SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1npc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMA_B_SAMB105_0
(PROTEIN (MET
REPRESSOR))		 1npc NEUTRAL PROTEASE
(Bacillus
cereus) 		5 / 11 LEU A 245
HIS A 251
ALA A 313
PHE A 311
GLY A 315
 None
 1.29A 1cmaA-1npcA:
undetectable
1cmaB-1npcA:
undetectable		 1cmaA-1npcA:
15.30
1cmaB-1npcA:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMC_A_SAMA105_0
(MET REPRESSOR)		 1npc NEUTRAL PROTEASE
(Bacillus
cereus) 		5 / 10 ALA A 313
PHE A 311
GLY A 315
LEU A 245
HIS A 251
 None
 1.38A 1cmcA-1npcA:
undetectable
1cmcB-1npcA:
undetectable		 1cmcA-1npcA:
15.30
1cmcB-1npcA:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMC_B_SAMB105_0
(MET REPRESSOR)		 1npc NEUTRAL PROTEASE
(Bacillus
cereus) 		5 / 10 LEU A 245
HIS A 251
ALA A 313
PHE A 311
GLY A 315
 None
 1.35A 1cmcA-1npcA:
undetectable
1cmcB-1npcA:
undetectable		 1cmcA-1npcA:
15.30
1cmcB-1npcA:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_B_HLTB4001_1
(SERUM ALBUMIN)		 1npc NEUTRAL PROTEASE
(Bacillus
cereus) 		4 / 4 ARG A  91
LYS A  86
ASP A  96
GLY A  98
 None
 1.46A 1e7bB-1npcA:
2.2		 1e7bB-1npcA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GRM_A_DVAA6_0
(GRAMICIDIN A)		 1npc NEUTRAL PROTEASE
(Bacillus
cereus) 		3 / 3 ALA A  74
VAL A  72
TRP A  56
 None
 0.89A 1grmA-1npcA:
undetectable		 1grmA-1npcA:
2.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GRM_B_DVAB6_0
(GRAMICIDIN A)		 1npc NEUTRAL PROTEASE
(Bacillus
cereus) 		3 / 3 ALA A  74
VAL A  72
TRP A  56
 None
 0.89A 1grmB-1npcA:
undetectable		 1grmB-1npcA:
2.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_A_ACTA1869_0
(FPRA)		 1npc NEUTRAL PROTEASE
(Bacillus
cereus) 		4 / 4 ASP A 171
HIS A 143
ARG A 204
GLU A 167
 None
ZN  A 323 ( 3.3A)
None
ZN  A 323 ( 2.0A)
 0.92A 1lqtA-1npcA:
0.0		 1lqtA-1npcA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_A_SAMA2200_0
(PROTEIN (METHIONINE
REPRESSOR))		 1npc NEUTRAL PROTEASE
(Bacillus
cereus) 		5 / 12 ALA A 313
PHE A 311
GLY A 315
LEU A 245
HIS A 251
 None
 1.26A 1mj2A-1npcA:
undetectable
1mj2B-1npcA:
undetectable		 1mj2A-1npcA:
15.30
1mj2B-1npcA:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_C_SAMC2199_0
(PROTEIN (METHIONINE
REPRESSOR))		 1npc NEUTRAL PROTEASE
(Bacillus
cereus) 		5 / 12 ALA A 313
PHE A 311
GLY A 315
LEU A 245
HIS A 251
 None
 1.28A 1mj2C-1npcA:
undetectable
1mj2D-1npcA:
undetectable		 1mj2C-1npcA:
15.30
1mj2D-1npcA:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_A_SAMA200_0
(METHIONINE REPRESSOR)		 1npc NEUTRAL PROTEASE
(Bacillus
cereus) 		5 / 11 LEU A 245
HIS A 251
ALA A 313
PHE A 311
GLY A 315
 None
 1.29A 1mjqA-1npcA:
undetectable
1mjqB-1npcA:
undetectable		 1mjqA-1npcA:
15.30
1mjqB-1npcA:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_C_SAMC199_0
(METHIONINE REPRESSOR)		 1npc NEUTRAL PROTEASE
(Bacillus
cereus) 		5 / 10 LEU A 245
HIS A 251
ALA A 313
PHE A 311
GLY A 315
 None
 1.29A 1mjqC-1npcA:
undetectable
1mjqD-1npcA:
undetectable		 1mjqC-1npcA:
15.30
1mjqD-1npcA:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_I_SAMI199_0
(METHIONINE REPRESSOR)		 1npc NEUTRAL PROTEASE
(Bacillus
cereus) 		5 / 11 LEU A 245
HIS A 251
ALA A 313
PHE A 311
GLY A 315
 None
 1.29A 1mjqI-1npcA:
undetectable
1mjqJ-1npcA:
undetectable		 1mjqI-1npcA:
15.30
1mjqJ-1npcA:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_A_CRNA401_1
(CREATININE
AMIDOHYDROLASE)		 1npc NEUTRAL PROTEASE
(Bacillus
cereus) 		5 / 8 GLU A 167
HIS A 143
HIS A 232
HIS A 147
GLU A 144
 ZN  A 323 ( 2.0A)
ZN  A 323 ( 3.3A)
None
ZN  A 323 ( 3.2A)
ZN  A 323 ( 4.5A)
 1.23A 1v7zA-1npcA:
undetectable		 1v7zA-1npcA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_B_CRNB3401_1
(CREATININE
AMIDOHYDROLASE)		 1npc NEUTRAL PROTEASE
(Bacillus
cereus) 		5 / 8 GLU A 167
HIS A 143
HIS A 232
HIS A 147
GLU A 144
 ZN  A 323 ( 2.0A)
ZN  A 323 ( 3.3A)
None
ZN  A 323 ( 3.2A)
ZN  A 323 ( 4.5A)
 1.23A 1v7zB-1npcA:
undetectable		 1v7zB-1npcA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_C_CRNC4401_1
(CREATININE
AMIDOHYDROLASE)		 1npc NEUTRAL PROTEASE
(Bacillus
cereus) 		5 / 8 GLU A 167
HIS A 143
HIS A 232
HIS A 147
GLU A 144
 ZN  A 323 ( 2.0A)
ZN  A 323 ( 3.3A)
None
ZN  A 323 ( 3.2A)
ZN  A 323 ( 4.5A)
 1.24A 1v7zC-1npcA:
undetectable		 1v7zC-1npcA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_D_CRND5401_1
(CREATININE
AMIDOHYDROLASE)		 1npc NEUTRAL PROTEASE
(Bacillus
cereus) 		5 / 8 GLU A 167
HIS A 143
HIS A 232
HIS A 147
GLU A 144
 ZN  A 323 ( 2.0A)
ZN  A 323 ( 3.3A)
None
ZN  A 323 ( 3.2A)
ZN  A 323 ( 4.5A)
 1.25A 1v7zD-1npcA:
undetectable		 1v7zD-1npcA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_E_CRNE6401_1
(CREATININE
AMIDOHYDROLASE)		 1npc NEUTRAL PROTEASE
(Bacillus
cereus) 		5 / 8 GLU A 167
HIS A 143
HIS A 232
HIS A 147
GLU A 144
 ZN  A 323 ( 2.0A)
ZN  A 323 ( 3.3A)
None
ZN  A 323 ( 3.2A)
ZN  A 323 ( 4.5A)
 1.24A 1v7zE-1npcA:
undetectable		 1v7zE-1npcA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_F_CRNF7401_1
(CREATININE
AMIDOHYDROLASE)		 1npc NEUTRAL PROTEASE
(Bacillus
cereus) 		5 / 8 GLU A 167
HIS A 143
HIS A 232
HIS A 147
GLU A 144
 ZN  A 323 ( 2.0A)
ZN  A 323 ( 3.3A)
None
ZN  A 323 ( 3.2A)
ZN  A 323 ( 4.5A)
 1.24A 1v7zF-1npcA:
undetectable		 1v7zF-1npcA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOJ_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 1npc NEUTRAL PROTEASE
(Bacillus
cereus) 		4 / 7 LEU A 165
GLY A 265
ILE A 267
ILE A 169
 None
 0.75A 2aojB-1npcA:
undetectable		 2aojB-1npcA:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_D_QPSD1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 1npc NEUTRAL PROTEASE
(Bacillus
cereus) 		5 / 10 THR A  81
VAL A 177
PHE A 173
SER A 170
VAL A 149
 None
None
None
ZN  A 323 ( 4.7A)
None
 1.40A 2x2iD-1npcA:
0.0		 2x2iD-1npcA:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A2Q_A_ACAA601_1
(6-AMINOHEXANOATE-CYC
LIC-DIMER HYDROLASE)		 1npc NEUTRAL PROTEASE
(Bacillus
