SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1nq6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_C_FUAC701_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1nq6 XYS1
(Streptomyces
halstedii) 		5 / 12 PHE A 217
LEU A 284
VAL A 298
PHE A  15
VAL A 267
 None
 1.28A 1q23C-1nq6A:
undetectable		 1q23C-1nq6A:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_F_FUAF704_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1nq6 XYS1
(Streptomyces
halstedii) 		5 / 11 PHE A 217
LEU A 284
VAL A 298
PHE A  15
VAL A 267
 None
 1.29A 1q23F-1nq6A:
undetectable		 1q23F-1nq6A:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_L_FUAL710_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1nq6 XYS1
(Streptomyces
halstedii) 		5 / 11 PHE A 217
LEU A 284
VAL A 298
PHE A  15
VAL A 267
 None
 1.32A 1q23L-1nq6A:
undetectable		 1q23L-1nq6A:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_C_VIAC903_2
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 1nq6 XYS1
(Streptomyces
halstedii) 		3 / 3 ASN A 170
ILE A 198
MET A 187
 None
 0.81A 2h42C-1nq6A:
0.0		 2h42C-1nq6A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HKK_A_ALEA300_1
(CARBONIC ANHYDRASE 2)		 1nq6 XYS1
(Streptomyces
halstedii) 		4 / 6 ASN A 170
HIS A  80
GLN A 232
THR A  41
 None
 1.22A 2hkkA-1nq6A:
undetectable		 2hkkA-1nq6A:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDV_E_SAME1287_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 1nq6 XYS1
(Streptomyces
halstedii) 		5 / 12 GLY A 240
GLY A 280
ILE A 238
ASN A 248
ALA A 244
 None
 1.12A 2vdvE-1nq6A:
undetectable		 2vdvE-1nq6A:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDV_F_SAMF1287_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 1nq6 XYS1
(Streptomyces
halstedii) 		5 / 11 GLY A 240
GLY A 280
ILE A 238
ASN A 248
ALA A 244
 None
 1.12A 2vdvF-1nq6A:
undetectable		 2vdvF-1nq6A:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_A_SAMA301_1
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 1nq6 XYS1
(Streptomyces
halstedii) 		3 / 3 SER A 121
ASP A 123
ASP A 230
 None
 0.80A 3iv6A-1nq6A:
0.7		 3iv6A-1nq6A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_C_SAMC301_1
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 1nq6 XYS1
(Streptomyces
halstedii) 		3 / 3 SER A 121
ASP A 123
ASP A 230
 None
 0.80A 3iv6C-1nq6A:
undetectable		 3iv6C-1nq6A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_B_ECLB600_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1nq6 XYS1
(Streptomyces
halstedii) 		4 / 8 LEU A 283
GLY A 242
ALA A 246
THR A 250
 None
 0.85A 3jusB-1nq6A:
undetectable		 3jusB-1nq6A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SOA_A_DB8A445_1
(CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II
SUBUNIT ALPHA WITH A
BETA 7 LINKER)		 1nq6 XYS1
(Streptomyces
halstedii) 		4 / 6 LEU A 236
VAL A 267
PHE A  15
VAL A 253
 None
 1.11A 3soaA-1nq6A:
undetectable		 3soaA-1nq6A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQ8_D_DVAD8_0
(VAL-GRAMICIDIN A)		 1nq6 XYS1
(Streptomyces
halstedii) 		3 / 3 TRP A 276
VAL A 267
TRP A 268
 None
 0.88A 3zq8C-1nq6A:
undetectable
3zq8D-1nq6A:
undetectable		 3zq8C-1nq6A:
9.76
3zq8D-1nq6A:
9.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_A_GCSA306_1
(CHITOSANASE)		 1nq6 XYS1
(Streptomyces
halstedii) 		3 / 3 SER A 275
ASP A 272
GLN A 245
 None
 0.72A 4oltA-1nq6A:
0.0
4oltB-1nq6A:
0.0		 4oltA-1nq6A:
22.98
4oltB-1nq6A:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB304_1
(CHITOSANASE)		 1nq6 XYS1
(Streptomyces
halstedii) 		3 / 3 GLN A 245
SER A 275
ASP A 272
 None
 0.68A 4qwpA-1nq6A:
0.0
4qwpB-1nq6A:
0.0		 4qwpA-1nq6A:
22.98
4qwpB-1nq6A:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V1F_B_BQ1B1087_0
(F0F1 ATP SYNTHASE
SUBUNIT C)		 1nq6 XYS1
(Streptomyces
halstedii) 		5 / 8 ALA A  21
ALA A  20
ALA A  27
TYR A  29
LEU A  33
 None
 1.05A 4v1fA-1nq6A:
undetectable
4v1fB-1nq6A:
undetectable		 4v1fA-1nq6A:
13.15
4v1fB-1nq6A:
13.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V1F_B_BQ1B1087_0
(F0F1 ATP SYNTHASE
SUBUNIT C)		 1nq6 XYS1
(Streptomyces
halstedii) 		5 / 8 ALA A  21
ALA A  20
ALA A  28
TYR A  29
LEU A  33
 None
 1.27A 4v1fA-1nq6A:
undetectable
4v1fB-1nq6A:
undetectable		 4v1fA-1nq6A:
13.15
4v1fB-1nq6A:
13.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP4_A_COCA706_1
(DOPAMINE TRANSPORTER)		 1nq6 XYS1
(Streptomyces
halstedii) 		5 / 11 PHE A 203
ASP A 171
VAL A 188
TYR A 169
PHE A 224
 None
 1.15A 4xp4A-1nq6A:
0.8		 4xp4A-1nq6A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XPB_A_COCA702_1
(TRANSPORTER)		 1nq6 XYS1
(Streptomyces
halstedii) 		5 / 10 PHE A 203
ASP A 171
VAL A 188
TYR A 169
PHE A 224
 None
 1.18A 4xpbA-1nq6A:
undetectable		 4xpbA-1nq6A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XYZ_A_ACTA103_0
(POLYUBIQUITIN-C)		 1nq6 XYS1
(Streptomyces
halstedii) 		4 / 4 LEU A  33
ILE A  66
HIS A  69
VAL A  40
 None
 1.22A 4xyzA-1nq6A:
0.0		 4xyzA-1nq6A:
13.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MWY_A_YNUA1101_1
(MINERALOCORTICOID
RECEPTOR)		 1nq6 XYS1
(Streptomyces
halstedii) 		4 / 6 ARG A 159
PHE A 155
THR A 174
PHE A 224
 None
 1.30A 5mwyA-1nq6A:
undetectable		 5mwyA-1nq6A:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND2_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 1nq6 XYS1
(Streptomyces
halstedii) 		5 / 12 VAL A 124
ALA A 158
ARG A 101
ARG A 159
PRO A 197
 None
 1.37A 5nd2B-1nq6A:
2.9		 5nd2B-1nq6A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6J20_A_GBQA1201_1
(SUBSTANCE-P
RECEPTOR,ENDOLYSIN)		 1nq6 XYS1
(Streptomyces
halstedii) 		4 / 7 ILE A 108
GLU A 152
VAL A 124
TRP A  48
 None
 1.17A 6j20A-1nq6A:
0.0		 6j20A-1nq6A:
20.44