SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1nr6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_A_FFOA1002_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1nr6 CYTOCHROME P450 2C5
(Oryctolagus
cuniculus) 		5 / 12 GLY A  98
LEU A  69
VAL A  67
SER A  99
SER A 387
 None
 1.10A 1dfoA-1nr6A:
undetectable		 1dfoA-1nr6A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_B_FFOB2002_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1nr6 CYTOCHROME P450 2C5
(Oryctolagus
cuniculus) 		5 / 12 GLY A  98
LEU A  69
VAL A  67
SER A  99
SER A 387
 None
 1.10A 1dfoB-1nr6A:
undetectable		 1dfoB-1nr6A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_C_FFOC3002_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1nr6 CYTOCHROME P450 2C5
(Oryctolagus
cuniculus) 		5 / 12 GLY A  98
LEU A  69
VAL A  67
SER A  99
SER A 387
 None
 1.10A 1dfoC-1nr6A:
undetectable		 1dfoC-1nr6A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_D_FFOD4002_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1nr6 CYTOCHROME P450 2C5
(Oryctolagus
cuniculus) 		5 / 12 GLY A  98
LEU A  69
VAL A  67
SER A  99
SER A 387
 None
 1.10A 1dfoD-1nr6A:
undetectable		 1dfoD-1nr6A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FXH_B_PACB1001_0
(PENICILLIN ACYLASE)		 1nr6 CYTOCHROME P450 2C5
(Oryctolagus
cuniculus) 		4 / 7 SER A 283
PHE A 279
ALA A 287
ILE A 112
 None
None
None
HEM  A 500 (-4.1A)
 0.99A 1fxhA-1nr6A:
undetectable
1fxhB-1nr6A:
0.9		 1fxhA-1nr6A:
18.22
1fxhB-1nr6A:
19.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OG5_A_SWFA502_1
(CYTOCHROME P450 2C9)		 1nr6 CYTOCHROME P450 2C5
(Oryctolagus
cuniculus) 		6 / 12 ARG A  97
LEU A 208
PHE A 114
THR A 361
LEU A 363
PRO A 364
 HEM  A 500 (-2.6A)
None
DIF  A 501 (-4.5A)
None
HEM  A 500 (-4.0A)
None
 1.14A 1og5A-1nr6A:
55.1		 1og5A-1nr6A:
77.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OG5_B_SWFB502_1
(CYTOCHROME P450 2C9)		 1nr6 CYTOCHROME P450 2C5
(Oryctolagus
cuniculus) 		5 / 12 ARG A  97
LEU A 208
THR A 361
LEU A 363
PRO A 364
 HEM  A 500 (-2.6A)
None
None
HEM  A 500 (-4.0A)
None
 1.07A 1og5B-1nr6A:
55.1		 1og5B-1nr6A:
77.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1R9O_A_FLPA501_1
(CYTOCHROME P450 2C9)		 1nr6 CYTOCHROME P450 2C5
(Oryctolagus
cuniculus) 		6 / 12 ASN A 204
ASP A 290
GLY A 293
ALA A 294
THR A 298
LEU A 363
 None
None
DIF  A 501 (-3.8A)
DIF  A 501 ( 3.3A)
HEM  A 500 ( 3.6A)
HEM  A 500 (-4.0A)
 0.55A 1r9oA-1nr6A:
53.3		 1r9oA-1nr6A:
76.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2BDM_A_TMIA501_1
(CYTOCHROME P450 2B4)		 1nr6 CYTOCHROME P450 2C5
(Oryctolagus
cuniculus) 		4 / 7 LEU A 291
PHE A 292
GLY A 295
THR A 299
 HEM  A 500 (-4.4A)
None
HEM  A 500 (-3.2A)
HEM  A 500 ( 4.3A)
 0.50A 2bdmA-1nr6A:
39.3		 2bdmA-1nr6A:
53.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WUZ_A_TPFA1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE
