SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1npb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1NKI_A_PPFA5001_1
(PROBABLE FOSFOMYCIN
RESISTANCE PROTEIN)		 1npb FOSFOMYCIN-RESISTANC
E PROTEIN
(Serratia
marcescens) 		5 / 9 TYR A  65
HIS A  67
TYR A 103
GLU A 113
ARG A 122
 None
SO4  A 403 (-3.8A)
SO4  A 403 (-4.6A)
SO4  A 403 (-3.1A)
SO4  A 403 ( 3.4A)
 0.20A 1nkiA-1npbA:
21.1
1nkiB-1npbA:
21.2		 1nkiA-1npbA:
60.43
1nkiB-1npbA:
60.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1NKI_B_PPFB5002_1
(PROBABLE FOSFOMYCIN
RESISTANCE PROTEIN)		 1npb FOSFOMYCIN-RESISTANC
E PROTEIN
(Serratia
marcescens) 		5 / 9 TYR A  65
HIS A  67
TYR A 103
GLU A 113
ARG A 122
 None
SO4  A 403 (-3.8A)
SO4  A 403 (-4.6A)
SO4  A 403 (-3.1A)
SO4  A 403 ( 3.4A)
 0.20A 1nkiA-1npbA:
21.1
1nkiB-1npbA:
21.2		 1nkiA-1npbA:
60.43
1nkiB-1npbA:
60.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJG_B_ADNB1502_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 1npb FOSFOMYCIN-RESISTANC
E PROTEIN
(Serratia
marcescens) 		4 / 7 ARG A 122
GLU A  98
ASN A  95
ALA A 100
 SO4  A 403 ( 3.4A)
None
None
None
 1.28A 2ejgB-1npbA:
undetectable		 2ejgB-1npbA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZGW_A_ADNA1301_1
(BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 1npb FOSFOMYCIN-RESISTANC
E PROTEIN
(Serratia
marcescens) 		4 / 7 ARG A 122
GLU A  98
ASN A  95
ALA A 100
 SO4  A 403 ( 3.4A)
None
None
None
 1.13A 2zgwA-1npbA:
undetectable		 2zgwA-1npbA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_R_CLMR221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1npb FOSFOMYCIN-RESISTANC
E PROTEIN
(Serratia
marcescens) 		5 / 10 PHE A  70
PHE A 104
PHE A  21
LEU A  49
VAL A  12
 None
 1.25A 3u9fR-1npbA:
undetectable		 3u9fR-1npbA:
17.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4IR0_A_FCNA202_1
(METALLOTHIOL
TRANSFERASE FOSB 2)		 1npb FOSFOMYCIN-RESISTANC
E PROTEIN
(Serratia
marcescens) 		5 / 11 TYR A  65
HIS A  67
TYR A 103
GLU A 113
ARG A 122
 None
SO4  A 403 (-3.8A)
SO4  A 403 (-4.6A)
SO4  A 403 (-3.1A)
SO4  A 403 ( 3.4A)
 0.48A 4ir0A-1npbA:
15.9
4ir0B-1npbA:
16.5		 4ir0A-1npbA:
35.17
4ir0B-1npbA:
35.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4IR0_B_FCNB202_1
(METALLOTHIOL
TRANSFERASE FOSB 2)		 1npb FOSFOMYCIN-RESISTANC
E PROTEIN
(Serratia
marcescens) 		5 / 11 TYR A  65
HIS A  67
TYR A 103
GLU A 113
ARG A 122
 None
SO4  A 403 (-3.8A)
SO4  A 403 (-4.6A)
SO4  A 403 (-3.1A)
SO4  A 403 ( 3.4A)
 0.48A 4ir0A-1npbA:
15.9
4ir0B-1npbA:
16.5		 4ir0A-1npbA:
35.17
4ir0B-1npbA:
35.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4JD1_A_FCNA202_1
