SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1nq4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1MX1_E_THAE5_1 (LIVER CARBOXYLESTERASE I)	1nq4	OXYTETRACYCLINE POLYKETIDE SYNTHASE ACYL CARRIER PROTEIN (Streptomyces rimosus)	5 / 12	LEU A 37 VAL A 29 LEU A 10 LEU A 6 LEU A 4	None	1.33A	1mx1E-1nq4A: 2.1	1mx1E-1nq4A: 13.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2W98_A_P1ZA1351_1 (PROSTAGLANDIN REDUCTASE 2)	1nq4	OXYTETRACYCLINE POLYKETIDE SYNTHASE ACYL CARRIER PROTEIN (Streptomyces rimosus)	5 / 10	ILE A 74 PHE A 34 TYR A 55 LEU A 12 LEU A 13	None	1.47A	2w98A-1nq4A: undetectable	2w98A-1nq4A: 14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5BYJ_A_OQRA302_0 (SULFOTRANSFERASE)	1nq4	OXYTETRACYCLINE POLYKETIDE SYNTHASE ACYL CARRIER PROTEIN (Streptomyces rimosus)	5 / 12	ILE A 51 LEU A 10 THR A 11 LEU A 81 THR A 2	None	1.20A	5byjA-1nq4A: undetectable	5byjA-1nq4A: 15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6EXI_A_ADNA502_1 (ADENOSYLHOMOCYSTEINA SE)	1nq4	OXYTETRACYCLINE POLYKETIDE SYNTHASE ACYL CARRIER PROTEIN (Streptomyces rimosus)	3 / 3	LEU A 37 ASN A 46 LEU A 73	None	0.65A	6exiA-1nq4A: undetectable	6exiA-1nq4A: 26.47

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1MX1_E_THAE5_1","LIVER CARBOXYLESTERASE I","1nq4","OXYTETRACYCLINE POLYKETIDE SYNTHASE ACYL CARRIER PROTEIN","Streptomyces rimosus",5,"LEU A  37;VAL A  29;LEU A  10;LEU A   6;LEU A   4","None","1.33A","1mx1E-1nq4A:2.1","1mx1E-1nq4A:13.16"],["2W98_A_P1ZA1351_1","PROSTAGLANDIN REDUCTASE 2","1nq4","OXYTETRACYCLINE POLYKETIDE SYNTHASE ACYL CARRIER PROTEIN","Streptomyces rimosus",5,"ILE A  74;PHE A  34;TYR A  55;LEU A  12;LEU A  13","None","1.47A","2w98A-1nq4A:undetectable","2w98A-1nq4A:14.37"],["5BYJ_A_OQRA302_0","SULFOTRANSFERASE","1nq4","OXYTETRACYCLINE POLYKETIDE SYNTHASE ACYL CARRIER PROTEIN","Streptomyces rimosus",5,"ILE A  51;LEU A  10;THR A  11;LEU A  81;THR A   2","None","1.20A","5byjA-1nq4A:undetectable","5byjA-1nq4A:15.95"],["6EXI_A_ADNA502_1","ADENOSYLHOMOCYSTEINASE","1nq4","OXYTETRACYCLINE POLYKETIDE SYNTHASE ACYL CARRIER PROTEIN","Streptomyces rimosus",3,"LEU A  37;ASN A  46;LEU A  73","None","0.65A","6exiA-1nq4A:undetectable","6exiA-1nq4A:26.47"]]