, PUTATIVE)		 1nr6 CYTOCHROME P450 2C5
(Oryctolagus
cuniculus) 		5 / 10 PHE A 114
ALA A 294
THR A 298
LEU A 359
VAL A 474
 DIF  A 501 (-4.5A)
DIF  A 501 ( 3.3A)
HEM  A 500 ( 3.6A)
DIF  A 501 (-4.4A)
None
 0.94A 2wuzA-1nr6A:
33.7		 2wuzA-1nr6A:
26.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WUZ_B_TPFB1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE
, PUTATIVE)		 1nr6 CYTOCHROME P450 2C5
(Oryctolagus
cuniculus) 		5 / 10 PHE A 114
ALA A 294
THR A 298
LEU A 359
VAL A 474
 DIF  A 501 (-4.5A)
DIF  A 501 ( 3.3A)
HEM  A 500 ( 3.6A)
DIF  A 501 (-4.4A)
None
 0.93A 2wuzB-1nr6A:
33.6		 2wuzB-1nr6A:
26.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WX2_A_TPFA1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 1nr6 CYTOCHROME P450 2C5
(Oryctolagus
cuniculus) 		4 / 7 PHE A 114
ALA A 294
THR A 298
LEU A 359
 DIF  A 501 (-4.5A)
DIF  A 501 ( 3.3A)
HEM  A 500 ( 3.6A)
DIF  A 501 (-4.4A)
 0.86A 2wx2A-1nr6A:
32.1		 2wx2A-1nr6A:
26.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WX2_B_TPFB1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 1nr6 CYTOCHROME P450 2C5
(Oryctolagus
cuniculus) 		4 / 8 PHE A 114
ALA A 294
THR A 298
LEU A 359
 DIF  A 501 (-4.5A)
DIF  A 501 ( 3.3A)
HEM  A 500 ( 3.6A)
DIF  A 501 (-4.4A)
 0.81A 2wx2B-1nr6A:
31.5		 2wx2B-1nr6A:
26.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRZ_B_ACTB1463_0
(DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE)		 1nr6 CYTOCHROME P450 2C5
(Oryctolagus
cuniculus) 		4 / 7 VAL A 367
ILE A 378
GLY A 381
THR A 382
 None
 0.76A 2xrzB-1nr6A:
undetectable		 2xrzB-1nr6A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGO_A_PCFA1213_1
(WNT INHIBITORY
FACTOR 1)		 1nr6 CYTOCHROME P450 2C5
(Oryctolagus
cuniculus) 		4 / 6 LEU A 464
ILE A 466
PRO A 478
VAL A 153
 None
 1.13A 2ygoA-1nr6A:
0.0		 2ygoA-1nr6A:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM8_A_ACAA511_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 1nr6 CYTOCHROME P450 2C5
(Oryctolagus
cuniculus) 		4 / 8 ALA A 468
ILE A 466
ILE A 356
HIS A 313
 None
 1.02A 2zm8A-1nr6A:
undetectable		 2zm8A-1nr6A:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZMA_A_ACAA501_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 1nr6 CYTOCHROME P450 2C5
(Oryctolagus
cuniculus) 		4 / 8 ALA A 468
ILE A 466
ILE A 356
HIS A 313
 None
 1.01A 2zmaA-1nr6A:
undetectable		 2zmaA-1nr6A:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A25_A_SAMA279_0
(UNCHARACTERIZED
PROTEIN PH0793)		 1nr6 CYTOCHROME P450 2C5
(Oryctolagus
cuniculus) 		5 / 12 ARG A 124
PHE A  94
GLY A  96
ASP A 383
PHE A 373
 HEM  A 500 (-4.0A)
None
None
None
None
 1.43A 3a25A-1nr6A:
undetectable		 3a25A-1nr6A:
22.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3E4E_A_4PZA501_1
(CYTOCHROME P450 2E1)		 1nr6 CYTOCHROME P450 2C5
(Oryctolagus
