SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1nr0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_A_FFOA1002_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1nr0 ACTIN INTERACTING
PROTEIN 1
(Caenorhabditis
elegans) 		5 / 12 GLY A 416
LEU A 390
VAL A 392
ALA A 429
SER A 420
 None
 0.88A 1dfoA-1nr0A:
undetectable		 1dfoA-1nr0A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_A_FFOA1002_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1nr0 ACTIN INTERACTING
PROTEIN 1
(Caenorhabditis
elegans) 		5 / 12 LEU A 417
GLY A 416
LEU A 390
VAL A 392
SER A 420
 None
 0.94A 1dfoA-1nr0A:
undetectable		 1dfoA-1nr0A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_B_FFOB2002_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1nr0 ACTIN INTERACTING
PROTEIN 1
(Caenorhabditis
elegans) 		5 / 12 GLY A 416
LEU A 390
VAL A 392
ALA A 429
SER A 420
 None
 0.88A 1dfoB-1nr0A:
undetectable		 1dfoB-1nr0A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_B_FFOB2002_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1nr0 ACTIN INTERACTING
PROTEIN 1
(Caenorhabditis
elegans) 		5 / 12 LEU A 417
GLY A 416
LEU A 390
VAL A 392
SER A 420
 None
 0.94A 1dfoB-1nr0A:
undetectable		 1dfoB-1nr0A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_C_FFOC3002_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1nr0 ACTIN INTERACTING
PROTEIN 1
(Caenorhabditis
elegans) 		5 / 12 GLY A 416
LEU A 390
VAL A 392
ALA A 429
SER A 420
 None
 0.88A 1dfoC-1nr0A:
undetectable		 1dfoC-1nr0A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_C_FFOC3002_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1nr0 ACTIN INTERACTING
PROTEIN 1
(Caenorhabditis
elegans) 		5 / 12 LEU A 417
GLY A 416
LEU A 390
VAL A 392
SER A 420
 None
 0.94A 1dfoC-1nr0A:
undetectable		 1dfoC-1nr0A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_D_FFOD4002_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1nr0 ACTIN INTERACTING
PROTEIN 1
(Caenorhabditis
elegans) 		5 / 12 GLY A 416
LEU A 390
VAL A 392
ALA A 429
SER A 420
 None
 0.88A 1dfoD-1nr0A:
undetectable		 1dfoD-1nr0A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_D_FFOD4002_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1nr0 ACTIN INTERACTING
PROTEIN 1
(Caenorhabditis
elegans) 		5 / 12 LEU A 417
GLY A 416
LEU A 390
VAL A 392
SER A 420
 None
 0.94A 1dfoD-1nr0A:
undetectable		 1dfoD-1nr0A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_FFOA1293_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1nr0 ACTIN INTERACTING
PROTEIN 1
(Caenorhabditis
elegans) 		6 / 12 LEU A 417
GLY A 416
LEU A 390
VAL A 392
ALA A 429
SER A 420
 None
 1.04A 1eqbA-1nr0A:
undetectable		 1eqbA-1nr0A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_B_FFOB2293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1nr0 ACTIN INTERACTING
PROTEIN 1
(Caenorhabditis
elegans) 		5 / 12 GLY A 416
LEU A 390
VAL A 392
ALA A 429
SER A 420
 None
 0.87A 1eqbB-1nr0A:
undetectable		 1eqbB-1nr0A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_B_FFOB2293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1nr0 ACTIN INTERACTING
PROTEIN 1
(Caenorhabditis
elegans) 		5 / 12 LEU A 417
GLY A 416
LEU A 390
VAL A 392
SER A 420
 None
 0.94A 1eqbB-1nr0A:
undetectable		 1eqbB-1nr0A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_FFOC3293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1nr0 ACTIN INTERACTING
