SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1nt2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_A_PFLA4001_1
(SERUM ALBUMIN)		 1nt2 FIBRILLARIN-LIKE
PRE-RRNA PROCESSING
PROTEIN
(Archaeoglobus
fulgidus) 		5 / 9 LEU A 143
ILE A 142
VAL A  87
GLY A  65
ALA A 114
 None
None
None
SAM  A 301 ( 3.8A)
SAM  A 301 (-3.4A)
 1.21A 1e7aA-1nt2A:
undetectable		 1e7aA-1nt2A:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSH_C_MK1C402_2
(HIV-II PROTEASE)		 1nt2 CONSERVED
HYPOTHETICAL PROTEIN
(Archaeoglobus
fulgidus) 		4 / 8 ARG B 135
ALA B 163
GLY B 158
ILE B 142
 None
 0.71A 1hshD-1nt2B:
undetectable		 1hshD-1nt2B:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KI7_A_ID2A1_0
(THYMIDINE KINASE)		 1nt2 FIBRILLARIN-LIKE
PRE-RRNA PROCESSING
PROTEIN
(Archaeoglobus
fulgidus) 		5 / 12 ILE A  83
ILE A 108
TYR A  85
ARG A  60
GLU A 125
 None
 1.44A 1ki7A-1nt2A:
0.0		 1ki7A-1nt2A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KI7_A_ID2A1_0
(THYMIDINE KINASE)		 1nt2 FIBRILLARIN-LIKE
PRE-RRNA PROCESSING
PROTEIN
CONSERVED
HYPOTHETICAL PROTEIN
(Archaeoglobus
fulgidus;
Archaeoglobus
fulgidus) 		5 / 12 ILE A  83
ILE A 108
TYR A  85
TYR B  61
ARG A  60
 None
 1.39A 1ki7A-1nt2A:
0.0		 1ki7A-1nt2A:
22.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1NT2_A_SAMA301_0
(FIBRILLARIN-LIKE
PRE-RRNA PROCESSING
PROTEIN)		 1nt2 FIBRILLARIN-LIKE
PRE-RRNA PROCESSING
PROTEIN
(Archaeoglobus
fulgidus) 		6 / 12 GLY A  65
ALA A  66
THR A  71
TYR A  89
ILE A 134
GLN A 136
 SAM  A 301 ( 3.8A)
None
SAM  A 301 (-4.1A)
SAM  A 301 (-3.5A)
SAM  A 301 (-3.9A)
SAM  A 301 (-3.4A)
 1.47A 1nt2A-1nt2A:
42.3		 1nt2A-1nt2A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1NT2_A_SAMA301_0
(FIBRILLARIN-LIKE
PRE-RRNA PROCESSING
PROTEIN)		 1nt2 FIBRILLARIN-LIKE
PRE-RRNA PROCESSING
PROTEIN
(Archaeoglobus
fulgidus) 		12 / 12 LYS A  42
TYR A  63
GLY A  65
ALA A  67
SER A  68
THR A  71
TYR A  89
SER A  90
ALA A 114
ASP A 133
ILE A 134
GLN A 136
 SAM  A 301 (-3.0A)
None
SAM  A 301 ( 3.8A)
SAM  A 301 (-3.1A)
SAM  A 301 ( 3.8A)
SAM  A 301 (-4.1A)
SAM  A 301 (-3.5A)
SAM  A 301 ( 4.9A)
SAM  A 301 (-3.4A)
SAM  A 301 (-3.7A)
SAM  A 301 (-3.9A)
SAM  A 301 (-3.4A)
 0.00A 1nt2A-1nt2A:
42.3		 1nt2A-1nt2A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1NT2_A_SAMA301_1
(FIBRILLARIN-LIKE
PRE-RRNA PROCESSING
PROTEIN)		 1nt2 FIBRILLARIN-LIKE
PRE-RRNA PROCESSING
PROTEIN
(Archaeoglobus
fulgidus) 		3 / 3 THR A  70
GLU A  88
ASP A 113
 SAM  A 301 (-3.1A)
SAM  A 301 (-2.4A)
SAM  A 301 (-3.6A)
 0.01A 1nt2A-1nt2A:
42.3		 1nt2A-1nt2A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_B_SAMB602_1
(HYPOTHETICAL PROTEIN)		 1nt2 FIBRILLARIN-LIKE
PRE-RRNA PROCESSING
PROTEIN
(Archaeoglobus
fulgidus) 		3 / 3 GLY A  65
GLU A  88
ASP A 133
 SAM  A 301 ( 3.8A)
SAM  A 301 (-2.4A)
SAM  A 301 (-3.7A)
 0.32A 2b25B-1nt2A:
13.7		 2b25B-1nt2A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4P_A_TPVA300_2
(PROTEASE)		 1nt2 CONSERVED
HYPOTHETICAL PROTEIN
(Archaeoglobus
fulgidus) 		5 / 9 ARG B 135
LEU B  95
ALA B 163
GLY B 158
ILE B 142
 None
 0.98A 2o4pB-1nt2B:
undetectable		 2o4pB-1nt2B:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_B_CHDB927_0
(FERROCHELATASE)		 1nt2 CONSERVED