cuniculus) 		3 / 3 ALA A 294
THR A 298
CYH A 432
 DIF  A 501 ( 3.3A)
HEM  A 500 ( 3.6A)
HEM  A 500 (-2.3A)
 0.47A 3e4eA-1nr6A:
51.4		 3e4eA-1nr6A:
57.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3E4E_B_4PZB501_1
(CYTOCHROME P450 2E1)		 1nr6 CYTOCHROME P450 2C5
(Oryctolagus
cuniculus) 		3 / 3 ALA A 294
THR A 298
CYH A 432
 DIF  A 501 ( 3.3A)
HEM  A 500 ( 3.6A)
HEM  A 500 (-2.3A)
 0.41A 3e4eB-1nr6A:
51.5		 3e4eB-1nr6A:
57.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCP_B_CHDB4_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1nr6 CYTOCHROME P450 2C5
(Oryctolagus
cuniculus) 		3 / 3 GLY A  27
PRO A 379
LEU A  29
 None
 0.59A 3hcpB-1nr6A:
undetectable		 3hcpB-1nr6A:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KHM_A_TPFA501_1
(STEROL 14
ALPHA-DEMETHYLASE)		 1nr6 CYTOCHROME P450 2C5
(Oryctolagus
cuniculus) 		4 / 8 PHE A 114
ALA A 294
THR A 298
LEU A 359
 DIF  A 501 (-4.5A)
DIF  A 501 ( 3.3A)
HEM  A 500 ( 3.6A)
DIF  A 501 (-4.4A)
 0.74A 3khmA-1nr6A:
32.7		 3khmA-1nr6A:
26.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L4D_A_TPFA490_1
(STEROL 14-ALPHA
DEMETHYLASE)		 1nr6 CYTOCHROME P450 2C5
(Oryctolagus
cuniculus) 		4 / 8 PHE A 114
ALA A 294
THR A 298
LEU A 359
 DIF  A 501 (-4.5A)
DIF  A 501 ( 3.3A)
HEM  A 500 ( 3.6A)
DIF  A 501 (-4.4A)
 0.78A 3l4dA-1nr6A:
33.3		 3l4dA-1nr6A:
27.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L4D_D_TPFD490_1
(STEROL 14-ALPHA
DEMETHYLASE)		 1nr6 CYTOCHROME P450 2C5
(Oryctolagus
cuniculus) 		4 / 8 PHE A 114
ALA A 294
THR A 298
LEU A 359
 DIF  A 501 (-4.5A)
DIF  A 501 ( 3.3A)
HEM  A 500 ( 3.6A)
DIF  A 501 (-4.4A)
 0.74A 3l4dD-1nr6A:
32.9		 3l4dD-1nr6A:
27.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXV_C_478C200_1
(HIV-1 PROTEASE)		 1nr6 CYTOCHROME P450 2C5
(Oryctolagus
cuniculus) 		5 / 9 GLY A 293
VAL A 177
GLY A 434
VAL A 433
ILE A 178
 DIF  A 501 (-3.8A)
None
HEM  A 500 (-3.6A)
HEM  A 500 ( 4.3A)
None
 0.92A 3oxvC-1nr6A:
undetectable		 3oxvC-1nr6A:
11.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RUK_A_AERA601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 1nr6 CYTOCHROME P450 2C5
(Oryctolagus
cuniculus) 		6 / 12 ALA A 113
PHE A 114
ASP A 290
ALA A 294
THR A 298
CYH A 432
 DIF  A 501 (-3.6A)
DIF  A 501 (-4.5A)
None
DIF  A 501 ( 3.3A)
HEM  A 500 ( 3.6A)
HEM  A 500 (-2.3A)
 0.70A 3rukA-1nr6A:
44.2		 3rukA-1nr6A:
32.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RUK_A_AERA601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 1nr6 CYTOCHROME P450 2C5
(Oryctolagus
cuniculus) 		6 / 12 ALA A 113
PHE A 114
ASP A 290
ALA A 294
THR A 298
VAL A 474
 DIF  A 501 (-3.6A)
DIF  A 501 (-4.5A)
None
DIF  A 501 ( 3.3A)
HEM  A 500 ( 3.6A)
None
 1.23A 3rukA-1nr6A:
44.2		 3rukA-1nr6A:
32.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RUK_B_AERB601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 1nr6 CYTOCHROME P450 2C5
