SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1nsv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG4_A_SAMA500_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 1nsv GALACTOSE MUTAROTASE
(Lactococcus
lactis) 		4 / 8 GLU A 222
GLY A 187
SER A 266
LEU A 175
 None
 0.74A 1jg4A-1nsvA:
undetectable		 1jg4A-1nsvA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AKE_A_TRPA479_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1nsv GALACTOSE MUTAROTASE
(Lactococcus
lactis) 		5 / 12 TYR A 155
THR A 168
GLY A 169
GLY A  62
CYH A 305
 None
 1.14A 2akeA-1nsvA:
undetectable		 2akeA-1nsvA:
24.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZX_A_TRPA601_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1nsv GALACTOSE MUTAROTASE
(Lactococcus
lactis) 		5 / 12 TYR A 155
THR A 168
GLY A 169
GLY A  62
CYH A 305
 None
 1.13A 2azxA-1nsvA:
undetectable		 2azxA-1nsvA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GL0_A_ADNA901_1
(CONSERVED
HYPOTHETICAL PROTEIN)		 1nsv GALACTOSE MUTAROTASE
(Lactococcus
lactis) 		5 / 10 ILE A 153
ALA A  69
ASN A 166
VAL A 269
TYR A 334
 None
 1.42A 2gl0A-1nsvA:
0.0
2gl0B-1nsvA:
0.0		 2gl0A-1nsvA:
18.02
2gl0B-1nsvA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GL0_B_ADNB902_1
(CONSERVED
HYPOTHETICAL PROTEIN)		 1nsv GALACTOSE MUTAROTASE
(Lactococcus
lactis) 		5 / 11 ILE A 153
ALA A  69
ASN A 166
VAL A 269
TYR A 334
 None
 1.47A 2gl0B-1nsvA:
undetectable
2gl0C-1nsvA:
0.0		 2gl0B-1nsvA:
18.02
2gl0C-1nsvA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GL0_C_ADNC903_1
(CONSERVED
HYPOTHETICAL PROTEIN)		 1nsv GALACTOSE MUTAROTASE
(Lactococcus
lactis) 		5 / 12 ILE A 153
ALA A  69
ASN A 166
VAL A 269
TYR A 334
 None
 1.41A 2gl0A-1nsvA:
undetectable
2gl0C-1nsvA:
undetectable		 2gl0A-1nsvA:
18.02
2gl0C-1nsvA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GL0_D_ADND904_1
(CONSERVED
HYPOTHETICAL PROTEIN)		 1nsv GALACTOSE MUTAROTASE
(Lactococcus
lactis) 		5 / 12 ILE A 153
ALA A  69
ASN A 166
VAL A 269
TYR A 334
 None
 1.45A 2gl0D-1nsvA:
undetectable
2gl0E-1nsvA:
undetectable		 2gl0D-1nsvA:
18.02
2gl0E-1nsvA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GL0_E_ADNE905_1
(CONSERVED
HYPOTHETICAL PROTEIN)		 1nsv GALACTOSE MUTAROTASE
(Lactococcus
lactis) 		5 / 11 ILE A 153
ALA A  69
ASN A 166
VAL A 269
TYR A 334
 None
 1.47A 2gl0E-1nsvA:
0.0
2gl0F-1nsvA:
0.0		 2gl0E-1nsvA:
18.02
2gl0F-1nsvA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GL0_F_ADNF906_1
(CONSERVED
HYPOTHETICAL PROTEIN)		 1nsv GALACTOSE MUTAROTASE
(Lactococcus
lactis) 		5 / 11 ILE A 153
ALA A  69
ASN A 166
VAL A 269
TYR A 334
 None
 1.41A 2gl0D-1nsvA:
0.0
2gl0F-1nsvA:
0.0		 2gl0D-1nsvA:
18.02
2gl0F-1nsvA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMZ_B_LDPB502_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE)		 1nsv GALACTOSE MUTAROTASE
(Lactococcus
lactis) 		4 / 5 GLN A 235
PHE A 195
PHE A 246
GLY A 241
 None
 1.29A 2qmzA-1nsvA:
undetectable
2qmzB-1nsvA:
undetectable		 2qmzA-1nsvA:
22.65
2qmzB-1nsvA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APX_A_Z80A190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 1nsv GALACTOSE MUTAROTASE
(Lactococcus
lactis) 		5 / 12 PHE A 173
VAL A 171
THR A 168
LEU A 248
ALA A 258
 None
 1.46A 3apxA-1nsvA:
undetectable		 3apxA-1nsvA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9M_A_SALA1200_1
(SERUM ALBUMIN)		 1nsv GALACTOSE MUTAROTASE
(Lactococcus
lactis) 		4 / 5 ILE A 102
HIS A 103
TYR A 133
GLY A  98
 None
 1.25A 3b9mA-1nsvA:
undetectable		 3b9mA-1nsvA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZG_B_NCAB302_0
(ADP-RIBOSYL CYCLASE
1)		 1nsv GALACTOSE MUTAROTASE
(Lactococcus
lactis) 		4 / 7 LEU A  14
ASP A  49
SER A  16
THR A  24
 None
 1.36A 3dzgB-1nsvA:
undetectable		 3dzgB-1nsvA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_P_TRPP1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1nsv GALACTOSE MUTAROTASE
(Lactococcus
lactis) 		4 / 7 GLY A 177
HIS A 291
ILE A  45
GLN A  38
 None
 0.88A 3fi0P-1nsvA:
undetectable		 3fi0P-1nsvA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H0A_A_9RAA500_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1nsv GALACTOSE MUTAROTASE
(Lactococcus
lactis) 		3 / 3 ILE A 278
PHE A 219
HIS A 298
 None
 0.73A 3h0aA-1nsvA:
undetectable		 3h0aA-1nsvA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW5_B_TOPB208_1
(DIHYDROFOLATE
REDUCTASE)		 1nsv GALACTOSE MUTAROTASE
(Lactococcus
lactis) 		5 / 10 ALA A  69
LEU A  95
VAL A 277
LEU A 198
THR A 168
 None
BGC  A1400 (-4.6A)
None
None
None
 1.14A 3jw5B-1nsvA:
undetectable		 3jw5B-1nsvA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKA_A_SAMA400_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE H)		 1nsv GALACTOSE MUTAROTASE
(Lactococcus
lactis) 		5 / 12 THR A 163
GLY A 135
GLY A 132
ASP A 160
GLU A 326
 None
 1.23A 3tkaA-1nsvA:
undetectable		 3tkaA-1nsvA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEV_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 1nsv GALACTOSE MUTAROTASE
(Lactococcus
lactis) 		4 / 7 ASP A  58
ASN A  96
GLU A 304
GLU A  90
 None
BGC  A1400 (-2.8A)
BGC  A1400 ( 4.8A)
None
 1.08A 4fevD-1nsvA:
undetectable		 4fevD-1nsvA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEV_E_KANE301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 1nsv GALACTOSE MUTAROTASE
(Lactococcus
lactis) 		5 / 11 GLN A 295
ASP A  58
ASN A  96
GLU A 304
GLU A  90
 None
None
BGC  A1400 (-2.8A)
BGC  A1400 ( 4.8A)
None
 1.14A 4fevE-1nsvA:
0.0		 4fevE-1nsvA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEW_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 1nsv GALACTOSE MUTAROTASE
(Lactococcus
lactis) 		4 / 8 ASP A  58
ASN A  96
GLU A 304
GLU A  90
 None
BGC  A1400 (-2.8A)
BGC  A1400 ( 4.8A)
None
 1.10A 4fewD-1nsvA:
0.0		 4fewD-1nsvA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEW_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 1nsv GALACTOSE MUTAROTASE
(Lactococcus
lactis) 		4 / 8 ASP A  58
ASN A  96
GLU A 304
GLU A  90
 None
BGC  A1400 (-2.8A)
BGC  A1400 ( 4.8A)
None
 1.11A 4fewF-1nsvA:
0.0		 4fewF-1nsvA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 1nsv GALACTOSE MUTAROTASE
(Lactococcus
lactis) 		4 / 8 ASP A  58
ASN A  96
GLU A 304
GLU A  90
 None
BGC  A1400 (-2.8A)
BGC  A1400 ( 4.8A)
None
 1.06A 4gkhF-1nsvA:
0.0		 4gkhF-1nsvA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_G_KANG301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 1nsv GALACTOSE MUTAROTASE
(Lactococcus
lactis) 		4 / 7 ASP A  58
ASN A  96
GLU A 304
GLU A  90
 None
BGC  A1400 (-2.8A)
BGC  A1400 ( 4.8A)
None
 1.11A 4gkhG-1nsvA:
0.0		 4gkhG-1nsvA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_K_KANK301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 1nsv GALACTOSE MUTAROTASE
(Lactococcus
lactis) 		4 / 8 ASP A  58
ASN A  96
GLU A 304
GLU A  90
 None
BGC  A1400 (-2.8A)
BGC  A1400 ( 4.8A)
None
 1.14A 4gkhC-1nsvA:
0.0
4gkhK-1nsvA:
0.0		 4gkhC-1nsvA:
21.55
4gkhK-1nsvA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_A_KANA301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 1nsv GALACTOSE MUTAROTASE