HYPOTHETICAL PROTEIN
(Archaeoglobus
fulgidus) 		3 / 3 LEU B 222
PRO B 223
ARG B 232
 None
 0.26A 2qd4B-1nt2B:
undetectable		 2qd4B-1nt2B:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIF_B_SAMB298_1
(PUTATIVE
MODIFICATION
METHYLASE)		 1nt2 FIBRILLARIN-LIKE
PRE-RRNA PROCESSING
PROTEIN
(Archaeoglobus
fulgidus) 		3 / 3 ASP A 113
THR A  71
GLU A  88
 SAM  A 301 (-3.6A)
SAM  A 301 (-4.1A)
SAM  A 301 (-2.4A)
 0.77A 2zifB-1nt2A:
4.1		 2zifB-1nt2A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARR_A_PNXA606_1
(CHITINASE A)		 1nt2 CONSERVED
HYPOTHETICAL PROTEIN
(Archaeoglobus
fulgidus) 		4 / 7 GLY B  53
ASP B  60
TYR B  61
ARG B  63
 None
 1.16A 3arrA-1nt2B:
undetectable		 3arrA-1nt2B:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA606_1
(CHITINASE A)		 1nt2 CONSERVED
HYPOTHETICAL PROTEIN
(Archaeoglobus
fulgidus) 		4 / 7 GLY B  53
ASP B  60
TYR B  61
ARG B  63
 None
 1.15A 3aruA-1nt2B:
undetectable		 3aruA-1nt2B:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUU_A_ADNA0_1
(DIMETHYLADENOSINE
TRANSFERASE)		 1nt2 FIBRILLARIN-LIKE
PRE-RRNA PROCESSING
PROTEIN
(Archaeoglobus
fulgidus) 		5 / 12 GLY A  65
GLU A  88
ASP A 113
ALA A 114
ILE A 142
 SAM  A 301 ( 3.8A)
SAM  A 301 (-2.4A)
SAM  A 301 (-3.6A)
SAM  A 301 (-3.4A)
None
 0.95A 3fuuA-1nt2A:
12.2		 3fuuA-1nt2A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HZN_D_ACTD229_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 1nt2 FIBRILLARIN-LIKE
PRE-RRNA PROCESSING
PROTEIN
(Archaeoglobus
fulgidus) 		4 / 4 ASP A 128
GLY A 155
LYS A 152
GLU A 153
 None
 1.24A 3hznD-1nt2A:
undetectable		 3hznD-1nt2A:
20.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ID5_B_SAMB301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 1nt2 FIBRILLARIN-LIKE
PRE-RRNA PROCESSING
PROTEIN
(Archaeoglobus
fulgidus) 		8 / 11 LYS A  42
THR A  70
GLU A  88
ASP A 113
ALA A 114
ASP A 133
ILE A 134
GLN A 136
 SAM  A 301 (-3.0A)
SAM  A 301 (-3.1A)
SAM  A 301 (-2.4A)
SAM  A 301 (-3.6A)
SAM  A 301 (-3.4A)
SAM  A 301 (-3.7A)
SAM  A 301 (-3.9A)
SAM  A 301 (-3.4A)
 1.23A 3id5B-1nt2A:
26.6		 3id5B-1nt2A:
41.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ID5_B_SAMB301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 1nt2 FIBRILLARIN-LIKE
PRE-RRNA PROCESSING
PROTEIN
(Archaeoglobus
fulgidus) 		9 / 11 LYS A  42
TYR A  63
GLY A  65
GLU A  88
ASP A 113
ALA A 114
ASP A 133
ILE A 134
GLN A 136
 SAM  A 301 (-3.0A)
None
SAM  A 301 ( 3.8A)
SAM  A 301 (-2.4A)
SAM  A 301 (-3.6A)
SAM  A 301 (-3.4A)
SAM  A 301 (-3.7A)
SAM  A 301 (-3.9A)
SAM  A 301 (-3.4A)
 0.81A 3id5B-1nt2A:
26.6		 3id5B-1nt2A:
41.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ID5_B_SAMB301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 1nt2 FIBRILLARIN-LIKE
PRE-RRNA PROCESSING
PROTEIN
(Archaeoglobus
fulgidus) 		9 / 11 TYR A  63
GLY A  65
THR A  71
GLU A  88
ASP A 113
ALA A 114
ASP A 133
ILE A 134
GLN A 136
 None
SAM  A 301 ( 3.8A)
SAM  A 301 (-4.1A)
SAM  A 301 (-2.4A)
SAM  A 301 (-3.6A)
SAM  A 301 (-3.4A)
SAM  A 301 (-3.7A)
SAM  A 301 (-3.9A)
SAM  A 301 (-3.4A)
 0.80A 3id5B-1nt2A:
26.6		 3id5B-1nt2A:
41.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ID5_B_SAMB301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 1nt2 FIBRILLARIN-LIKE