PROTEIN 1
(Caenorhabditis
elegans) 		5 / 12 GLY A 416
LEU A 390
VAL A 392
ALA A 429
SER A 420
 None
 0.88A 1eqbC-1nr0A:
undetectable		 1eqbC-1nr0A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_FFOC3293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1nr0 ACTIN INTERACTING
PROTEIN 1
(Caenorhabditis
elegans) 		5 / 12 LEU A 417
GLY A 416
LEU A 390
VAL A 392
SER A 420
 None
 0.95A 1eqbC-1nr0A:
undetectable		 1eqbC-1nr0A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_D_FFOD4293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1nr0 ACTIN INTERACTING
PROTEIN 1
(Caenorhabditis
elegans) 		5 / 12 GLY A 416
LEU A 390
VAL A 392
ALA A 429
SER A 420
 None
 0.87A 1eqbD-1nr0A:
undetectable		 1eqbD-1nr0A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_D_FFOD4293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1nr0 ACTIN INTERACTING
PROTEIN 1
(Caenorhabditis
elegans) 		5 / 12 LEU A 417
GLY A 416
LEU A 390
VAL A 392
SER A 420
 None
 0.94A 1eqbD-1nr0A:
undetectable		 1eqbD-1nr0A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5Q_B_CFFB1864_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 1nr0 ACTIN INTERACTING
PROTEIN 1
(Caenorhabditis
elegans) 		3 / 3 TRP A 544
HIS A 528
MET A 565
 None
 1.37A 1l5qB-1nr0A:
0.0		 1l5qB-1nr0A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B7Z_B_MK1B200_1
(HIV-1 PROTEASE)		 1nr0 ACTIN INTERACTING
PROTEIN 1
(Caenorhabditis
elegans) 		5 / 12 GLY A 577
ALA A 578
ILE A 595
ALA A 540
VAL A 584
 None
 1.03A 2b7zA-1nr0A:
undetectable		 2b7zA-1nr0A:
10.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1294_1
(FICOLIN-2)		 1nr0 ACTIN INTERACTING
PROTEIN 1
(Caenorhabditis
elegans) 		5 / 9 VAL A  23
SER A 195
LEU A 245
ASP A 154
ASP A 108
 None
None
None
MN  A 700 (-2.6A)
None
 1.37A 2j2pB-1nr0A:
0.0
2j2pC-1nr0A:
0.0		 2j2pB-1nr0A:
16.02
2j2pC-1nr0A:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDY_B_HCYB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 1nr0 ACTIN INTERACTING
PROTEIN 1
(Caenorhabditis
elegans) 		5 / 12 SER A 519
VAL A 520
ASN A 502
PHE A 499
TRP A 544
 None
 1.37A 2vdyB-1nr0A:
0.0		 2vdyB-1nr0A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YOE_C_FL7C1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 1nr0 ACTIN INTERACTING
PROTEIN 1
(Caenorhabditis
elegans) 		4 / 8 GLY A 356
ILE A  33
THR A  52
TYR A  35
 None
 0.86A 2yoeB-1nr0A:
0.0
2yoeC-1nr0A:
0.0		 2yoeB-1nr0A:
20.40
2yoeC-1nr0A:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM6_A_017A200_1
(PROTEASE)		 1nr0 ACTIN INTERACTING
PROTEIN 1
(Caenorhabditis
elegans) 		4 / 8 ASP A  31
GLY A  30
ALA A  29
GLY A  71
 None
 0.62A 3em6A-1nr0A:
undetectable		 3em6A-1nr0A:
10.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_A_ECLA600_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1nr0 ACTIN INTERACTING
PROTEIN 1
(Caenorhabditis
elegans) 		4 / 8 LEU A 339
THR A 338
GLY A 379
THR A 383
 None
 0.82A 3jusA-1nr0A:
undetectable		 3jusA-1nr0A:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_A_ECNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1nr0 ACTIN INTERACTING
PROTEIN 1
(Caenorhabditis
elegans) 		4 / 8 LEU A 339
THR A 338
GLY A 379
THR A 383
 None
 0.82A 3jusA-1nr0A:
undetectable		 3jusA-1nr0A:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGL_A_GLYA301_0
(GLYCYL-TRNA
SYNTHETASE ALPHA
SUBUNIT)		 1nr0 ACTIN INTERACTING
PROTEIN 1
(Caenorhabditis
