SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1nst'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DXR_A_SORA1002_0
(LACTOTRANSFERRIN)		 1nst HEPARAN SULFATE
N-DEACETYLASE/N-SULF
OTRANSFERASE
(Homo
sapiens) 		3 / 3 THR A 615
PRO A 706
TYR A 757
 A3P  A 301 (-4.9A)
None
None
 0.92A 2dxrA-1nstA:
0.0		 2dxrA-1nstA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_B_SAMB500_1
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 1nst HEPARAN SULFATE
N-DEACETYLASE/N-SULF
OTRANSFERASE
(Homo
sapiens) 		4 / 6 THR A 759
ARG A 763
THR A 615
ASP A 708
 None
None
A3P  A 301 (-4.9A)
None
 1.13A 2okcB-1nstA:
undetectable		 2okcB-1nstA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ERD_B_DESB800_1
(ESTROGEN RECEPTOR
ALPHA)		 1nst HEPARAN SULFATE
N-DEACETYLASE/N-SULF
OTRANSFERASE
(Homo
sapiens) 		5 / 10 ALA A 758
GLU A 762
LEU A 863
LEU A 862
LEU A 703
 None
 1.44A 3erdB-1nstA:
undetectable		 3erdB-1nstA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JAY_A_SAMA1102_0
(STRUCTURAL PROTEIN
VP3)		 1nst HEPARAN SULFATE
N-DEACETYLASE/N-SULF
OTRANSFERASE
(Homo
sapiens) 		5 / 12 ILE A 704
GLY A 616
ALA A 619
PRO A 612
ALA A 678
 None
A3P  A 301 (-3.2A)
A3P  A 301 ( 3.7A)
None
None
 1.03A 3jayA-1nstA:
0.0		 3jayA-1nstA:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID800_0
(GLUTAMATE RECEPTOR 2)		 1nst HEPARAN SULFATE
N-DEACETYLASE/N-SULF
OTRANSFERASE
(Homo
sapiens) 		4 / 7 SER A 632
TYR A 804
MET A 626
LEU A 624
 None
 1.43A 3lslA-1nstA:
undetectable
3lslD-1nstA:
undetectable		 3lslA-1nstA:
21.35
3lslD-1nstA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1479_0
(MJ0495-LIKE PROTEIN)		 1nst HEPARAN SULFATE
N-DEACETYLASE/N-SULF
OTRANSFERASE
(Homo
sapiens) 		4 / 5 THR A 617
ILE A 609
LYS A 676
GLU A 675
 A3P  A 301 (-3.0A)
None
A3P  A 301 ( 4.5A)
None
 1.27A 4ac9C-1nstA:
2.9		 4ac9C-1nstA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1479_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 1nst HEPARAN SULFATE
N-DEACETYLASE/N-SULF
OTRANSFERASE
(Homo
sapiens) 		4 / 5 THR A 617
ILE A 609
LYS A 676
GLU A 675
 A3P  A 301 (-3.0A)
None
A3P  A 301 ( 4.5A)
None
 1.27A 4acaC-1nstA:
5.3		 4acaC-1nstA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1479_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 1nst HEPARAN SULFATE
N-DEACETYLASE/N-SULF
OTRANSFERASE
(Homo
sapiens) 		4 / 5 THR A 617
ILE A 609
LYS A 676
GLU A 675
 A3P  A 301 (-3.0A)
None
A3P  A 301 ( 4.5A)
None
 1.38A 4acbC-1nstA:
3.2		 4acbC-1nstA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AD9_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1nst HEPARAN SULFATE
N-DEACETYLASE/N-SULF
OTRANSFERASE
(Homo
sapiens) 		4 / 7 VAL A 775
PHE A 681
HIS A 760
GLU A 762
 None
 1.28A 5ad9A-1nstA:
undetectable
5ad9B-1nstA:
undetectable		 5ad9A-1nstA:
21.36
5ad9B-1nstA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIX_A_OQRA302_0
(SULFOTRANSFERASE)		 1nst HEPARAN SULFATE
N-DEACETYLASE/N-SULF
OTRANSFERASE
(Homo
sapiens) 		5 / 9 PRO A 871
VAL A 775
LEU A 776
ILE A 773
PHE A 681
 None
 1.35A 5tixA-1nstA:
8.7		 5tixA-1nstA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W3J_B_TA1B502_1
(TUBULIN BETA CHAIN)		 1nst HEPARAN SULFATE
N-DEACETYLASE/N-SULF
OTRANSFERASE
(Homo
sapiens) 		4 / 8 ASP A 790
HIS A 627
PRO A 785
LEU A 808
 None
 0.90A 5w3jB-1nstA:
3.0		 5w3jB-1nstA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_C_AQ4C602_0
(CYTOCHROME P450 1A1)		 1nst HEPARAN SULFATE
N-DEACETYLASE/N-SULF
OTRANSFERASE
(Homo
sapiens) 		5 / 12 LEU A 859
ASN A 856
ASP A 708
ILE A 734
LEU A 752
 None
 0.99A 6dwnC-1nstA:
0.0		 6dwnC-1nstA:
14.95