PRE-RRNA PROCESSING
PROTEIN
(Archaeoglobus
fulgidus) 		6 / 11 TYR A 131
THR A  71
ALA A 114
ASP A 133
ILE A 134
GLN A 136
 None
SAM  A 301 (-4.1A)
SAM  A 301 (-3.4A)
SAM  A 301 (-3.7A)
SAM  A 301 (-3.9A)
SAM  A 301 (-3.4A)
 1.48A 3id5B-1nt2A:
26.6		 3id5B-1nt2A:
41.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ID5_F_SAMF301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 1nt2 FIBRILLARIN-LIKE
PRE-RRNA PROCESSING
PROTEIN
(Archaeoglobus
fulgidus) 		8 / 11 LYS A  42
THR A  70
GLU A  88
ASP A 113
ALA A 114
ASP A 133
ILE A 134
GLN A 136
 SAM  A 301 (-3.0A)
SAM  A 301 (-3.1A)
SAM  A 301 (-2.4A)
SAM  A 301 (-3.6A)
SAM  A 301 (-3.4A)
SAM  A 301 (-3.7A)
SAM  A 301 (-3.9A)
SAM  A 301 (-3.4A)
 1.23A 3id5F-1nt2A:
26.7		 3id5F-1nt2A:
41.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ID5_F_SAMF301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 1nt2 FIBRILLARIN-LIKE
PRE-RRNA PROCESSING
PROTEIN
(Archaeoglobus
fulgidus) 		9 / 11 LYS A  42
TYR A  63
GLY A  65
GLU A  88
ASP A 113
ALA A 114
ASP A 133
ILE A 134
GLN A 136
 SAM  A 301 (-3.0A)
None
SAM  A 301 ( 3.8A)
SAM  A 301 (-2.4A)
SAM  A 301 (-3.6A)
SAM  A 301 (-3.4A)
SAM  A 301 (-3.7A)
SAM  A 301 (-3.9A)
SAM  A 301 (-3.4A)
 0.80A 3id5F-1nt2A:
26.7		 3id5F-1nt2A:
41.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ID5_F_SAMF301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 1nt2 FIBRILLARIN-LIKE
PRE-RRNA PROCESSING
PROTEIN
(Archaeoglobus
fulgidus) 		9 / 11 TYR A  63
GLY A  65
THR A  71
GLU A  88
ASP A 113
ALA A 114
ASP A 133
ILE A 134
GLN A 136
 None
SAM  A 301 ( 3.8A)
SAM  A 301 (-4.1A)
SAM  A 301 (-2.4A)
SAM  A 301 (-3.6A)
SAM  A 301 (-3.4A)
SAM  A 301 (-3.7A)
SAM  A 301 (-3.9A)
SAM  A 301 (-3.4A)
 0.79A 3id5F-1nt2A:
26.7		 3id5F-1nt2A:
41.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ID5_F_SAMF301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 1nt2 FIBRILLARIN-LIKE
PRE-RRNA PROCESSING
PROTEIN
(Archaeoglobus
fulgidus) 		6 / 11 TYR A 131
THR A  71
ALA A 114
ASP A 133
ILE A 134
GLN A 136
 None
SAM  A 301 (-4.1A)
SAM  A 301 (-3.4A)
SAM  A 301 (-3.7A)
SAM  A 301 (-3.9A)
SAM  A 301 (-3.4A)
 1.48A 3id5F-1nt2A:
26.7		 3id5F-1nt2A:
41.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ID6_C_SAMC301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 1nt2 FIBRILLARIN-LIKE
PRE-RRNA PROCESSING
PROTEIN
(Archaeoglobus
fulgidus) 		10 / 12 GLY A  65
ALA A  67
THR A  70
GLU A  88
SER A  90
ASP A 113
ALA A 114
ASP A 133
ILE A 134
GLN A 136
 SAM  A 301 ( 3.8A)
SAM  A 301 (-3.1A)
SAM  A 301 (-3.1A)
SAM  A 301 (-2.4A)
SAM  A 301 ( 4.9A)
SAM  A 301 (-3.6A)
SAM  A 301 (-3.4A)
SAM  A 301 (-3.7A)
SAM  A 301 (-3.9A)
SAM  A 301 (-3.4A)
 1.28A 3id6C-1nt2A:
27.9		 3id6C-1nt2A:
41.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ID6_C_SAMC301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 1nt2 FIBRILLARIN-LIKE
PRE-RRNA PROCESSING
PROTEIN
(Archaeoglobus
fulgidus) 		11 / 12 TYR A  63
GLY A  65
ALA A  67
THR A  71
GLU A  88
SER A  90
ASP A 113
ALA A 114
ASP A 133
ILE A 134
GLN A 136
 None
SAM  A 301 ( 3.8A)
SAM  A 301 (-3.1A)
SAM  A 301 (-4.1A)
SAM  A 301 (-2.4A)
SAM  A 301 ( 4.9A)
SAM  A 301 (-3.6A)
