SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1nrj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EUP_A_ASDA452_1
(CYTOCHROME P450ERYF)		 1nrj SIGNAL RECOGNITION
PARTICLE RECEPTOR
ALPHA SUBUNIT
HOMOLOG
(Saccharomyces
cerevisiae) 		4 / 8 SER A 119
ILE A 122
LEU A 123
LEU A  85
 None
 0.66A 1eupA-1nrjA:
0.0		 1eupA-1nrjA:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_5
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1nrj SIGNAL RECOGNITION
PARTICLE RECEPTOR
ALPHA SUBUNIT
HOMOLOG
(Saccharomyces
cerevisiae) 		3 / 3 THR A 102
LEU A 106
VAL A 109
 None
 0.53A 1mz9E-1nrjA:
undetectable		 1mz9E-1nrjA:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NR6_A_DIFA501_1
(CYTOCHROME P450 2C5)		 1nrj SIGNAL RECOGNITION
PARTICLE RECEPTOR
BETA SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 9 LEU B 112
ALA B 152
GLY B  45
THR B 128
LEU B 171
 None
 1.08A 1nr6A-1nrjB:
undetectable		 1nr6A-1nrjB:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_C_STRC3001_1
(MINERALOCORTICOID
RECEPTOR)		 1nrj SIGNAL RECOGNITION
PARTICLE RECEPTOR
ALPHA SUBUNIT
HOMOLOG
SIGNAL RECOGNITION
PARTICLE RECEPTOR
BETA SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 12 LEU B  73
LEU B  55
LEU B  54
ARG B 237
THR A   9
 None
 1.16A 1ya3C-1nrjB:
undetectable		 1ya3C-1nrjB:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_F_SNLF6001_2
(MINERALOCORTICOID
RECEPTOR)		 1nrj SIGNAL RECOGNITION
PARTICLE RECEPTOR
ALPHA SUBUNIT
HOMOLOG
(Saccharomyces
cerevisiae) 		4 / 5 LEU A  60
LEU A  76
LEU A   5
MET A   1
 None
 1.11A 2oaxF-1nrjA:
0.0		 2oaxF-1nrjA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEO_A_LNRA200_1
(D7R4 PROTEIN)		 1nrj SIGNAL RECOGNITION
PARTICLE RECEPTOR
ALPHA SUBUNIT
HOMOLOG
(Saccharomyces
cerevisiae) 		5 / 12 TYR A  18
VAL A 109
TYR A  16
PHE A 155
MET A   1
 None
 1.47A 2qeoA-1nrjA:
undetectable		 2qeoA-1nrjA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LTW_A_HLZA300_1
(ARYLAMINE
N-ACETYLTRANSFERASE
NAT)		 1nrj SIGNAL RECOGNITION
PARTICLE RECEPTOR
ALPHA SUBUNIT
HOMOLOG
(Saccharomyces
cerevisiae) 		4 / 6 PHE A 151
VAL A  89
THR A 105
PHE A 155
 None
 1.17A 3ltwA-1nrjA:
undetectable		 3ltwA-1nrjA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGY_B_GLYB509_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1nrj SIGNAL RECOGNITION
PARTICLE RECEPTOR
ALPHA SUBUNIT
HOMOLOG
(Saccharomyces
cerevisiae) 		4 / 4 PHE A  56
THR A  53
LEU A 110
TYR A  78
 None
 1.26A 3pgyB-1nrjA:
undetectable		 3pgyB-1nrjA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TTR_A_LQZA90_1
(LACTOTRANSFERRIN)		 1nrj SIGNAL RECOGNITION
PARTICLE RECEPTOR
ALPHA SUBUNIT
HOMOLOG
SIGNAL RECOGNITION
PARTICLE RECEPTOR
BETA SUBUNIT
(Saccharomyces
cerevisiae) 		3 / 3 PRO A  10
THR A   9
LEU B  73
 None
 0.69A 3ttrA-1nrjA:
undetectable		 3ttrA-1nrjA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQ4_A_SALA601_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 1nrj SIGNAL RECOGNITION
PARTICLE RECEPTOR
ALPHA SUBUNIT
HOMOLOG
SIGNAL RECOGNITION
PARTICLE RECEPTOR
BETA SUBUNIT
(Saccharomyces
cerevisiae) 		4 / 7 LEU B  73
THR B  56
THR A   9
GLY A  12
 None
 0.92A 4eq4A-1nrjB:
1.5		 4eq4A-1nrjB:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZT_A_ACTA202_0
(RETINOL-BINDING
PROTEIN 2)		 1nrj SIGNAL RECOGNITION
PARTICLE RECEPTOR
ALPHA SUBUNIT
HOMOLOG
SIGNAL RECOGNITION
PARTICLE RECEPTOR
BETA SUBUNIT
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		4 / 6 TYR A 137
THR B  52
LEU B  55
GLN A  13
 None
MG  B   1 ( 3.0A)
None
None
 1.18A 4qztA-1nrjA:
undetectable		 4qztA-1nrjA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FXT_A_0LAA1376_1
(DNA POLYMERASE III
SUBUNIT BETA)		 1nrj SIGNAL RECOGNITION
PARTICLE RECEPTOR
BETA SUBUNIT
(Saccharomyces
cerevisiae) 		4 / 7 LEU B 102
THR B 139
ILE B 149
LEU B 217
 None
 0.88A 5fxtA-1nrjB:
undetectable		 5fxtA-1nrjB:
21.47