(Lactococcus
lactis) 		4 / 8 ASP A  58
ASN A  96
GLU A 304
GLU A  90
 None
BGC  A1400 (-2.8A)
BGC  A1400 ( 4.8A)
None
 1.06A 4gkiA-1nsvA:
0.0		 4gkiA-1nsvA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_G_KANG301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 1nsv GALACTOSE MUTAROTASE
(Lactococcus
lactis) 		4 / 8 ASP A  58
ASN A  96
GLU A 304
GLU A  90
 None
BGC  A1400 (-2.8A)
BGC  A1400 ( 4.8A)
None
 1.12A 4gkiE-1nsvA:
undetectable
4gkiG-1nsvA:
0.0		 4gkiE-1nsvA:
21.55
4gkiG-1nsvA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_J_ACTJ701_0
(RNA (33-MER)
RNA POLYMERASE
3D-POL)		 1nsv GALACTOSE MUTAROTASE
(Lactococcus
lactis) 		3 / 3 HIS A 143
GLY A  62
ILE A  34
 None
 0.63A 4k50I-1nsvA:
undetectable		 4k50I-1nsvA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1A_A_AB1A101_1
(MDR769 HIV-1
PROTEASE)		 1nsv GALACTOSE MUTAROTASE
(Lactococcus
lactis) 		5 / 11 ASN A  96
GLY A  70
ALA A  69
ILE A 276
VAL A  65
 BGC  A1400 (-2.8A)
None
None
None
None
 1.00A 4l1aA-1nsvA:
undetectable		 4l1aA-1nsvA:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1A_A_AB1A101_1
(MDR769 HIV-1
PROTEASE)		 1nsv GALACTOSE MUTAROTASE
(Lactococcus
lactis) 		5 / 11 ASN A  96
GLY A  70
ALA A  69
ILE A 278
VAL A  65
 BGC  A1400 (-2.8A)
None
None
None
None
 0.93A 4l1aA-1nsvA:
undetectable		 4l1aA-1nsvA:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L8F_D_MTXD301_1
(GAMMA-GLUTAMYL
HYDROLASE)		 1nsv GALACTOSE MUTAROTASE
(Lactococcus
lactis) 		5 / 11 GLY A  66
GLY A  97
GLY A  98
ALA A  69
GLN A  93
 None
 1.06A 4l8fD-1nsvA:
undetectable		 4l8fD-1nsvA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4POO_A_SAMA301_0
(PUTATIVE RNA
METHYLASE)		 1nsv GALACTOSE MUTAROTASE
(Lactococcus
lactis) 		5 / 12 THR A 302
GLY A 300
ASN A 174
HIS A 186
LEU A  46
 None
 1.32A 4pooA-1nsvA:
undetectable		 4pooA-1nsvA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DPD_A_SAMA601_0
(PROTEIN LYSINE
METHYLTRANSFERASE 1)		 1nsv GALACTOSE MUTAROTASE
(Lactococcus
lactis) 		5 / 12 GLU A 312
GLY A 310
GLN A 306
ILE A 314
VAL A 205
 None
 1.12A 5dpdA-1nsvA:
undetectable		 5dpdA-1nsvA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E3I_B_HISB502_0
(HISTIDINE--TRNA
LIGASE)		 1nsv GALACTOSE MUTAROTASE
(Lactococcus
lactis) 		5 / 11 GLU A 304
GLN A 306
GLY A  66
TYR A  60
ALA A  69
 BGC  A1400 ( 4.8A)
None
None
BGC  A1400 ( 4.8A)
None
 1.28A 5e3iB-1nsvA:
undetectable		 5e3iB-1nsvA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWX_A_SAMA301_1
(GLYCINE SARCOSINE
N-METHYLTRANSFERASE)		 1nsv GALACTOSE MUTAROTASE
(Lactococcus
lactis) 		3 / 3 ARG A  71
ASN A  96
ASP A  58
 BGC  A1400 (-2.9A)
BGC  A1400 (-2.8A)
None
 0.81A 5gwxA-1nsvA:
undetectable		 5gwxA-1nsvA:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DYN_A_HSMA901_0
(EBONY)		 1nsv GALACTOSE MUTAROTASE
(Lactococcus
lactis) 		4 / 4 GLU A 312
VAL A  77
LEU A  86
THR A  68
 None
 1.09A 6dynA-1nsvA:
0.0		 6dynA-1nsvA:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DYO_A_LDPA901_0
(EBONY)		 1nsv GALACTOSE MUTAROTASE
(Lactococcus
lactis) 		4 / 5 GLU A 312
VAL A  77
LEU A  86
THR A  68
 None
 1.07A 6dyoA-1nsvA:
undetectable		 6dyoA-1nsvA:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QYA_D_FOZD401_0
(THYMIDYLATE SYNTHASE)		 1nsv GALACTOSE MUTAROTASE
(Lactococcus
lactis) 		5 / 12 LEU A 260
ILE A 301
HIS A 170
PHE A 303
ILE A 242
 None
None
BGC  A1400 (-4.0A)
None
None
 1.27A 6qyaD-1nsvA:
0.0		 6qyaD-1nsvA:
23.85