SAM  A 301 (-3.4A)
SAM  A 301 (-3.7A)
SAM  A 301 (-3.9A)
SAM  A 301 (-3.4A)
 0.68A 3id6C-1nt2A:
27.9		 3id6C-1nt2A:
41.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IHT_A_SAMA200_0
(S-ADENOSYL-L-METHION
INE METHYL
TRANSFERASE)		 1nt2 FIBRILLARIN-LIKE
PRE-RRNA PROCESSING
PROTEIN
(Archaeoglobus
fulgidus) 		5 / 12 GLY A  65
GLY A  69
THR A  71
ASP A 113
ASP A 133
 SAM  A 301 ( 3.8A)
None
SAM  A 301 (-4.1A)
SAM  A 301 (-3.6A)
SAM  A 301 (-3.7A)
 0.78A 3ihtA-1nt2A:
11.5		 3ihtA-1nt2A:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MB5_A_SAMA301_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 1nt2 FIBRILLARIN-LIKE
PRE-RRNA PROCESSING
PROTEIN
(Archaeoglobus
fulgidus) 		4 / 4 GLY A  65
GLU A  88
ASP A 113
ASP A 133
 SAM  A 301 ( 3.8A)
SAM  A 301 (-2.4A)
SAM  A 301 (-3.6A)
SAM  A 301 (-3.7A)
 0.48A 3mb5A-1nt2A:
16.3		 3mb5A-1nt2A:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NMU_F_SAMF228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
NOP5/NOP56 RELATED
PROTEIN)		 1nt2 FIBRILLARIN-LIKE
PRE-RRNA PROCESSING
PROTEIN
(Archaeoglobus
fulgidus) 		9 / 12 LYS A  42
GLY A  65
ALA A  67
GLU A  88
SER A  90
ASP A 113
ALA A 114
ASP A 133
GLN A 136
 SAM  A 301 (-3.0A)
SAM  A 301 ( 3.8A)
SAM  A 301 (-3.1A)
SAM  A 301 (-2.4A)
SAM  A 301 ( 4.9A)
SAM  A 301 (-3.6A)
SAM  A 301 (-3.4A)
SAM  A 301 (-3.7A)
SAM  A 301 (-3.4A)
 0.67A 3nmuA-1nt2A:
0.2
3nmuF-1nt2A:
21.3		 3nmuA-1nt2A:
21.39
3nmuF-1nt2A:
42.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NMU_J_SAMJ228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
NOP5/NOP56 RELATED
PROTEIN)		 1nt2 FIBRILLARIN-LIKE
PRE-RRNA PROCESSING
PROTEIN
(Archaeoglobus
fulgidus) 		6 / 11 GLY A  65
ALA A  67
GLU A  88
ALA A 114
ASP A 133
GLN A 136
 SAM  A 301 ( 3.8A)
SAM  A 301 (-3.1A)
SAM  A 301 (-2.4A)
SAM  A 301 (-3.4A)
SAM  A 301 (-3.7A)
SAM  A 301 (-3.4A)
 0.64A 3nmuB-1nt2A:
undetectable
3nmuJ-1nt2A:
31.3		 3nmuB-1nt2A:
21.39
3nmuJ-1nt2A:
42.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3NVK_I_SAMI228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 1nt2 FIBRILLARIN-LIKE
PRE-RRNA PROCESSING
PROTEIN
(Archaeoglobus
fulgidus) 		7 / 12 LYS A  42
GLY A  65
ALA A  67
ASP A 113
ALA A 114
ASP A 133
GLN A 136
 SAM  A 301 (-3.0A)
SAM  A 301 ( 3.8A)
SAM  A 301 (-3.1A)
SAM  A 301 (-3.6A)
SAM  A 301 (-3.4A)
SAM  A 301 (-3.7A)
SAM  A 301 (-3.4A)
 0.71A 3nvkI-1nt2A:
29.4		 3nvkI-1nt2A:
42.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3NVK_I_SAMI228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 1nt2 FIBRILLARIN-LIKE
PRE-RRNA PROCESSING
PROTEIN
(Archaeoglobus
fulgidus) 		7 / 12 LYS A  42
GLY A  65
ALA A  67
THR A  71
ASP A 113
ALA A 114
ASP A 133
 SAM  A 301 (-3.0A)
SAM  A 301 ( 3.8A)
SAM  A 301 (-3.1A)
SAM  A 301 (-4.1A)
SAM  A 301 (-3.6A)
SAM  A 301 (-3.4A)
SAM  A 301 (-3.7A)
 0.83A 3nvkI-1nt2A:
29.4		 3nvkI-1nt2A:
42.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NVK_J_SAMJ228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
NOP5/NOP56 RELATED
PROTEIN)		 1nt2 FIBRILLARIN-LIKE
PRE-RRNA PROCESSING
PROTEIN
(Archaeoglobus
fulgidus) 		7 / 12 GLY A  65
ALA A  67
GLU A  88
ASP A 113
ALA A 114
ASP A 133
GLN A 136
 SAM  A 301 ( 3.8A)
SAM  A 301 (-3.1A)
