SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1nr9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_3
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1nr9 PROTEIN YCGM
(Escherichia
coli) 		3 / 3 THR A 190
LEU A 189
LEU A 102
 None
 0.64A 1mz9C-1nr9A:
undetectable		 1mz9C-1nr9A:
12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_B_SAMB300_1
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 1nr9 PROTEIN YCGM
(Escherichia
coli) 		4 / 5 SER A 131
GLY A  97
HIS A  69
ASP A 194
 None
 0.95A 2oxtB-1nr9A:
undetectable		 2oxtB-1nr9A:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X7H_B_PFNB1374_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 1nr9 PROTEIN YCGM
(Escherichia
coli) 		4 / 4 TYR A   2
LEU A  54
LEU A 130
HIS A   4
 None
 1.42A 2x7hB-1nr9A:
undetectable		 2x7hB-1nr9A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YS6_A_GLYA431_0
(PHOSPHORIBOSYLGLYCIN
AMIDE SYNTHETASE)		 1nr9 PROTEIN YCGM
(Escherichia
coli) 		4 / 8 ASP A 101
LYS A 122
GLY A 191
GLU A  72
 MG  A 301 (-3.5A)
MG  A 301 (-3.2A)
None
MG  A 301 (-3.8A)
 0.88A 2ys6A-1nr9A:
undetectable		 2ys6A-1nr9A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_C_SAMC300_1
(PUTATIVE RRNA
METHYLASE)		 1nr9 PROTEIN YCGM
(Escherichia
coli) 		3 / 3 ASN A   6
ASP A  53
GLN A  56
 None
 0.79A 3eeyC-1nr9A:
undetectable		 3eeyC-1nr9A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_E_SAME300_1
(PUTATIVE RRNA
METHYLASE)		 1nr9 PROTEIN YCGM
(Escherichia
coli) 		3 / 3 ASN A   6
ASP A  53
GLN A  56
 None
 0.80A 3eeyE-1nr9A:
undetectable		 3eeyE-1nr9A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8W_A_FLPA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1nr9 PROTEIN YCGM
(Escherichia
coli) 		6 / 12 VAL A  19
LEU A  54
TYR A   2
GLY A  97
ALA A  74
LEU A 189
 None
 1.24A 3n8wA-1nr9A:
undetectable		 3n8wA-1nr9A:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Z_A_FLPA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1nr9 PROTEIN YCGM
(Escherichia
coli) 		6 / 12 VAL A  19
LEU A  54
TYR A   2
GLY A  97
ALA A  74
LEU A 189
 None
 1.26A 3n8zA-1nr9A:
undetectable		 3n8zA-1nr9A:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_C_FLPC701_1
(CYCLOOXYGENASE-2)		 1nr9 PROTEIN YCGM
(Escherichia
coli) 		6 / 12 VAL A  19
LEU A  54
TYR A   2
GLY A  97
ALA A  74
LEU A 189
 None
 1.28A 3pghC-1nr9A:
undetectable		 3pghC-1nr9A:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QKN_A_JMSA602_1
(ALPHA-KETOGLUTARATE-
DEPENDENT
DIOXYGENASE FTO)		 1nr9 PROTEIN YCGM
(Escherichia
coli) 		4 / 8 THR A 192
PRO A 193
LEU A 100
SER A 149
 None
 0.84A 4qknA-1nr9A:
undetectable		 4qknA-1nr9A:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4E_D_EDPD402_1
(PROTON-GATED ION
CHANNEL)		 1nr9 PROTEIN YCGM
(Escherichia
coli) 		4 / 8 THR A 208
SER A 149
THR A 206
SER A 151
 None
 0.96A 5l4eA-1nr9A:
undetectable
5l4eB-1nr9A:
undetectable
5l4eC-1nr9A:
undetectable
5l4eD-1nr9A:
undetectable
5l4eE-1nr9A:
undetectable		 5l4eA-1nr9A:
18.18
5l4eB-1nr9A:
18.18
5l4eC-1nr9A:
18.18
5l4eD-1nr9A:
18.18
5l4eE-1nr9A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1806_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1nr9 PROTEIN YCGM
(Escherichia
coli) 		4 / 6 ILE A  93
LEU A 130
PHE A 133
HIS A   4
 None
 0.93A 5vkqB-1nr9A:
undetectable
5vkqC-1nr9A:
undetectable		 5vkqB-1nr9A:
8.98
5vkqC-1nr9A:
8.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1807_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1nr9 PROTEIN YCGM
(Escherichia
coli) 		4 / 6 ILE A  93
LEU A 130
PHE A 133
HIS A   4
 None
 0.92A 5vkqC-1nr9A:
undetectable
5vkqD-1nr9A:
undetectable		 5vkqC-1nr9A:
8.98
5vkqD-1nr9A:
8.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_A_STIA603_1
(TYROSINE-PROTEIN
KINASE ABL1)		 1nr9 PROTEIN YCGM
(Escherichia
coli) 		4 / 5 LEU A  12
TYR A  14
ILE A  45
GLY A  95
 None
 1.05A 6hd6A-1nr9A:
undetectable		 6hd6A-1nr9A:
17.33