SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1np3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JC9_A_ADNA1497_1
(CYTOSOLIC PURINE
5'-NUCLEOTIDASE)		 1np3 KETOL-ACID
REDUCTOISOMERASE
(Pseudomonas
aeruginosa) 		4 / 7 ARG A 280
ILE A 281
PHE A 192
GLN A 195
 None
 1.14A 2jc9A-1np3A:
undetectable		 2jc9A-1np3A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYN_A_1UNA1001_3
(PROTEASE RETROPEPSIN)		 1np3 KETOL-ACID
REDUCTOISOMERASE
(Pseudomonas
aeruginosa) 		3 / 3 ASP A  65
THR A  80
PRO A  81
 None
 0.59A 2pynB-1np3A:
undetectable		 2pynB-1np3A:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q64_B_1UNB1001_4
(PROTEASE RETROPEPSIN)		 1np3 KETOL-ACID
REDUCTOISOMERASE
(Pseudomonas
aeruginosa) 		3 / 3 ASP A  65
THR A  80
PRO A  81
 None
 0.64A 2q64B-1np3A:
undetectable		 2q64B-1np3A:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QAK_A_1UNA1001_4
(PROTEASE RETROPEPSIN)		 1np3 KETOL-ACID
REDUCTOISOMERASE
(Pseudomonas
aeruginosa) 		3 / 3 ASP A  65
THR A  80
PRO A  81
 None
 0.59A 2qakB-1np3A:
undetectable		 2qakB-1np3A:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_A_DIFA1376_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 1np3 KETOL-ACID
REDUCTOISOMERASE
(Pseudomonas
aeruginosa) 		4 / 8 TYR A 224
LEU A 320
ALA A 322
HIS A 229
 None
 0.94A 2wekA-1np3A:
6.4		 2wekA-1np3A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROX_A_TEPA266_1
(APOLIPOPROTEIN
A-I-BINDING PROTEIN)		 1np3 KETOL-ACID
REDUCTOISOMERASE
(Pseudomonas
aeruginosa) 		4 / 8 ALA A 160
VAL A 163
LEU A 103
THR A 102
 None
 0.71A 3roxA-1np3A:
5.4		 3roxA-1np3A:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_A_SORA1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 1np3 KETOL-ACID
REDUCTOISOMERASE
(Pseudomonas
aeruginosa) 		4 / 7 ILE A  21
LEU A  79
GLY A  25
GLY A  28
 None
 0.74A 5a06A-1np3A:
7.1		 5a06A-1np3A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_B_SORB1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 1np3 KETOL-ACID
REDUCTOISOMERASE
(Pseudomonas
aeruginosa) 		4 / 7 ILE A  21
LEU A  79
GLY A  25
GLY A  28
 None
 0.73A 5a06B-1np3A:
7.2		 5a06B-1np3A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_C_SORC1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 1np3 KETOL-ACID
REDUCTOISOMERASE
(Pseudomonas
aeruginosa) 		4 / 7 ILE A  21
LEU A  79
GLY A  25
GLY A  28
 None
 0.75A 5a06C-1np3A:
7.1		 5a06C-1np3A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_E_SORE1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 1np3 KETOL-ACID
REDUCTOISOMERASE
(Pseudomonas
aeruginosa) 		4 / 7 ILE A  21
LEU A  79
GLY A  25
GLY A  28
 None
 0.73A 5a06E-1np3A:
7.0		 5a06E-1np3A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_F_SORF1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 1np3 KETOL-ACID
REDUCTOISOMERASE
(Pseudomonas
aeruginosa) 		4 / 7 ILE A  21
LEU A  79
GLY A  25
GLY A  28
 None
 0.75A 5a06F-1np3A:
7.1		 5a06F-1np3A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB307_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 1np3 KETOL-ACID
REDUCTOISOMERASE
(Pseudomonas
aeruginosa) 		3 / 3 LEU A 103
ALA A 104
LEU A  97
 None
 0.54A 5uunB-1np3A:
undetectable		 5uunB-1np3A:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EF6_A_BEZA401_0
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 1np3 KETOL-ACID
REDUCTOISOMERASE
(Pseudomonas
aeruginosa) 		5 / 9 LEU A  88
THR A  80
ILE A  22
VAL A  70
ILE A  93
 None
 1.26A 6ef6A-1np3A:
0.0		 6ef6A-1np3A:
21.59