SAM  A 301 (-2.4A)
SAM  A 301 (-3.6A)
SAM  A 301 (-3.4A)
SAM  A 301 (-3.7A)
SAM  A 301 (-3.4A)
 0.76A 3nvkF-1nt2A:
0.0
3nvkJ-1nt2A:
29.4		 3nvkF-1nt2A:
21.39
3nvkJ-1nt2A:
42.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RFM_A_CFFA330_1
(ADENOSINE RECEPTOR
A2A)		 1nt2 FIBRILLARIN-LIKE
PRE-RRNA PROCESSING
PROTEIN
(Archaeoglobus
fulgidus) 		4 / 7 VAL A  61
LEU A  55
MET A   5
ILE A  78
 None
 0.97A 3rfmA-1nt2A:
undetectable		 3rfmA-1nt2A:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_A_SAMA401_1
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 1nt2 FIBRILLARIN-LIKE
PRE-RRNA PROCESSING
PROTEIN
(Archaeoglobus
fulgidus) 		4 / 5 SER A  68
THR A  70
GLU A  88
ASP A 113
 SAM  A 301 ( 3.8A)
SAM  A 301 (-3.1A)
SAM  A 301 (-2.4A)
SAM  A 301 (-3.6A)
 0.64A 3tm4A-1nt2A:
14.4		 3tm4A-1nt2A:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_B_SAMB401_1
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 1nt2 FIBRILLARIN-LIKE
PRE-RRNA PROCESSING
PROTEIN
(Archaeoglobus
fulgidus) 		4 / 5 SER A  68
THR A  70
GLU A  88
ASP A 113
 SAM  A 301 ( 3.8A)
SAM  A 301 (-3.1A)
SAM  A 301 (-2.4A)
SAM  A 301 (-3.6A)
 0.63A 3tm4B-1nt2A:
14.3		 3tm4B-1nt2A:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_A_ZPCA1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 1nt2 FIBRILLARIN-LIKE
PRE-RRNA PROCESSING
PROTEIN
(Archaeoglobus
fulgidus) 		4 / 7 TYR A 208
VAL A 157
ILE A 130
GLU A 184
 None
 1.10A 4a97E-1nt2A:
undetectable		 4a97E-1nt2A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_D_ZPCD1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 1nt2 FIBRILLARIN-LIKE
PRE-RRNA PROCESSING
PROTEIN
(Archaeoglobus
fulgidus) 		4 / 8 TYR A 208
VAL A 157
ILE A 130
GLU A 184
 None
 1.06A 4a97C-1nt2A:
0.0		 4a97C-1nt2A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_H_ZPCH1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 1nt2 FIBRILLARIN-LIKE
PRE-RRNA PROCESSING
PROTEIN
(Archaeoglobus
fulgidus) 		4 / 8 TYR A 208
VAL A 157
ILE A 130
GLU A 184
 None
 1.01A 4a97G-1nt2A:
0.0		 4a97G-1nt2A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_J_ZPCJ1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 1nt2 FIBRILLARIN-LIKE
PRE-RRNA PROCESSING
PROTEIN
(Archaeoglobus
fulgidus) 		4 / 8 TYR A 208
VAL A 157
ILE A 130
GLU A 184
 None
 1.06A 4a97I-1nt2A:
undetectable		 4a97I-1nt2A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CCQ_A_ACTA1317_0
(THIOREDOXIN
REDUCTASE)		 1nt2 CONSERVED
HYPOTHETICAL PROTEIN
(Archaeoglobus
fulgidus) 		3 / 3 LEU B 255
GLU B 253
SER B 258
 None
 0.79A 4ccqA-1nt2B:
undetectable		 4ccqA-1nt2B:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF2_A_4CHA506_0
(NADPH DEHYDROGENASE)		 1nt2 FIBRILLARIN-LIKE
PRE-RRNA PROCESSING
PROTEIN
(Archaeoglobus
fulgidus) 		4 / 6 THR A  71
HIS A 199
HIS A 202
TYR A  63
 SAM  A 301 (-4.1A)
None
None
None
 1.35A 4df2A-1nt2A:
undetectable		 4df2A-1nt2A:
20.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DF3_A_SAMA301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 1nt2 FIBRILLARIN-LIKE
PRE-RRNA PROCESSING
PROTEIN
(Archaeoglobus
fulgidus) 		6 / 12 GLY A  65
ALA A  67
THR A  70
ASP A 113
ALA A 114
ASP A 133
 SAM  A 301 ( 3.8A)
SAM  A 301 (-3.1A)
SAM  A 301 (-3.1A)