cereus) 		4 / 7 ASN A 272
ALA A 289
ALA A 292
ILE A 169
 None
 0.80A 3a2qA-1npcA:
undetectable		 3a2qA-1npcA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_A_CRNA303_1
(CREATININE
AMIDOHYDROLASE)		 1npc NEUTRAL PROTEASE
(Bacillus
cereus) 		5 / 8 GLU A 167
HIS A 143
HIS A 232
HIS A 147
GLU A 144
 ZN  A 323 ( 2.0A)
ZN  A 323 ( 3.3A)
None
ZN  A 323 ( 3.2A)
ZN  A 323 ( 4.5A)
 1.21A 3a6jA-1npcA:
undetectable		 3a6jA-1npcA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_B_CRNB304_1
(CREATININE
AMIDOHYDROLASE)		 1npc NEUTRAL PROTEASE
(Bacillus
cereus) 		5 / 7 GLU A 167
HIS A 143
HIS A 232
HIS A 147
GLU A 144
 ZN  A 323 ( 2.0A)
ZN  A 323 ( 3.3A)
None
ZN  A 323 ( 3.2A)
ZN  A 323 ( 4.5A)
 1.19A 3a6jB-1npcA:
undetectable		 3a6jB-1npcA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_C_CRNC305_1
(CREATININE
AMIDOHYDROLASE)		 1npc NEUTRAL PROTEASE
(Bacillus
cereus) 		5 / 8 GLU A 167
HIS A 143
HIS A 232
HIS A 147
GLU A 144
 ZN  A 323 ( 2.0A)
ZN  A 323 ( 3.3A)
None
ZN  A 323 ( 3.2A)
ZN  A 323 ( 4.5A)
 1.20A 3a6jC-1npcA:
undetectable		 3a6jC-1npcA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_E_CRNE306_1
(CREATININE
AMIDOHYDROLASE)		 1npc NEUTRAL PROTEASE
(Bacillus
cereus) 		5 / 8 GLU A 167
HIS A 143
HIS A 232
HIS A 147
GLU A 144
 ZN  A 323 ( 2.0A)
ZN  A 323 ( 3.3A)
None
ZN  A 323 ( 3.2A)
ZN  A 323 ( 4.5A)
 1.21A 3a6jE-1npcA:
undetectable		 3a6jE-1npcA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_F_CRNF307_1
(CREATININE
AMIDOHYDROLASE)		 1npc NEUTRAL PROTEASE
(Bacillus
cereus) 		5 / 8 GLU A 167
HIS A 143
HIS A 232
HIS A 147
GLU A 144
 ZN  A 323 ( 2.0A)
ZN  A 323 ( 3.3A)
None
ZN  A 323 ( 3.2A)
ZN  A 323 ( 4.5A)
 1.20A 3a6jF-1npcA:
undetectable		 3a6jF-1npcA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BC9_A_ACRA901_1
(ALPHA AMYLASE,
CATALYTIC REGION)		 1npc NEUTRAL PROTEASE
(Bacillus
cereus) 		4 / 7 SER A 235
SER A 205
GLU A 188
ASP A 186
 None
None
None
CA  A 320 ( 2.9A)
 1.34A 3bc9A-1npcA:
undetectable		 3bc9A-1npcA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEO_A_SAMA328_0
(MODIFICATION
METHYLASE HHAI)		 1npc NEUTRAL PROTEASE
(Bacillus
cereus) 		5 / 12 LEU A  24
GLY A   3
TRP A  56
ASP A  58
ASP A  44
 None
None
None
CA  A 321 ( 2.2A)
None
 1.05A 3eeoA-1npcA:
undetectable		 3eeoA-1npcA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N3I_A_ROCA201_2
(PROTEASE)		 1npc NEUTRAL PROTEASE
(Bacillus
cereus) 		4 / 6 ILE A 169
ASP A 181
ILE A 138
GLY A 142
 None
 0.75A 3n3iA-1npcA:
undetectable		 3n3iA-1npcA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_C_9PLC1_1
(CYTOCHROME P450 2A13)		 1npc NEUTRAL PROTEASE
(Bacillus
cereus) 		4 / 7 PHE A 282
ALA A 285
THR A 280
LEU A 156
 None
 1.05A 3t3sC-1npcA:
0.0		 3t3sC-1npcA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4APJ_A_ACTA1635_0
(ANGIOTENSIN-CONVERTI
NG ENZYME
BRADYKININ-POTENTIAT
ING PEPTIDE B)		 1npc NEUTRAL PROTEASE
(Bacillus
cereus) 		4 / 6 HIS A 147
GLU A 167
ASP A 171
SER A 235
 ZN  A 323 ( 3.2A)