(Oryctolagus
cuniculus) 		6 / 12 ALA A 113
PHE A 114
ASP A 290
GLY A 293
ALA A 294
THR A 298
 DIF  A 501 (-3.6A)
DIF  A 501 (-4.5A)
None
DIF  A 501 (-3.8A)
DIF  A 501 ( 3.3A)
HEM  A 500 ( 3.6A)
 0.76A 3rukB-1nr6A:
44.1		 3rukB-1nr6A:
32.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RUK_D_AERD601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 1nr6 CYTOCHROME P450 2C5
(Oryctolagus
cuniculus) 		7 / 11 ALA A 113
PHE A 114
ASP A 290
GLY A 293
ALA A 294
THR A 298
VAL A 474
 DIF  A 501 (-3.6A)
DIF  A 501 (-4.5A)
None
DIF  A 501 (-3.8A)
DIF  A 501 ( 3.3A)
HEM  A 500 ( 3.6A)
None
 1.38A 3rukD-1nr6A:
43.4		 3rukD-1nr6A:
32.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3T3S_D_9PLD1_1
(CYTOCHROME P450 2A13)		 1nr6 CYTOCHROME P450 2C5
(Oryctolagus
cuniculus) 		4 / 8 ALA A 113
PHE A 114
ALA A 294
THR A 298
 DIF  A 501 (-3.6A)
DIF  A 501 (-4.5A)
DIF  A 501 ( 3.3A)
HEM  A 500 ( 3.6A)
 0.78A 3t3sD-1nr6A:
49.4		 3t3sD-1nr6A:
54.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3T3Z_A_9PLA501_1
(CYTOCHROME P450 2E1)		 1nr6 CYTOCHROME P450 2C5
(Oryctolagus
cuniculus) 		4 / 6 PHE A 114
ALA A 294
THR A 298
LEU A 363
 DIF  A 501 (-4.5A)
DIF  A 501 ( 3.3A)
HEM  A 500 ( 3.6A)
HEM  A 500 (-4.0A)
 0.70A 3t3zA-1nr6A:
50.9		 3t3zA-1nr6A:
57.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3T3Z_B_9PLB501_1
(CYTOCHROME P450 2E1)		 1nr6 CYTOCHROME P450 2C5
(Oryctolagus
cuniculus) 		4 / 6 PHE A 114
ALA A 294
THR A 298
LEU A 363
 DIF  A 501 (-4.5A)
DIF  A 501 ( 3.3A)
HEM  A 500 ( 3.6A)
HEM  A 500 (-4.0A)
 0.69A 3t3zB-1nr6A:
50.7		 3t3zB-1nr6A:
57.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3T3Z_C_9PLC501_1
(CYTOCHROME P450 2E1)		 1nr6 CYTOCHROME P450 2C5
(Oryctolagus
cuniculus) 		4 / 5 PHE A 114
ALA A 294
THR A 298
LEU A 363
 DIF  A 501 (-4.5A)
DIF  A 501 ( 3.3A)
HEM  A 500 ( 3.6A)
HEM  A 500 (-4.0A)
 0.73A 3t3zC-1nr6A:
50.7		 3t3zC-1nr6A:
57.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3T3Z_D_9PLD501_1
(CYTOCHROME P450 2E1)		 1nr6 CYTOCHROME P450 2C5
(Oryctolagus
cuniculus) 		4 / 6 PHE A 114
ALA A 294
THR A 298
LEU A 363
 DIF  A 501 (-4.5A)
DIF  A 501 ( 3.3A)
HEM  A 500 ( 3.6A)
HEM  A 500 (-4.0A)
 0.70A 3t3zD-1nr6A:
50.7		 3t3zD-1nr6A:
57.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW1_B_CVIB301_0
(PUTATIVE REGULATORY
PROTEIN)		 1nr6 CYTOCHROME P450 2C5
(Oryctolagus
cuniculus) 		5 / 12 ILE A 169
ALA A 317
LEU A 152
PHE A 484
LEU A 455
 None
 1.00A 3vw1B-1nr6A:
0.8		 3vw1B-1nr6A:
20.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EJG_B_NCTB501_1
(CYTOCHROME P450 2A13)		 1nr6 CYTOCHROME P450 2C5
(Oryctolagus
cuniculus) 		4 / 8 PHE A 114
ALA A 294
THR A 298
LEU A 359
 DIF  A 501 (-4.5A)
DIF  A 501 ( 3.3A)
HEM  A 500 ( 3.6A)
DIF  A 501 (-4.4A)
 0.82A 4ejgB-1nr6A:
50.0		 4ejgB-1nr6A:
54.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EJG_D_NCTD501_1
