SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1npm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1AQ7_B_AG2B4_1
(TRYPSIN
AERUGINOSIN 98-B)		 1npm NEUROPSIN
(Mus
musculus) 		5 / 8 HIS A  57
ASP A 189
SER A 195
GLY A 216
GLY A 226
 None
 0.72A 1aq7A-1npmA:
37.2		 1aq7A-1npmA:
45.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_A_DVAA6_0
(GRAMICIDIN A)		 1npm NEUROPSIN
(Mus
musculus) 		3 / 3 ALA A  32
VAL A  45
TRP A  29
 None
 0.91A 1av2A-1npmA:
undetectable
1av2B-1npmA:
undetectable		 1av2A-1npmA:
5.26
1av2B-1npmA:
5.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1BCU_H_PRLH280_0
(ALPHA-THROMBIN)		 1npm NEUROPSIN
(Mus
musculus) 		5 / 9 ASP A 189
SER A 195
TRP A 215
GLY A 216
GLY A 226
 None
 0.29A 1bcuH-1npmA:
17.9		 1bcuH-1npmA:
33.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DWC_H_MITH1_1
(ALPHA-THROMBIN
(LARGE SUBUNIT))		 1npm NEUROPSIN
(Mus
musculus) 		5 / 9 HIS A  57
ASP A 189
SER A 195
TRP A 215
GLY A 226
 None
 0.51A 1dwcH-1npmA:
33.3		 1dwcH-1npmA:
33.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ESW_A_ACRA652_1
(AMYLOMALTASE)		 1npm NEUROPSIN
(Mus
musculus) 		4 / 6 GLY A 220
ASP A 189
GLY A 216
SER A 146
 None
 0.83A 1eswA-1npmA:
undetectable		 1eswA-1npmA:
16.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ETR_H_MITH1_1
(EPSILON-THROMBIN)		 1npm NEUROPSIN
(Mus
musculus) 		6 / 12 HIS A  57
ASP A 189
SER A 195
TRP A 215
GLY A 216
GLY A 226
 None
 0.65A 1etrH-1npmA:
33.1		 1etrH-1npmA:
34.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1F5L_A_AMRA301_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 1npm NEUROPSIN
(Mus
musculus) 		4 / 8 ASP A 189
SER A 195
GLY A 216
GLY A 226
 None
 0.35A 1f5lA-1npmA:
33.4		 1f5lA-1npmA:
35.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RA8_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 1npm NEUROPSIN
(Mus
musculus) 		5 / 12 THR A 235
ILE A 238
LEU A  53
ILE A 231
THR A 177
 None
 0.95A 1ra8A-1npmA:
undetectable		 1ra8A-1npmA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RD7_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 1npm NEUROPSIN
(Mus
musculus) 		5 / 12 THR A 235
ILE A 238
LEU A  53
ILE A 231
THR A 177
 None
 1.01A 1rd7A-1npmA:
undetectable		 1rd7A-1npmA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RD7_B_FOLB361_0
(DIHYDROFOLATE
REDUCTASE)		 1npm NEUROPSIN
(Mus
musculus) 		5 / 12 THR A 235
ILE A 238
LEU A  53
ILE A 231
THR A 177
 None
 0.97A 1rd7B-1npmA:
undetectable		 1rd7B-1npmA:
21.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TNL_A_TPAA900_1
(TRYPSIN)		 1npm NEUROPSIN
(Mus
musculus) 		4 / 6 ASP A 189
SER A 195
GLY A 216
GLY A 226
 None
 0.40A 1tnlA-1npmA:
37.7		 1tnlA-1npmA:
45.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OTV_A_NCAA1301_0
(CATIONIC TRYPSIN)		 1npm NEUROPSIN
(Mus
musculus) 		4 / 6 ASP A 189
SER A 195
GLY A 216
GLY A 226
 None
 0.27A 2otvA-1npmA:
37.8		 2otvA-1npmA:
45.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_D_SAMD300_0
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 1npm NEUROPSIN
(Mus
musculus) 		6 / 12 GLY A 142
GLY A  44
GLY A 196
GLY A 193
THR A  54
LEU A  53
 None
 1.39A 2oxtD-1npmA:
undetectable		 2oxtD-1npmA:
21.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2P16_A_GG2A298_1
(COAGULATION FACTOR X
(EC 3.4.21.6)
(STUART FACTOR)
(STUART-PROWER
FACTOR))		 1npm NEUROPSIN
(Mus
musculus) 		6 / 12 ASP A 189
SER A 195
TRP A 215
GLY A 216
GLY A 226
TYR A 228
 None
 0.30A 2p16A-1npmA:
34.0		 2p16A-1npmA:
34.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_B_SAMB400_0
(UNCHARACTERIZED
PROTEIN TFU_2867)		 1npm NEUROPSIN
(Mus
musculus) 		5 / 12 ILE A 103
ALA A  55
GLY A 196
VAL A  47
GLY A 211
 None
 1.02A 2qe6B-1npmA:
undetectable		 2qe6B-1npmA:
21.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2VIN_A_505A1247_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR CHAIN B)		 1npm NEUROPSIN
(Mus
musculus) 		5 / 8 ASP A 189
GLN A 192
SER A 195
GLY A 216
GLY A 226
 None
 0.63A 2vinA-1npmA:
11.5		 2vinA-1npmA:
35.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W26_A_RIVA1001_1
(ACTIVATED FACTOR XA
HEAVY CHAIN)		 1npm NEUROPSIN
(Mus
musculus) 		6 / 12 ASP A 189
SER A 195
TRP A 215
GLY A 216
GLY A 226
TYR A 228
 None
 0.33A 2w26A-1npmA:
13.4		 2w26A-1npmA:
34.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_C_IBPC1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)		 1npm NEUROPSIN
