SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1npr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2NV4_A_ACTA148_0 (UPF0066 PROTEIN AF_0241)	1npr	TRANSCRIPTION ANTITERMINATION PROTEIN NUSG (Aquifex aeolicus)	3 / 3	VAL A 99 GLU A 121 GLU A 100	None	0.80A	2nv4A-1nprA: undetectable	2nv4A-1nprA: 20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3KP6_B_SALB3008_1 (TRANSCRIPTIONAL REGULATOR TCAR)	1npr	TRANSCRIPTION ANTITERMINATION PROTEIN NUSG (Aquifex aeolicus)	4 / 7	VAL A 18 GLN A 17 VAL A 163 ALA A 15	None	0.98A	3kp6B-1nprA: undetectable	3kp6B-1nprA: 20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4EM2_A_SALA502_1 (UNCHARACTERIZED HTH-TYPE TRANSCRIPTIONAL REGULATOR SAR2349)	1npr	TRANSCRIPTION ANTITERMINATION PROTEIN NUSG (Aquifex aeolicus)	5 / 8	TYR A 138 LEU A 172 VAL A 170 VAL A 163 GLN A 17	None	1.11A	4em2A-1nprA: undetectable	4em2A-1nprA: 22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4FGZ_A_CQAA302_0 (PHOSPHOETHANOLAMINE N-METHYLTRANSFERASE)	1npr	TRANSCRIPTION ANTITERMINATION PROTEIN NUSG (Aquifex aeolicus)	4 / 7	GLU A 52 GLU A 51 ARG A 65 LYS A 127	None	1.05A	4fgzA-1nprA: undetectable	4fgzA-1nprA: 22.34

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2NV4_A_ACTA148_0","UPF0066 PROTEIN AF_0241","1npr","TRANSCRIPTION ANTITERMINATION PROTEIN NUSG","Aquifex aeolicus",3,"VAL A  99;GLU A 121;GLU A 100","None","0.80A","2nv4A-1nprA:undetectable","2nv4A-1nprA:20.33"],["3KP6_B_SALB3008_1","TRANSCRIPTIONAL REGULATOR TCAR","1npr","TRANSCRIPTION ANTITERMINATION PROTEIN NUSG","Aquifex aeolicus",4,"VAL A  18;GLN A  17;VAL A 163;ALA A  15","None","0.98A","3kp6B-1nprA:undetectable","3kp6B-1nprA:20.46"],["4EM2_A_SALA502_1","UNCHARACTERIZED HTH-TYPE TRANSCRIPTIONAL REGULATOR SAR2349","1npr","TRANSCRIPTION ANTITERMINATION PROTEIN NUSG","Aquifex aeolicus",5,"TYR A 138;LEU A 172;VAL A 170;VAL A 163;GLN A  17","None","1.11A","4em2A-1nprA:undetectable","4em2A-1nprA:22.05"],["4FGZ_A_CQAA302_0","PHOSPHOETHANOLAMINE N-METHYLTRANSFERASE","1npr","TRANSCRIPTION ANTITERMINATION PROTEIN NUSG","Aquifex aeolicus",4,"GLU A  52;GLU A  51;ARG A  65;LYS A 127","None","1.05A","4fgzA-1nprA:undetectable","4fgzA-1nprA:22.34"]]