(CYTOCHROME P450 2A13)		 1nr6 CYTOCHROME P450 2C5
(Oryctolagus
cuniculus) 		4 / 6 PHE A 114
ALA A 294
THR A 298
LEU A 359
 DIF  A 501 (-4.5A)
DIF  A 501 ( 3.3A)
HEM  A 500 ( 3.6A)
DIF  A 501 (-4.4A)
 0.81A 4ejgD-1nr6A:
50.1		 4ejgD-1nr6A:
54.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_E_ACTE504_0
(RNA POLYMERASE
3D-POL)		 1nr6 CYTOCHROME P450 2C5
(Oryctolagus
cuniculus) 		3 / 3 VAL A  88
GLY A  91
LYS A 429
 None
 0.78A 4k50E-1nr6A:
undetectable		 4k50E-1nr6A:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_I_ACTI504_0
(RNA POLYMERASE
3D-POL)		 1nr6 CYTOCHROME P450 2C5
(Oryctolagus
cuniculus) 		3 / 3 VAL A  88
GLY A  91
LYS A 429
 None
 0.79A 4k50I-1nr6A:
undetectable		 4k50I-1nr6A:
22.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NKV_A_AERA601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 1nr6 CYTOCHROME P450 2C5
(Oryctolagus
cuniculus) 		5 / 12 LEU A 103
ALA A 113
GLY A 293
ALA A 294
THR A 298
 DIF  A 501 (-3.9A)
DIF  A 501 (-3.6A)
DIF  A 501 (-3.8A)
DIF  A 501 ( 3.3A)
HEM  A 500 ( 3.6A)
 1.02A 4nkvA-1nr6A:
44.1		 4nkvA-1nr6A:
32.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NKV_C_AERC601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 1nr6 CYTOCHROME P450 2C5
(Oryctolagus
cuniculus) 		5 / 12 LEU A 103
ALA A 113
PHE A 114
ALA A 294
THR A 298
 DIF  A 501 (-3.9A)
DIF  A 501 (-3.6A)
DIF  A 501 (-4.5A)
DIF  A 501 ( 3.3A)
HEM  A 500 ( 3.6A)
 1.15A 4nkvC-1nr6A:
44.0		 4nkvC-1nr6A:
32.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NKX_A_STRA601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 1nr6 CYTOCHROME P450 2C5
(Oryctolagus
cuniculus) 		6 / 12 LEU A 103
ALA A 113
PHE A 114
GLY A 293
ALA A 294
THR A 298
 DIF  A 501 (-3.9A)
DIF  A 501 (-3.6A)
DIF  A 501 (-4.5A)
DIF  A 501 (-3.8A)
DIF  A 501 ( 3.3A)
HEM  A 500 ( 3.6A)
 1.13A 4nkxA-1nr6A:
44.1		 4nkxA-1nr6A:
32.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NKX_B_STRB601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 1nr6 CYTOCHROME P450 2C5
(Oryctolagus
cuniculus) 		6 / 12 LEU A 103
ALA A 113
PHE A 114
GLY A 293
ALA A 294
THR A 298
 DIF  A 501 (-3.9A)
DIF  A 501 (-3.6A)
DIF  A 501 (-4.5A)
DIF  A 501 (-3.8A)
DIF  A 501 ( 3.3A)
HEM  A 500 ( 3.6A)
 1.12A 4nkxB-1nr6A:
44.1		 4nkxB-1nr6A:
32.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NKX_C_STRC601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 1nr6 CYTOCHROME P450 2C5
(Oryctolagus
cuniculus) 		6 / 12 LEU A 103
ALA A 113
PHE A 114
GLY A 293
ALA A 294
THR A 298
 DIF  A 501 (-3.9A)
DIF  A 501 (-3.6A)
DIF  A 501 (-4.5A)
DIF  A 501 (-3.8A)
DIF  A 501 ( 3.3A)
HEM  A 500 ( 3.6A)
 1.07A 4nkxC-1nr6A:
44.0		 4nkxC-1nr6A:
32.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NKX_D_STRD601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 1nr6 CYTOCHROME P450 2C5
(Oryctolagus
