SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1nph'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_A_9CRA165_2
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 1nph GELSOLIN
(Mus
musculus) 		4 / 7 ALA A 551
PHE A 539
VAL A 541
VAL A 568
 None
 0.47A 1epbA-1nphA:
undetectable		 1epbA-1nphA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_B_9CRB165_2
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 1nph GELSOLIN
(Mus
musculus) 		4 / 8 ALA A 551
PHE A 539
VAL A 541
VAL A 568
 None
 0.45A 1epbB-1nphA:
undetectable		 1epbB-1nphA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 1nph GELSOLIN
(Mus
musculus) 		4 / 7 LEU A 674
PHE A 681
THR A 626
LEU A 630
 None
 1.08A 2eikA-1nphA:
undetectable
2eikJ-1nphA:
0.0		 2eikA-1nphA:
19.58
2eikJ-1nphA:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_E_SC2E1289_1
(FICOLIN-2)		 1nph GELSOLIN
(Mus
musculus) 		4 / 6 ARG A 711
ASP A 712
THR A 715
ASP A 675
 None
 0.76A 2j2pE-1nphA:
0.0
2j2pF-1nphA:
0.0		 2j2pE-1nphA:
22.12
2j2pF-1nphA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX6_B_ML1B233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1nph GELSOLIN
(Mus
musculus) 		4 / 6 GLY A 582
GLY A 731
GLN A 540
PHE A 567
 None
 0.90A 2qx6A-1nphA:
undetectable
2qx6B-1nphA:
undetectable		 2qx6A-1nphA:
18.86
2qx6B-1nphA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJX_H_HCZH800_1
(GLUTAMATE RECEPTOR 2)		 1nph GELSOLIN
(Mus
musculus) 		4 / 5 PRO A 727
SER A 623
LEU A 630
SER A 563
 None
 1.34A 3ijxH-1nphA:
0.0		 3ijxH-1nphA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_H_HFZH800_1
(GLUTAMATE RECEPTOR 2)		 1nph GELSOLIN
(Mus
musculus) 		4 / 5 PRO A 727
SER A 623
LEU A 630
SER A 563
 None
 1.42A 3iluH-1nphA:
undetectable		 3iluH-1nphA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U15_B_0HKB1201_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,LYSOZYME,MUSCARIN
IC ACETYLCHOLINE
RECEPTOR M3)		 1nph GELSOLIN
(Mus
musculus) 		4 / 4 ASN A 738
TRP A 736
LEU A 666
PHE A 724
 None
 1.20A 4u15B-1nphA:
undetectable		 4u15B-1nphA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZDY_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1nph GELSOLIN
(Mus
musculus) 		5 / 12 GLY A 547
TYR A 464
ILE A 448
PHE A 441
THR A 549
 None
 1.08A 4zdyA-1nphA:
0.0		 4zdyA-1nphA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE2_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1nph GELSOLIN
(Mus
musculus) 		5 / 12 GLY A 547
TYR A 464
ILE A 448
PHE A 441
THR A 549
 None
 1.09A 4ze2A-1nphA:
0.0		 4ze2A-1nphA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESK_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1nph GELSOLIN
(Mus
musculus) 		5 / 12 GLY A 547
TYR A 464
ILE A 448
PHE A 441
THR A 549
 None
 1.11A 5eskA-1nphA:
undetectable		 5eskA-1nphA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESK_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1nph GELSOLIN
(Mus
musculus) 		5 / 12 GLY A 547
TYR A 464
PHE A 441
THR A 549
MET A 517
 None
 1.19A 5eskA-1nphA:
undetectable		 5eskA-1nphA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESL_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1nph GELSOLIN
(Mus
musculus) 		5 / 12 GLY A 547
TYR A 464
ILE A 448
PHE A 441
THR A 549
 None
 1.10A 5eslA-1nphA:
undetectable		 5eslA-1nphA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESL_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1nph GELSOLIN
(Mus
musculus) 		5 / 12 GLY A 547
TYR A 464
PHE A 441
THR A 549
MET A 517
 None
 1.19A 5eslA-1nphA:
undetectable		 5eslA-1nphA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJE_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 1nph GELSOLIN
(Mus
musculus) 		4 / 6 LEU A 661
ILE A 519
MET A 517
TRP A 466
 None
 0.99A 5ljeA-1nphA:
0.0		 5ljeA-1nphA:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WYQ_B_SAMB301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 1nph GELSOLIN
(Mus
musculus) 		5 / 12 GLN A 485
LEU A 490
GLY A 491
GLY A 492
PRO A 494
 None
 0.95A 5wyqB-1nphA:
undetectable		 5wyqB-1nphA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E8Q_A_X2NA602_0
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1nph GELSOLIN
(Mus
musculus) 		5 / 12 GLY A 547
TYR A 464
PHE A 441
THR A 549
MET A 517
 None
 1.19A 6e8qA-1nphA:
undetectable		 6e8qA-1nphA:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_A_TKTA508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 1nph GELSOLIN
(Mus
musculus) 		4 / 8 ASP A 675
TRP A 732
ARG A 711
ASN A 564
 None
None
None
CA  A 744 (-2.9A)
 1.19A 6hisA-1nphA:
0.0
6hisB-1nphA:
0.0		 6hisA-1nphA:
10.70
6hisB-1nphA:
10.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_D_TKTD501_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 1nph GELSOLIN
(Mus
musculus) 		4 / 8 ASP A 675
TRP A 732
ARG A 711
ASN A 564
 None
None
None
CA  A 744 (-2.9A)
 1.18A 6hisD-1nphA:
0.0
6hisE-1nphA:
undetectable		 6hisD-1nphA:
10.70
6hisE-1nphA:
10.70