SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1nrf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GHM_A_CEDA1_1
(BETA-LACTAMASE)		 1nrf REGULATORY PROTEIN
BLAR1
(Bacillus
licheniformis) 		7 / 12 ALA A 401
SER A 402
LYS A 405
TYR A 434
SER A 450
LYS A 539
GLY A 541
 None
 0.81A 1ghmA-1nrfA:
18.1		 1ghmA-1nrfA:
25.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_A_CFXA1300_1
(BETA-LACTAMASE)		 1nrf REGULATORY PROTEIN
BLAR1
(Bacillus
licheniformis) 		6 / 12 ALA A 401
SER A 402
LYS A 405
SER A 450
LYS A 539
GLY A 541
 None
 0.58A 1i2wA-1nrfA:
19.3		 1i2wA-1nrfA:
24.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW3_A_SAMA500_0
(HISTONE
METHYLTRANSFERASE
DOT1L)		 1nrf REGULATORY PROTEIN
BLAR1
(Bacillus
licheniformis) 		5 / 12 GLY A 556
VAL A 406
ALA A 583
LEU A 378
PHE A 507
 None
 1.13A 1nw3A-1nrfA:
undetectable		 1nw3A-1nrfA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_A_BEZA1003_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 1nrf REGULATORY PROTEIN
BLAR1
(Bacillus
licheniformis) 		4 / 7 ARG A 534
LEU A 536
PHE A 565
THR A 560
 None
 0.95A 2f78A-1nrfA:
undetectable		 2f78A-1nrfA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_B_BEZB1004_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 1nrf REGULATORY PROTEIN
BLAR1
(Bacillus
licheniformis) 		4 / 7 ARG A 534
LEU A 536
PHE A 565
THR A 560
 None
 1.10A 2f78B-1nrfA:
undetectable		 2f78B-1nrfA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_A_SAMA601_0
(HYPOTHETICAL PROTEIN)		 1nrf REGULATORY PROTEIN
BLAR1
(Bacillus
licheniformis) 		5 / 12 GLY A 552
GLY A 579
SER A 580
ALA A 401
PHE A 398
 None
 0.88A 2yvlA-1nrfA:
undetectable		 2yvlA-1nrfA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZMB_A_PXBA692_1
(LACTOTRANSFERRIN)		 1nrf REGULATORY PROTEIN
BLAR1
(Bacillus
licheniformis) 		3 / 3 PRO A 400
GLU A 479
TYR A 476
 None
 0.75A 2zmbA-1nrfA:
undetectable		 2zmbA-1nrfA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NY4_A_SMXA308_1
(BETA-LACTAMASE)		 1nrf REGULATORY PROTEIN
BLAR1
(Bacillus
licheniformis) 		6 / 12 SER A 402
SER A 450
LYS A 539
THR A 540
GLY A 541
THR A 542
 None
 0.35A 3ny4A-1nrfA:
19.0		 3ny4A-1nrfA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SH8_A_CEDA1_1
(BETA-LACTAMASE)		 1nrf REGULATORY PROTEIN
BLAR1
(Bacillus
licheniformis) 		6 / 12 ALA A 401
SER A 402
SER A 450
LYS A 539
THR A 540
GLY A 541
 None
 0.43A 3sh8A-1nrfA:
19.6		 3sh8A-1nrfA:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EUZ_A_MEMA401_1
(CARBAPENEM-HYDROLIZI
NG BETA-LACTAMASE
SFC-1)		 1nrf REGULATORY PROTEIN
BLAR1
(Bacillus
licheniformis) 		6 / 12 LYS A 405
SER A 450
LYS A 539
THR A 540
GLY A 541
THR A 542
 None
 0.73A 4euzA-1nrfA:
18.7		 4euzA-1nrfA:
24.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N9K_A_CEDA301_1
(BETA-LACTAMASE)		 1nrf REGULATORY PROTEIN
BLAR1
(Bacillus
licheniformis) 		6 / 12 ALA A 401
SER A 402
SER A 450
LYS A 539
THR A 540
