SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1npy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7R_A_NCTA440_1
(CYTOCHROME P450-CAM)		 1npy HYPOTHETICAL
SHIKIMATE
5-DEHYDROGENASE-LIKE
PROTEIN HI0607
(Haemophilus
influenzae) 		4 / 7 VAL A 182
VAL A 238
ASP A 103
ILE A 107
 None
 0.96A 1p7rA-1npyA:
0.0		 1p7rA-1npyA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PRG_A_BRLA1_2
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 1npy HYPOTHETICAL
SHIKIMATE
5-DEHYDROGENASE-LIKE
PROTEIN HI0607
(Haemophilus
influenzae) 		3 / 3 ILE A 178
ILE A 233
LEU A 171
 None
 0.58A 2prgA-1npyA:
undetectable		 2prgA-1npyA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX4_B_ML1B233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1npy HYPOTHETICAL
SHIKIMATE
5-DEHYDROGENASE-LIKE
PROTEIN HI0607
(Haemophilus
influenzae) 		4 / 7 GLY A 126
THR A 183
PHE A 198
PHE A 202
 None
 1.15A 2qx4A-1npyA:
undetectable
2qx4B-1npyA:
2.8		 2qx4A-1npyA:
21.84
2qx4B-1npyA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKI_A_IMNA201_1
(TRANSTHYRETIN)		 1npy HYPOTHETICAL
SHIKIMATE
5-DEHYDROGENASE-LIKE
PROTEIN HI0607
(Haemophilus
influenzae) 		3 / 3 LYS A 132
LEU A 162
ALA A 136
 None
 0.73A 4ikiA-1npyA:
undetectable		 4ikiA-1npyA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLB_A_TRPA901_0
(PROTEIN ARGONAUTE-2)		 1npy HYPOTHETICAL
SHIKIMATE
5-DEHYDROGENASE-LIKE
PROTEIN HI0607
(Haemophilus
influenzae) 		3 / 3 VAL A 240
ALA A 263
PHE A  19
 None
 0.74A 4olbA-1npyA:
undetectable		 4olbA-1npyA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PCL_A_SAMA301_0
(O-METHYLTRANSFERASE
FAMILY PROTEIN)		 1npy HYPOTHETICAL
SHIKIMATE
5-DEHYDROGENASE-LIKE
PROTEIN HI0607
(Haemophilus
influenzae) 		5 / 12 LEU A  97
ASP A 103
ASN A 101
ALA A  61
TYR A  37
 None
 1.08A 4pclA-1npyA:
5.8		 4pclA-1npyA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5N_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 1npy HYPOTHETICAL
SHIKIMATE
5-DEHYDROGENASE-LIKE
PROTEIN HI0607
(Haemophilus
influenzae) 		3 / 3 VAL A 240
ALA A 263
PHE A  19
 None
 0.73A 4w5nA-1npyA:
undetectable		 4w5nA-1npyA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5N_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 1npy HYPOTHETICAL
SHIKIMATE
5-DEHYDROGENASE-LIKE
PROTEIN HI0607
(Haemophilus
influenzae) 		4 / 6 LEU A 259
ILE A 260
LEU A  27
TYR A  26
 None
 0.94A 4w5nA-1npyA:
undetectable		 4w5nA-1npyA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_D_CVID301_0
(REGULATORY PROTEIN
TETR)		 1npy HYPOTHETICAL
SHIKIMATE
5-DEHYDROGENASE-LIKE
PROTEIN HI0607
(Haemophilus
influenzae) 		5 / 12 ALA A 133
LEU A 159
VAL A 180
TYR A 149
THR A 183
 None
 1.36A 5vlmD-1npyA:
0.0		 5vlmD-1npyA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA608_0
(ALPHA-AMYLASE)		 1npy HYPOTHETICAL
SHIKIMATE
5-DEHYDROGENASE-LIKE
PROTEIN HI0607
(Haemophilus
influenzae) 		4 / 6 GLY A  20
GLN A 246
TYR A 250
TYR A  37
 None
 1.02A 6ag0A-1npyA:
undetectable		 6ag0A-1npyA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA608_0
(ALPHA-AMYLASE)		 1npy HYPOTHETICAL
SHIKIMATE
5-DEHYDROGENASE-LIKE
PROTEIN HI0607
(Haemophilus
influenzae) 		4 / 6 PHE A  66
GLY A  14
THR A  41
GLN A  43
 None
 1.30A 6ag0A-1npyA:
undetectable		 6ag0A-1npyA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC606_0
(ALPHA-AMYLASE)		 1npy HYPOTHETICAL
SHIKIMATE
5-DEHYDROGENASE-LIKE
PROTEIN HI0607
(Haemophilus
influenzae) 		4 / 6 GLY A  20
GLN A 246
TYR A 250
TYR A  37
 None
 1.01A 6ag0C-1npyA:
undetectable		 6ag0C-1npyA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC606_0
(ALPHA-AMYLASE)		 1npy HYPOTHETICAL
SHIKIMATE
5-DEHYDROGENASE-LIKE
PROTEIN HI0607
(Haemophilus
influenzae) 		4 / 6 PHE A  66
GLY A  14
THR A  41
GLN A  43
 None
 1.25A 6ag0C-1npyA:
undetectable		 6ag0C-1npyA:
15.44