SAM  A 301 (-3.6A)
SAM  A 301 (-3.4A)
SAM  A 301 (-3.7A)
 0.50A 4df3A-1nt2A:
26.1		 4df3A-1nt2A:
44.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DF3_A_SAMA301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 1nt2 FIBRILLARIN-LIKE
PRE-RRNA PROCESSING
PROTEIN
(Archaeoglobus
fulgidus) 		6 / 12 GLY A  65
ALA A  67
THR A  70
ASP A 113
ALA A 114
GLN A 136
 SAM  A 301 ( 3.8A)
SAM  A 301 (-3.1A)
SAM  A 301 (-3.1A)
SAM  A 301 (-3.6A)
SAM  A 301 (-3.4A)
SAM  A 301 (-3.4A)
 0.69A 4df3A-1nt2A:
26.1		 4df3A-1nt2A:
44.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DF3_A_SAMA301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 1nt2 FIBRILLARIN-LIKE
PRE-RRNA PROCESSING
PROTEIN
(Archaeoglobus
fulgidus) 		6 / 12 LYS A  42
GLY A  65
ALA A  67
ASP A 113
ALA A 114
ASP A 133
 SAM  A 301 (-3.0A)
SAM  A 301 ( 3.8A)
SAM  A 301 (-3.1A)
SAM  A 301 (-3.6A)
SAM  A 301 (-3.4A)
SAM  A 301 (-3.7A)
 0.64A 4df3A-1nt2A:
26.1		 4df3A-1nt2A:
44.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DF3_A_SAMA301_1
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 1nt2 FIBRILLARIN-LIKE
PRE-RRNA PROCESSING
PROTEIN
(Archaeoglobus
fulgidus) 		3 / 3 TYR A  63
THR A  71
GLU A  88
 None
SAM  A 301 (-4.1A)
SAM  A 301 (-2.4A)
 0.35A 4df3A-1nt2A:
26.1		 4df3A-1nt2A:
44.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DF3_B_SAMB301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 1nt2 FIBRILLARIN-LIKE
PRE-RRNA PROCESSING
PROTEIN
(Archaeoglobus
fulgidus) 		6 / 12 GLY A  65
ALA A  67
THR A  70
ASP A 113
ALA A 114
ASP A 133
 SAM  A 301 ( 3.8A)
SAM  A 301 (-3.1A)
SAM  A 301 (-3.1A)
SAM  A 301 (-3.6A)
SAM  A 301 (-3.4A)
SAM  A 301 (-3.7A)
 0.54A 4df3B-1nt2A:
26.3		 4df3B-1nt2A:
44.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DF3_B_SAMB301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 1nt2 FIBRILLARIN-LIKE
PRE-RRNA PROCESSING
PROTEIN
(Archaeoglobus
fulgidus) 		6 / 12 GLY A  65
ALA A  67
THR A  70
ASP A 113
ALA A 114
GLN A 136
 SAM  A 301 ( 3.8A)
SAM  A 301 (-3.1A)
SAM  A 301 (-3.1A)
SAM  A 301 (-3.6A)
SAM  A 301 (-3.4A)
SAM  A 301 (-3.4A)
 0.74A 4df3B-1nt2A:
26.3		 4df3B-1nt2A:
44.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DF3_B_SAMB301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 1nt2 FIBRILLARIN-LIKE
PRE-RRNA PROCESSING
PROTEIN
(Archaeoglobus
fulgidus) 		6 / 12 LYS A  42
GLY A  65
ALA A  67
ASP A 113
ALA A 114
ASP A 133
 SAM  A 301 (-3.0A)
SAM  A 301 ( 3.8A)
SAM  A 301 (-3.1A)
SAM  A 301 (-3.6A)
SAM  A 301 (-3.4A)
SAM  A 301 (-3.7A)
 0.61A 4df3B-1nt2A:
26.3		 4df3B-1nt2A:
44.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DF3_B_SAMB301_1
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 1nt2 FIBRILLARIN-LIKE
PRE-RRNA PROCESSING
PROTEIN
(Archaeoglobus
fulgidus) 		3 / 3 TYR A  63
THR A  71
GLU A  88
 None
SAM  A 301 (-4.1A)
SAM  A 301 (-2.4A)
 0.33A 4df3B-1nt2A:
26.3		 4df3B-1nt2A:
44.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJU_A_TPVA500_2
(PROTEASE)		 1nt2 CONSERVED
HYPOTHETICAL PROTEIN
(Archaeoglobus
fulgidus) 		5 / 10 ARG B 135
LEU B  95
ALA B 163
GLY B 158
ILE B 142
 None
 0.93A 4njuB-1nt2B:
undetectable		 4njuB-1nt2B:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJU_C_TPVC500_2