(Mus
musculus) 		5 / 10 ILE A  41
LEU A  33
GLY A 196
GLY A 193
GLN A 192
 None
 1.12A 2wd9C-1npmA:
undetectable		 2wd9C-1npmA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DVAC59_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 1npm NEUROPSIN
(Mus
musculus) 		3 / 3 GLY A 197
GLY A 193
GLY A  43
 None
 0.35A 3bogC-1npmA:
undetectable		 3bogC-1npmA:
18.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GY3_A_PNTA246_0
(CATIONIC TRYPSIN)		 1npm NEUROPSIN
(Mus
musculus) 		6 / 11 HIS A  57
ASP A 189
SER A 195
TRP A 215
GLY A 216
GLY A 226
 None
 0.50A 3gy3A-1npmA:
36.8		 3gy3A-1npmA:
45.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NVK_I_SAMI228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 1npm NEUROPSIN
(Mus
musculus) 		5 / 12 LYS A  16
GLY A 197
ILE A 212
ALA A  55
ASP A 194
 None
 1.07A 3nvkI-1npmA:
undetectable		 3nvkI-1npmA:
18.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RXF_A_4APA9_1
(CATIONIC TRYPSIN)		 1npm NEUROPSIN
(Mus
musculus) 		4 / 6 SER A 195
TRP A 215
GLY A 216
GLY A 226
 None
 0.36A 3rxfA-1npmA:
15.8		 3rxfA-1npmA:
45.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U6T_A_KANA4699_1
(RIBOSOME
INACTIVATING PROTEIN)		 1npm NEUROPSIN
(Mus
musculus) 		5 / 10 ILE A  16
SER A 195
TYR A 228
ILE A 138
ALA A 188
 None
 1.29A 3u6tA-1npmA:
undetectable		 3u6tA-1npmA:
20.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FU8_A_ACTA302_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 1npm NEUROPSIN
(Mus
musculus) 		4 / 5 HIS A  57
GLN A 192
GLY A 193
SER A 195
 None
 0.82A 4fu8A-1npmA:
33.4		 4fu8A-1npmA:
35.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JJK_A_FOLA601_0
(FORMATE--TETRAHYDROF
OLATE LIGASE)		 1npm NEUROPSIN
(Mus
musculus) 		4 / 8 ASN A 113
ALA A 112
LEU A  46
LEU A  67
 None
 0.80A 4jjkA-1npmA:
undetectable		 4jjkA-1npmA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KJL_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1npm NEUROPSIN
(Mus
musculus) 		5 / 12 THR A 235
ILE A 238
LEU A  53
ILE A 231
THR A 177
 None
 1.04A 4kjlA-1npmA:
undetectable		 4kjlA-1npmA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PST_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1npm NEUROPSIN
(Mus
musculus) 		5 / 12 THR A 235
ILE A 238
LEU A  53
ILE A 231
THR A 177
 None
 1.01A 4pstA-1npmA:
undetectable		 4pstA-1npmA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTH_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1npm NEUROPSIN
(Mus
musculus) 		5 / 12 THR A 235
ILE A 238
LEU A  53
ILE A 231
THR A 177
 None
 1.04A 4pthA-1npmA:
undetectable		 4pthA-1npmA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5G_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 1npm NEUROPSIN
(Mus
musculus) 		5 / 12 THR A 235
ILE A 238
LEU A  53
ILE A 231
THR A 177
 None
 0.97A 4x5gB-1npmA:
undetectable		 4x5gB-1npmA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5I_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1npm NEUROPSIN
(Mus
musculus) 		5 / 12 THR A 235
ILE A 238
LEU A  53
ILE A 231
THR A 177
 None
 0.93A 4x5iA-1npmA:
undetectable		 4x5iA-1npmA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EAJ_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1npm NEUROPSIN
(Mus
musculus) 		5 / 12 THR A 235
ILE A 238
LEU A  53
ILE A 231
THR A 177
 None
 0.95A 5eajA-1npmA:
undetectable		 5eajA-1npmA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UJX_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1npm NEUROPSIN
(Mus
musculus) 		5 / 12 THR A 235
ILE A 238
LEU A  53
ILE A 231
THR A 177
 None
 0.97A 5ujxA-1npmA:
undetectable		 5ujxA-1npmA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6J_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1npm NEUROPSIN
(Mus
musculus) 		5 / 12 THR A 235
ILE A 238
LEU A  53
ILE A 231
THR A 177
 None
 0.99A 5z6jA-1npmA:
undetectable		 5z6jA-1npmA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6K_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1npm NEUROPSIN
(Mus
musculus) 		5 / 12 THR A 235
ILE A 238
LEU A  53
ILE A 231
THR A 177
 None
 1.00A 5z6kA-1npmA:
undetectable		 5z6kA-1npmA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EU9_B_REAB601_1
(RETINOIC ACID
RECEPTOR)		 1npm NEUROPSIN
(Mus
musculus) 		5 / 10 ARG A  66
VAL A  65
GLY A  69
GLY A  48
VAL A  52
 None
 1.08A 6eu9B-1npmA:
undetectable		 6eu9B-1npmA:
15.79