SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1nq7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7X_A_CFFA864_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 1nq7 NUCLEAR RECEPTOR
ROR-BETA
(Rattus
norvegicus) 		3 / 3 TRP A 259
HIS A 423
LYS A 426
 None
ARL  A 800 ( 4.3A)
None
 1.40A 1l7xA-1nq7A:
1.2		 1l7xA-1nq7A:
15.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1N4H_A_REAA500_1
(NUCLEAR RECEPTOR
ROR-BETA)		 1nq7 NUCLEAR RECEPTOR
ROR-BETA
(Rattus
norvegicus) 		11 / 11 GLN A 228
CYH A 262
ILE A 266
ALA A 269
VAL A 303
ARG A 306
MET A 307
ARG A 309
VAL A 318
LEU A 338
ALA A 342
 ARL  A 800 (-4.7A)
ARL  A 800 (-3.5A)
None
ARL  A 800 ( 3.9A)
ARL  A 800 ( 4.7A)
ARL  A 800 (-4.4A)
ARL  A 800 (-3.7A)
ARL  A 800 ( 4.9A)
None
ARL  A 800 ( 4.8A)
ARL  A 800 ( 4.1A)
 0.23A 1n4hA-1nq7A:
41.5		 1n4hA-1nq7A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QFI_B_DVAB8_0
(ACTINOMYCIN X2)		 1nq7 NUCLEAR RECEPTOR
ROR-BETA
(Rattus
norvegicus) 		3 / 3 THR A 415
THR A 417
PRO A 414
 None
 0.86A 1qfiB-1nq7A:
undetectable		 1qfiB-1nq7A:
3.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_B_CHDB1130_0
(FATTY ACID-BINDING
PROTEIN)		 1nq7 NUCLEAR RECEPTOR
ROR-BETA
(Rattus
norvegicus) 		5 / 12 TYR A 389
ILE A 413
HIS A 400
ILE A 396
LEU A 392
 None
 1.27A 1tw4B-1nq7A:
undetectable		 1tw4B-1nq7A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_W_DVAW8_0
(7-AMINO-ACTINOMYCIN
D)		 1nq7 NUCLEAR RECEPTOR
ROR-BETA
(Rattus
norvegicus) 		3 / 3 THR A 415
THR A 417
PRO A 414
 None
 0.84A 1unjW-1nq7A:
undetectable		 1unjW-1nq7A:
3.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_X_DVAX8_0
(7-AMINO-ACTINOMYCIN
D)		 1nq7 NUCLEAR RECEPTOR
ROR-BETA
(Rattus
norvegicus) 		3 / 3 THR A 415
THR A 417
PRO A 414
 None
 0.85A 1unjX-1nq7A:
undetectable		 1unjX-1nq7A:
3.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNM_E_DVAE8_0
(7-AMINOACTINOMYCIN D)		 1nq7 NUCLEAR RECEPTOR
ROR-BETA
(Rattus
norvegicus) 		3 / 3 THR A 415
THR A 417
PRO A 414
 None
 0.82A 1unmE-1nq7A:
undetectable		 1unmE-1nq7A:
3.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNM_F_DVAF8_0
(7-AMINOACTINOMYCIN D)		 1nq7 NUCLEAR RECEPTOR
ROR-BETA
(Rattus
norvegicus) 		3 / 3 THR A 415
THR A 417
PRO A 414
 None
 0.85A 1unmF-1nq7A:
undetectable		 1unmF-1nq7A:
3.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3B0W_A_DGXA1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		 1nq7 NUCLEAR RECEPTOR
ROR-BETA
(Rattus
norvegicus) 		7 / 12 GLN A 228
CYH A 262
ALA A 269
VAL A 318
PHE A 330
LEU A 338
HIS A 423
 ARL  A 800 (-4.7A)
ARL  A 800 (-3.5A)
ARL  A 800 ( 3.9A)
None
ARL  A 800 (-3.6A)
ARL  A 800 ( 4.8A)
ARL  A 800 ( 4.3A)
 1.11A 3b0wA-1nq7A:
28.5		 3b0wA-1nq7A:
49.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3B0W_A_DGXA1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		 1nq7 NUCLEAR RECEPTOR
ROR-BETA
(Rattus
norvegicus) 		9 / 12 GLN A 228
LEU A 234
CYH A 262
ALA A 269
MET A 307
ALA A 310
VAL A 318
PHE A 330
LEU A 338
 ARL  A 800 (-4.7A)
None
ARL  A 800 (-3.5A)
ARL  A 800 ( 3.9A)
ARL  A 800 (-3.7A)
ARL  A 800 ( 4.1A)
None
ARL  A 800 (-3.6A)
ARL  A 800 ( 4.8A)
 0.87A 3b0wA-1nq7A:
28.5		 3b0wA-1nq7A:
49.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3B0W_A_DGXA1_2
(NUCLEAR RECEPTOR
ROR-GAMMA)		 1nq7 NUCLEAR RECEPTOR
ROR-BETA
(Rattus
norvegicus) 		3 / 3 TRP A 259
VAL A 303
ARG A 309
 None
ARL  A 800 ( 4.7A)
ARL  A 800 ( 4.9A)
 0.71A 3b0wA-1nq7A:
28.5		 3b0wA-1nq7A:
49.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3B0W_B_DGXB1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		 1nq7 NUCLEAR RECEPTOR
ROR-BETA
(Rattus
norvegicus) 		5 / 12 GLN A 228
CYH A 262
ALA A 269
LEU A 333
HIS A 423
 ARL  A 800 (-4.7A)
ARL  A 800 (-3.5A)
ARL  A 800 ( 3.9A)
None
ARL  A 800 ( 4.3A)
 1.16A 3b0wB-1nq7A:
28.9		 3b0wB-1nq7A:
49.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3B0W_B_DGXB1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		 1nq7 NUCLEAR RECEPTOR
ROR-BETA
(Rattus
norvegicus) 		10 / 12 GLN A 228
LEU A 234
CYH A 262
ALA A 269
MET A 307
ALA A 310
VAL A 318
PHE A 330
LEU A 333
LEU A 338
 ARL  A 800 (-4.7A)
None
ARL  A 800 (-3.5A)
ARL  A 800 ( 3.9A)
ARL  A 800 (-3.7A)
ARL  A 800 ( 4.1A)
None
ARL  A 800 (-3.6A)
None
ARL  A 800 ( 4.8A)
 0.83A 3b0wB-1nq7A:
28.9		 3b0wB-1nq7A:
49.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3B0W_B_DGXB1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		 1nq7 NUCLEAR RECEPTOR
ROR-BETA
(Rattus
norvegicus) 		6 / 12 GLN A 228
LEU A 237
CYH A 262
PHE A 330
LEU A 333
LEU A 338
 ARL  A 800 (-4.7A)
None
ARL  A 800 (-3.5A)
ARL  A 800 (-3.6A)
None
ARL  A 800 ( 4.8A)
 1.23A 3b0wB-1nq7A:
28.9		 3b0wB-1nq7A:
49.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3B0W_B_DGXB1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		 1nq7 NUCLEAR RECEPTOR
ROR-BETA
(Rattus
norvegicus) 		8 / 12 LEU A 234
CYH A 262
ALA A 269
MET A 307
ALA A 310
VAL A 318
PHE A 330
LEU A 258
 None
ARL  A 800 (-3.5A)
ARL  A 800 ( 3.9A)
ARL  A 800 (-3.7A)
ARL  A 800 ( 4.1A)
None
ARL  A 800 (-3.6A)
None
 1.50A 3b0wB-1nq7A:
28.9		 3b0wB-1nq7A:
49.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R55_A_PZAA598_0
(LACTOPEROXIDASE)		 1nq7 NUCLEAR RECEPTOR
ROR-BETA
(Rattus
norvegicus) 		3 / 3 GLU A 256
PHE A 430
GLN A 260
 None
 0.88A 3r55A-1nq7A:
undetectable		 3r55A-1nq7A:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 1nq7 NUCLEAR RECEPTOR
ROR-BETA
(Rattus
norvegicus) 		4 / 8 HIS A 223
GLU A 225
ARG A 306
ILE A 280
 None
None
ARL  A 800 (-4.4A)
None
 1.29A 4cx7A-1nq7A:
undetectable
4cx7B-1nq7A:
undetectable		 4cx7A-1nq7A:
20.89
4cx7B-1nq7A:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 2)		 1nq7 NUCLEAR RECEPTOR
ROR-BETA
(Rattus
norvegicus) 		5 / 12 PHE A 362
ILE A 410
ALA A 365
VAL A 419
LEU A 349
 None
 1.37A 4qzuA-1nq7A:
undetectable		 4qzuA-1nq7A:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XEY_B_1N1B601_2
(TYROSINE-PROTEIN
KINASE ABL1)		 1nq7 NUCLEAR RECEPTOR
ROR-BETA
(Rattus
norvegicus) 		3 / 3 MET A 327
ASP A 344
PHE A 345
 None
 1.02A 4xeyB-1nq7A:
undetectable		 4xeyB-1nq7A:
19.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5G44_A_YTZA1512_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		 1nq7 NUCLEAR RECEPTOR
ROR-BETA
(Rattus
norvegicus) 		5 / 9 GLN A 228
LEU A 234
ARG A 306
ARG A 309
ALA A 310
 ARL  A 800 (-4.7A)
None
ARL  A 800 (-4.4A)
ARL  A 800 ( 4.9A)
ARL  A 800 ( 4.1A)
 1.10A 5g44A-1nq7A:
34.0		 5g44A-1nq7A:
46.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5G44_A_YTZA1512_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		 1nq7 NUCLEAR RECEPTOR
ROR-BETA
(Rattus
norvegicus) 		7 / 9 LEU A 234
ALA A 269
VAL A 303
ARG A 306
MET A 307
ARG A 309
ALA A 310
 None
ARL  A 800 ( 3.9A)
ARL  A 800 ( 4.7A)
ARL  A 800 (-4.4A)
ARL  A 800 (-3.7A)
ARL  A 800 ( 4.9A)
ARL  A 800 ( 4.1A)
 0.63A 5g44A-1nq7A:
34.0		 5g44A-1nq7A:
46.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_C_IPHC101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 1nq7 NUCLEAR RECEPTOR
ROR-BETA
(Rattus
norvegicus) 		4 / 5 CYH A 262
ILE A 266
LEU A 333
HIS A 423
 ARL  A 800 (-3.5A)
None
None
ARL  A 800 ( 4.3A)
 1.40A 5hrqC-1nq7A:
undetectable
5hrqD-1nq7A:
undetectable
5hrqL-1nq7A:
undetectable		 5hrqC-1nq7A:
5.61
5hrqD-1nq7A:
10.81
5hrqL-1nq7A:
10.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGZ_A_SPRA404_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 1nq7 NUCLEAR RECEPTOR
ROR-BETA
(Rattus
norvegicus) 		5 / 9 LEU A 295
ILE A 280
GLU A 285
PHE A 283
GLU A 275
 None
 1.42A 5igzA-1nq7A:
undetectable		 5igzA-1nq7A:
22.61