SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1nrz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EIZ_A_SAMA301_0
(FTSJ)		 1nrz PTS SYSTEM,
SORBOSE-SPECIFIC IIB
COMPONENT
(Klebsiella
pneumoniae) 		5 / 12 GLY A 106
GLY A 107
LEU A 155
LEU A 141
LYS A 114
 None
 1.00A 1eizA-1nrzA:
undetectable		 1eizA-1nrzA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETB_1_T441128_1
(TRANSTHYRETIN)		 1nrz PTS SYSTEM,
SORBOSE-SPECIFIC IIB
COMPONENT
(Klebsiella
pneumoniae) 		4 / 6 MET A  56
LEU A  48
ALA A  51
LEU A  47
 None
 1.07A 1etb1-1nrzA:
0.0		 1etb1-1nrzA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_A_BEZA1001_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 1nrz PTS SYSTEM,
SORBOSE-SPECIFIC IIB
COMPONENT
(Klebsiella
pneumoniae) 		5 / 9 LEU A 103
LEU A 143
LEU A 141
ILE A 154
ILE A   9
 None
 1.13A 2f78A-1nrzA:
undetectable		 2f78A-1nrzA:
25.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_C_X2NC1479_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 1nrz PTS SYSTEM,
SORBOSE-SPECIFIC IIB
COMPONENT
(Klebsiella
pneumoniae) 		5 / 12 PRO A  87
VAL A  90
ALA A 120
THR A 118
LEU A 143
 None
 0.98A 2x2nC-1nrzA:
undetectable		 2x2nC-1nrzA:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_A_VDYA6178_1
(VITAMIN D
HYDROXYLASE)		 1nrz PTS SYSTEM,
SORBOSE-SPECIFIC IIB
COMPONENT
(Klebsiella
pneumoniae) 		5 / 11 MET A 108
ILE A   9
ILE A 154
VAL A 139
LEU A 134
 None
 1.22A 3a51A-1nrzA:
undetectable		 3a51A-1nrzA:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_C_VDYC6178_1
(VITAMIN D
HYDROXYLASE)		 1nrz PTS SYSTEM,
SORBOSE-SPECIFIC IIB
COMPONENT
(Klebsiella
pneumoniae) 		5 / 12 MET A 108
ILE A   9
ILE A 154
VAL A 139
LEU A 134
 None
 1.16A 3a51C-1nrzA:
undetectable		 3a51C-1nrzA:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_D_VDYD6178_1
(VITAMIN D
HYDROXYLASE)		 1nrz PTS SYSTEM,
SORBOSE-SPECIFIC IIB
COMPONENT
(Klebsiella
pneumoniae) 		5 / 12 MET A 108
ILE A   9
ILE A 154
VAL A 139
LEU A 134
 None
 1.20A 3a51D-1nrzA:
0.0		 3a51D-1nrzA:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_E_VDYE6178_1
(VITAMIN D
HYDROXYLASE)		 1nrz PTS SYSTEM,
SORBOSE-SPECIFIC IIB
COMPONENT
(Klebsiella
pneumoniae) 		5 / 12 MET A 108
ILE A   9
ILE A 154
VAL A 139
LEU A 134
 None
 1.18A 3a51E-1nrzA:
undetectable		 3a51E-1nrzA:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM4_V_DR7V100_2
(PROTEASE)		 1nrz PTS SYSTEM,
SORBOSE-SPECIFIC IIB
COMPONENT
(Klebsiella
pneumoniae) 		5 / 10 ASP A 127
ILE A   9
GLY A 107
VAL A 152
ILE A 154
 None
 1.05A 3em4V-1nrzA:
undetectable		 3em4V-1nrzA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y03_A_SALA801_1
(PROTEIN POLYBROMO-1)		 1nrz PTS SYSTEM,
SORBOSE-SPECIFIC IIB
COMPONENT
(Klebsiella
pneumoniae) 		4 / 7 ILE A 128
ALA A 162
ASN A 159
ILE A 158
 None
 0.77A 4y03A-1nrzA:
undetectable		 4y03A-1nrzA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6J_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 1nrz PTS SYSTEM,
SORBOSE-SPECIFIC IIB
COMPONENT
(Klebsiella
pneumoniae) 		3 / 3 MET A 108
ASP A 124
ARG A 132
 None
 1.06A 5z6jA-1nrzA:
2.6		 5z6jA-1nrzA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJ2_B_AB1B201_0
(HIV-1 PROTEASE)		 1nrz PTS SYSTEM,
SORBOSE-SPECIFIC IIB
COMPONENT
(Klebsiella
pneumoniae) 		5 / 10 ASP A 127
ILE A   9
GLY A 107
VAL A 152
ILE A 154
 None
 0.96A 6dj2A-1nrzA:
undetectable		 6dj2A-1nrzA:
19.75