SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1npe'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YI4_A_ADNA306_1
(PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 1npe NIDOGEN
(Mus
musculus) 		5 / 10 ILE A 972
PRO A 993
ASP A 989
LEU A 990
ILE A 986
 None
 1.07A 1yi4A-1npeA:
2.0		 1yi4A-1npeA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PKK_A_2FAA501_2
(ADENOSINE KINASE)		 1npe NIDOGEN
(Mus
musculus) 		4 / 4 ALA A1098
VAL A1096
PHE A1124
THR A1051
 None
 1.33A 2pkkA-1npeA:
undetectable		 2pkkA-1npeA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_A_SAMA601_0
(HYPOTHETICAL PROTEIN)		 1npe NIDOGEN
(Mus
musculus) 		5 / 12 ILE A1015
GLY A1038
GLY A 995
ALA A1125
VAL A1040
 None
 1.14A 2yvlA-1npeA:
undetectable		 2yvlA-1npeA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3M_A_DLUA398_1
(PFV INTEGRASE)		 1npe NIDOGEN
(Mus
musculus) 		4 / 8 GLY A 973
PRO A 970
GLU A 969
ARG A1025
 None
 0.99A 3s3mA-1npeA:
undetectable		 3s3mA-1npeA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_A_ADNA401_2
(ADENOSINE KINASE,
PUTATIVE)		 1npe NIDOGEN
(Mus
musculus) 		4 / 5 LEU A1117
ALA A1149
MET A1154
ASN A1132
 None
 1.38A 3uq6A-1npeA:
undetectable		 3uq6A-1npeA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H5F_A_SAMA301_1
(PROTEIN ARGININE
N-METHYLTRANSFERASE
SFM1)		 1npe NIDOGEN
(Mus
musculus) 		4 / 5 GLY A 995
PRO A 970
THR A 965
THR A1008
 None
 1.23A 5h5fA-1npeA:
undetectable		 5h5fA-1npeA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NY7_A_NCAA303_0
(AMIDASE)		 1npe NIDOGEN
(Mus
musculus) 		4 / 6 GLY A1038
THR A1008
GLU A 994
SER A1010
 None
 0.99A 5ny7A-1npeA:
undetectable		 5ny7A-1npeA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXT_A_NIZA807_1
(CATALASE-PEROXIDASE)		 1npe NIDOGEN
(Mus
musculus) 		4 / 8 ARG A1055
GLY A1079
LEU A1080
THR A1100
 None
 0.96A 5sxtA-1npeA:
2.0		 5sxtA-1npeA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXT_B_NIZB808_1
(CATALASE-PEROXIDASE)		 1npe NIDOGEN
(Mus
musculus) 		4 / 8 ARG A1055
GLY A1079
LEU A1080
THR A1100
 None
 0.98A 5sxtB-1npeA:
undetectable		 5sxtB-1npeA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECE_C_DVAC3010_0
(VLM2
DODECADEPSIPEPTIDE)		 1npe NIDOGEN
(Mus
musculus) 		3 / 3 ALA A 939
PHE A 918
GLN A 920
 None
 0.81A 6eceA-1npeA:
undetectable		 6eceA-1npeA:
22.12