ZN  A 323 ( 2.0A)
None
None
 0.87A 4apjA-1npcA:
4.6
4apjP-1npcA:
undetectable		 4apjA-1npcA:
18.88
4apjP-1npcA:
3.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJE_A_C2FA300_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 1npc NEUTRAL PROTEASE
(Bacillus
cereus) 		5 / 12 GLU A 178
ASN A 184
ASP A  73
GLY A 137
ILE A 138
 CA  A 319 ( 2.5A)
CA  A 320 ( 4.9A)
None
None
None
 1.32A 4djeA-1npcA:
undetectable		 4djeA-1npcA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_A_ACTA506_0
(RNA POLYMERASE
3D-POL)		 1npc NEUTRAL PROTEASE
(Bacillus
cereus) 		3 / 3 VAL A  13
GLY A  15
LYS A  11
 None
 0.59A 4k50A-1npcA:
undetectable		 4k50A-1npcA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_E_ACTE504_0
(RNA POLYMERASE
3D-POL)		 1npc NEUTRAL PROTEASE
(Bacillus
cereus) 		3 / 3 VAL A  13
GLY A  15
LYS A  11
 None
 0.57A 4k50E-1npcA:
undetectable		 4k50E-1npcA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_I_ACTI504_0
(RNA POLYMERASE
3D-POL)		 1npc NEUTRAL PROTEASE
(Bacillus
cereus) 		3 / 3 VAL A  13
GLY A  15
LYS A  11
 None
 0.58A 4k50I-1npcA:
1.0		 4k50I-1npcA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_A_SPMA201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 1npc NEUTRAL PROTEASE
(Bacillus
cereus) 		4 / 8 MET A 121
GLU A 144
TYR A  77
TYR A 194
 None
ZN  A 323 ( 4.5A)
None
None
 1.09A 4mj8A-1npcA:
undetectable
4mj8C-1npcA:
undetectable		 4mj8A-1npcA:
17.43
4mj8C-1npcA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PAH_A_LNRA600_1
(PHENYLALANINE
HYDROXYLASE)		 1npc NEUTRAL PROTEASE
(Bacillus
cereus) 		4 / 6 HIS A 143
HIS A 147
TYR A 158
GLU A 167
 ZN  A 323 ( 3.3A)
ZN  A 323 ( 3.2A)
None
ZN  A 323 ( 2.0A)
 0.83A 4pahA-1npcA:
undetectable		 4pahA-1npcA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ALC_L_TIQL1210_2
(ANTI-TICAGRELOR FAB
72, LIGHT CHAIN)		 1npc NEUTRAL PROTEASE
(Bacillus
cereus) 		4 / 8 GLY A 224
ILE A 237
SER A 235
GLY A 230
 None
 0.80A 5alcL-1npcA:
undetectable		 5alcL-1npcA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DWK_C_ACTC207_0
(DIACYLGLYCEROL
KINASE)		 1npc NEUTRAL PROTEASE
(Bacillus
cereus) 		4 / 5 GLU A 191
ALA A 202
GLU A 188
GLU A 178
 CA  A 319 ( 2.3A)
None
None
CA  A 319 ( 2.5A)
 1.24A 5dwkC-1npcA:
undetectable		 5dwkC-1npcA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1npc NEUTRAL PROTEASE
(Bacillus
cereus) 		4 / 8 THR A 150
SER A 170
GLY A 163
ALA A 168
 None
ZN  A 323 ( 4.7A)
None
None
 0.91A 5eevL-1npcA:
undetectable
5eevV-1npcA:
undetectable		 5eevL-1npcA:
12.93
5eevV-1npcA:
12.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1npc NEUTRAL PROTEASE
(Bacillus
cereus) 		4 / 8 THR A 150
SER A 170
GLY A 163
ALA A 168
 None
ZN  A 323 ( 4.7A)
None
None
 0.91A 5eewL-1npcA:
undetectable
5eewV-1npcA:
undetectable		 5eewL-1npcA:
12.93
5eewV-1npcA:
12.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1npc NEUTRAL PROTEASE
(Bacillus
cereus) 		4 / 8 THR A 150
SER A 170
GLY A 163
ALA A 168
 None