cuniculus) 		6 / 12 LEU A 103
ALA A 113
PHE A 114
GLY A 293
ALA A 294
THR A 298
 DIF  A 501 (-3.9A)
DIF  A 501 (-3.6A)
DIF  A 501 (-4.5A)
DIF  A 501 (-3.8A)
DIF  A 501 ( 3.3A)
HEM  A 500 ( 3.6A)
 1.11A 4nkxD-1nr6A:
44.1		 4nkxD-1nr6A:
32.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4R1Z_A_AERA601_1
(CYP17A1 PROTEIN)		 1nr6 CYTOCHROME P450 2C5
(Oryctolagus
cuniculus) 		5 / 9 ALA A 113
ASP A 290
GLY A 293
ALA A 294
THR A 298
 DIF  A 501 (-3.6A)
None
DIF  A 501 (-3.8A)
DIF  A 501 ( 3.3A)
HEM  A 500 ( 3.6A)
 0.95A 4r1zA-1nr6A:
44.1		 4r1zA-1nr6A:
32.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4R20_B_AERB602_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 1nr6 CYTOCHROME P450 2C5
(Oryctolagus
cuniculus) 		5 / 9 ALA A 113
PHE A 114
ILE A 240
THR A 298
VAL A 205
 DIF  A 501 (-3.6A)
DIF  A 501 (-4.5A)
None
HEM  A 500 ( 3.6A)
None
 1.23A 4r20B-1nr6A:
43.5		 4r20B-1nr6A:
35.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_B_RBFB201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 1nr6 CYTOCHROME P450 2C5
(Oryctolagus
cuniculus) 		4 / 8 ILE A 485
LEU A 446
VAL A 153
LEU A 156
 None
 0.93A 4r38B-1nr6A:
undetectable		 4r38B-1nr6A:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R3A_A_RBFA402_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 1nr6 CYTOCHROME P450 2C5
(Oryctolagus
cuniculus) 		4 / 8 THR A 298
GLU A 435
LEU A 363
GLY A 295
 HEM  A 500 ( 3.6A)
None
HEM  A 500 (-4.0A)
HEM  A 500 (-3.2A)
 0.78A 4r3aA-1nr6A:
undetectable		 4r3aA-1nr6A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G48_B_1FLB1375_1
(DNA POLYMERASE III
SUBUNIT BETA)		 1nr6 CYTOCHROME P450 2C5
(Oryctolagus
cuniculus) 		5 / 9 LEU A 213
THR A 210
LEU A 208
PRO A 101
LEU A 207
 None
 1.37A 5g48B-1nr6A:
0.0		 5g48B-1nr6A:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE8_C_08JC602_1
(CYTOCHROME P450 3A4)		 1nr6 CYTOCHROME P450 2C5
(Oryctolagus
cuniculus) 		4 / 7 SER A 127
LEU A 291
ALA A 287
ILE A 244
 None
HEM  A 500 (-4.4A)
None
None
 0.81A 5te8C-1nr6A:
34.8		 5te8C-1nr6A:
29.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TL8_A_X2NA502_1
(PROTEIN CYP51)		 1nr6 CYTOCHROME P450 2C5
(Oryctolagus
cuniculus) 		6 / 12 ALA A  47
PHE A 114
ALA A 113
ALA A 294
THR A 298
LEU A 359
 None
DIF  A 501 (-4.5A)
DIF  A 501 (-3.6A)
DIF  A 501 ( 3.3A)
HEM  A 500 ( 3.6A)
DIF  A 501 (-4.4A)
 1.38A 5tl8A-1nr6A:
34.9		 5tl8A-1nr6A:
28.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VEU_B_RITB602_1
(CYTOCHROME P450 3A5)		 1nr6 CYTOCHROME P450 2C5
(Oryctolagus
cuniculus) 		5 / 12 LEU A  69
ILE A  45
ALA A  47
ILE A 229
GLY A 209
 None
 1.04A 5veuB-1nr6A:
37.8		 5veuB-1nr6A:
30.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X23_A_LSNA502_1
(CYTOCHROME P450 2C9)		 1nr6 CYTOCHROME P450 2C5
(Oryctolagus
cuniculus) 		5 / 12 PHE A 114
GLY A 293
ALA A 294
LEU A 359
LEU A 363