(PROTEASE)		 1nt2 CONSERVED
HYPOTHETICAL PROTEIN
(Archaeoglobus
fulgidus) 		5 / 10 ARG B 135
LEU B  95
ALA B 163
GLY B 158
ILE B 142
 None
 0.93A 4njuD-1nt2B:
undetectable		 4njuD-1nt2B:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_D_AERD601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 1nt2 CONSERVED
HYPOTHETICAL PROTEIN
(Archaeoglobus
fulgidus) 		4 / 5 GLY B 249
ASP B 245
GLU B  84
VAL B  89
 None
 0.73A 4nkvD-1nt2B:
0.0		 4nkvD-1nt2B:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_B_STRB601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 1nt2 CONSERVED
HYPOTHETICAL PROTEIN
(Archaeoglobus
fulgidus) 		5 / 12 LEU B 238
ALA B 150
ILE B 212
GLY B 158
ALA B 159
 None
 0.90A 4nkxB-1nt2B:
undetectable		 4nkxB-1nt2B:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6V_E_RBFE201_1
(NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT B
NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT E)		 1nt2 FIBRILLARIN-LIKE
PRE-RRNA PROCESSING
PROTEIN
(Archaeoglobus
fulgidus) 		4 / 5 HIS A 206
VAL A 157
GLU A 156
VAL A 190
 None
 1.10A 4p6vB-1nt2A:
0.0
4p6vE-1nt2A:
undetectable		 4p6vB-1nt2A:
18.84
4p6vE-1nt2A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6V_E_RBFE201_1
(NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT B
NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT E)		 1nt2 FIBRILLARIN-LIKE
PRE-RRNA PROCESSING
PROTEIN
(Archaeoglobus
fulgidus) 		4 / 5 HIS A 206
VAL A 158
GLU A 156
VAL A 190
 None
 1.45A 4p6vB-1nt2A:
0.0
4p6vE-1nt2A:
undetectable		 4p6vB-1nt2A:
18.84
4p6vE-1nt2A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YMG_B_SAMB1001_0
(PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE)		 1nt2 FIBRILLARIN-LIKE
PRE-RRNA PROCESSING
PROTEIN
(Archaeoglobus
fulgidus) 		5 / 12 GLY A  65
TYR A  89
SER A  90
ALA A 114
ASP A 133
 SAM  A 301 ( 3.8A)
SAM  A 301 (-3.5A)
SAM  A 301 ( 4.9A)
SAM  A 301 (-3.4A)
SAM  A 301 (-3.7A)
 0.50A 4ymgB-1nt2A:
12.7		 4ymgB-1nt2A:
25.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_2_BEZ2801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 1nt2 CONSERVED
HYPOTHETICAL PROTEIN
(Archaeoglobus
fulgidus) 		4 / 4 LEU B 109
ARG B 132
ILE B 128
ILE B 102
 None
 1.13A 5dzk2-1nt2B:
undetectable
5dzkM-1nt2B:
undetectable
5dzkN-1nt2B:
undetectable		 5dzk2-1nt2B:
1.29
5dzkM-1nt2B:
22.10
5dzkN-1nt2B:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_V_BEZV801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 1nt2 CONSERVED
HYPOTHETICAL PROTEIN
(Archaeoglobus
fulgidus) 		4 / 4 ILE B 128
ILE B 102
ARG B 132
LEU B 109
 None
 1.14A 5dzkh-1nt2B:
undetectable
5dzkn-1nt2B:
undetectable
5dzkv-1nt2B:
undetectable		 5dzkh-1nt2B:
22.10
5dzkn-1nt2B:
22.10
5dzkv-1nt2B:
1.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERG_B_SAMB401_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61)		 1nt2 FIBRILLARIN-LIKE
PRE-RRNA PROCESSING
PROTEIN
(Archaeoglobus
fulgidus) 		4 / 7 GLY A  65
GLU A  88
ASP A 113
ASP A 133
 SAM  A 301 ( 3.8A)
SAM  A 301 (-2.4A)
SAM  A 301 (-3.6A)
SAM  A 301 (-3.7A)
 0.62A 5ergB-1nt2A:
12.7		 5ergB-1nt2A:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_A_SAMA301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 1nt2 FIBRILLARIN-LIKE
