SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1no5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_B_STIB600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 1no5 HYPOTHETICAL PROTEIN
HI0073
(Haemophilus
influenzae) 		4 / 6 LEU A  24
VAL A  37
VAL A  78
ILE A 101
 None
 1.23A 2hyyB-1no5A:
undetectable		 2hyyB-1no5A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_B_9CRB501_1
(CYTOCHROME P450 2C8)		 1no5 HYPOTHETICAL PROTEIN
HI0073
(Haemophilus
influenzae) 		5 / 9 GLY A  39
SER A  35
ILE A   9
VAL A  99
VAL A  30
 None
ZN  A 501 ( 4.2A)
None
None
None
 1.27A 2nnhB-1no5A:
undetectable		 2nnhB-1no5A:
13.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFH_A_CL6A1414_1
(ERYTHROMYCIN B/D
C-12 HYDROXYLASE)		 1no5 HYPOTHETICAL PROTEIN
HI0073
(Haemophilus
influenzae) 		4 / 8 LEU A  65
ILE A  20
LEU A  21
LEU A  80
 None
 0.81A 2xfhA-1no5A:
undetectable		 2xfhA-1no5A:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_A_SAMA301_1
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 1no5 HYPOTHETICAL PROTEIN
HI0073
(Haemophilus
influenzae) 		3 / 3 SER A  35
ASP A  48
ASP A   8
 ZN  A 501 ( 4.2A)
ZN  A 501 ( 2.6A)
None
 0.70A 3iv6A-1no5A:
undetectable		 3iv6A-1no5A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_C_SAMC301_1
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 1no5 HYPOTHETICAL PROTEIN
HI0073
(Haemophilus
influenzae) 		3 / 3 SER A  35
ASP A  48
ASP A   8
 ZN  A 501 ( 4.2A)
ZN  A 501 ( 2.6A)
None
 0.74A 3iv6C-1no5A:
undetectable		 3iv6C-1no5A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9J_A_TYLA1188_1
(BROMODOMAIN
CONTAINING 2)		 1no5 HYPOTHETICAL PROTEIN
HI0073
(Haemophilus
influenzae) 		4 / 5 VAL A  78
LEU A  49
LEU A  80
ILE A  20
 None
 0.96A 4a9jA-1no5A:
undetectable		 4a9jA-1no5A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9J_B_TYLB1187_1
(BROMODOMAIN
CONTAINING 2)		 1no5 HYPOTHETICAL PROTEIN
HI0073
(Haemophilus
influenzae) 		4 / 5 VAL A  78
LEU A  49
LEU A  80
ILE A  20
 None
 0.88A 4a9jB-1no5A:
undetectable		 4a9jB-1no5A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9J_C_TYLC1184_1
(BROMODOMAIN
CONTAINING 2)		 1no5 HYPOTHETICAL PROTEIN
HI0073
(Haemophilus
influenzae) 		4 / 5 VAL A  78
LEU A  49
LEU A  80
ILE A  20
 None
 0.93A 4a9jC-1no5A:
undetectable		 4a9jC-1no5A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1B_C_ECNC403_1
(FLAVOHEMOGLOBIN)		 1no5 HYPOTHETICAL PROTEIN
HI0073
(Haemophilus
influenzae) 		5 / 9 ILE A 101
LEU A  49
VAL A  78
VAL A  25
LEU A  21
 None
 1.13A 4g1bC-1no5A:
undetectable		 4g1bC-1no5A:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LZR_A_LOCA201_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 1no5 HYPOTHETICAL PROTEIN
HI0073
(Haemophilus
influenzae) 		4 / 8 VAL A  78
LEU A  49
LEU A  80
ILE A  20
 None
 0.92A 4lzrA-1no5A:
undetectable		 4lzrA-1no5A:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_D_29SD601_2
(ESTROGEN RECEPTOR)		 1no5 HYPOTHETICAL PROTEIN
HI0073
(Haemophilus
influenzae) 		3 / 3 LEU A  80
ASP A  46
ILE A  52
 None
ZN  A 511 ( 2.5A)
None
 0.69A 4xi3D-1no5A:
undetectable		 4xi3D-1no5A:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUE_A_VIVA302_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 1no5 HYPOTHETICAL PROTEIN
HI0073
(Haemophilus
influenzae) 		6 / 12 ILE A  94
VAL A  37
ILE A 101
VAL A  17
LEU A  21
ILE A  51
 None
 1.41A 5mueA-1no5A:
undetectable		 5mueA-1no5A:
16.67