 DIF  A 501 (-4.5A)
DIF  A 501 (-3.8A)
DIF  A 501 ( 3.3A)
DIF  A 501 (-4.4A)
HEM  A 500 (-4.0A)
 0.58A 5x23A-1nr6A:
55.6		 5x23A-1nr6A:
76.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X24_A_LSNA502_1
(CYTOCHROME P450 2C9)		 1nr6 CYTOCHROME P450 2C5
(Oryctolagus
cuniculus) 		6 / 12 ASN A 204
LEU A 233
ASP A 290
GLY A 293
THR A 298
LEU A 363
 None
None
None
DIF  A 501 (-3.8A)
HEM  A 500 ( 3.6A)
HEM  A 500 (-4.0A)
 0.86A 5x24A-1nr6A:
55.2		 5x24A-1nr6A:
76.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X24_A_LSNA502_1
(CYTOCHROME P450 2C9)		 1nr6 CYTOCHROME P450 2C5
(Oryctolagus
cuniculus) 		5 / 12 PHE A 114
LEU A 233
ASP A 290
THR A 298
LEU A 363
 DIF  A 501 (-4.5A)
None
None
HEM  A 500 ( 3.6A)
HEM  A 500 (-4.0A)
 0.84A 5x24A-1nr6A:
55.2		 5x24A-1nr6A:
76.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5XXI_A_LSNA501_1
(CYTOCHROME P450 2C9)		 1nr6 CYTOCHROME P450 2C5
(Oryctolagus
cuniculus) 		6 / 12 ASN A 204
ASP A 290
GLY A 293
ALA A 294
LEU A 359
LEU A 363
 None
None
DIF  A 501 (-3.8A)
DIF  A 501 ( 3.3A)
DIF  A 501 (-4.4A)
HEM  A 500 (-4.0A)
 0.61A 5xxiA-1nr6A:
55.4		 5xxiA-1nr6A:
76.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5XXI_A_LSNA503_1
(CYTOCHROME P450 2C9)		 1nr6 CYTOCHROME P450 2C5
(Oryctolagus
cuniculus) 		5 / 12 PHE A 114
LEU A 359
PRO A 360
THR A 361
PRO A 364
 DIF  A 501 (-4.5A)
DIF  A 501 (-4.4A)
None
None
None
 0.67A 5xxiA-1nr6A:
55.4		 5xxiA-1nr6A:
76.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA412_0
(UNCHARACTERIZED
PROTEIN KDOO)		 1nr6 CYTOCHROME P450 2C5
(Oryctolagus
cuniculus) 		3 / 3 LYS A  72
ASN A 218
SER A  99
 None
 1.27A 5yw0A-1nr6A:
0.0		 5yw0A-1nr6A:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YWM_X_NIOX403_0
(CASEIN KINASE II
SUBUNIT ALPHA')		 1nr6 CYTOCHROME P450 2C5
(Oryctolagus
cuniculus) 		4 / 7 VAL A  76
VAL A  67
ILE A  45
ILE A  50
 None
 0.79A 5ywmX-1nr6A:
undetectable		 5ywmX-1nr6A:
10.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AYC_A_1YNA502_1
(PROTEIN CYP51)		 1nr6 CYTOCHROME P450 2C5
(Oryctolagus
cuniculus) 		6 / 12 ALA A  47
PHE A 114
ALA A 113
ALA A 294
THR A 298
LEU A 359
 None
DIF  A 501 (-4.5A)
DIF  A 501 (-3.6A)
DIF  A 501 ( 3.3A)
HEM  A 500 ( 3.6A)
DIF  A 501 (-4.4A)
 1.45A 6aycA-1nr6A:
35.2		 6aycA-1nr6A:
11.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXN_B_SAMB901_0
(DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2)		 1nr6 CYTOCHROME P450 2C5
(Oryctolagus
cuniculus) 		5 / 12 LEU A 437
GLY A 436
SER A 306
ILE A 349
ASP A 346
 HEM  A 500 ( 4.3A)
None
None
None
None
 1.38A 6bxnB-1nr6A:
undetectable		 6bxnB-1nr6A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CGD_A_AKNA600_1
(BIFUNCTIONAL AAC/APH)		 1nr6 CYTOCHROME P450 2C5
(Oryctolagus
cuniculus) 		5 / 10 ASP A 420
TYR A  80
GLU A  81
VAL A  88
GLU A  85
 None
 1.14A 6cgdA-1nr6A:
0.4		 6cgdA-1nr6A:
10.82