PRE-RRNA PROCESSING
PROTEIN
(Archaeoglobus
fulgidus) 		5 / 12 ASP A 113
ALA A 114
ASP A 133
THR A  70
GLU A  88
 SAM  A 301 (-3.6A)
SAM  A 301 (-3.4A)
SAM  A 301 (-3.7A)
SAM  A 301 (-3.1A)
SAM  A 301 (-2.4A)
 0.98A 5hfjA-1nt2A:
4.0		 5hfjA-1nt2A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_D_SAMD301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 1nt2 FIBRILLARIN-LIKE
PRE-RRNA PROCESSING
PROTEIN
(Archaeoglobus
fulgidus) 		6 / 12 ASP A 113
ALA A 114
ASP A 133
SER A  68
THR A  70
GLU A  88
 SAM  A 301 (-3.6A)
SAM  A 301 (-3.4A)
SAM  A 301 (-3.7A)
SAM  A 301 ( 3.8A)
SAM  A 301 (-3.1A)
SAM  A 301 (-2.4A)
 1.08A 5hfjD-1nt2A:
4.0		 5hfjD-1nt2A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_E_SAME301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 1nt2 FIBRILLARIN-LIKE
PRE-RRNA PROCESSING
PROTEIN
(Archaeoglobus
fulgidus) 		6 / 12 ASP A 113
ALA A 114
ASP A 133
SER A  68
THR A  70
GLU A  88
 SAM  A 301 (-3.6A)
SAM  A 301 (-3.4A)
SAM  A 301 (-3.7A)
SAM  A 301 ( 3.8A)
SAM  A 301 (-3.1A)
SAM  A 301 (-2.4A)
 1.11A 5hfjE-1nt2A:
3.9		 5hfjE-1nt2A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_F_SAMF301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 1nt2 FIBRILLARIN-LIKE
PRE-RRNA PROCESSING
PROTEIN
(Archaeoglobus
fulgidus) 		5 / 12 ASP A 113
ALA A 114
ASP A 133
SER A  68
GLU A  88
 SAM  A 301 (-3.6A)
SAM  A 301 (-3.4A)
SAM  A 301 (-3.7A)
SAM  A 301 ( 3.8A)
SAM  A 301 (-2.4A)
 0.74A 5hfjF-1nt2A:
3.7		 5hfjF-1nt2A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_A_CUA602_0
(THIOCYANATE
DEHYDROGENASE)		 1nt2 FIBRILLARIN-LIKE
PRE-RRNA PROCESSING
PROTEIN
(Archaeoglobus
fulgidus) 		3 / 3 LYS A  42
HIS A 202
HIS A 199
 SAM  A 301 (-3.0A)
None
None
 1.27A 5oexA-1nt2A:
0.0		 5oexA-1nt2A:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_B_CUB602_0
(THIOCYANATE
DEHYDROGENASE)		 1nt2 FIBRILLARIN-LIKE
PRE-RRNA PROCESSING
PROTEIN
(Archaeoglobus
fulgidus) 		3 / 3 LYS A  42
HIS A 202
HIS A 199
 SAM  A 301 (-3.0A)
None
None
 1.30A 5oexB-1nt2A:
0.0		 5oexB-1nt2A:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_C_CUC603_0
(THIOCYANATE
DEHYDROGENASE)		 1nt2 FIBRILLARIN-LIKE
PRE-RRNA PROCESSING
PROTEIN
(Archaeoglobus
fulgidus) 		3 / 3 LYS A  42
HIS A 202
HIS A 199
 SAM  A 301 (-3.0A)
None
None
 1.28A 5oexC-1nt2A:
0.0		 5oexC-1nt2A:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_D_CUD603_0
(THIOCYANATE
DEHYDROGENASE)		 1nt2 FIBRILLARIN-LIKE
PRE-RRNA PROCESSING
PROTEIN
(Archaeoglobus
fulgidus) 		3 / 3 LYS A  42
HIS A 202
HIS A 199
 SAM  A 301 (-3.0A)
None
None
 1.25A 5oexD-1nt2A:
0.0		 5oexD-1nt2A:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_A_8LXA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1nt2 FIBRILLARIN-LIKE
PRE-RRNA PROCESSING
PROTEIN
(Archaeoglobus
fulgidus) 		5 / 12 LEU A  55
LEU A 195
ILE A  47
MET A 160
LEU A 180
 None
 1.28A 5y2tA-1nt2A:
0.0		 5y2tA-1nt2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA609_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 1nt2 FIBRILLARIN-LIKE
PRE-RRNA PROCESSING
PROTEIN
(Archaeoglobus
fulgidus) 		3 / 3 HIS A 206
HIS A  51
ARG A  52
 None
 1.03A 6b58A-1nt2A:
3.5		 6b58A-1nt2A:
16.29