elegans) 		4 / 8 ALA A  29
GLY A  30
THR A  27
GLN A 295
 None
 0.90A 3rglA-1nr0A:
undetectable		 3rglA-1nr0A:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 1nr0 ACTIN INTERACTING
PROTEIN 1
(Caenorhabditis
elegans) 		5 / 12 GLY A  19
ILE A 214
GLY A 240
ALA A 259
ALA A 257
 None
 1.04A 3sudB-1nr0A:
undetectable		 3sudB-1nr0A:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_A_SAMA401_1
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 1nr0 ACTIN INTERACTING
PROTEIN 1
(Caenorhabditis
elegans) 		4 / 5 HIS A  93
THR A  56
GLU A  53
ASP A  31
 None
 1.38A 3tm4A-1nr0A:
undetectable		 3tm4A-1nr0A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_B_SAMB401_1
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 1nr0 ACTIN INTERACTING
PROTEIN 1
(Caenorhabditis
elegans) 		4 / 5 HIS A  93
THR A  56
GLU A  53
ASP A  31
 None
 1.38A 3tm4B-1nr0A:
undetectable		 3tm4B-1nr0A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW1_B_CVIB301_0
(PUTATIVE REGULATORY
PROTEIN)		 1nr0 ACTIN INTERACTING
PROTEIN 1
(Caenorhabditis
elegans) 		5 / 12 LEU A 330
ILE A 353
ILE A 327
LEU A 590
PHE A  10
 None
 1.44A 3vw1B-1nr0A:
undetectable		 3vw1B-1nr0A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WXO_A_NIZA803_1
(CATALASE-PEROXIDASE)		 1nr0 ACTIN INTERACTING
PROTEIN 1
(Caenorhabditis
elegans) 		4 / 4 ASP A  78
THR A  63
VAL A 101
SER A  76
 None
 1.36A 3wxoA-1nr0A:
0.0		 3wxoA-1nr0A:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_A_SAMA401_0
(METHYLTRANSFERASE
NSUN4)		 1nr0 ACTIN INTERACTING
PROTEIN 1
(Caenorhabditis
elegans) 		6 / 12 CYH A 430
GLY A 466
GLY A 467
LEU A 417
PRO A 414
LEU A 410
 None
 1.41A 4fp9A-1nr0A:
undetectable		 4fp9A-1nr0A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_C_SAMC401_0
(METHYLTRANSFERASE
NSUN4)		 1nr0 ACTIN INTERACTING
PROTEIN 1
(Caenorhabditis
elegans) 		6 / 12 CYH A 430
GLY A 466
GLY A 467
LEU A 417
PRO A 414
LEU A 410
 None
 1.42A 4fp9C-1nr0A:
undetectable		 4fp9C-1nr0A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_F_SAMF401_0
(METHYLTRANSFERASE
NSUN4)		 1nr0 ACTIN INTERACTING
PROTEIN 1
(Caenorhabditis
elegans) 		6 / 12 CYH A 430
GLY A 466
GLY A 467
LEU A 417
PRO A 414
LEU A 410
 None
 1.41A 4fp9F-1nr0A:
undetectable		 4fp9F-1nr0A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8F_B_BRLB501_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1nr0 ACTIN INTERACTING
PROTEIN 1
(Caenorhabditis
elegans) 		4 / 6 ILE A 488
ILE A 434
ILE A 494
LEU A 506
 None
 0.75A 4o8fB-1nr0A:
undetectable		 4o8fB-1nr0A:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLB_A_TRPA901_0
(PROTEIN ARGONAUTE-2)		 1nr0 ACTIN INTERACTING
PROTEIN 1
(Caenorhabditis
elegans) 		3 / 3 VAL A 121
ALA A 149
PHE A 102
 None
 0.73A 4olbA-1nr0A:
undetectable		 4olbA-1nr0A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4POO_A_SAMA301_0
(PUTATIVE RNA
METHYLASE)		 1nr0 ACTIN INTERACTING
PROTEIN 1
(Caenorhabditis
elegans) 		5 / 12 THR A 171
GLY A 166
ASN A 151
HIS A 194
ASN A 170
 None
 1.36A 4pooA-1nr0A:
undetectable		 4pooA-1nr0A:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QB9_D_PARD500_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)		 1nr0 ACTIN INTERACTING
PROTEIN 1
(Caenorhabditis
elegans) 		4 / 8 SER A 256
THR A 208
SER A 195
ASP A 211
 None
 1.35A 4qb9D-1nr0A:
undetectable		 4qb9D-1nr0A:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V32_B_EF2B151_1