(METALLOTHIOL
TRANSFERASE FOSB 2)		 1npb FOSFOMYCIN-RESISTANC
E PROTEIN
(Serratia
marcescens) 		5 / 12 TYR A  65
HIS A  67
TYR A 103
GLU A 113
ARG A 122
 None
SO4  A 403 (-3.8A)
SO4  A 403 (-4.6A)
SO4  A 403 (-3.1A)
SO4  A 403 ( 3.4A)
 0.52A 4jd1A-1npbA:
16.1
4jd1B-1npbA:
16.0		 4jd1A-1npbA:
35.17
4jd1B-1npbA:
35.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4JD1_B_FCNB203_1
(METALLOTHIOL
TRANSFERASE FOSB 2)		 1npb FOSFOMYCIN-RESISTANC
E PROTEIN
(Serratia
marcescens) 		5 / 12 TYR A  65
HIS A  67
TYR A 103
GLU A 113
ARG A 122
 None
SO4  A 403 (-3.8A)
SO4  A 403 (-4.6A)
SO4  A 403 (-3.1A)
SO4  A 403 ( 3.4A)
 0.45A 4jd1A-1npbA:
16.1
4jd1B-1npbA:
16.0		 4jd1A-1npbA:
35.17
4jd1B-1npbA:
35.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4JH3_A_FCNA204_1
(METALLOTHIOL
TRANSFERASE FOSB)		 1npb FOSFOMYCIN-RESISTANC
E PROTEIN
(Serratia
marcescens) 		5 / 12 TYR A  65
HIS A  67
TYR A 103
GLU A 113
ARG A 122
 None
SO4  A 403 (-3.8A)
SO4  A 403 (-4.6A)
SO4  A 403 (-3.1A)
SO4  A 403 ( 3.4A)
 0.44A 4jh3A-1npbA:
17.0
4jh3B-1npbA:
17.1		 4jh3A-1npbA:
40.43
4jh3B-1npbA:
40.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4JH3_B_FCNB203_1
(METALLOTHIOL
TRANSFERASE FOSB)		 1npb FOSFOMYCIN-RESISTANC
E PROTEIN
(Serratia
marcescens) 		5 / 11 TYR A  65
HIS A  67
TYR A 103
GLU A 113
ARG A 122
 None
SO4  A 403 (-3.8A)
SO4  A 403 (-4.6A)
SO4  A 403 (-3.1A)
SO4  A 403 ( 3.4A)
 0.41A 4jh3A-1npbA:
17.0
4jh3B-1npbA:
17.1		 4jh3A-1npbA:
40.43
4jh3B-1npbA:
40.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4JH4_A_FCNA202_1
(METALLOTHIOL
TRANSFERASE FOSB)		 1npb FOSFOMYCIN-RESISTANC
E PROTEIN
(Serratia
marcescens) 		5 / 11 TYR A  65
HIS A  67
TYR A 103
GLU A 113
ARG A 122
 None
SO4  A 403 (-3.8A)
SO4  A 403 (-4.6A)
SO4  A 403 (-3.1A)
SO4  A 403 ( 3.4A)
 0.44A 4jh4A-1npbA:
17.0
4jh4B-1npbA:
16.9		 4jh4A-1npbA:
40.43
4jh4B-1npbA:
40.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4JH4_B_FCNB202_1
(METALLOTHIOL
TRANSFERASE FOSB)		 1npb FOSFOMYCIN-RESISTANC
E PROTEIN
(Serratia
marcescens) 		5 / 11 TYR A  65
HIS A  67
TYR A 103
GLU A 113
ARG A 122
 None
SO4  A 403 (-3.8A)
SO4  A 403 (-4.6A)
SO4  A 403 (-3.1A)
SO4  A 403 ( 3.4A)
 0.44A 4jh4A-1npbA:
17.0
4jh4B-1npbA:
16.9		 4jh4A-1npbA:
40.43
4jh4B-1npbA:
40.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4JH5_A_FCNA202_1
(METALLOTHIOL
TRANSFERASE FOSB)		 1npb FOSFOMYCIN-RESISTANC
E PROTEIN
(Serratia
marcescens) 		5 / 11 TYR A  65
HIS A  67
TYR A 103
GLU A 113
ARG A 122
 None
SO4  A 403 (-3.8A)
SO4  A 403 (-4.6A)
SO4  A 403 (-3.1A)
SO4  A 403 ( 3.4A)
 0.44A 4jh5A-1npbA:
17.0
4jh5B-1npbA:
16.9		 4jh5A-1npbA:
40.43
4jh5B-1npbA:
40.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4JH5_B_FCNB203_1
(METALLOTHIOL
TRANSFERASE FOSB)		 1npb FOSFOMYCIN-RESISTANC
E PROTEIN
(Serratia
marcescens) 		5 / 11 TYR A  65
HIS A  67
TYR A 103
GLU A 113
ARG A 122
 None
SO4  A 403 (-3.8A)
SO4  A 403 (-4.6A)
SO4  A 403 (-3.1A)
SO4  A 403 ( 3.4A)
 0.46A 4jh5A-1npbA:
17.0
4jh5B-1npbA:
16.9		 4jh5A-1npbA:
40.43
4jh5B-1npbA:
40.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4JH6_A_FCNA202_1
(METALLOTHIOL
TRANSFERASE FOSB)		 1npb FOSFOMYCIN-RESISTANC
E PROTEIN
(Serratia
marcescens) 		5 / 10 TYR A  65
HIS A  67
TYR A 103
GLU A 113
ARG A 122
 None
SO4  A 403 (-3.8A)
SO4  A 403 (-4.6A)
SO4  A 403 (-3.1A)
SO4  A 403 ( 3.4A)
 0.41A 4jh6A-1npbA:
17.2
4jh6B-1npbA:
16.9		 4jh6A-1npbA:
40.43
4jh6B-1npbA:
40.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4JH6_B_FCNB202_1
(METALLOTHIOL
TRANSFERASE FOSB)		 1npb FOSFOMYCIN-RESISTANC
E PROTEIN
(Serratia
marcescens) 		5 / 10 TYR A  65
HIS A  67
TYR A 103
GLU A 113
ARG A 122
 None
SO4  A 403 (-3.8A)
SO4  A 403 (-4.6A)
SO4  A 403 (-3.1A)
SO4  A 403 ( 3.4A)
 0.43A 4jh6A-1npbA:
17.2
4jh6B-1npbA:
16.9		 4jh6A-1npbA:
40.43
4jh6B-1npbA:
40.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4JH8_A_FCNA204_1
(METALLOTHIOL
TRANSFERASE FOSB)		 1npb FOSFOMYCIN-RESISTANC
E PROTEIN
(Serratia
marcescens) 		5 / 10 TYR A  65
HIS A  67
TYR A 103
GLU A 113
ARG A 122
 None
SO4  A 403 (-3.8A)
SO4  A 403 (-4.6A)
SO4  A 403 (-3.1A)
SO4  A 403 ( 3.4A)
 0.45A 4jh8A-1npbA:
17.0
4jh8B-1npbA:
16.8		 4jh8A-1npbA:
40.43
4jh8B-1npbA:
40.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4JH8_B_FCNB203_1
(METALLOTHIOL
TRANSFERASE FOSB)		 1npb FOSFOMYCIN-RESISTANC
E PROTEIN
(Serratia
marcescens) 		5 / 10 TYR A  65
HIS A  67
TYR A 103
GLU A 113
ARG A 122
 None
SO4  A 403 (-3.8A)
SO4  A 403 (-4.6A)
SO4  A 403 (-3.1A)
SO4  A 403 ( 3.4A)
 0.47A 4jh8A-1npbA:
17.0
4jh8B-1npbA:
16.8		 4jh8A-1npbA:
40.43
4jh8B-1npbA:
40.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B2Q_A_ACTA1728_0
(CRISPR-ASSOCIATED
ENDONUCLEASE CAS9)		 1npb FOSFOMYCIN-RESISTANC
E PROTEIN
(Serratia
marcescens) 		3 / 3 ASN A  95
SER A  97
ARG A 122
 None
SO4  A 402 ( 3.9A)
SO4  A 403 ( 3.4A)
 0.86A 5b2qA-1npbA:
1.2		 5b2qA-1npbA:
6.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5V3D_A_FCNA205_1
(FOSFOMYCIN
RESISTANCE PROTEIN)		 1npb FOSFOMYCIN-RESISTANC
E PROTEIN
(Serratia
marcescens) 		5 / 10 TYR A  65
HIS A  67
TYR A 103
GLU A 113
ARG A 122
 None
SO4  A 403 (-3.8A)
SO4  A 403 (-4.6A)
SO4  A 403 (-3.1A)
SO4  A 403 ( 3.4A)
 0.20A 5v3dA-1npbA:
23.0
5v3dB-1npbA:
13.0		 5v3dA-1npbA:
68.79
5v3dB-1npbA:
68.79