GLY A 541
 None
 0.47A 4n9kA-1nrfA:
19.5		 4n9kA-1nrfA:
24.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N9K_B_CEDB301_1
(BETA-LACTAMASE)		 1nrf REGULATORY PROTEIN
BLAR1
(Bacillus
licheniformis) 		6 / 12 ALA A 401
SER A 402
SER A 450
LYS A 539
THR A 540
GLY A 541
 None
 0.44A 4n9kB-1nrfA:
19.5		 4n9kB-1nrfA:
24.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD9_A_ADNA501_2
(NUPC FAMILY PROTEIN)		 1nrf REGULATORY PROTEIN
BLAR1
(Bacillus
licheniformis) 		3 / 3 THR A 564
ASN A 510
PHE A 512
 None
 0.83A 4pd9A-1nrfA:
undetectable		 4pd9A-1nrfA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y4D_A_CFFA411_1
(ENDOTHIAPEPSIN)		 1nrf REGULATORY PROTEIN
BLAR1
(Bacillus
licheniformis) 		4 / 6 LEU A 590
PHE A 567
ILE A 388
PHE A 376
 None
 1.21A 4y4dA-1nrfA:
0.0		 4y4dA-1nrfA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_S_BEZS801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 1nrf REGULATORY PROTEIN
BLAR1
(Bacillus
licheniformis) 		4 / 6 PHE A 407
SER A 473
LEU A 411
LEU A 410
 None
 1.03A 5dzke-1nrfA:
undetectable
5dzks-1nrfA:
undetectable		 5dzke-1nrfA:
22.18
5dzks-1nrfA:
2.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESE_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1nrf REGULATORY PROTEIN
BLAR1
(Bacillus
licheniformis) 		4 / 8 LEU A 587
PHE A 567
PHE A 554
GLY A 538
 None
 0.86A 5eseA-1nrfA:
undetectable		 5eseA-1nrfA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESE_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1nrf REGULATORY PROTEIN
BLAR1
(Bacillus
licheniformis) 		4 / 8 TYR A 596
LEU A 587
PHE A 554
GLY A 556
 None
 0.87A 5eseA-1nrfA:
undetectable		 5eseA-1nrfA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESF_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1nrf REGULATORY PROTEIN
BLAR1
(Bacillus
licheniformis) 		4 / 8 PHE A 567
TYR A 596
PHE A 554
GLY A 538
 None
 0.82A 5esfA-1nrfA:
undetectable		 5esfA-1nrfA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_A_X2NA590_1
(CYP51 VARIANT1)		 1nrf REGULATORY PROTEIN
BLAR1
(Bacillus
licheniformis) 		5 / 12 TYR A 596
LEU A 587
PHE A 567
PHE A 554
GLY A 538
 None
 1.05A 5fsaA-1nrfA:
undetectable		 5fsaA-1nrfA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GHZ_A_CEDA301_1
(BETA-LACTAMASE)		 1nrf REGULATORY PROTEIN
BLAR1
(Bacillus
licheniformis) 		6 / 11 ALA A 401
SER A 402
SER A 450
LYS A 539
THR A 540
GLY A 541
 None
 0.45A 5ghzA-1nrfA:
19.5		 5ghzA-1nrfA:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GHZ_B_CEDB301_1
(BETA-LACTAMASE)		 1nrf REGULATORY PROTEIN
BLAR1
(Bacillus
licheniformis) 		6 / 10 ALA A 401
SER A 402
SER A 450
LYS A 539
THR A 540
GLY A 541
 None
 0.46A 5ghzB-1nrfA:
19.5		 5ghzB-1nrfA:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5Y_B_9F2B400_1
(BETA-LACTAMASE)		 1nrf REGULATORY PROTEIN
BLAR1
(Bacillus
licheniformis) 		6 / 12 SER A 402
SER A 450
LYS A 539
THR A 540
GLY A 541
THR A 542
 None
