PROTEIN
(Pyrococcus
furiosus) 		3 / 3 SER A 194
ALA A 174
VAL A 173
 None
 0.48A 4x20C-1nnwA:
undetectable		 4x20C-1nnwA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0Q_A_PX9A201_1
(BETA-LACTOGLOBULIN)		 1nnw HYPOTHETICAL PROTEIN
(Pyrococcus
furiosus) 		3 / 3 LYS A  72
ILE A  76
ILE A  90
 None
 0.68A 4y0qA-1nnwA:
undetectable		 4y0qA-1nnwA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E5J_A_017A201_2
(PROTEASE)		 1nnw HYPOTHETICAL PROTEIN
(Pyrococcus
furiosus) 		6 / 12 LEU A 238
GLY A  45
ILE A 245
GLY A 196
ILE A 233
ILE A 242
 None
 1.19A 5e5jB-1nnwA:
undetectable		 5e5jB-1nnwA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E5K_B_017B201_2
(HIV-1 PROTEASE)		 1nnw HYPOTHETICAL PROTEIN
(Pyrococcus
furiosus) 		6 / 12 LEU A 238
GLY A  45
ILE A 245
GLY A 196
ILE A 233
ILE A 242
 None
 1.18A 5e5kB-1nnwA:
undetectable		 5e5kB-1nnwA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EYP_B_LOCB502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 1nnw HYPOTHETICAL PROTEIN
(Pyrococcus
furiosus) 		3 / 3 SER A 194
ALA A 174
VAL A 173
 None
 0.57A 5eypA-1nnwA:
undetectable		 5eypA-1nnwA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JHD_J_EDTJ301_0
(TCRBETA CHAIN)		 1nnw HYPOTHETICAL PROTEIN
(Pyrococcus
furiosus) 		4 / 5 TYR A 138
LYS A  72
GLY A 147
SER A 175
 None
 1.07A 5jhdJ-1nnwA:
0.0		 5jhdJ-1nnwA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_A_CELA602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1nnw HYPOTHETICAL PROTEIN
(Pyrococcus
furiosus) 		4 / 6 VAL A 134
LEU A 209
ILE A 220
PHE A 207
 None
 0.83A 5jw1A-1nnwA:
undetectable		 5jw1A-1nnwA:
19.36