ZN  A 323 ( 4.7A)
None
None
 0.91A 5ef3L-1npcA:
undetectable
5ef3V-1npcA:
undetectable		 5ef3L-1npcA:
12.93
5ef3V-1npcA:
12.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0R_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 1npc NEUTRAL PROTEASE
(Bacillus
cereus) 		4 / 4 SER A 135
ALA A  74
GLN A 120
THR A  42
 None
 1.23A 5n0rA-1npcA:
undetectable		 5n0rA-1npcA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0S_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 1npc NEUTRAL PROTEASE
(Bacillus
cereus) 		4 / 4 SER A 135
ALA A  74
GLN A 120
THR A  42
 None
 1.24A 5n0sA-1npcA:
0.0		 5n0sA-1npcA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0T_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 1npc NEUTRAL PROTEASE
(Bacillus
cereus) 		4 / 5 SER A 135
ALA A  74
GLN A 120
THR A  42
 None
 1.21A 5n0tA-1npcA:
undetectable		 5n0tA-1npcA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 1npc NEUTRAL PROTEASE
(Bacillus
cereus) 		4 / 4 SER A 135
ALA A  74
GLN A 120
THR A  42
 None
 1.26A 5n0wA-1npcA:
0.0		 5n0wA-1npcA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_B_SAMB501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 1npc NEUTRAL PROTEASE
(Bacillus
cereus) 		4 / 5 SER A 135
ALA A  74
GLN A 120
THR A  42
 None
 1.29A 5n0wB-1npcA:
0.0		 5n0wB-1npcA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0X_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 1npc NEUTRAL PROTEASE
(Bacillus
cereus) 		4 / 4 SER A 135
ALA A  74
GLN A 120
THR A  42
 None
 1.25A 5n0xA-1npcA:
undetectable		 5n0xA-1npcA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0X_B_SAMB501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 1npc NEUTRAL PROTEASE
(Bacillus
cereus) 		3 / 3 SER A 135
ALA A  74
THR A  42
 None
 0.75A 5n0xB-1npcA:
undetectable		 5n0xB-1npcA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4I_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 1npc NEUTRAL PROTEASE
(Bacillus
cereus) 		4 / 5 SER A 135
ALA A  74
GLN A 120
THR A  42
 None
 1.28A 5n4iA-1npcA:
undetectable		 5n4iA-1npcA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5PAH_A_LDPA600_1
(PHENYLALANINE
4-MONOOXYGENASE)		 1npc NEUTRAL PROTEASE
(Bacillus
cereus) 		4 / 4 HIS A 143
HIS A 147
TYR A 158
GLU A 167
 ZN  A 323 ( 3.3A)
ZN  A 323 ( 3.2A)
None
ZN  A 323 ( 2.0A)
 0.83A 5pahA-1npcA:
undetectable		 5pahA-1npcA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MHT_D_SAMD328_0
(CYTOSINE-SPECIFIC
METHYLTRANSFERASE
HHAI)		 1npc NEUTRAL PROTEASE
(Bacillus
cereus) 		5 / 12 LEU A  24
GLY A   3
TRP A  56
ASP A  58
ASP A  44
 None
None
None
CA  A 321 ( 2.2A)
None
 1.07A 6mhtA-1npcA:
undetectable		 6mhtA-1npcA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6PAH_A_DAHA600_1
(PHENYLALANINE
4-MONOOXYGENASE)		 1npc NEUTRAL PROTEASE
(Bacillus
cereus) 		4 / 6 HIS A 143
HIS A 147
TYR A 158
GLU A 167
 ZN  A 323 ( 3.3A)
ZN  A 323 ( 3.2A)
None
ZN  A 323 ( 2.0A)
 0.82A 6pahA-1npcA:
undetectable		 6pahA-1npcA:
20.87