(CEREBLON ISOFORM 4)		 1nr0 ACTIN INTERACTING
PROTEIN 1
(Caenorhabditis
elegans) 		4 / 7 ASN A 199
PRO A 200
TRP A 247
PHE A 228
 None
 1.28A 4v32B-1nr0A:
0.0		 4v32B-1nr0A:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5N_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 1nr0 ACTIN INTERACTING
PROTEIN 1
(Caenorhabditis
elegans) 		3 / 3 VAL A 121
ALA A 149
PHE A 102
 None
 0.74A 4w5nA-1nr0A:
undetectable		 4w5nA-1nr0A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_O_BEZO801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 1nr0 ACTIN INTERACTING
PROTEIN 1
(Caenorhabditis
elegans) 		4 / 6 PHE A 505
PRO A 517
MET A 565
LEU A 506
 None
 1.33A 5dzka-1nr0A:
undetectable
5dzko-1nr0A:
undetectable		 5dzka-1nr0A:
16.53
5dzko-1nr0A:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_R_BEZR801_1
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 1nr0 ACTIN INTERACTING
PROTEIN 1
(Caenorhabditis
elegans) 		4 / 8 SER A  76
ALA A  75
HIS A  58
LEU A  95
 None
 1.15A 5dzkd-1nr0A:
undetectable
5dzkr-1nr0A:
undetectable		 5dzkd-1nr0A:
16.53
5dzkr-1nr0A:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_A_X2NA590_2
(CYP51 VARIANT1)		 1nr0 ACTIN INTERACTING
PROTEIN 1
(Caenorhabditis
elegans) 		3 / 3 PRO A  69
ILE A  94
SER A 113
 None
 0.79A 5fsaA-1nr0A:
undetectable		 5fsaA-1nr0A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HES_A_032A401_2
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)		 1nr0 ACTIN INTERACTING
PROTEIN 1
(Caenorhabditis
elegans) 		4 / 6 PHE A 175
PHE A 134
SER A 165
VAL A 153
 None
 1.03A 5hesA-1nr0A:
undetectable		 5hesA-1nr0A:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K9D_A_ACTA405_0
(DIHYDROOROTATE
DEHYDROGENASE
(QUINONE),
MITOCHONDRIAL)		 1nr0 ACTIN INTERACTING
PROTEIN 1
(Caenorhabditis
elegans) 		3 / 3 GLN A 146
THR A 171
ASP A 169
 None
 0.64A 5k9dA-1nr0A:
undetectable		 5k9dA-1nr0A:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_B_6V8B304_0
(PROTEASOME SUBUNIT
BETA TYPE-6
PROTEASOME SUBUNIT
BETA TYPE-7)		 1nr0 ACTIN INTERACTING
PROTEIN 1
(Caenorhabditis
elegans) 		5 / 12 TYR A 437
THR A 371
THR A 383
GLY A 416
ALA A 428
 None
 1.07A 5lf7V-1nr0A:
undetectable
5lf7b-1nr0A:
undetectable		 5lf7V-1nr0A:
17.88
5lf7b-1nr0A:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_N_6V8N305_0
(PROTEASOME SUBUNIT
BETA TYPE-6
PROTEASOME SUBUNIT
BETA TYPE-7)		 1nr0 ACTIN INTERACTING
PROTEIN 1
(Caenorhabditis
elegans) 		5 / 12 TYR A 437
THR A 371
THR A 383
GLY A 416
ALA A 428
 None
 1.08A 5lf7H-1nr0A:
undetectable
5lf7N-1nr0A:
undetectable		 5lf7H-1nr0A:
17.88
5lf7N-1nr0A:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUK_A_Z80A201_1
(BETA-LACTOGLOBULIN)		 1nr0 ACTIN INTERACTING
PROTEIN 1
(Caenorhabditis
elegans) 		5 / 10 ALA A 464
VAL A 472
ILE A 516
VAL A 542
ALA A 455
 None
 1.19A 5nukA-1nr0A:
0.0		 5nukA-1nr0A:
8.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWV_A_ACAA18_2
(SCRFP-TAG,GP41)		 1nr0 ACTIN INTERACTING
PROTEIN 1
(Caenorhabditis
elegans) 		4 / 7 LEU A 590
ALA A 552
LEU A 551
TRP A 563
 None
 0.88A 5nwvA-1nr0A:
0.0		 5nwvA-1nr0A:
4.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXN_B_SAMB901_0
(DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2)		 1nr0 ACTIN INTERACTING
PROTEIN 1
(Caenorhabditis
elegans) 		5 / 12 GLY A 226
SER A 256
LYS A 264
VAL A 242
ASP A 211
 None
 1.20A 6bxnB-1nr0A:
undetectable		 6bxnB-1nr0A:
19.67