 0.51A 6b5yB-1nrfA:
18.9		 6b5yB-1nrfA:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5Y_D_9F2D400_1
(BETA-LACTAMASE)		 1nrf REGULATORY PROTEIN
BLAR1
(Bacillus
licheniformis) 		6 / 12 SER A 402
SER A 450
LYS A 539
THR A 540
GLY A 541
THR A 542
 None
 0.52A 6b5yD-1nrfA:
18.9		 6b5yD-1nrfA:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B68_B_9F2B301_1
(BETA-LACTAMASE)		 1nrf REGULATORY PROTEIN
BLAR1
(Bacillus
licheniformis) 		6 / 12 SER A 402
SER A 450
LYS A 539
THR A 540
GLY A 541
THR A 542
 None
 0.46A 6b68B-1nrfA:
18.8		 6b68B-1nrfA:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B68_D_9F2D400_1
(BETA-LACTAMASE)		 1nrf REGULATORY PROTEIN
BLAR1
(Bacillus
licheniformis) 		5 / 12 SER A 402
SER A 450
LYS A 539
GLY A 541
THR A 542
 None
 0.49A 6b68D-1nrfA:
18.9		 6b68D-1nrfA:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B69_B_9F2B301_1
(BETA-LACTAMASE)		 1nrf REGULATORY PROTEIN
BLAR1
(Bacillus
licheniformis) 		6 / 12 SER A 402
SER A 450
LYS A 539
THR A 540
GLY A 541
THR A 542
 None
 0.52A 6b69A-1nrfA:
18.9
6b69B-1nrfA:
18.8		 6b69A-1nrfA:
14.34
6b69B-1nrfA:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B69_D_9F2D301_1
(BETA-LACTAMASE)		 1nrf REGULATORY PROTEIN
BLAR1
(Bacillus
licheniformis) 		6 / 12 SER A 402
SER A 450
LYS A 539
THR A 540
GLY A 541
THR A 542
 None
 0.50A 6b69D-1nrfA:
18.8		 6b69D-1nrfA:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B6A_B_9F2B301_1
(BETA-LACTAMASE)		 1nrf REGULATORY PROTEIN
BLAR1
(Bacillus
licheniformis) 		6 / 12 SER A 402
SER A 450
LYS A 539
THR A 540
GLY A 541
THR A 542
 None
 0.50A 6b6aB-1nrfA:
18.8		 6b6aB-1nrfA:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B6A_D_9F2D301_1
(BETA-LACTAMASE)		 1nrf REGULATORY PROTEIN
BLAR1
(Bacillus
licheniformis) 		6 / 12 SER A 402
SER A 450
LYS A 539
THR A 540
GLY A 541
THR A 542
 None
 0.49A 6b6aD-1nrfA:
18.7		 6b6aD-1nrfA:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B6C_A_9F2A301_1
(BETA-LACTAMASE)		 1nrf REGULATORY PROTEIN
BLAR1
(Bacillus
licheniformis) 		6 / 12 SER A 402
SER A 450
LYS A 539
THR A 540
GLY A 541
THR A 542
 None
 0.56A 6b6cA-1nrfA:
18.9		 6b6cA-1nrfA:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B6D_A_9F2A302_1
(BETA-LACTAMASE)		 1nrf REGULATORY PROTEIN
BLAR1
(Bacillus
licheniformis) 		6 / 12 SER A 402
SER A 450
LYS A 539
THR A 540
GLY A 541
THR A 542
 None
 0.44A 6b6dA-1nrfA:
18.8		 6b6dA-1nrfA:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B6E_A_9F2A302_1
(BETA-LACTAMASE)		 1nrf REGULATORY PROTEIN
BLAR1
(Bacillus
licheniformis) 		6 / 12 SER A 402
SER A 450
LYS A 539
THR A 540
GLY A 541
THR A 542
 None
 0.53A 6b6eA-1nrfA:
19.0		 6b6eA-1nrfA:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B6F_A_9F2A301_1
(BETA-LACTAMASE)		 1nrf REGULATORY PROTEIN
BLAR1
(Bacillus
licheniformis) 		6 / 12 SER A 402
SER A 450
LYS A 539
THR A 540
GLY A 541
THR A 542
 None
 0.66A 6b6fA-1nrfA:
18.7		 6b6fA-1nrfA:
14.34