SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1nov'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSG_B_MK1B902_1
(HIV-1 PROTEASE)		 1nov NODAMURA VIRUS COAT
PROTEINS
(Nodamura
virus) 		5 / 10 LEU A 113
ALA A 173
VAL A 190
VAL A 301
ILE A 299
 None
 0.96A 1hsgA-1novA:
undetectable		 1hsgA-1novA:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXB_A_ROCA100_3
(HIV-1 PROTEASE)		 1nov NODAMURA VIRUS COAT
PROTEINS
(Nodamura
virus) 		5 / 12 LEU A 113
ALA A 173
VAL A 190
VAL A 301
ILE A 299
 None
 0.92A 1hxbB-1novA:
undetectable		 1hxbB-1novA:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T3R_A_017A1200_2
(PROTEASE RETROPEPSIN)		 1nov NODAMURA VIRUS COAT
PROTEINS
(Nodamura
virus) 		5 / 11 LEU A 113
ALA A 173
VAL A 190
VAL A 301
ILE A 299
 None
 0.89A 1t3rB-1novA:
undetectable		 1t3rB-1novA:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TT6_B_DESB128_1
(TRANSTHYRETIN)		 1nov NODAMURA VIRUS COAT
PROTEINS
(Nodamura
virus) 		4 / 5 LEU A 114
ALA A 126
LEU A 124
SER A 142
 None
 1.07A 1tt6B-1novA:
undetectable		 1tt6B-1novA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4P_A_TPVA300_2
(PROTEASE)		 1nov NODAMURA VIRUS COAT
PROTEINS
(Nodamura
virus) 		5 / 9 LEU A 113
ALA A 173
VAL A 190
VAL A 301
ILE A 299
 None
 1.02A 2o4pB-1novA:
undetectable		 2o4pB-1novA:
12.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYN_A_1UNA1001_2
(PROTEASE RETROPEPSIN)		 1nov NODAMURA VIRUS COAT
PROTEINS
(Nodamura
virus) 		5 / 12 LEU A 113
ALA A 173
VAL A 190
VAL A 301
ILE A 299
 None
 1.01A 2pynB-1novA:
undetectable		 2pynB-1novA:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM3_B_478B200_2
(PROTEASE)		 1nov NODAMURA VIRUS COAT
PROTEINS
(Nodamura
virus) 		5 / 10 LEU A 113
ALA A 173
VAL A 190
VAL A 301
ILE A 299
 None
 0.97A 3em3B-1novA:
undetectable		 3em3B-1novA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_D_ROCD201_1
(HIV-1 PROTEASE)		 1nov NODAMURA VIRUS COAT
PROTEINS
(Nodamura
virus) 		5 / 12 LEU A 113
ALA A 173
VAL A 190
VAL A 301
ILE A 299
 None
 0.96A 3k4vC-1novA:
undetectable		 3k4vC-1novA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MWS_B_017B201_2
(HIV-1 PROTEASE)		 1nov NODAMURA VIRUS COAT
PROTEINS
(Nodamura
virus) 		5 / 12 LEU A 113
ALA A 173
VAL A 190
VAL A 301
ILE A 299
 None
 0.92A 3mwsB-1novA:
undetectable		 3mwsB-1novA:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWR_A_ROCA401_3
(PROTEASE)		 1nov NODAMURA VIRUS COAT
PROTEINS
(Nodamura
virus) 		5 / 12 LEU A 113
ALA A 173
VAL A 190
VAL A 301
ILE A 299
 None
 0.96A 3pwrB-1novA:
undetectable		 3pwrB-1novA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWW_A_ROCA1001_1
(ENDOTHIAPEPSIN)		 1nov NODAMURA VIRUS COAT
PROTEINS
(Nodamura
virus) 		5 / 12 ILE A 193
ASP A 295
GLY A 290
LEU A 278
PHE A 148
 None
 1.10A 3pwwA-1novA:
undetectable		 3pwwA-1novA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQB_B_017B101_1
(ASPARTYL PROTEASE)		 1nov NODAMURA VIRUS COAT
PROTEINS
(Nodamura
virus) 		5 / 12 LEU A 113
ALA A 173
VAL A 190
VAL A 301
ILE A 299
 None
 0.89A 4dqbA-1novA:
undetectable		 4dqbA-1novA:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQE_B_017B101_1
(ASPARTYL PROTEASE)		 1nov NODAMURA VIRUS COAT
PROTEINS
(Nodamura
virus) 		5 / 11 LEU A 113
ALA A 173
VAL A 190
VAL A 301
ILE A 299
 None
 0.94A 4dqeA-1novA:
undetectable		 4dqeA-1novA:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQH_B_017B101_1
(WILD-TYPE HIV-1
PROTEASE DIMER)		 1nov NODAMURA VIRUS COAT
PROTEINS
(Nodamura
virus) 		5 / 11 LEU A 113
ALA A 173
VAL A 190
VAL A 301
ILE A 299
 None
 0.91A 4dqhA-1novA:
undetectable		 4dqhA-1novA:
14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_A_P06A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1nov NODAMURA VIRUS COAT
PROTEINS
(Nodamura
virus) 		3 / 3 PHE A  71
ILE A 354
ASP A 362
 None
 0.75A 5cswA-1novA:
undetectable		 5cswA-1novA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_G_FK5G201_1
(FK506-BINDING
PROTEIN 1)		 1nov NODAMURA VIRUS COAT
PROTEINS
(Nodamura
virus) 		3 / 3 ILE A 118
PRO A 119
ILE A 121
 None
 0.30A 5hw8F-1novA:
undetectable		 5hw8F-1novA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQY_B_017B101_1
(PROTEASE E35D-DRV)		 1nov NODAMURA VIRUS COAT
PROTEINS
(Nodamura
virus) 		5 / 12 LEU A 113
ALA A 173
VAL A 190
VAL A 301
ILE A 299
 None
 1.01A 5kqyA-1novA:
undetectable		 5kqyA-1novA:
15.38